Well to moderately differentiated HCC manifesting hyperattenuation on both CT during arteriography and arterial portography

Soo Ryang Kim, Susumu Imoto, Hirotsugu Ikawa, Kenji Ando, Keiji Mita, Shuichi Fuki, Michiie Sakamoto, Yoshihiro Kanbara, Toshiyuki Matsuoka, Masatoshi Kudo, Yoshitake Hayashi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We present a rare case of well- to moderately-differentiated hepatocellular carcinoma (HCC) in a 71-year-old woman with hepatitis C virus-related cirrhosis and unusual radiologic features. A 20-mm hypoechoic nodule disclosed by ultrasound in segment two showed hyperattenuation on both computed tomography hepatic arteriography and computed tomography during arterial portography. Contrast-enhanced ultrasound revealed hypervascularity in the early vascular phase and defect in the post-vascular phase, with the same pattern detected by the two imaging techniques. SPIO-MRI revealed a hyperintense nodule. These findings were compatible with those of moderately-differentiated HCC. An ultrasound-guided biopsy showed histological features of well- to moderately-differentiated HCC characterized by more than two-fold the cellularity of the non-tumorous area, fatty change, clear cell change and mild cell atypia with a thin to mid-trabecular pattern. Further studies may provide insights into the correlation between tumor neovascularity in multistep hepatocarcinogenesis and dual hemodynamics, including the artery and the portal vein.

Original languageEnglish
Pages (from-to)5775-5778
Number of pages4
JournalWorld Journal of Gastroenterology
Volume13
Issue number43
DOIs
Publication statusPublished - 2007 Nov 21

Keywords

  • CT during arterial portography
  • CT hepatic arteriography
  • Dual hemodynamics
  • Hepatocarcinogenesis
  • Hperattenuation
  • Well- to moderately-differentiated hepatocellular carcinoma

ASJC Scopus subject areas

  • Gastroenterology

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