What can we learn from gene expression profiling of mouse oocytes?

Toshio Hamatani, Mitsutoshi Yamada, Hidenori Akutsu, Naoaki Kuji, Yoshiyuki Mochimaru, Mitsuko Takano, Masashi Toyoda, Kenji Miyado, Akihiro Umezawa, Yasunori Yoshimura

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32 Citations (Scopus)

Abstract

Mammalian ooplasm supports the preimplantation development and reprograms the introduced nucleus transferred from a somatic cell to confer pluripotency in a cloning experiment. However, the underlying molecular mechanisms of oocyte competence remain unknown. Recent advances in microarray technologies have allowed gene expression profiling of such tiny specimens as oocytes and preimplantation embryos, generating a flood of information about gene expressions. So, what can we learn from it? Here, we review the initiative global gene expression studies of mouse and/or human oocytes, focusing on the lists of maternal transcripts and their expression patterns during oogenesis and preimplantation development. Especially, the genes expressed exclusively in oocytes should contribute to the uniqueness of oocyte competence, driving mammalian development systems of oocytes and preimplantation embryos. Furthermore, we discuss future directions for oocyte gene expression profiling, including discovering biomarkers of oocyte quality and exploiting the microarray data for 'making oocytes'.

Original languageEnglish
Pages (from-to)581-592
Number of pages12
JournalReproduction
Volume135
Issue number5
DOIs
Publication statusPublished - 2008 May

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ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Cell Biology
  • Endocrinology
  • Embryology

Cite this

Hamatani, T., Yamada, M., Akutsu, H., Kuji, N., Mochimaru, Y., Takano, M., Toyoda, M., Miyado, K., Umezawa, A., & Yoshimura, Y. (2008). What can we learn from gene expression profiling of mouse oocytes? Reproduction, 135(5), 581-592. https://doi.org/10.1530/REP-07-0430