White matter endophenotypes and correlates for the clinical diagnosis of autism spectrum disorder

Bun Yamagata, Takashi Itahashi, Motoaki Nakamura, Masaru Mimura, Ryu Ichiro Hashimoto, Nobumasa Kato, Yuta Aoki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Since prior diffusion tensor imaging (DTI) studies reported no significant differences in white matter organizations between individuals with autism spectrum disorder (ASD) and their unaffected siblings, the neural correlates for developing a clinical diagnosis among people with endophenotypes remain undetermined. We obtained DTI data from a total of 60 participants consisting of 30 people with endophenotypes and 30 people without. We first followed a conventional approach by comparing individuals with ASD and their unaffected siblings. Using region-of-interest approach, we then performed bootstrapping to examine whether the differences in white matter organizations between individuals with ASD and their unaffected siblings were substantially large, considering the distribution of differences between typically developing (TD) siblings. Conventional approaches revealed no significant differences in white matter organizations between individuals with ASD and their unaffected siblings. Bootstrapping revealed a significantly large difference in axial diffusivity in the left stria terminalis between individuals with ASD and their unaffected siblings after accounting for the distribution of differences in axial diffusivity among TD siblings (99.998 percentile). The results remained significant after controlling for multiple comparisons with Bonferroni method. We assumed that one aspect of this tract was associated with the development of a clinical diagnosis.

Original languageEnglish
Pages (from-to)765-773
Number of pages9
JournalSocial Cognitive and Affective Neuroscience
Volume13
Issue number7
DOIs
Publication statusPublished - 2018 Jan 1

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Keywords

  • ASD
  • Bootstrapping
  • Diffusion tensor imaging
  • Endophenotypes
  • Siblings

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

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