Whole-cell simulation: A grand challenge of the 21st century

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Study of the cell will never be complete unless its dynamic behavior is understood. The complex behavior of the cell cannot be determined or predicted unless a computer model of the cell is constructed and computer simulation is undertaken. Rapid accumulation of biological data from genome, proteome, transcriptome and metabolome projects can bring us to the point where it is no longer purely speculative to discuss how to construct virtual cells in silico. This article describes attempts to construct whole cell models. The E-CELL project has completed a couple of virtual cell models, and computer simulations have revealed some biological surprises.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalTrends in Biotechnology
Volume19
Issue number6
DOIs
Publication statusPublished - 2001 Jun 1

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Computer Simulation
Computer simulation
Proteome
Genes
Cells
Proteins
Metabolome
Transcriptome
Genome

ASJC Scopus subject areas

  • Bioengineering

Cite this

Whole-cell simulation : A grand challenge of the 21st century. / Tomita, Masaru.

In: Trends in Biotechnology, Vol. 19, No. 6, 01.06.2001, p. 205-210.

Research output: Contribution to journalArticle

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