Within-Subject Correlation Analysis to Detect Functional Areas Associated With Response Inhibition

Tomoko Yamasaki, Akitoshi Ogawa, Takahiro Osada, Koji Jimura, Seiki Konishi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Functional areas in fMRI studies are often detected by brain-behavior correlation, calculating across-subject correlation between the behavioral index and the brain activity related to a function of interest. Within-subject correlation analysis is also employed in a single subject level, which utilizes cognitive fluctuations in a shorter time period by correlating the behavioral index with the brain activity across trials. In the present study, the within-subject analysis was applied to the stop-signal task, a standard task to probe response inhibition, where efficiency of response inhibition can be evaluated by the stop-signal reaction time (SSRT). Since the SSRT is estimated, by definition, not in a trial basis but from pooled trials, the correlation across runs was calculated between the SSRT and the brain activity related to response inhibition. The within-subject correlation revealed negative correlations in the anterior cingulate cortex and the cerebellum. Moreover, the dissociation pattern was observed in the within-subject analysis when earlier vs. later parts of the runs were analyzed: negative correlation was dominant in earlier runs, whereas positive correlation was dominant in later runs. Regions of interest analyses revealed that the negative correlation in the anterior cingulate cortex, but not in the cerebellum, was dominant in earlier runs, suggesting multiple mechanisms associated with inhibitory processes that fluctuate on a run-by-run basis. These results indicate that the within-subject analysis compliments the across-subject analysis by highlighting different aspects of cognitive/affective processes related to response inhibition.

Original languageEnglish
Article number208
JournalFrontiers in Human Neuroscience
Volume12
DOIs
Publication statusPublished - 2018 May 22

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Gyrus Cinguli
Brain
Cerebellum
Magnetic Resonance Imaging

Keywords

  • Cognitive control
  • Executive function
  • Functional magnetic resonance imaging
  • Human
  • Performance

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Within-Subject Correlation Analysis to Detect Functional Areas Associated With Response Inhibition. / Yamasaki, Tomoko; Ogawa, Akitoshi; Osada, Takahiro; Jimura, Koji; Konishi, Seiki.

In: Frontiers in Human Neuroscience, Vol. 12, 208, 22.05.2018.

Research output: Contribution to journalArticle

Yamasaki, Tomoko ; Ogawa, Akitoshi ; Osada, Takahiro ; Jimura, Koji ; Konishi, Seiki. / Within-Subject Correlation Analysis to Detect Functional Areas Associated With Response Inhibition. In: Frontiers in Human Neuroscience. 2018 ; Vol. 12.
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