Wnt Signaling in the Niche

Toshio Suda, Fumio Arai

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

There is much interest in understanding the signals in the bone marrow niche that keep hematopoietic stem cells (HSCs) in a quiescent state. In the current issue of Cell Stem Cell, Fleming et al. (2008) report that blocking Wnt signaling in the niche increases the number of proliferating HSCs and reduces their ability to reconstitute the hematopoietic system of irradiated recipient mice. These findings show that Wnt/β-catenin activity is crucial for the maintenance of HSC quiescence in the bone marrow niche.

Original languageEnglish
Pages (from-to)729-730
Number of pages2
JournalCell
Volume132
Issue number5
DOIs
Publication statusPublished - 2008 Mar 7

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Hematopoietic Stem Cells
Stem cells
Bone Marrow
Hematopoietic System
Catenins
Bone
Stem Cells
Maintenance

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Suda, T., & Arai, F. (2008). Wnt Signaling in the Niche. Cell, 132(5), 729-730. https://doi.org/10.1016/j.cell.2008.02.017

Wnt Signaling in the Niche. / Suda, Toshio; Arai, Fumio.

In: Cell, Vol. 132, No. 5, 07.03.2008, p. 729-730.

Research output: Contribution to journalArticle

Suda, T & Arai, F 2008, 'Wnt Signaling in the Niche', Cell, vol. 132, no. 5, pp. 729-730. https://doi.org/10.1016/j.cell.2008.02.017
Suda, Toshio ; Arai, Fumio. / Wnt Signaling in the Niche. In: Cell. 2008 ; Vol. 132, No. 5. pp. 729-730.
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