Work engagement and high-sensitivity C-reactive protein levels among Japanese workers: a 1-year prospective cohort study

Hisashi Eguchi, Akihito Shimazu, Norito Kawakami, Akiomi Inoue, Akinori Nakata, Akizumi Tsutsumi

Research output: Contribution to journalArticle

11 Citations (Scopus)


Purpose: Evidence on the association between psychological well-being and high-sensitivity C-reactive protein (hs-CRP) levels is limited. We carried out a prospective study to investigate the association between work engagement and hs-CRP levels in a group of Japanese workers. Methods: Our cohort included 1,857 men and 657 women aged 65 and under, and free from major illness, working at two manufacturing worksites in Japan. Baseline examinations were conducted from April to June 2011 to determine the demographic and lifestyle characteristics and levels of work engagement. Blood samples were obtained from participants at baseline and after 1 year. Participants were classified into tertiles of low, moderate, and high work engagement at baseline. Hs-CRP levels were split into low (≤3.0 mg/L) and high (>3.0 mg/L). We used multiple logistic regression analyses to evaluate the association between work engagement at baseline and hs-CRP levels at follow-up, adjusting for hs-CRP at baseline and potential confounding factors. Results: Participants reporting moderate and high levels of work engagement at baseline had significantly lower odds ratios (ORs) of having high hs-CRP levels at follow-up than those with low levels of work engagement at baseline [OR of moderate level 0.44, 95 % confidence interval (CI) 0.24–0.81; OR of high level 0.57, 95 % CI 0.33–0.99; p for trend <0.05]. Conclusion: Findings suggest that work engagement has beneficial effects on workers’ cardiovascular health.

Original languageEnglish
Pages (from-to)651-658
Number of pages8
JournalInternational Archives of Occupational and Environmental Health
Issue number6
Publication statusPublished - 2015 Aug 27
Externally publishedYes



  • C-reactive protein
  • Cardiovascular disease
  • Inflammation
  • Prospective studies
  • Work engagement

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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