TY - JOUR
T1 - Xanthones and a benzophenone from the roots of Pentadesma butyracea and their antiproliferative activity
AU - Wabo, Hippolyte K.
AU - Kikuchi, Haruhisa
AU - Katou, Yasuhiro
AU - Tane, Pierre
AU - Oshima, Yoshiteru
N1 - Funding Information:
H.K.W. is grateful to The Matsumae International Foundation (MIF) for a four-month fellowship at the Graduate School of Pharmaceutical Sciences, Tohoku University, Japan.
PY - 2010/6/11
Y1 - 2010/6/11
N2 - A new xanthone, 3,4-dihydro-8,10,12-trihydroxy-2,2-dimethylpyrano[2,3-b]xanthen-11(2H)-one or butyraxanthone E (1), along with the known compounds 30-epi-cambogin (2), 1,7-dihydroxyxanthone (3) and 1,5-dihydroxyxanthone (4) were isolated from the roots of Pentadesma butyracea. Their structures were elucidated by spectroscopic means and comparison with published data. Their antiproliferative activities were evaluated against Drosophila S2 cells and two human cancer cell lines, THP-1 (leukemia) and HCT116 (colon cancer). Compounds 1 and 2 showed moderate antiproliferative activity against Drosophila S2 cells and the HCT116 cell line, respectively. Compound 2 was active against Drosophila S2 cells.
AB - A new xanthone, 3,4-dihydro-8,10,12-trihydroxy-2,2-dimethylpyrano[2,3-b]xanthen-11(2H)-one or butyraxanthone E (1), along with the known compounds 30-epi-cambogin (2), 1,7-dihydroxyxanthone (3) and 1,5-dihydroxyxanthone (4) were isolated from the roots of Pentadesma butyracea. Their structures were elucidated by spectroscopic means and comparison with published data. Their antiproliferative activities were evaluated against Drosophila S2 cells and two human cancer cell lines, THP-1 (leukemia) and HCT116 (colon cancer). Compounds 1 and 2 showed moderate antiproliferative activity against Drosophila S2 cells and the HCT116 cell line, respectively. Compound 2 was active against Drosophila S2 cells.
KW - Antiproliferative activity
KW - Benzophenone
KW - Butyraxanthone E
KW - Guttiferae
KW - Pentadesma butyracea
KW - Xanthone
UR - http://www.scopus.com/inward/record.url?scp=77951974926&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951974926&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2010.02.006
DO - 10.1016/j.phytol.2010.02.006
M3 - Article
AN - SCOPUS:77951974926
VL - 3
SP - 104
EP - 107
JO - Phytochemistry Letters
JF - Phytochemistry Letters
SN - 1874-3900
IS - 2
ER -