Xylogranin B: A potent Wnt signal inhibitory limonoid from Xylocarpus granatum

Kazufumi Toume, Kentaro Kamiya, Midori A. Arai, Naomi Mori, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Xylogranin B (2) was isolated from Xylocarpus granatum (Meliaceae) leaves, by use of a cell-based luciferase screening system targeting a Wnt signaling pathway. Compound 2 inhibited TCF/β-catenin transcriptional activity (IC50 48.9 nM) and exhibited strong cytotoxicity against colon cancer cell lines. Compound 2 significantly decreased β-catenin protein levels in nuclei but not in the cytosol. These results indicated that a decrease in β-catenin levels in nuclei by 2 resulted in the Wnt signal inhibitory effects of 2.

Original languageEnglish
Pages (from-to)6106-6109
Number of pages4
JournalOrganic Letters
Volume15
Issue number23
DOIs
Publication statusPublished - 2013 Dec 6
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Toume, K., Kamiya, K., Arai, M. A., Mori, N., Sadhu, S. K., Ahmed, F., & Ishibashi, M. (2013). Xylogranin B: A potent Wnt signal inhibitory limonoid from Xylocarpus granatum. Organic Letters, 15(23), 6106-6109. https://doi.org/10.1021/ol4029995