Yamadazyma farinosa IFO 10896-mediated reduction of 4,4-dimethoxy-2- butanone as the key-step for the preparation of 1,3-diols with unsymmetrical substituents

Takahiro Yamazaki, Atsuhito Kuboki, Hiromichi Ohta, Thomas M. Mitzel, Leo A. Paquette, Takeshi Sugai

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(R)-4,4-Dimethoxy-2-butanol was prepared with the action of Yamadazyma farinosa IFO 10896 on 4,4-dimethoxy-2-butanone, and subsequently converted to (2R,4R)- and (2R,4S)-isomers of 6-hepten-2,4-diol by the treatment with allyl bromide and indium in aqueous solution.

Original languageEnglish
Pages (from-to)3061-3072
Number of pages12
JournalSynthetic Communications
Issue number16
Publication statusPublished - 2000 Jan 1


ASJC Scopus subject areas

  • Organic Chemistry

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