Yamadazyma farinosa IFO 10896-mediated reduction of 4,4-dimethoxy-2- butanone as the key-step for the preparation of 1,3-diols with unsymmetrical substituents

Takahiro Yamazaki, Atsuhito Kuboki, Hiromichi Ohta, Thomas M. Mitzel, Leo A. Paquette, Takeshi Sugai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

(R)-4,4-Dimethoxy-2-butanol was prepared with the action of Yamadazyma farinosa IFO 10896 on 4,4-dimethoxy-2-butanone, and subsequently converted to (2R,4R)- and (2R,4S)-isomers of 6-hepten-2,4-diol by the treatment with allyl bromide and indium in aqueous solution.

Original languageEnglish
Pages (from-to)3061-3072
Number of pages12
JournalSynthetic Communications
Volume30
Issue number16
Publication statusPublished - 2000

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Indium
Isomers
allyl bromide
2-butanol
methylethyl ketone

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Yamadazyma farinosa IFO 10896-mediated reduction of 4,4-dimethoxy-2- butanone as the key-step for the preparation of 1,3-diols with unsymmetrical substituents. / Yamazaki, Takahiro; Kuboki, Atsuhito; Ohta, Hiromichi; Mitzel, Thomas M.; Paquette, Leo A.; Sugai, Takeshi.

In: Synthetic Communications, Vol. 30, No. 16, 2000, p. 3061-3072.

Research output: Contribution to journalArticle

Yamazaki, Takahiro ; Kuboki, Atsuhito ; Ohta, Hiromichi ; Mitzel, Thomas M. ; Paquette, Leo A. ; Sugai, Takeshi. / Yamadazyma farinosa IFO 10896-mediated reduction of 4,4-dimethoxy-2- butanone as the key-step for the preparation of 1,3-diols with unsymmetrical substituents. In: Synthetic Communications. 2000 ; Vol. 30, No. 16. pp. 3061-3072.
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AU - Mitzel, Thomas M.

AU - Paquette, Leo A.

AU - Sugai, Takeshi

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