Yokukansankachimpihange increased body weight but not food-incentive motivation in wild-type mice

Takuya Hamaguchi, Iku Tsutsui-Kimura, Kenji Tanaka, Masaru Mimura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Yokukansankachimpihange (YKSCH), a traditional Japanese medicine, is widely used for the amelioration of the behavioral and psychological symptoms of dementia with digestive dysfunction. Regardless of its successful use for digestive dysfunction, the effect of YKSCH on body weight was unknown. Furthermore, if YKSCH increased body weight, it might increase motivation according to Kampo medicine theory. Therefore, we investigated whether YKSCH had the potential to increase body weight and enhance motivation in mice. To address this, C57BL/6J mice were used to evaluate the long-term effect of YKSCH on body weight and food-incentive motivation. As part of the evaluation, we optimized an operant test for use over the long-term. We found that feeding mice YKSCH-containing chow increased body weight, but did not increase their motivation to food reward. We propose that YKSCH may be a good treatment option for preventing decrease in body weight in patients with dementia.

Original languageEnglish
Pages (from-to)351-362
Number of pages12
JournalNagoya Journal of Medical Science
Volume79
Issue number3
DOIs
Publication statusPublished - 2017 Aug 1

Keywords

  • Break point
  • Kampo
  • Long-term
  • Operant test
  • Progressive ratio

ASJC Scopus subject areas

  • Medicine(all)

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