Zamamistatin, a significant antibacterial bromotyrosine derivative, from the Okinawan sponge Pseudoceratina purpurea

Noboru Takada, Reiko Watanabe, Kiyotake Suenaga, Kaoru Yamada, Katsuhiro Ueda, Masaki Kita, Daisuke Uemura

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Zamamistatin was isolated from the Okinawan sponge Pseudoceratina purpurea. It was determined to be a novel bromotyrosine derivative by careful analysis of 2D NMR spectra and comparison of its 1H NMR spectrum with those of structurally related compounds. The absolute stereostructure of zamamistatin was determined by the modified Mosher's method. Zamamistatin exhibited significant antibacterial activity against Rhodospirillum salexigens, which has adhering properties.

Original languageEnglish
Pages (from-to)5265-5267
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number31
DOIs
Publication statusPublished - 2001 Jul 30
Externally publishedYes

Keywords

  • Absolute stereochemistry
  • Antibacterial activity
  • Antifouling agent
  • Isolation
  • Structural determination

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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