Zamamistatin, a significant antibacterial bromotyrosine derivative, from the Okinawan sponge Pseudoceratina purpurea

Noboru Takada; Reiko Watanabe; Kiyotake Suenaga; Kaoru Yamada; Katsuhiro Ueda; Masaki Kita; Daisuke Uemura

doi:10.1016/S0040-4039(01)00993-5

Zamamistatin, a significant antibacterial bromotyrosine derivative, from the Okinawan sponge Pseudoceratina purpurea

Noboru Takada, Reiko Watanabe, Kiyotake Suenaga, Kaoru Yamada, Katsuhiro Ueda, Masaki Kita, Daisuke Uemura

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Zamamistatin was isolated from the Okinawan sponge Pseudoceratina purpurea. It was determined to be a novel bromotyrosine derivative by careful analysis of 2D NMR spectra and comparison of its ¹H NMR spectrum with those of structurally related compounds. The absolute stereostructure of zamamistatin was determined by the modified Mosher's method. Zamamistatin exhibited significant antibacterial activity against Rhodospirillum salexigens, which has adhering properties.

Original language	English
Pages (from-to)	5265-5267
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	31
DOIs	https://doi.org/10.1016/S0040-4039(01)00993-5
Publication status	Published - 2001 Jul 30
Externally published	Yes

Keywords

Absolute stereochemistry
Antibacterial activity
Antifouling agent
Isolation
Structural determination

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Zamamistatin, a significant antibacterial bromotyrosine derivative, from the Okinawan sponge Pseudoceratina purpurea. / Takada, Noboru; Watanabe, Reiko; Suenaga, Kiyotake; Yamada, Kaoru; Ueda, Katsuhiro; Kita, Masaki; Uemura, Daisuke.

In: Tetrahedron Letters, Vol. 42, No. 31, 30.07.2001, p. 5265-5267.

Research output: Contribution to journal › Article › peer-review

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AU - Kita, Masaki

AU - Uemura, Daisuke

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KW - Isolation

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