Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells

Atsushi Miyawaki, Hiroshi Homma, Hiroomi Tamura, Michio Matsui, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

We have immunolocalized phenol sulfotransferase (PST)G, an isoform of PST in sustentacular cells which reside in the dorso-medial portion of the nasal cavity of the mouse. The same topographical pattern of gene expression has been reported for some olfactory neuron-specific genes. When several established (phenol-containing) odorants were used as substrate, mouse nasal tissue cytosol showed a significant level of PST activity, as does mouse liver cytosol. This study is the first to demonstrate that gene expression in the olfactory sustentacular cells is also organized zonally, and indicates the involvement of sulfo-conjugation in olfactory perireceptor processes, such as odorant clearance and xenobiotic detoxification.

Original languageEnglish
Pages (from-to)2050-2055
Number of pages6
JournalEMBO Journal
Volume15
Issue number9
Publication statusPublished - 1996 May 1

Fingerprint

Arylsulfotransferase
Gene expression
Cytosol
Gene Expression
Detoxification
Nasal Cavity
Xenobiotics
Phenol
Nose
Liver
Neurons
Protein Isoforms
Genes
Tissue
Substrates
Odorants

Keywords

  • Olfactory epithelium
  • Perireceptor processes
  • Phenol sulfotransferase
  • Sustentacular cells

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Miyawaki, A., Homma, H., Tamura, H., Matsui, M., & Mikoshiba, K. (1996). Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells. EMBO Journal, 15(9), 2050-2055.

Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells. / Miyawaki, Atsushi; Homma, Hiroshi; Tamura, Hiroomi; Matsui, Michio; Mikoshiba, Katsuhiko.

In: EMBO Journal, Vol. 15, No. 9, 01.05.1996, p. 2050-2055.

Research output: Contribution to journalArticle

Miyawaki, A, Homma, H, Tamura, H, Matsui, M & Mikoshiba, K 1996, 'Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells', EMBO Journal, vol. 15, no. 9, pp. 2050-2055.
Miyawaki A, Homma H, Tamura H, Matsui M, Mikoshiba K. Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells. EMBO Journal. 1996 May 1;15(9):2050-2055.
Miyawaki, Atsushi ; Homma, Hiroshi ; Tamura, Hiroomi ; Matsui, Michio ; Mikoshiba, Katsuhiko. / Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells. In: EMBO Journal. 1996 ; Vol. 15, No. 9. pp. 2050-2055.
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