Zonal heterogeneity in action of angiotensin-converting enzyme inhibitor on renal microcirculation

Role of intrarenal bradykinin

Hiroto Matsuda, Koichi Hayashi, Koki Arakawa, Mareo Naitoh, Eiji Kubota, Masanori Honda, Akira Matsumoto, Hiromichi Suzuki, Tokunori Yamamoto, Fumihiko Kajiya, Takao Saruta

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The present study examined the role of intrarenal bradykinin in angiotensin-converting enzyme inhibitor (ACEI)-induced dilation of renal afferent (AFF) and efferent arterioles (EFF) in vivo, and further evaluated whether ACEI-stimulated bradykinin activity differed in superficial (SP) and juxtamedullary nephrons (JM). Arterioles of canine kidneys were visualized with an intravital charge-coupled device camera microscope. E4177 (an angiotensin receptor antagonist, 30 μg/kg) dilated AFF and EFF in SP (15 ± 3% and 19 ± 5%) and JM (15 ± 3% and 18 ± 4%). Subsequently, cilazaprilat (30 μg/kg) caused further dilation of both AFF (29 ± 4%) and EFF (36 ± 4%) in JM, whereas in SP it dilated only EFF (29 ± 3%). Similarly, in the presence of E4177, cilazaprilat caused further increases in sodium excretion. This cilazaprilat-induced vasodilation and natriuresis was abolished by a bradykinin antagonist (N(α)-adamantaneacetyl-D-Arg-[Hyp3,Thi5.8,D- Phe7]bradykinin). In parallel with these results, cilazaprilat increased renal bradykinin content, more greatly in the medulla than in the cortex (5.7 ± 0.4 versus 4.6 ± 0.1 ng/g). Similarly, cilazaprilat elicited greater bradykinin-dependent increases of nitrite/nitrate in the medulla. In conclusion, zonal heterogeneity in renal bradykinin/nitric oxide levels and segmental differences in reactivity to bradykinin contribute to the diverse responsiveness of renal AFF and EFF to ACEI. ACEI-enhanced kinin action would participate in the amelioration of glomerular hemodynamics and renal sodium excretion by ACEI.

Original languageEnglish
Pages (from-to)2272-2282
Number of pages11
JournalJournal of the American Society of Nephrology
Volume10
Issue number11
Publication statusPublished - 1999 Nov

Fingerprint

Bradykinin
Microcirculation
Angiotensin-Converting Enzyme Inhibitors
Arterioles
Kidney
Nephrons
Dilatation
Sodium
Natriuresis
Kinins
Angiotensin Receptor Antagonists
Nitrites
Vasodilation
Nitrates
Canidae
Nitric Oxide
Hemodynamics
cilazaprilat
Equipment and Supplies

ASJC Scopus subject areas

  • Nephrology

Cite this

Matsuda, H., Hayashi, K., Arakawa, K., Naitoh, M., Kubota, E., Honda, M., ... Saruta, T. (1999). Zonal heterogeneity in action of angiotensin-converting enzyme inhibitor on renal microcirculation: Role of intrarenal bradykinin. Journal of the American Society of Nephrology, 10(11), 2272-2282.

Zonal heterogeneity in action of angiotensin-converting enzyme inhibitor on renal microcirculation : Role of intrarenal bradykinin. / Matsuda, Hiroto; Hayashi, Koichi; Arakawa, Koki; Naitoh, Mareo; Kubota, Eiji; Honda, Masanori; Matsumoto, Akira; Suzuki, Hiromichi; Yamamoto, Tokunori; Kajiya, Fumihiko; Saruta, Takao.

In: Journal of the American Society of Nephrology, Vol. 10, No. 11, 11.1999, p. 2272-2282.

Research output: Contribution to journalArticle

Matsuda, H, Hayashi, K, Arakawa, K, Naitoh, M, Kubota, E, Honda, M, Matsumoto, A, Suzuki, H, Yamamoto, T, Kajiya, F & Saruta, T 1999, 'Zonal heterogeneity in action of angiotensin-converting enzyme inhibitor on renal microcirculation: Role of intrarenal bradykinin', Journal of the American Society of Nephrology, vol. 10, no. 11, pp. 2272-2282.
Matsuda, Hiroto ; Hayashi, Koichi ; Arakawa, Koki ; Naitoh, Mareo ; Kubota, Eiji ; Honda, Masanori ; Matsumoto, Akira ; Suzuki, Hiromichi ; Yamamoto, Tokunori ; Kajiya, Fumihiko ; Saruta, Takao. / Zonal heterogeneity in action of angiotensin-converting enzyme inhibitor on renal microcirculation : Role of intrarenal bradykinin. In: Journal of the American Society of Nephrology. 1999 ; Vol. 10, No. 11. pp. 2272-2282.
@article{9ecc45432dd046328a4c692c72cd3003,
title = "Zonal heterogeneity in action of angiotensin-converting enzyme inhibitor on renal microcirculation: Role of intrarenal bradykinin",
abstract = "The present study examined the role of intrarenal bradykinin in angiotensin-converting enzyme inhibitor (ACEI)-induced dilation of renal afferent (AFF) and efferent arterioles (EFF) in vivo, and further evaluated whether ACEI-stimulated bradykinin activity differed in superficial (SP) and juxtamedullary nephrons (JM). Arterioles of canine kidneys were visualized with an intravital charge-coupled device camera microscope. E4177 (an angiotensin receptor antagonist, 30 μg/kg) dilated AFF and EFF in SP (15 ± 3{\%} and 19 ± 5{\%}) and JM (15 ± 3{\%} and 18 ± 4{\%}). Subsequently, cilazaprilat (30 μg/kg) caused further dilation of both AFF (29 ± 4{\%}) and EFF (36 ± 4{\%}) in JM, whereas in SP it dilated only EFF (29 ± 3{\%}). Similarly, in the presence of E4177, cilazaprilat caused further increases in sodium excretion. This cilazaprilat-induced vasodilation and natriuresis was abolished by a bradykinin antagonist (N(α)-adamantaneacetyl-D-Arg-[Hyp3,Thi5.8,D- Phe7]bradykinin). In parallel with these results, cilazaprilat increased renal bradykinin content, more greatly in the medulla than in the cortex (5.7 ± 0.4 versus 4.6 ± 0.1 ng/g). Similarly, cilazaprilat elicited greater bradykinin-dependent increases of nitrite/nitrate in the medulla. In conclusion, zonal heterogeneity in renal bradykinin/nitric oxide levels and segmental differences in reactivity to bradykinin contribute to the diverse responsiveness of renal AFF and EFF to ACEI. ACEI-enhanced kinin action would participate in the amelioration of glomerular hemodynamics and renal sodium excretion by ACEI.",
author = "Hiroto Matsuda and Koichi Hayashi and Koki Arakawa and Mareo Naitoh and Eiji Kubota and Masanori Honda and Akira Matsumoto and Hiromichi Suzuki and Tokunori Yamamoto and Fumihiko Kajiya and Takao Saruta",
year = "1999",
month = "11",
language = "English",
volume = "10",
pages = "2272--2282",
journal = "Journal of the American Society of Nephrology : JASN",
issn = "1046-6673",
publisher = "American Society of Nephrology",
number = "11",

}

TY - JOUR

T1 - Zonal heterogeneity in action of angiotensin-converting enzyme inhibitor on renal microcirculation

T2 - Role of intrarenal bradykinin

AU - Matsuda, Hiroto

AU - Hayashi, Koichi

AU - Arakawa, Koki

AU - Naitoh, Mareo

AU - Kubota, Eiji

AU - Honda, Masanori

AU - Matsumoto, Akira

AU - Suzuki, Hiromichi

AU - Yamamoto, Tokunori

AU - Kajiya, Fumihiko

AU - Saruta, Takao

PY - 1999/11

Y1 - 1999/11

N2 - The present study examined the role of intrarenal bradykinin in angiotensin-converting enzyme inhibitor (ACEI)-induced dilation of renal afferent (AFF) and efferent arterioles (EFF) in vivo, and further evaluated whether ACEI-stimulated bradykinin activity differed in superficial (SP) and juxtamedullary nephrons (JM). Arterioles of canine kidneys were visualized with an intravital charge-coupled device camera microscope. E4177 (an angiotensin receptor antagonist, 30 μg/kg) dilated AFF and EFF in SP (15 ± 3% and 19 ± 5%) and JM (15 ± 3% and 18 ± 4%). Subsequently, cilazaprilat (30 μg/kg) caused further dilation of both AFF (29 ± 4%) and EFF (36 ± 4%) in JM, whereas in SP it dilated only EFF (29 ± 3%). Similarly, in the presence of E4177, cilazaprilat caused further increases in sodium excretion. This cilazaprilat-induced vasodilation and natriuresis was abolished by a bradykinin antagonist (N(α)-adamantaneacetyl-D-Arg-[Hyp3,Thi5.8,D- Phe7]bradykinin). In parallel with these results, cilazaprilat increased renal bradykinin content, more greatly in the medulla than in the cortex (5.7 ± 0.4 versus 4.6 ± 0.1 ng/g). Similarly, cilazaprilat elicited greater bradykinin-dependent increases of nitrite/nitrate in the medulla. In conclusion, zonal heterogeneity in renal bradykinin/nitric oxide levels and segmental differences in reactivity to bradykinin contribute to the diverse responsiveness of renal AFF and EFF to ACEI. ACEI-enhanced kinin action would participate in the amelioration of glomerular hemodynamics and renal sodium excretion by ACEI.

AB - The present study examined the role of intrarenal bradykinin in angiotensin-converting enzyme inhibitor (ACEI)-induced dilation of renal afferent (AFF) and efferent arterioles (EFF) in vivo, and further evaluated whether ACEI-stimulated bradykinin activity differed in superficial (SP) and juxtamedullary nephrons (JM). Arterioles of canine kidneys were visualized with an intravital charge-coupled device camera microscope. E4177 (an angiotensin receptor antagonist, 30 μg/kg) dilated AFF and EFF in SP (15 ± 3% and 19 ± 5%) and JM (15 ± 3% and 18 ± 4%). Subsequently, cilazaprilat (30 μg/kg) caused further dilation of both AFF (29 ± 4%) and EFF (36 ± 4%) in JM, whereas in SP it dilated only EFF (29 ± 3%). Similarly, in the presence of E4177, cilazaprilat caused further increases in sodium excretion. This cilazaprilat-induced vasodilation and natriuresis was abolished by a bradykinin antagonist (N(α)-adamantaneacetyl-D-Arg-[Hyp3,Thi5.8,D- Phe7]bradykinin). In parallel with these results, cilazaprilat increased renal bradykinin content, more greatly in the medulla than in the cortex (5.7 ± 0.4 versus 4.6 ± 0.1 ng/g). Similarly, cilazaprilat elicited greater bradykinin-dependent increases of nitrite/nitrate in the medulla. In conclusion, zonal heterogeneity in renal bradykinin/nitric oxide levels and segmental differences in reactivity to bradykinin contribute to the diverse responsiveness of renal AFF and EFF to ACEI. ACEI-enhanced kinin action would participate in the amelioration of glomerular hemodynamics and renal sodium excretion by ACEI.

UR - http://www.scopus.com/inward/record.url?scp=0032737390&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032737390&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 2272

EP - 2282

JO - Journal of the American Society of Nephrology : JASN

JF - Journal of the American Society of Nephrology : JASN

SN - 1046-6673

IS - 11

ER -