医学部基礎教室

研究成果 1978 2020

フィルター
Article
2020

Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis

Grandjean, J., Canella, C., Anckaerts, C., Ayrancı, G., Bougacha, S., Bienert, T., Buehlmann, D., Coletta, L., Gallino, D., Gass, N., Garin, C. M., Nadkarni, N. A., Hübner, N. S., Karatas, M., Komaki, Y., Kreitz, S., Mandino, F., Mechling, A. E., Sato, C., Sauer, K. および28人, Shah, D., Strobelt, S., Takata, N., Wank, I., Wu, T., Yahata, N., Yeow, L. Y., Yee, Y., Aoki, I., Chakravarty, M. M., Chang, W. T., Dhenain, M., von Elverfeldt, D., Harsan, L. A., Hess, A., Jiang, T., Keliris, G. A., Lerch, J. P., Meyer-Lindenberg, A., Okano, H., Rudin, M., Sartorius, A., Van der Linden, A., Verhoye, M., Weber-Fahr, W., Wenderoth, N., Zerbi, V. & Gozzi, A., 2020 1 15, : : NeuroImage. 205, 116278.

研究成果: Article

公開
Magnetic Resonance Imaging
Brain
Medetomidine
Equipment and Supplies
Isoflurane
Tight Junctions
Cochlea
Inner Ear
Primates
Endolymph

Monitoring the morphological evolution of giant vesicles by azo dye-based sum-frequency generation (SFG) microscopy

Momotake, A., Mizuguchi, T., Hishida, M., Yamamoto, Y., Yasui, M. & Nuriya, M., 2020 2, : : Colloids and Surfaces B: Biointerfaces. 186, 110716.

研究成果: Article

Azo Compounds
Azo dyes
Microscopy
Microscopic examination
Coloring Agents

Quantitative MALDI-MS/MS assay for serum cortisol through charged derivatization

Nakamura, M., Moritsuna, M., Yuda, K., Fujimura, S., Sugiura, Y., Shimma, S., Nishimoto, K., Nishikawa, T., Suematsu, M., Ogawa, S. & Higashi, T., 2020 1 30, : : Journal of Pharmaceutical and Biomedical Analysis. 178, 112912.

研究成果: Article

Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Hydrocortisone
Assays
Serum
Electrospray ionization
2019

Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons

Akiyama, T., Suzuki, N., Ishikawa, M., Fujimori, K., Sone, T., Kawada, J., Funayama, R., Fujishima, F., Mitsuzawa, S., Ikeda, K., Ono, H., Shijo, T., Osana, S., Shirota, M., Nakagawa, T., Kitajima, Y., Nishiyama, A., Izumi, R., Morimoto, S., Okada, Y. および11人, Kamei, T., Nishida, M., Nogami, M., Kaneda, S., Ikeuchi, Y., Mitsuhashi, H., Nakayama, K., Fujii, T., Warita, H., Okano, H. & Aoki, M., 2019 7 1, : : EBioMedicine. 45, p. 362-378 17 p.

研究成果: Article

公開
Amyotrophic Lateral Sclerosis
Motor Neurons
Sarcoma
Neurons
Axons

Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model

Ono, S., Egawa, G., Nomura, T., Kitoh, A., Dainichi, T., Otsuka, A., Nakajima, S., Amagai, M., Matsumoto, F., Yamamoto, M., Kubota, Y., Takai, T., Honda, T. & Kabashima, K., 2019 12 1, : : Nature communications. 10, 1, 4432.

研究成果: Article

公開
Pemphigus
tyrosine
Protein-Tyrosine Kinases
blood cells
Skin
Intracranial Subdural Hematoma
Subdural Hematoma
Hemangiosarcoma
Skull
Meningeal Arteries

A combinational treatment of carotenoids decreases Aβ secretion in human neurons via β-secretase inhibition

Sho, M., Ichiyanagi, N., Imaizumi, K., Ishikawa, M., Morimoto, S., Watanabe, H. & Okano, H., 2019 1 1, (Accepted/In press) : : Neuroscience Research.

研究成果: Article

Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Carotenoids
Amyloid
Induced Pluripotent Stem Cells

Activity-Dependent Secretion of Synaptic Organizer Cbln1 from Lysosomes in Granule Cell Axons

Ibata, K., Kono, M., Narumi, S., Motohashi, J., Kakegawa, W., Kohda, K. & Yuzaki, M., 2019 6 19, : : Neuron. 102, 6, p. 1184-1198.e10

研究成果: Article

Lysosomes
Cathepsin B
Axons
Synapses
Exocytosis

Actual practice of standard treatment for pulmonary nontuberculous mycobacteriosis in Japan

Morimoto, K., Izumi, K., Ato, M., Hasegawa, N. & Mitarai, S., 2019 10 1, : : Respiratory Medicine. 158, p. 67-69 3 p.

研究成果: Article

Japan
Lung
Macrolides
Therapeutics
Lung Diseases
1 引用 (Scopus)
公開
Interstitial Nephritis
Epithelial Cells
Kidney
Therapeutics
Immunosuppressive Agents
Type 2 Diabetes Mellitus
Randomized Controlled Trials
Insulin
Blood Glucose
Hypoglycemia
61 引用 (Scopus)

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., Shiota, A., Takeshita, K., Yasuma-Mitobe, K., Riethmacher, D., Kaisho, T., Norman, J. M., Mucida, D., Suematsu, M., Yaguchi, T., Bucci, V. および8人, Inoue, T., Kawakami, Y., Olle, B., Roberts, B., Hattori, M., Xavier, R. J., Atarashi, K. & Honda, K., 2019 1 31, : : Nature. 565, 7741, p. 600-605 6 p.

研究成果: Article

Immunity
T-Lymphocytes
Listeriosis
Histocompatibility
Microbiota

Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke

Monai, H., Wang, X., Yahagi, K., Lou, N., Mestre, H., Xu, Q., Abe, Y., Yasui, M., Iwai, Y., Nedergaard, M. & Hirase, H., 2019 5 28, : : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 11010-11019 10 p.

研究成果: Article

Adrenergic Receptors
Stroke
Aquaporin 4
Aquaporins
Adrenergic Antagonists
3 引用 (Scopus)

A high-throughput neurohistological pipeline for brain-wide mesoscale connectivity mapping of the common marmoset

Lin, M. K., Takahashi, Y. S., Huo, B. X., Hanada, M., Nagashima, J., Hata, J., Tolpygo, A. S., Ram, K., Lee, B. C., Miller, M. I., Rosa, M. G., Sasaki, E., Iriki, A., Okano, H. & Mitra, P., 2019 2 5, : : eLife. 8

研究成果: Article

公開
Callithrix
Brain
Pipelines
Throughput
Atlases

Alteration of Musashi1 Intra-cellular Distribution During Regeneration Following Gentamicin-Induced Hair Cell Loss in the Guinea Pig Crista Ampullaris

Kinoshita, M., Fujimoto, C., Iwasaki, S., Kashio, A., Kikkawa, Y. S., Kondo, K., Okano, H. & Yamasoba, T., 2019 10 25, : : Frontiers in Cellular Neuroscience. 13, 481.

研究成果: Article

公開
Semicircular Ducts
Alopecia
Gentamicins
Regeneration
Guinea Pigs
2 引用 (Scopus)

A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis

Kim, Y. H., Choi, J., Yang, M. J., Hong, S. P., Lee, C. K., Kubota, Y., Lim, D. S. & Koh, G. Y., 2019 12 1, : : Nature communications. 10, 1, 838.

研究成果: Article

angiogenesis
Cell Polarity
Mitochondria
Endothelial cells
Reactive Oxygen Species

Analysis of skeletal-muscle condition after excessive loading of the lower legs by sequential magnetic resonance imaging

Hata, J., Endo, K., Tsuji, O., Arakawa, S., Sato, M., Yagi, K., Fujiyoshi, K., Okano, H. & Nakamura, M., 2019 1 1, : : Journal of Orthopaedic Science.

研究成果: Article

Leg
Skeletal Muscle
Magnetic Resonance Imaging
Exercise
Anisotropy

Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma

Goto, M., Chamoto, K., Higuchi, K., Yamashita, S., Noda, K., Iino, T., Miura, M., Yamasaki, T., Ogawa, O., Sonobe, M., Date, H., Hamanishi, J., Mandai, M., Tanaka, Y., Chikuma, S., Hatae, R., Muto, M., Minamiguchi, S., Minato, N. & Honjo, T., 2019 12 1, : : Scientific reports. 9, 1, 10144.

研究成果: Article

公開
Immunoassay
Neoplasms
Biomarkers
Immunotherapy
Enzyme-Linked Immunosorbent Assay
1 引用 (Scopus)

A novel cell-free, non-fluorescent method to measure lox-1-binding activity corresponding to the functional activity of hdl

Kakino, A., Usami, Y., Horiuchi, S., Fujita, Y., Kotani, K., Chen, C. H., Okamura, T. & Sawamura, T., 2019 1 1, : : Journal of atherosclerosis and thrombosis. 26, 11, p. 947-958 12 p.

研究成果: Article

公開
HDL Lipoproteins
Immunosorbents
Assays
Enzyme-Linked Immunosorbent Assay
Fusion reactions
公開
Feasibility Studies
Cognitive Therapy
Japan
Anxiety
Students
1 引用 (Scopus)
Radiosurgery
Neoplasm Metastasis
Brain
Neoplasms
Survival
5 引用 (Scopus)
公開
spinal cord injuries
Hepatocyte Growth Factor
Spinal Cord Injuries
roads
Rats
3 引用 (Scopus)

Application of high-performance magnetic nanobeads to biological sensing devices

Kabe, Y., Sakamoto, S., Hatakeyama, M., Yamaguchi, Y., Suematsu, M., Itonaga, M. & Handa, H., 2019 1 1, (Accepted/In press) : : Analytical and Bioanalytical Chemistry.

研究成果: Article

Exosomes
Equipment and Supplies
Technology
Immunoassay
Drug Receptors
公開
Metabolomics
Epidemiologic Studies
Atherosclerosis
Cardiovascular Diseases
Metabolites
Brain Diseases
Water
Brain
Astrocytes
Neurodegenerative Diseases
公開
Aquaporin 4
Synaptic Transmission
Fatigue
Retina
Knockout Mice

Armitage determines Piwi−piRISC processing from precursor formation and quality control to inter-organelle translocation

Yamashiro, H., Negishi, M., Kinoshita, T., Ishizu, H., Ohtani, H. & Siomi, M. C., 2019 1 1, (Accepted/In press) : : EMBO Reports. e48769.

研究成果: Article

Quality Control
Organelles
Small Interfering RNA
Quality control
Processing
3 引用 (Scopus)

Association between blood manganese level during pregnancy and birth size: The Japan environment and children's study (JECS)

The Japan Environment and Children's Study Group, 2019 5 1, : : Environmental Research. p. 117-126 10 p.

研究成果: Article

公開
Manganese
pregnancy
manganese
Japan
Blood

Association between body mass index and all-cause death in japanese population: Pooled individual participant data analysis of 13 cohort studies

Hozawa, A., Hirata, T., Yatsuya, H., Murakami, Y., Kuriyama, S., Tsuji, I., Sugiyama, D., Satoh, A., Tanaka-Mizuno, S., Miura, K., Ueshima, H. & Okamura, T., 2019 1 1, : : Journal of epidemiology. 29, 12, p. 457-463 7 p.

研究成果: Article

公開
Cause of Death
Body Mass Index
Cohort Studies
Smoking
Mortality
1 引用 (Scopus)

Association Between CD133, CD44, and Nestin Expression and Prognostic Factors in High-Grade Meningioma

Kamamoto, D., Saga, I., Ohara, K., Yoshida, K. & Sasaki, H., 2019 1 1, (Accepted/In press) : : World Neurosurgery.

研究成果: Article

Nestin
Meningioma
Neoplastic Stem Cells
Disease-Free Survival
Recurrence
公開
Branched Chain Amino Acids
Dyslipidemias
Diabetes Mellitus
Population
LDL Cholesterol
公開
Kyphosis
Muscle Strength
Cohort Studies
Independent Living
Odds Ratio
Independent Living
Kyphosis
Activities of Daily Living
Cohort Studies
Certification
1 引用 (Scopus)

Association of alcohol consumption with fat deposition in a community-based sample of Japanese men: The Shiga epidemiological study of subclinical atherosclerosis (SESSA)

Sumi, M., Hisamatsu, T., Fujiyoshi, A., Kadota, A., Miyagawa, N., Kondo, K., Kadowaki, S., Suzuki, S., Torii, S., Zaid, M., Sato, A., Arima, H., Terada, T., Miura, K., Ueshima, H., Horie, M., Nakano, Y., Yamamoto, T., Hayashi, H., Ogawa, E. および37人, Maegawa, H., Miyazawa, I., Murata, K., Mitsunami, K., Nozaki, K., Tooyama, I., Shiino, A., Tsuru, T., Ogita, H., Shimizu, A., Miyamatsu, N., Kita, T., Kimura, T., Nishio, Y., Nakamura, Y., Okamura, T., Sekikawa, A., Barinas-Mitchell, E. J., Edmundowicz, D., Ohkubo, T., Hozawa, A., Miyagi, S., Murakami, Y., Okuda, N., Kita, Y., Higashiyama, A., Nagasawa, S., Azuma, K., Yanagita, M., Abbott, R. D., Ohno, S., Takashima, N., Kadowaki, T., Saito, Y., Ito, T., Satoh, A. & Yamazoe, M., 2019 6, : : Journal of epidemiology. 29, 6, p. 205-212 8 p.

研究成果: Article

公開
Intra-Abdominal Fat
Alcohol Drinking
Epidemiologic Studies
Atherosclerosis
Fats
1 引用 (Scopus)
公開
Cardiovascular Diseases
Mortality
Japan
Administrative Personnel
Blood Pressure
1 引用 (Scopus)

Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly: NIPPON DATA 80, 90, and 2010

Shibata, Y., Ojima, T., Nakamura, M., Kuwabara, K., Miyagawa, N., Saito, Y., Nakamura, Y., Kiyohara, Y., Nakagawa, H., Fujiyoshi, A., Kadota, A., Ohkubo, T., Okamura, T., Ueshima, H., Okayama, A. & Miura, K., 2019 4 5, : : Journal of epidemiology. 29, 4, p. 133-138 6 p.

研究成果: Article

公開
Thinness
Obesity
Cholesterol
Confidence Intervals
Serum

A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

Hayakawa, T., Kawasaki, S., Hirayama, Y., Tsutsui, T., Sugiyama, E., Adachi, K., Kon, R., Suematsu, M. & Sugiura, Y., 2019 12 1, : : Scientific reports. 9, 1, 3559.

研究成果: Article

公開
Peptic Esophagitis
Sucralfate
Epithelium
Gastric Juice
Pepsin A

atlasBREX: Automated template-derived brain extraction in animal MRI

Lohmeier, J., Kaneko, T., Hamm, B., Makowski, M. R. & Okano, H., 2019 12 1, : : Scientific reports. 9, 1, 12219.

研究成果: Article

公開
Brain
Rodentia
Callithrix
Atlases
Macaca
12 引用 (Scopus)

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., Okuda, S., Lee, H. C., Ikeda, K., Kanegae, Y., Saito, I., Auwerx, J., Motohashi, H., Suematsu, M., Soga, T., Yokomizo, T., Waguri, S., Mizushima, N. & Komatsu, M., 2019 12 1, : : Nature communications. 10, 1, 1567.

研究成果: Article

公開
Nuclear Receptor Co-Repressor 1
lipid metabolism
Peroxisome Proliferator-Activated Receptors
Autophagy
Lipid Metabolism

A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology

Yoshimatsu, S., Sone, T., Nakajima, M., Sato, T., Okochi, R., Ishikawa, M., Nakamura, M., Sasaki, E., Shiozawa, S. & Okano, H., 2019 1 1, : : PloS one. 14, 8, e0221164.

研究成果: Article

公開
Gene Targeting
gene targeting
Callithrix
Genes
Stem cells
公開
Drinking
Cross-Sectional Studies
Linear Models
Regression Analysis
Heat Stroke
1 引用 (Scopus)
公開
2-toluidine
Environmental Monitoring
Urine
Monitoring
Metabolites

Blastemal predominant type Wilms tumor in Japan: Japan Children's Cancer Group

Koshinaga, T., Takimoto, T., Okita, H., Tanaka, Y., Inoue, E., Oue, T., Nozaki, M., Tsuchiya, K., Haruta, M., Kaneko, Y. & Fukuzawa, M., 2019 4 1, : : Pediatrics International. 61, 4, p. 351-357 7 p.

研究成果: Article

Wilms Tumor
Japan
Neoplasms
Survival
Drug Therapy
2 引用 (Scopus)
公開
Mercury (metal)
Selenium
Manganese
Mercury
Cadmium

Body mass index as a tool for optimizing surgical care in coronary artery bypass grafting through understanding risks of specific complications

Nishioka, N., Ichihara, N., Bando, K., Motomura, N., Koyama, N., Miyata, H., Kohsaka, S., Takamoto, S. & Hashimoto, K., 2019 1 1, (Accepted/In press) : : Journal of Thoracic and Cardiovascular Surgery.

研究成果: Article

Coronary Artery Bypass
Body Mass Index
Morbidity
Odds Ratio
Confidence Intervals
Neocortex
Neurons
Interneurons
Primates
Occipital Lobe
1 引用 (Scopus)

Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Yamanaka, S., Nishihara, H., Toh, H., Eijy Nagai, L. A., Hashimoto, K., Park, S. J., Shibuya, A., Suzuki, A. M., Tanaka, Y., Nakai, K., Carninci, P., Sasaki, H. & Siomi, H., 2019 10 7, : : Developmental Cell. 51, 1, p. 21-34.e5

研究成果: Article

DNA Methylation
Genes
Genome
Methyltransferases
Chromatin
1 引用 (Scopus)

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M. & Suzuki, H., 2019 1 1, : : CMGH. 8, 3, p. 319-334 16 p.

研究成果: Article

公開
Helicobacter
Neoplastic Stem Cells
Catenins
Protein Splicing
Histones

Cardiovascular risk assessment chart by dietary factors in Japan: NIPPON DATA80

NIPPON DATA80 Research Group, 2019 1 1, : : Circulation Journal. 83, 6, p. 1254-1260 7 p.

研究成果: Article

公開
Japan
Vegetables
Cardiovascular Diseases
Fruit
Salts