研究成果 1978 2019

2019

Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model

Ono, S., Egawa, G., Nomura, T., Kitoh, A., Dainichi, T., Otsuka, A., Nakajima, S., Amagai, M., Matsumoto, F., Yamamoto, M., Kubota, Y., Takai, T., Honda, T. & Kabashima, K., 2019 12 1, : : Nature communications. 10, 1, 4432.

研究成果: Article

公開
Pemphigus
tyrosine
Protein-Tyrosine Kinases
blood cells
Skin
2 引用 (Scopus)

A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis

Kim, Y. H., Choi, J., Yang, M. J., Hong, S. P., Lee, C. K., Kubota, Y., Lim, D. S. & Koh, G. Y., 2019 12 1, : : Nature communications. 10, 1, 838.

研究成果: Article

angiogenesis
Cell Polarity
Mitochondria
Endothelial cells
Reactive Oxygen Species
Neocortex
Neurons
Interneurons
Primates
Occipital Lobe
2 引用 (Scopus)

Drebrin-like (Dbnl) controls neuronal migration via regulating N-cadherin expression in the developing cerebral cortex

Inoue, S., Hayashi, K., Fujita, K., Tagawa, K., Okazawa, H., Kubo, K. & Nakajima, K., 2019 1 23, : : Journal of Neuroscience. 39, 4, p. 678-691 14 p.

研究成果: Article

Cadherins
Cerebral Cortex
Neurons
Actin Cytoskeleton
Time-Lapse Imaging

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis

Zahra, F. T., Sajib, M. S., Ichiyama, Y., Akwii, R. G., Tullar, P. E., Cobos, C., Minchew, S. A., Doçi, C. L., Zheng, Y., Kubota, Y., Gutkind, J. S. & Mikelis, C. M., 2019 12 1, : : Scientific reports. 9, 1, 11666.

研究成果: Article

公開
GTP Phosphohydrolases
Embryonic Development
rho GTP-Binding Proteins
Cell Movement
Physiologic Neovascularization

Endothelial specific deletion of FOXO1 alters pericyte coverage in the developing retina

Niimi, K., Adachi, Y., Ishikawa, H., Yamaguchi, W., Kubota, Y., Inagaki, S. & Furuyama, T., 2019 12 3, : : Biochemical and Biophysical Research Communications. 520, 2, p. 304-310 7 p.

研究成果: Article

Pericytes
Retina
Endothelium
Thrombospondin 1
Endothelial cells

Neuron-derived VEGF contributes to cortical and hippocampal development independently of VEGFR1/2-mediated neurotrophism

Okabe, K., Fukada, H., Tai-Nagara, I., Ando, T., Honda, T., Nakajima, K., Takeda, N., Fong, G. H., Ema, M. & Kubota, Y., 2019 1 1, (Accepted/In press) : : Developmental Biology.

研究成果: Article

公開
Vascular Endothelial Growth Factor A
Neurons
Blood Vessels
Brain
Vascular Endothelial Growth Factor Receptor

Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent

Kono, T., Imanishi, N., Nozawa, K., Takashima, A., Maheswari, R. U., Gonome, H. & Yamada, J., 2019 8 1, : : Biomedical Optics Express. 10, 8, p. 3747-3759 13 p., 366571.

研究成果: Article

Hyperpigmentation
pyrimidines
Antineoplastic Agents
Skin
scattering coefficients
6 引用 (Scopus)

p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia

Yokoyama, M., Shimizu, I., Nagasawa, A., Yoshida, Y., Katsuumi, G., Wakasugi, T., Hayashi, Y., Ikegami, R., Suda, M., Ota, Y., Okada, S., Fruttiger, M., Kobayashi, Y., Tsuchida, M., Kubota, Y. & Minamino, T., 2019 4 1, : : Journal of Molecular and Cellular Cardiology. 129, p. 105-117 13 p.

研究成果: Article

Vasodilation
Hyperglycemia
Ischemia
Endothelium
Endothelial Cells
公開
Immune System
Central Nervous System
Brain
Lymphatic Vessels
Toll-Like Receptors
3 引用 (Scopus)

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity

Naito, H., Iba, T., Wakabayashi, T., Tai-Nagara, I., Suehiro, J. I., Jia, W., Eino, D., Sakimoto, S., Muramatsu, F., Kidoya, H., Sakurai, H., Satoh, T., Akira, S., Kubota, Y. & Takakura, N., 2019 1 28, : : Developmental Cell. 48, 2, p. 151-166.e7

研究成果: Article

Endothelial cells
Blood Vessels
Endothelial Cells
Apoptosis
Myeloid Cells
1 引用 (Scopus)

Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

Kim, J., Park, J. R., Choi, J., Park, I., Hwang, Y., Bae, H., Kim, Y., Choi, W. J., Yang, J. M., Han, S., Chung, T. Y., Kim, P., Kubota, Y., Augustin, H. G., Oh, W. Y. & Koh, G. Y., 2019 2 13, : : Science Advances. 5, 2, eaau6732.

研究成果: Article

degeneration
regeneration
activation
antibodies
angiogenesis

Timing and shaping mechanisms of neural development

Kageyama, R. & Nakajima, K., 2019 1 1, : : Neuroscience Research. 138, p. 1-2 2 p.

研究成果: Editorial

2018
Hypoglossal Nerve
Arteriovenous Fistula
Hypoglossal Nerve Diseases
Veins
Digital Subtraction Angiography
3 引用 (Scopus)

Anatomic basis for flap thinning

Park, S. O., Chang, H. & Imanishi, N., 2018 7 1, : : Archives of Plastic Surgery. 45, 4, p. 298-303 6 p.

研究成果: Article

Perforator Flap
Epigastric Arteries
Thigh
Blood Vessels
Anatomy
7 引用 (Scopus)

Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction

Lee, S. J., Lee, C. K., Kang, S., Park, I., Kim, Y. H., Kim, S. K., Hong, S. P., Bae, H., He, Y., Kubota, Y. & Koh, G. Y., 2018 11 1, : : The Journal of clinical investigation. 128, 11, p. 5018-5033 16 p.

研究成果: Article

Angiopoietin-2
Myocardial Infarction
Inflammation
Myocardial Ischemia
Macrophages
6 引用 (Scopus)
Cerebral Cortex
Neurons
Neocortex
Brain
Integrins
4 引用 (Scopus)

Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells

Si, S., Nakajima-Takagi, Y., Iga, T., Tsuji, M., Hou, L., Oshima, M., Koide, S., Saraya, A., Yamazaki, S., Takubo, K., Kubota, Y., Minamino, T. & Iwama, A., 2018 7 1, : : Experimental Hematology. 63, p. 41-51.e1

研究成果: Article

Hematopoietic Stem Cells
Endothelial Cells
Bone Marrow
Blood Vessels
Inflammation
3 引用 (Scopus)

Placebo effects in adult and adolescent patients with schizophrenia: combined analysis of nine RCTs

Kubo, K., Fleischhacker, W. W., Suzuki, T., Yasui-Furukori, N., Mimura, M. & Uchida, H., 2018 1 1, (Accepted/In press) : : Acta Psychiatrica Scandinavica.

研究成果: Article

Placebo Effect
Schizophrenia
Placebos
Antipsychotic Agents
Logistic Models

Virtual Blood Vessels in Complex Background Using Stereo X-Ray Images

Chen, Q., Bise, R., Gu, L., Zheng, Y., Sato, I., Hwang, J. N., Aiso, S. & Imanishi, N., 2018 1 19, Proceedings - 2017 IEEE International Conference on Computer Vision Workshops, ICCVW 2017. Institute of Electrical and Electronics Engineers Inc., 巻 2018-January. p. 99-106 8 p.

研究成果: Conference contribution

Blood vessels
Augmented reality
X rays
Affine transforms
Oils and fats
2017

A crossroad of neuronal diversity to build circuitry

Yoshinaga, S. & Nakajima, K., 2017 4 28, : : Science. 356, 6336, p. 376-377 2 p.

研究成果: Article

cells and cell components
Nerve Net
genetic analysis
rodent
brain
Mandibular Reconstruction
Fibula
Jugular Veins
Arteries
Blood Vessels

Anatomical Study of Perfusion of a Periosteal Flap with a Lateral Pedicle

Kim, B., Inoue, Y., Imanishi, N., Chang, H., Shimizu, Y., Okumoto, T. & Kishi, K., 2017 9 1, : : Plastic and Reconstructive Surgery - Global Open. 5, 9, e1476.

研究成果: Article

Temporal Arteries
Perfusion
Temporal Muscle
Surgical Flaps
Skull Base
5 引用 (Scopus)

Association of impaired neuronal migration with cognitive deficits in extremely preterm infants

Kubo, K., Deguchi, K., Nagai, T., Ito, Y., Yoshida, K., Endo, T., Benner, S., Shan, W., Kitazawa, A., Aramaki, M., Ishii, K., Shin, M., Matsunaga, Y., Hayashi, K., Kakeyama, M., Tohyama, C., Tanaka, K., Tanaka, K., Takashima, S., Nakayama, M. および7人, Itoh, M., Hirata, Y., Antalffy, B., Armstrong, D. D., Yamada, K., Inoue, K. & Nakajima, K., 2017 5 18, : : JCI insight. 2, 10

研究成果: Article

公開
Extremely Premature Infants
Brain Injuries
Neocortex
Neurons
Uterine Artery
15 引用 (Scopus)
CHARGE Syndrome
Induced Pluripotent Stem Cells
Neural Crest
Stem cells
Mutation
13 引用 (Scopus)
Cerebral Cortex
Neurons
Neocortex
Periventricular Nodular Heterotopia
Lissencephaly
5 引用 (Scopus)

Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma

Shiihashi, G., Ito, D., Arai, I., Kobayashi, Y., Hayashi, K., Otsuka, S., Nakajima, K., Yuzaki, M., Itohara, S. & Suzuki, N., 2017, (Accepted/In press) : : EBioMedicine.

研究成果: Article

Frontotemporal Dementia
Sarcoma
Homeostasis
Messenger RNA
Brain
4 引用 (Scopus)

Distinct expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after myocardial infarction

Kurotsu, S., Osakabe, R., Isomi, M., Tamura, F., Sadahiro, T., Muraoka, N., Kojima, H., Haginiwa, S., Tani, H., Nara, K., Kubota, Y., Ema, M., Fukuda, K., Suzuki, T. & Ieda, M., 2017 1 1, (Accepted/In press) : : Biochemical and Biophysical Research Communications.

研究成果: Article

Endothelial cells
Blood Vessels
Myocardial Infarction
Coronary Vessels
Vascular Endothelial Growth Factor A
1 引用 (Scopus)
Drainage
Veins
Iliac Vein
Blood Vessels
Arteries

Enhanced expression of Pafah1b1 causes over-migration of cerebral cortical neurons into the marginal zone

Katayama, K. I., Hayashi, K., Inoue, S., Sakaguchi, K. & Nakajima, K., 2017 8 23, (Accepted/In press) : : Brain Structure and Function. p. 1-9 9 p.

研究成果: Article

Neurons
Lissencephaly
Electroporation
Brain
Nervous System Diseases
9 引用 (Scopus)
Hippocampal CA1 Region
Aryl Hydrocarbon Receptors
Chemical activation
Dioxins
Xenobiotics

External jugular veno-accompanying artery adipofascial flap: A novel and convenient flap for head and neck reconstruction

Park, S. O., Ahn, K. C., Hong, K. Y., Chang, H. & Imanishi, N., 2017 11 1, : : Head and Neck. 39, 11, p. 2249-2255 7 p.

研究成果: Article

Neck
Arteries
Head
Jugular Veins
Reconstructive Surgical Procedures
12 引用 (Scopus)

Heterogeneity of D-serine distribution in the human central nervous system

Suzuki, M., Imanishi, N., Mita, M., Hamase, K., Aiso, S. & Sasabe, J., 2017 5 1, : : ASN Neuro. 9, 3

研究成果: Article

Serine
Central Nervous System
Cerebrum
4 alpha-glucanotransferase
Neurophysiology
14 引用 (Scopus)

Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma

Kim, J., Park, D. Y., Bae, H., Park, D. Y., Kim, D., Lee, C. K., Song, S., Chung, T. Y., Lim, D. H., Kubota, Y., Hong, Y. K., He, Y., Augustin, H. G., Oliver, G. & Koh, G. Y., 2017 10 2, : : Journal of Clinical Investigation. 127, 10, p. 3877-3896 20 p.

研究成果: Article

Angiopoietins
Aqueous Humor
Glaucoma
Transcytosis
Intraocular Pressure
4 引用 (Scopus)

Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouse

Kimura, E., Kubo, K., Endo, T., Ling, W., Nakajima, K., Kakeyama, M. & Tohyama, C., 2017 8 1, : : PLoS One. 12, 8, e0183497.

研究成果: Article

Aryl Hydrocarbon Receptors
Pyramidal Cells
Neurons
hydrocarbons
neurons
5 引用 (Scopus)

Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling

Tai-Nagara, I., Yoshikawa, Y., Numata, N., Ando, T., Okabe, K., Sugiura, Y., Ieda, M., Takakura, N., Nakagawa, O., Zhou, B., Okabayashi, K., Suematsu, M., Kitagawa, Y., Bastmeyer, M., Sato, K., Klein, R., Navankasattusas, S., Li, D. Y., Yamagishi, S. & Kubota, Y., 2017, : : Development (Cambridge). 144, 13, p. 2392-2401 10 p.

研究成果: Article

Inner Ear
Fibronectins
Leucine
Endothelial Cells
Proteins
50 引用 (Scopus)

Plastic roles of pericytes in the blood-retinal barrier

Park, D. Y., Lee, J., Kim, J., Kim, K., Hong, S., Han, S., Kubota, Y., Augustin, H. G., Ding, L., Kim, J. W., Kim, H., He, Y., Adams, R. H. & Koh, G. Y., 2017 5 16, : : Nature Communications. 8, 15296.

研究成果: Article

Blood-Retinal Barrier
Pericytes
Plastics
blood
Blood
13 引用 (Scopus)

Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development

Matsunaga, Y., Noda, M., Murakawa, H., Hayashi, K., Nagasaka, A., Inoue, S., Miyata, T., Miura, T., Kubo, K. & Nakajima, K., 2017 2 21, : : Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. 2048-2053 6 p.

研究成果: Article

Cadherins
Neurons
Ependymoglial Cells
Adhesiveness
Neocortex
8 引用 (Scopus)

Semi-supervised learning for biomedical image segmentation via forest oriented super pixels(voxels)

Gu, L., Zheng, Y., Bise, R., Sato, I., Imanishi, N. & Aiso, S., 2017, Medical Image Computing and Computer Assisted Intervention − MICCAI 2017 - 20th International Conference, Proceedings. Springer Verlag, 巻 10433 LNCS. p. 702-710 9 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); 巻数 10433 LNCS).

研究成果: Conference contribution

Semi-supervised Learning
Supervised learning
Voxel
Image segmentation
Image Segmentation
1 引用 (Scopus)

Subtype Specification of Cerebral Cortical Neurons in Their Immature Stages

Oishi, K. & Nakajima, K., 2017 11 28, (Accepted/In press) : : Neurochemical Research. p. 1-7 7 p.

研究成果: Article

Neurons
Specifications
Cues
Plasticity
Axons
3 引用 (Scopus)

The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination

Hayashi, K., Furuya, A., Sakamaki, Y., Akagi, T., Shinoda, Y., Sadakata, T., Hashikawa, T., Shimizu, K., Minami, H., Sano, Y., Nakayama, M. & Furuichi, T., 2017 3 1, : : PLoS One. 12, 3, e0173175.

研究成果: Article

Knockout Mice
granules
Brain
Animals
brain
5 引用 (Scopus)

Three-dimensional innate mobility of the human foot bones under axial loading using biplane X-ray fluoroscopy

Ito, K., Hosoda, K., Shimizu, M., Ikemoto, S., Nagura, T., Seki, H., Kitashiro, M., Imanishi, N., Aiso, S., Jinzaki, M. & Ogihara, N., 2017 10 18, : : Royal Society Open Science. 4, 10, 171086.

研究成果: Article

Foot Bones
Fluoroscopy
Weight-Bearing
Foot
X-Rays

Three-dimensional measurement of the human cadaver foot bone kinematics under axial loading condition using biplane X-ray fluoroscopy

Ito, K., Hosoda, K., Shimizu, M., Ikemoto, S., Nagura, T., Seki, H., Kitashiro, M., Jinzaki, M., Imanishi, N., Aiso, S. & Ogihara, N., 2017 6 30, : : Footwear Science. 9, p. S148-S150

研究成果: Article

30 引用 (Scopus)

Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature

Yamazaki, T., Nalbandian, A., Uchida, Y., Li, W., Arnold, T. D., Kubota, Y., Yamamoto, S., Ema, M. & Mukouyama, Y. S., 2017 3 21, : : Cell Reports. 18, 12, p. 2991-3004 14 p.

研究成果: Article

Pericytes
Transforming Growth Factors
Skin
Tissue
Myeloid Progenitor Cells
3 引用 (Scopus)

Transplanted mesenchymal stem cells are effective for skin regeneration in acute cutaneous wounds of pigs

Ochiai, H., Kishi, K., Kubota, Y., Oka, A., Hirata, E., Yabuki, H., Iso, Y., Suzuki, H. & Umezawa, A., 2017 12 1, : : Regenerative Therapy. 7, p. 8-16 9 p.

研究成果: Article

Stem cells
Mesenchymal Stromal Cells
Regeneration
Skin
Swine
7 引用 (Scopus)

VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis

Jang, J. Y., Choi, S. Y., Park, I., Park, D. Y., Choe, K., Kim, P., Kim, Y. K., Lee, B. J., Hirashima, M., Kubota, Y., Park, J. W., Cheng, S. Y., Nagy, A., Park, Y. J., Alitalo, K., Shong, M. & Koh, G. Y., 2017 6 1, : : EMBO Molecular Medicine. 9, 6, p. 750-769 20 p.

研究成果: Article

Thyroid Gland
Thyrotropin
Vascular Endothelial Growth Factor A
Blood Vessels
Maintenance
1 引用 (Scopus)
Hyperemia
Veins
Leg
Necrosis
Extremities
55 引用 (Scopus)

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

Kim, J., Kim, Y. H., Kim, J., Park, D. Y., Bae, H., Lee, D. H., Kim, K. H., Hong, S. P., Jang, S. P., Kubota, Y., Kwon, Y. G., Lim, D. S. & Koh, G. Y., 2017 9 1, : : Journal of Clinical Investigation. 127, 9, p. 3441-3461 21 p.

研究成果: Article

Blood Vessels
Endothelial Cells
Pseudopodia
Cell Proliferation
Pathologic Neovascularization
2016
2 引用 (Scopus)

Abnormal D-serine metabolism in amyotrophic lateral sclerosis

Sasabe, J. & Aiso, S., 2016 1 1, D-Amino Acids: Physiology, Metabolism, and Application. Springer Japan, p. 137-149 13 p.

研究成果: Chapter

Amyotrophic Lateral Sclerosis
Metabolism
Serine
D-Amino-Acid Oxidase
Motor Neurons