年別の研究成果
年別の研究成果
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2022
3D imaging of supraspinal inputs to the thoracic and lumbar spinal cord mapped by retrograde tracing and light-sheet microscopy
Lu, T., Shinozaki, M., Nagoshi, N., Nakamura, M. & Okano, H., 2022 8月, In: Journal of Neurochemistry. 162, 4, p. 352-370 19 p.研究成果: Article › 査読
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A new approach to analysis of intracellular proteins and subcellular localization using cellprofiler and imageJ in combination
Hattori, A., Ohta, E., Nagai, M., Iwabuchi, K. & Okano, H., 2022 7月, In: Methods. 203, p. 233-241 9 p.研究成果: Article › 査読
3 被引用数 (Scopus) -
biPACT: A method for three-dimensional visualization of mouse spinal cord circuits of long segments with high resolution
Nakanishi, K., Shinozaki, M., Nagoshi, N., Nakamura, M. & Okano, H., 2022 9月 1, In: Journal of Neuroscience Methods. 379, 109672.研究成果: Article › 査読
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Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue
Ojima, K., Kakegawa, W., Yamasaki, T., Miura, Y., Itoh, M., Michibata, Y., Kubota, R., Doura, T., Miura, E., Nonaka, H., Mizuno, S., Takahashi, S., Yuzaki, M., Hamachi, I. & Kiyonaka, S., 2022 12月, In: Nature communications. 13, 1, 3167.研究成果: Article › 査読
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Correlation Between Genetic Abnormalities in Induced Pluripotent Stem Cell-Derivatives and Abnormal Tissue Formation in Tumorigenicity Tests
Yamamoto, T., Sato, Y., Yasuda, S., Shikamura, M., Tamura, T., Takenaka, C., Takasu, N., Nomura, M., Dohi, H., Takahashi, M., Mandai, M., Kanemura, Y., Nakamura, M., Okano, H. & Kawamata, S., 2022 5月 27, In: Stem Cells Translational Medicine. 11, 5, p. 527-538 12 p.研究成果: Article › 査読
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Cortical neural dynamics unveil the rhythm of natural visual behavior in marmosets
Kaneko, T., Komatsu, M., Yamamori, T., Ichinohe, N. & Okano, H., 2022 12月, In: Communications biology. 5, 1, 108.研究成果: Article › 査読
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Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice
Matsubara, T., Iga, T., Sugiura, Y., Kusumoto, D., Sanosaka, T., Tai-Nagara, I., Takeda, N., Fong, G. H., Ito, K., Ema, M., Okano, H., Kohyama, J., Suematsu, M. & Kubota, Y., 2022 4月 4, In: Journal of Experimental Medicine. 219, 4, e20211789.研究成果: Article › 査読
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Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish
Saeki, T., Yoshimatsu, S., Ishikawa, M., Hon, C. C., Koya, I., Shibata, S., Hosoya, M., Saegusa, C., Ogawa, K., Shin, J. W., Fujioka, M. & Okano, H., 2022 6月, In: Regenerative Therapy. 20, p. 165-186 22 p.研究成果: Article › 査読
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Early development of the cochlea of the common marmoset, a non-human primate model
Hosoya, M., Fujioka, M., Okahara, J., Yoshimatsu, S., Okano, H. & Ozawa, H., 2022 12月, In: Neural Development. 17, 1, 6.研究成果: Article › 査読
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Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa
Ozawa, Y., Toda, E., Homma, K., Osada, H., Nagai, N., Tsubota, K. & Okano, H., 2022 5月 1, In: Cells. 11, 9, 1497.研究成果: Article › 査読
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Establishment of KEIOi005-A iPSC line from urine-derived cells (UDCs) of a mild Alzheimer's disease (AD) donor with multiple risk SNPs for sporadic Alzheimer's disease (sAD)
Supakul, S., Leventoux, N., Tabuchi, H., Mimura, M., Ito, D., Maeda, S. & Okano, H., 2022 7月, In: Stem Cell Research. 62, 102802.研究成果: Article › 査読
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Exploration of the role of the subodontoblastic layer in odontoblast-like cell differentiation after tooth drilling using Nestin-enhanced green fluorescent protein transgenic mice
Imai, C., Sano, H., Quispe-Salcedo, A., Saito, K., Nakatomi, M., Ida-Yonemochi, H., Okano, H. & Ohshima, H., 2022 3月, In: Journal of Oral Biosciences. 64, 1, p. 77-84 8 p.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Functional reorganization of locomotor kinematic synergies reflects the neuropathology in a mouse model of spinal cord injury
Sato, Y., Kondo, T., Shibata, R., Nakamura, M., Okano, H. & Ushiba, J., 2022 4月, In: Neuroscience Research. 177, p. 78-84 7 p.研究成果: Article › 査読
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Glycosaminoglycans promote osteogenesis from human induced pluripotent stem cells via neural crest induction
Yanagisawa, T., Ouchi, T., Shibata, S., Negishi, T. & Okano, H., 2022 5月 7, In: Biochemical and Biophysical Research Communications. 603, p. 49-56 8 p.研究成果: Article › 査読
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Homologous Recombination-Enhancing Factors Identified by Comparative Transcriptomic Analyses of Pluripotent Stem Cell of Human and Common Marmoset
Yoshimatsu, S., Nakajima, M., Qian, E., Sanosaka, T., Sato, T. & Okano, H., 2022 1月 21, In: Cells. 11, 3研究成果: Article › 査読
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Influence of a clinical trial in the decision-making processes of patients with amyotrophic lateral sclerosis
Kato, C., Morimoto, S., Takahashi, S., Date, Y., Okada, K., Okano, H., Nakahara, J. & Ito, D., 2022 5月, In: Journal of Neurology. 269, 5, p. 2634-2640 7 p.研究成果: Article › 査読
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Markerless analysis of hindlimb kinematics in spinal cord-injured mice through deep learning
Sato, Y., Kondo, T., Shinozaki, M., Shibata, R., Nagoshi, N., Ushiba, J., Nakamura, M. & Okano, H., 2022 3月, In: Neuroscience Research. 176, p. 49-56 8 p.研究成果: Article › 査読
1 被引用数 (Scopus) -
Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury
Kitagawa, T., Nagoshi, N., Kamata, Y., Kawai, M., Ago, K., Kajikawa, K., Shibata, R., Sato, Y., Imaizumi, K., Shindo, T., Shinozaki, M., Kohyama, J., Shibata, S., Matsumoto, M., Nakamura, M. & Okano, H., 2022 1月 11, In: Stem cell reports. 17, 1, p. 127-142 16 p.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Otic Organoids Containing Spiral Ganglion Neuron-like Cells Derived from Human-induced Pluripotent Stem Cells as a Model of Drug-induced Neuropathy
Kurihara, S., Fujioka, M., Hirabayashi, M., Yoshida, T., Hosoya, M., Nagase, M., Kato, F., Ogawa, K., Okano, H., Kojima, H. & Okano, H. J., 2022 3月 31, In: Stem Cells Translational Medicine. 11, 3, p. 282-296 15 p.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Pathogenic Mutation of TDP-43 Impairs RNA Processing in a Cell Type-Specific Manner: Implications for the Pathogenesis of ALS/FTLD
Imaizumi, K., Ideno, H., Sato, T., Morimoto, S. & Okano, H., 2022 5月 1, In: eNeuro. 9, 3, ENEURO.0061-22.2022.研究成果: Article › 査読
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Preserved intersegmental coordination during locomotion after cervical spinal cord injury in common marmosets
Sato, Y., Kondo, T., Uchida, A., Sato, K., Yoshino-Saito, K., Nakamura, M., Okano, H. & Ushiba, J., 2022 5月 3, In: Behavioural Brain Research. 425, 113816.研究成果: Article › 査読
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Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia
Sonn, I., Honda-Ozaki, F., Yoshimatsu, S., Morimoto, S., Watanabe, H. & Okano, H., 2022 12月, In: Inflammation and Regeneration. 42, 1, 20.研究成果: Article › 査読
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The GADD45G/p38 MAPK/CDC25B signaling pathway enhances neurite outgrowth by promoting microtubule polymerization
Kase, Y., Sato, T., Okano, Y. & Okano, H., 2022 4月 15, In: iScience. 25, 4, 104089.研究成果: Article › 査読
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TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF)
Morimoto, Y., Tokumitsu, A., Sone, T., Hirota, Y., Tamura, R., Sakamoto, A., Nakajima, K., Toda, M., Kawakami, Y., Okano, H. & Ohta, S., 2022, (Accepted/In press) In: Neurochemical Research.研究成果: Article › 査読
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Treadmill Training for Common Marmoset to Strengthen Corticospinal Connections After Thoracic Contusion Spinal Cord Injury
Kondo, T., Saito, R., Sato, Y., Sato, K., Uchida, A., Yoshino-Saito, K., Shinozaki, M., Tashiro, S., Nagoshi, N., Nakamura, M., Ushiba, J. & Okano, H., 2022 4月 22, In: Frontiers in Cellular Neuroscience. 16, 858562.研究成果: Article › 査読
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2021
Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson’s disease patient (PARK4) with SNCA triplication
Fukusumi, H., Togo, K., Sumida, M., Nakamori, M., Obika, S., Baba, K., Shofuda, T., Ito, D., Okano, H., Mochizuki, H. & Kanemura, Y., 2021 2月, In: FEBS Open Bio. 11, 2, p. 354-366 13 p.研究成果: Article › 査読
Open Access3 被引用数 (Scopus) -
A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury
Kamata, Y., Isoda, M., Sanosaka, T., Shibata, R., Ito, S., Okubo, T., Shinozaki, M., Inoue, M., Koya, I., Shibata, S., Shindo, T., Matsumoto, M., Nakamura, M., Okano, H., Nagoshi, N. & Kohyama, J., 2021 3月, In: Stem Cells Translational Medicine. 10, 3, p. 398-413 16 p.研究成果: Article › 査読
Open Access9 被引用数 (Scopus) -
Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians
Sasaki, T., Abe, Y., Takayama, M., Adachi, T., Okano, H., Hirose, N. & Arai, Y., 2021 12月, In: Scientific reports. 11, 1, 8539.研究成果: Article › 査読
Open Access4 被引用数 (Scopus) -
Comparison of Drug Availability in the Inner Ear After Oral, Transtympanic, and Combined Administration
Li, Y., Kanzaki, S., Shibata, S., Nakamura, M., Ozaki, M., Okano, H. & Ogawa, K., 2021 8月 19, In: Frontiers in Neurology. 12, 641593.研究成果: Article › 査読
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Dctn1 binds to tdp-43 and regulates tdp-43 aggregation
Deshimaru, M., Kinoshita-Kawada, M., Kubota, K., Watanabe, T., Tanaka, Y., Hirano, S., Ishidate, F., Hiramoto, M., Ishikawa, M., Uehara, Y., Okano, H., Hirose, S., Fujioka, S., Iwasaki, K., Yuasa-Kawada, J., Mishima, T. & Tsuboi, Y., 2021 4月 2, In: International journal of molecular sciences. 22, 8, 3985.研究成果: Article › 査読
Open Access5 被引用数 (Scopus) -
Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons
Toritsuka, M., Yoshino, H., Makinodan, M., Ikawa, D., Kimoto, S., Yamamuro, K., Okamura, K., Akamatsu, W., Okada, Y., Matsumoto, T., Hashimoto, K., Ogawa, Y., Saito, Y., Watanabe, K., Aoki, C., Takada, R., Fukami, S. I., Hamano-Iwasa, K., Okano, H. & Kishimoto, T., 2021 11月, In: Neurochemistry International. 150, 105179.研究成果: Article › 査読
2 被引用数 (Scopus) -
DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2
Nogami, M., Miyamoto, K., Hayakawa-Yano, Y., Nakanishi, A., Yano, M. & Okano, H., 2021 1月 1, In: Journal of Biological Chemistry. 296, 100409.研究成果: Article › 査読
Open Access3 被引用数 (Scopus) -
Direct neuronal reprogramming of common marmoset fibroblasts by ascl1, microrna-9/9*, and microrna-124 overexpression
Nemoto, A., Kobayashi, R., Yoshimatsu, S., Sato, Y., Kondo, T., Yoo, A. S., Shiozawa, S. & Okano, H., 2021 1月, In: Cells. 10, 1, p. 1-14 14 p., 6.研究成果: Article › 査読
Open Access2 被引用数 (Scopus) -
Dynamic spatiotemporal expression changes in connexins of the developing primate’s cochlea
Hosoya, M., Fujioka, M., Murayama, A. Y., Ogawa, K., Okano, H. & Ozawa, H., 2021 7月, In: Genes. 12, 7, 1082.研究成果: Article › 査読
Open Access3 被引用数 (Scopus) -
Establishing an induced pluripotent stem cell line from neonatal common marmoset fibroblasts by an all-in-one episomal vector approach
Yoshimatsu, S., Qian, E., Sato, T., Yamamoto, M., Ishikawa, M. & Okano, H., 2021 5月, In: Stem Cell Research. 53, 102380.研究成果: Article › 査読
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Establishment of an induced pluripotent stem cell line from a female domestic ferret (Mustela putorius furo) with an X chromosome instability
Yoshimatsu, S., Murakami, R., Nakajima, M., Sato, T., Kawasaki, H. & Okano, H., 2021 5月, In: Stem Cell Research. 53, 102385.研究成果: Article › 査読
Open Access2 被引用数 (Scopus) -
Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons
Yokota, M., Kakuta, S., Shiga, T., Ishikawa, K. I., Okano, H., Hattori, N., Akamatsu, W. & Koike, M., 2021 12月, In: Molecular brain. 14, 1, 58.研究成果: Article › 査読
Open Access4 被引用数 (Scopus) -
First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol
Sugai, K., Sumida, M., Shofuda, T., Yamaguchi, R., Tamura, T., Kohzuki, T., Abe, T., Shibata, R., Kamata, Y., Ito, S., Okubo, T., Tsuji, O., Nori, S., Nagoshi, N., Yamanaka, S., Kawamata, S., Kanemura, Y., Nakamura, M. & Okano, H., 2021 12月, In: Regenerative Therapy. 18, p. 321-333 13 p.研究成果: Article › 査読
Open Access8 被引用数 (Scopus) -
Flexible and accurate substrate processing with distinct presenilin/γ-secretases in human cortical neurons
Watanabe, H., Imaizumi, K., Cai, T., Zhou, Z., Tomita, T. & Okano, H., 2021, In: eNeuro. 8, 2, p. 1-20 20 p., ENEURO.0500-20.2021.研究成果: Article › 査読
Open Access3 被引用数 (Scopus) -
Flexible annotation atlas of the mouse brain: combining and dividing brain structures of the Allen Brain Atlas while maintaining anatomical hierarchy
Takata, N., Sato, N., Komaki, Y., Okano, H. & Tanaka, K. F., 2021 12月, In: Scientific reports. 11, 1, 6234.研究成果: Article › 査読
Open Access3 被引用数 (Scopus) -
FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells
Harada, S., Mabuchi, Y., Kohyama, J., Shimojo, D., Suzuki, S., Kawamura, Y., Araki, D., Suyama, T., Kajikawa, M., Akazawa, C., Okano, H. & Matsuzaki, Y., 2021 3月, In: Stem Cells. 39, 3, p. 318-330 13 p.研究成果: Article › 査読
Open Access8 被引用数 (Scopus) -
Generation and validation of a common marmoset embryonic stem cell line ActiCre-B1 that ubiquitously expresses a tamoxifen-inducible Cre-driver
Yoshimatsu, S., Ohtsu, K., Sato, T., Yamamoto, M., Sasaki, E., Shiozawa, S. & Okano, H., 2021 3月, In: Stem Cell Research. 51, 102164.研究成果: Article › 査読
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Generation of a common marmoset embryonic stem cell line CMES40-OC harboring a POU5F1 (OCT4)-2A-mCerulean3 knock-in reporter allele
Yoshimatsu, S., Murakami, R., Sato, T., Saeki, T., Yamamoto, M., Sasaki, E., Noce, T. & Okano, H., 2021 5月, In: Stem Cell Research. 53, 102308.研究成果: Article › 査読
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Generation of a control human induced pluripotent stem cell line using the defective and persistent Sendai virus vector system
Zhou, Z., Yoshimatsu, S., Qian, E., Ishikawa, M., Sato, T., Ohtaka, M., Nakanishi, M. & Okano, H., 2021 10月, In: Stem Cell Research. 56, 102549.研究成果: Article › 査読
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Generation of region-specific and high-purity neurons from human feeder-free iPSCs
Sato, T., Imaizumi, K., Watanabe, H., Ishikawa, M. & Okano, H., 2021 2月 16, In: Neuroscience Letters. 746, 135676.研究成果: Article › 査読
Open Access6 被引用数 (Scopus) -
Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in in vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures
Fukuyama, M., Tsukashima, A., Kimishima, M., Yamazaki, Y., Okano, H. & Ohyama, M., 2021 8月 2, In: Frontiers in Cell and Developmental Biology. 9, 590333.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN
Nogami, M., Ishikawa, M., Doi, A., Sano, O., Sone, T., Akiyama, T., Aoki, M., Nakanishi, A., Ogi, K., Yano, M. & Okano, H., 2021 7月, In: Neurobiology of Disease. 155, 105364.研究成果: Article › 査読
Open Access2 被引用数 (Scopus) -
Impaired neuronal activity and differential gene expression in STXBP1 encephalopathy patient iPSC-derived GABAergic neurons
Ichise, E., Chiyonobu, T., Ishikawa, M., Tanaka, Y., Shibata, M., Tozawa, T., Taura, Y., Yamashita, S., Yoshida, M., Morimoto, M., Higurashi, N., Yamamoto, T., Okano, H. & Hirose, S., 2021 7月 15, In: Human molecular genetics. 30, 14, p. 1337-1348 12 p.研究成果: Article › 査読
Open Access2 被引用数 (Scopus) -
Integrated Collection of Stem Cell Bank Data, a Data Portal for Standardized Stem Cell Information
Chen, Y., Sakurai, K., Maeda, S., Masui, T., Okano, H., Dewender, J., Seltmann, S., Kurtz, A., Masuya, H., Nakamura, Y., Sheldon, M., Schneider, J., Stacey, G. N., Panina, Y. & Fujibuchi, W., 2021 4月 13, In: Stem cell reports. 16, 4, p. 997-1005 9 p.研究成果: Article › 査読
Open Access2 被引用数 (Scopus) -
Involvement of ferroptosis in human motor neuron cell death
Matsuo, T., Adachi-Tominari, K., Sano, O., Kamei, T., Nogami, M., Ogi, K., Okano, H. & Yano, M., 2021 8月 20, In: Biochemical and Biophysical Research Communications. 566, p. 24-29 6 p.研究成果: Article › 査読
Open Access6 被引用数 (Scopus)