年別の研究成果
年別の研究成果
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2021
Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson’s disease patient (PARK4) with SNCA triplication
Fukusumi, H., Togo, K., Sumida, M., Nakamori, M., Obika, S., Baba, K., Shofuda, T., Ito, D., Okano, H., Mochizuki, H. & Kanemura, Y., 2021 2, In: FEBS Open Bio. 11, 2, p. 354-366 13 p.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
A new approach to analysis of intracellular proteins and subcellular localization using cellprofiler and imageJ in combination
Hattori, A., Ohta, E., Nagai, M., Iwabuchi, K. & Okano, H., 2021, (Accepted/In press) In: Methods.研究成果: Article › 査読
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A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury
Kamata, Y., Isoda, M., Sanosaka, T., Shibata, R., Ito, S., Okubo, T., Shinozaki, M., Inoue, M., Koya, I., Shibata, S., Shindo, T., Matsumoto, M., Nakamura, M., Okano, H., Nagoshi, N. & Kohyama, J., 2021 3, In: Stem Cells Translational Medicine. 10, 3, p. 398-413 16 p.研究成果: Article › 査読
Open Access5 被引用数 (Scopus) -
Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians
Sasaki, T., Abe, Y., Takayama, M., Adachi, T., Okano, H., Hirose, N. & Arai, Y., 2021 12, In: Scientific reports. 11, 1, 8539.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Comparison of Drug Availability in the Inner Ear After Oral, Transtympanic, and Combined Administration
Li, Y., Kanzaki, S., Shibata, S., Nakamura, M., Ozaki, M., Okano, H. & Ogawa, K., 2021 8 19, In: Frontiers in Neurology. 12, 641593.研究成果: Article › 査読
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Dctn1 binds to tdp-43 and regulates tdp-43 aggregation
Deshimaru, M., Kinoshita-Kawada, M., Kubota, K., Watanabe, T., Tanaka, Y., Hirano, S., Ishidate, F., Hiramoto, M., Ishikawa, M., Uehara, Y., Okano, H., Hirose, S., Fujioka, S., Iwasaki, K., Yuasa-Kawada, J., Mishima, T. & Tsuboi, Y., 2021 4 2, In: International journal of molecular sciences. 22, 8, 3985.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons
Toritsuka, M., Yoshino, H., Makinodan, M., Ikawa, D., Kimoto, S., Yamamuro, K., Okamura, K., Akamatsu, W., Okada, Y., Matsumoto, T., Hashimoto, K., Ogawa, Y., Saito, Y., Watanabe, K., Aoki, C., Takada, R., Fukami, S. I., Hamano-Iwasa, K., Okano, H. & Kishimoto, T., 2021 11, In: Neurochemistry International. 150, 105179.研究成果: Article › 査読
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DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2
Nogami, M., Miyamoto, K., Hayakawa-Yano, Y., Nakanishi, A., Yano, M. & Okano, H., 2021 1 1, In: Journal of Biological Chemistry. 296, 100409.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Dynamic spatiotemporal expression changes in connexins of the developing primate’s cochlea
Hosoya, M., Fujioka, M., Murayama, A. Y., Ogawa, K., Okano, H. & Ozawa, H., 2021 7, In: Genes. 12, 7, 1082.研究成果: Article › 査読
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Establishing an induced pluripotent stem cell line from neonatal common marmoset fibroblasts by an all-in-one episomal vector approach
Yoshimatsu, S., Qian, E., Sato, T., Yamamoto, M., Ishikawa, M. & Okano, H., 2021 5, In: Stem Cell Research. 53, 102380.研究成果: Article › 査読
Open Access -
Establishment of an induced pluripotent stem cell line from a female domestic ferret (Mustela putorius furo) with an X chromosome instability
Yoshimatsu, S., Murakami, R., Nakajima, M., Sato, T., Kawasaki, H. & Okano, H., 2021 5, In: Stem Cell Research. 53, 102385.研究成果: Article › 査読
Open Access -
Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons
Yokota, M., Kakuta, S., Shiga, T., Ishikawa, K. I., Okano, H., Hattori, N., Akamatsu, W. & Koike, M., 2021 12, In: Molecular brain. 14, 1, 58.研究成果: Article › 査読
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First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol
Sugai, K., Sumida, M., Shofuda, T., Yamaguchi, R., Tamura, T., Kohzuki, T., Abe, T., Shibata, R., Kamata, Y., Ito, S., Okubo, T., Tsuji, O., Nori, S., Nagoshi, N., Yamanaka, S., Kawamata, S., Kanemura, Y., Nakamura, M. & Okano, H., 2021 12, In: Regenerative Therapy. 18, p. 321-333 13 p.研究成果: Article › 査読
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Flexible and accurate substrate processing with distinct presenilin/γ-secretases in human cortical neurons
Watanabe, H., Imaizumi, K., Cai, T., Zhou, Z., Tomita, T. & Okano, H., 2021, In: eNeuro. 8, 2, p. 1-20 20 p., ENEURO.0500-20.2021.研究成果: Article › 査読
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Flexible annotation atlas of the mouse brain: combining and dividing brain structures of the Allen Brain Atlas while maintaining anatomical hierarchy
Takata, N., Sato, N., Komaki, Y., Okano, H. & Tanaka, K. F., 2021 12, In: Scientific reports. 11, 1, 6234.研究成果: Article › 査読
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FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells
Harada, S., Mabuchi, Y., Kohyama, J., Shimojo, D., Suzuki, S., Kawamura, Y., Araki, D., Suyama, T., Kajikawa, M., Akazawa, C., Okano, H. & Matsuzaki, Y., 2021 3, In: Stem Cells. 39, 3, p. 318-330 13 p.研究成果: Article › 査読
3 被引用数 (Scopus) -
Generation and validation of a common marmoset embryonic stem cell line ActiCre-B1 that ubiquitously expresses a tamoxifen-inducible Cre-driver
Yoshimatsu, S., Ohtsu, K., Sato, T., Yamamoto, M., Sasaki, E., Shiozawa, S. & Okano, H., 2021 3, In: Stem Cell Research. 51, 102164.研究成果: Article › 査読
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Generation of a common marmoset embryonic stem cell line CMES40-OC harboring a POU5F1 (OCT4)-2A-mCerulean3 knock-in reporter allele
Yoshimatsu, S., Murakami, R., Sato, T., Saeki, T., Yamamoto, M., Sasaki, E., Noce, T. & Okano, H., 2021 5, In: Stem Cell Research. 53, 102308.研究成果: Article › 査読
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Generation of region-specific and high-purity neurons from human feeder-free iPSCs
Sato, T., Imaizumi, K., Watanabe, H., Ishikawa, M. & Okano, H., 2021 2 16, In: Neuroscience Letters. 746, 135676.研究成果: Article › 査読
Open Access2 被引用数 (Scopus) -
Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in in vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures
Fukuyama, M., Tsukashima, A., Kimishima, M., Yamazaki, Y., Okano, H. & Ohyama, M., 2021 8 2, In: Frontiers in Cell and Developmental Biology. 9, 590333.研究成果: Article › 査読
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Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN
Nogami, M., Ishikawa, M., Doi, A., Sano, O., Sone, T., Akiyama, T., Aoki, M., Nakanishi, A., Ogi, K., Yano, M. & Okano, H., 2021 7, In: Neurobiology of Disease. 155, 105364.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Impaired neuronal activity and differential gene expression in STXBP1 encephalopathy patient iPSC-derived GABAergic neurons
Ichise, E., Chiyonobu, T., Ishikawa, M., Tanaka, Y., Shibata, M., Tozawa, T., Taura, Y., Yamashita, S., Yoshida, M., Morimoto, M., Higurashi, N., Yamamoto, T., Okano, H. & Hirose, S., 2021 7 15, In: Human molecular genetics. 30, 14, p. 1337-1348 12 p.研究成果: Article › 査読
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Integrated Collection of Stem Cell Bank Data, a Data Portal for Standardized Stem Cell Information
Chen, Y., Sakurai, K., Maeda, S., Masui, T., Okano, H., Dewender, J., Seltmann, S., Kurtz, A., Masuya, H., Nakamura, Y., Sheldon, M., Schneider, J., Stacey, G. N., Panina, Y. & Fujibuchi, W., 2021 4 13, In: Stem cell reports. 16, 4, p. 997-1005 9 p.研究成果: Article › 査読
Open Access -
Involvement of ferroptosis in human motor neuron cell death
Matsuo, T., Adachi-Tominari, K., Sano, O., Kamei, T., Nogami, M., Ogi, K., Okano, H. & Yano, M., 2021 8 20, In: Biochemical and Biophysical Research Communications. 566, p. 24-29 6 p.研究成果: Article › 査読
1 被引用数 (Scopus) -
Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking
Ojima, K., Shiraiwa, K., Soga, K., Doura, T., Takato, M., Komatsu, K., Yuzaki, M., Hamachi, I. & Kiyonaka, S., 2021 12, In: Nature communications. 12, 1, 831.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury
Ito, S., Nagoshi, N., Kamata, Y., Kojima, K., Nori, S., Matsumoto, M., Takei, K., Nakamura, M. & Okano, H., 2021 11 9, In: Stem cell reports. 16, 11, p. 2703-2717 15 p.研究成果: Article › 査読
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Markerless analysis of hindlimb kinematics in spinal cord-injured mice through deep learning
Sato, Y., Kondo, T., Shinozaki, M., Shibata, R., Nagoshi, N., Ushiba, J., Nakamura, M. & Okano, H., 2021, (Accepted/In press) In: Neuroscience Research.研究成果: Article › 査読
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MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling
Nakashima, H., Tsujimura, K., Irie, K., Imamura, T., Trujillo, C. A., Ishizu, M., Uesaka, M., Pan, M., Noguchi, H., Okada, K., Aoyagi, K., Andoh-Noda, T., Okano, H., Muotri, A. R. & Nakashima, K., 2021 5 18, In: Cell Reports. 35, 7, 109124.研究成果: Article › 査読
Open Access2 被引用数 (Scopus) -
MKK7 deficiency in mature neurons impairs parental behavior in mice
Shin, T., Hiraoka, Y., Yamasaki, T., Marth, J. D., Penninger, J. M., Kanai-Azuma, M., Tanaka, K., Kofuji, S. & Nishina, H., 2021 1, In: Genes to Cells. 26, 1, p. 5-17 13 p.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Modeling neurodevelopment in a dish with pluripotent stem cells
Imaizumi, K. & Okano, H., 2021 1, In: Development Growth and Differentiation. 63, 1, p. 18-25 8 p.研究成果: Article › 査読
Open Access2 被引用数 (Scopus) -
NEAT1 lncRNA and amyotrophic lateral sclerosis
Nishimoto, Y., Nakagawa, S. & Okano, H., 2021 11, In: Neurochemistry International. 150, 105175.研究成果: Article › 査読
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Neuronal development in the cochlea of a nonhuman primate model, the common marmoset
Hosoya, M., Fujioka, M., Murayama, A. Y., Ozawa, H., Okano, H. & Ogawa, K., 2021 11 1, In: Developmental Neurobiology. 81, 8, p. 905-938 34 p.研究成果: Article › 査読
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Non-viral derivation of a transgene-free induced pluripotent stem cell line from a male beagle dog
Yoshimatsu, S., Edamura, K., Yoshii, Y., Iguchi, A., Kondo, H., Shibuya, H., Sato, T., Shiozawa, S. & Okano, H., 2021 5, In: Stem Cell Research. 53, 102375.研究成果: Article › 査読
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Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species
Yoshimatsu, S., Nakajima, M., Iguchi, A., Sanosaka, T., Sato, T., Nakamura, M., Nakajima, R., Arai, E., Ishikawa, M., Imaizumi, K., Watanabe, H., Okahara, J., Noce, T., Takeda, Y., Sasaki, E., Behr, R., Edamura, K., Shiozawa, S. & Okano, H., 2021 4 13, In: Stem cell reports. 16, 4, p. 754-770 17 p.研究成果: Article › 査読
Open Access3 被引用数 (Scopus) -
Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice
Abe, Y., Kwon, S., Oishi, M., Unekawa, M., Takata, N., Seki, F., Koyama, R., Abe, M., Sakimura, K., Masamoto, K., Tomita, Y., Okano, H., Mushiake, H. & Tanaka, K. F., 2021 7 27, In: Cell Reports. 36, 4, 109427.研究成果: Article › 査読
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Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration
Ishii, S., Sasaki, T., Mohammad, S., Hwang, H., Tomy, E., Somaa, F., Ishibashi, N., Okano, H., Rakic, P., Hashimoto-Torii, K. & Torii, M., 2021 1 5, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 1, e2012482118.研究成果: Article › 査読
1 被引用数 (Scopus) -
Reduced PHOX2B stability causes axonal growth impairment in motor neurons with TARDBP mutations
Mitsuzawa, S., Suzuki, N., Akiyama, T., Ishikawa, M., Sone, T., Kawada, J., Funayama, R., Shirota, M., Mitsuhashi, H., Morimoto, S., Ikeda, K., Shijo, T., Ohno, A., Nakamura, N., Ono, H., Ono, R., Osana, S., Nakagawa, T., Nishiyama, A., Izumi, R. & 7 others, , 2021 6 8, In: Stem cell reports. 16, 6, p. 1527-1541 15 p.研究成果: Article › 査読
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Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS
Hirunagi, T., Sahashi, K., Tachikawa, K., Leu, A. I., Nguyen, M., Mukthavaram, R., Karmali, P. P., Chivukula, P., Tohnai, G., Iida, M., Onodera, K., Ohyama, M., Okada, Y., Okano, H. & Katsuno, M., 2021 6 4, In: Molecular Therapy - Nucleic Acids. 24, p. 1-10 10 p.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent
Thimaradka, V., Hoon Oh, J., Heroven, C., Radu Aricescu, A., Yuzaki, M., Tamura, T. & Hamachi, I., 2021 1 15, In: Bioorganic and Medicinal Chemistry. 30, 115947.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
Subunit-dependent and subunit-independent rules of AMPA receptor trafficking during chemical long-term depression in hippocampal neurons
Matsuda, S. & Yuzaki, M., 2021 8 1, In: Journal of Biological Chemistry. 297, 2, 100949.研究成果: Article › 査読
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Taurine rescues mitochondria-related metabolic impairments in the patient-derived induced pluripotent stem cells and epithelial-mesenchymal transition in the retinal pigment epithelium
Homma, K., Toda, E., Osada, H., Nagai, N., Era, T., Tsubota, K., Okano, H. & Ozawa, Y., 2021 5, In: Redox Biology. 41, 101921.研究成果: Article › 査読
Open Access4 被引用数 (Scopus) -
The autism-associated protein CHD8 is required for cerebellar development and motor function
Kawamura, A., Katayama, Y., Kakegawa, W., Ino, D., Nishiyama, M., Yuzaki, M. & Nakayama, K. I., 2021 4 6, In: Cell Reports. 35, 1, 108932.研究成果: Article › 査読
Open Access1 被引用数 (Scopus) -
The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development
Hosoya, M., Fujioka, M., Murayama, A. Y., Okano, H. & Ogawa, K., 2021 1, In: FEBS Journal. 288, 1, p. 325-353 29 p.研究成果: Article › 査読
Open Access3 被引用数 (Scopus) -
Treadmill training based on the overload principle promotes locomotor recovery in a mouse model of chronic spinal cord injury
Shibata, T., Tashiro, S., Shinozaki, M., Hashimoto, S., Matsumoto, M., Nakamura, M., Okano, H. & Nagoshi, N., 2021 11, In: Experimental Neurology. 345, 113834.研究成果: Article › 査読
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Umbilical artery tissue contains p75 neurotrophin receptor-positive pericyte-like cells that possess neurosphere formation capacity and neurogenic differentiation potential
Fujii-Tezuka, R., Ishige-Wada, M., Nagoshi, N., Okano, H., Mugishima, H., Takahashi, S., Morioka, I. & Matsumoto, T., 2021 3, In: Regenerative Therapy. 16, p. 1-11 11 p.研究成果: Article › 査読
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β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells
Chee, W. Y., Kurahashi, Y., Kim, J., Miura, K., Okuzaki, D., Ishitani, T., Kajiwara, K., Nada, S., Okano, H. & Okada, M., 2021 12, In: Communications biology. 4, 1, 357.研究成果: Article › 査読
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2020
A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling
Shiba-Fukushima, K., Inoshita, T., Sano, O., Iwata, H., Ishikawa, K. I., Okano, H., Akamatsu, W., Imai, Y. & Hattori, N., 2020 5 22, In: iScience. 23, 5, 101048.研究成果: Article › 査読
Open Access9 被引用数 (Scopus) -
A combinational treatment of carotenoids decreases Aβ secretion in human neurons via β-secretase inhibition
Sho, M., Ichiyanagi, N., Imaizumi, K., Ishikawa, M., Morimoto, S., Watanabe, H. & Okano, H., 2020 9, In: Neuroscience Research. 158, p. 47-55 9 p.研究成果: Article › 査読
1 被引用数 (Scopus) -
Analysis of the nucleocytoplasmic shuttling RNA-binding protein HNRNPU using optimized HITS-CLIP method
Yugami, M., Okano, H., Nakanishi, A. & Yano, M., 2020 4, In: PloS one. 15, 4, e0231450.研究成果: Article › 査読
Open Access2 被引用数 (Scopus) -
An improved de novo genome assembly of the common marmoset genome yields improved contiguity and increased mapping rates of sequence data
Jayakumar, V., Ishii, H., Seki, M., Kumita, W., Inoue, T., Hase, S., Sato, K., Okano, H., Sasaki, E. & Sakakibara, Y., 2020 4 2, In: BMC Genomics. 21, 243.研究成果: Article › 査読
Open Access4 被引用数 (Scopus)