生理学

Article

In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN

Ishii, T., Ishikawa, M., Fujimori, K., Maeda, T., Kushima, I., Arioka, Y., Mori, D., Nakatake, Y., Yamagata, B., Nio, S., Kato, T. A., Yang, N., Wernig, M., Kanba, S., Mimura, M., Ozaki, N. & Okano, H., 2019, In: eNeuro. 6, 5, ENEURO.0403-18.2019.

研究成果: Article › 査読

Open Access

30 被引用数 (Scopus)

In vitro screening of exogenous factors for human neural stem/progenitor cell proliferation using measurement of total ATP content in viable cells

Kanemura, Y., Mori, H., Nakagawa, A., Islam, M. O., Kodama, E., Yamamoto, A., Shofuda, T., Kobayashi, S., Miyake, J., Yamazaki, T., Hirano, S. I., Yamasaki, M. & Okano, H., 2005, In: Cell Transplantation. 14, 9, p. 673-682 10 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

In vivo imaging of engrafted neural stem cells: Its application in evaluating the optimal timing of transplantation for spinal cord injury

Okada, S., Ishii, K., Yamane, J., Iwanami, A., Ikegami, T., Katoh, H., Iwamoto, Y., Nakamura, M., Miyoshi, H., Okano, H. J., Contag, C. H., Toyama, Y. & Okano, H., 2005 11月, In: FASEB Journal. 19, 13, p. 1839-1841 3 p.

研究成果: Article › 査読

193 被引用数 (Scopus)

In vivo microscopic voxel-based morphometry with a brain template to characterize strainspecific structures in the mouse brain

Hikishima, K., Komaki, Y., Seki, F., Ohnishi, Y., Okano, H. J. & Okano, H., 2017, In: Scientific reports. 7, 1, 85.

研究成果: Article › 査読

Open Access

28 被引用数 (Scopus)

In vivo nanoscopic landscape of neurexin ligands underlying anterograde synapse specification

Nozawa, K., Sogabe, T., Hayashi, A., Motohashi, J., Miura, E., Arai, I. & Yuzaki, M., 2022 10月 5, In: Neuron.

研究成果: Article › 査読

3 被引用数 (Scopus)

In vivo PET measurements with [¹¹C]PE2I to evaluate fetal mesencephalic transplantations to unilateral 6-OHDA-lesioned rats

Inaji, M., Yoshizaki, T., Okauchi, T., Maeda, J., Nagai, Y., Nariai, T., Ohno, K., Ando, K., Okano, H., Obayashi, S. & Suhara, T., 2005, In: Cell Transplantation. 14, 9, p. 655-663 9 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

In vivo tracing of neural tracts in the intact and injured spinal cord of marmosets by diffusion tensor tractography

Fujiyoshi, K., Yamada, M., Nakamura, M., Yamane, J., Katoh, H., Kitamura, K., Kawai, K., Okada, S., Momoshima, S., Toyama, Y. & Okano, H., 2007 10月 31, In: Journal of Neuroscience. 27, 44, p. 11991-11998 8 p.

研究成果: Article › 査読

85 被引用数 (Scopus)

In vivo tracing of neural tracts in tiptoe walking yoshimura mice by diffusion tensor tractography

Takano, M., Komaki, Y., Hikishima, K., Konomi, T., Fujiyoshi, K., Tsuji, O., Toyama, Y., Okano, H. & Nakamura, M., 2013 1月 15, In: Spine. 38, 2, p. E66-E72

研究成果: Article › 査読

12 被引用数 (Scopus)

In vivoTwo-photon imaging of anesthesia-specific alterations in microglial surveillance and photodamage-directed motility in mouse cortex

Sun, W., Suzuki, K., Toptunov, D., Stoyanov, S., Yuzaki, M., Khiroug, L. & Dityatev, A., 2019, In: Frontiers in Neuroscience. 13, MAY, 421.

研究成果: Article › 査読

Open Access

22 被引用数 (Scopus)

Involvement of ER stress in dysmyelination of pelizaeus-merzbacher disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes

Numasawa-Kuroiwa, Y., Okada, Y., Shibata, S., Kishi, N., Akamatsu, W., Shoji, M., Nakanishi, A., Ohyama, M., Osaka, H., Inoue, K., Takahashi, K., Yamanaka, S., Kosaki, K., Takahashi, T. & Okano, H., 2014 5月 6, In: Stem cell reports. 2, 5, p. 648-661 14 p.

研究成果: Article › 査読

86 被引用数 (Scopus)

Involvement of ferroptosis in human motor neuron cell death

Matsuo, T., Adachi-Tominari, K., Sano, O., Kamei, T., Nogami, M., Ogi, K., Okano, H. & Yano, M., 2021 8月 20, In: Biochemical and Biophysical Research Communications. 566, p. 24-29 6 p.

研究成果: Article › 査読

Open Access

12 被引用数 (Scopus)

Involvement of GluD2 in fear-conditioned bradycardia in mice

Kotajima-Murakami, H., Narumi, S., Yuzaki, M. & Yanagihara, D., 2016 11月, In: PloS one. 11, 11, e0166144.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation

Yano, M., Okano, H. J. & Okano, H., 2005 4月 1, In: Journal of Biological Chemistry. 280, 13, p. 12690-12699 10 p.

研究成果: Article › 査読

108 被引用数 (Scopus)

Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling

Kase, Y., Otsu, K., Shimazaki, T. & Okano, H., 2019 6月 11, In: Stem cell reports. 12, 6, p. 1313-1328 16 p.

研究成果: Article › 査読

Open Access

26 被引用数 (Scopus)

Involvement of the septo-hippocampal cholinergic pathway in association with septal acetylcholinesterase upregulation in a mouse model of tauopathy

Hara, Y., Motoi, Y., Hikishima, K., Mizuma, H., Onoe, H., Matsumoto, S. E., Elahi, M., Okano, H., Aoki, S. & Hattori, N., 2017 1月 1, In: Current Alzheimer Research. 14, 1, p. 94-103 10 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Ionotropic glutamate receptor AMPA 1 is associated with ovulation rate

Sugimoto, M., Sasaki, S., Watanabe, T., Nishimura, S., Ideta, A., Yamazaki, M., Matsuda, K., Yuzaki, M., Sakimura, K., Aoyagi, Y. & Sugimoto, Y., 2010, In: PloS one. 5, 11, e13817.

研究成果: Article › 査読

23 被引用数 (Scopus)

IPS cell technologies: Significance and applications to CNS regeneration and disease

Okano, H. & Yamanaka, S., 2014 3月 31, In: Molecular brain. 7, 1, 22.

研究成果: Article › 査読

179 被引用数 (Scopus)

Isolation and characterization of dendritic cells from common marmosets for preclinical cell therapy studies

Ohta, S., Ueda, Y., Yaguchi, M., Matsuzaki, Y., Nakamura, M., Toyama, Y., Tanioka, Y., Tamaoki, N., Nomura, T., Okano, H., Kawakami, Y. & Toda, M., 2008 4月, In: Immunology. 123, 4, p. 566-574 9 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood

Al-Bakri, Z., Ishige-Wada, M., Fukuda, N., Yoshida-Noro, C., Nagoshi, N., Okano, H., Mugishima, H. & Matsumoto, T., 2020 12月, In: Regenerative Therapy. 15, p. 53-63 11 p.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

Isolation and identification of putative stem/progenitor cells from human cycling endometrium

Okano, H., 2007 9月 1, In: Journal of Obstetrics and Gynaecology Research. 33, SUPPL.1, p. S56-S57

研究成果: Article › 査読

Isolation and transplantation of dopaminergic neurons and neural stem cells

Okano, H., Yoshizaki, T., Shimazaki, T. & Sawamoto, K., 2002 10月 1, In: Parkinsonism and Related Disorders. 9, 1, p. 23-28 6 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells

Yoshizaki, T., Inaji, M., Kouike, H., Shimazaki, T., Sawamoto, K., Ando, K., Date, I., Kobayashi, K., Suhara, T., Uchiyama, Y. & Okano, H., 2004 6月 3, In: Neuroscience Letters. 363, 1, p. 33-37 5 p.

研究成果: Article › 査読

76 被引用数 (Scopus)

Isolation of mouse mesenchymal stem cells on the basis of expression of Sca-1 and PDGFR-α

Houlihan, D. D., Mabuchi, Y., Morikawa, S., Niibe, K., Araki, D., Suzuki, S., Okano, H. & Matsuzaki, Y., 2012 12月, In: Nature Protocols. 7, 12, p. 2103-2111 9 p.

研究成果: Article › 査読

197 被引用数 (Scopus)

Isolation of multipotent neural crest-derived stem cells from the adult mouse cornea

Yoshida, S., Shimmura, S., Nagoshi, N., Fukuda, K., Matsuzaki, Y., Okano, H. & Tsubota, K., 2006 12月, In: Stem Cells. 24, 12, p. 2714-2722 9 p.

研究成果: Article › 査読

155 被引用数 (Scopus)

JMJD1C exhibits multiple functions in epigenetic regulation during spermatogenesis

Nakajima, R., Okano, H. & Noce, T., 2016 9月, In: PloS one. 11, 9, e163466.

研究成果: Article › 査読

Open Access

11 被引用数 (Scopus)

Kidney Specific Protein-Positive Cells Derived from Embryonic Stem Cells Reproduce Tubular Structures In Vitro and Differentiate into Renal Tubular Cells

Morizane, R., Monkawa, T., Fujii, S., Yamaguchi, S., Homma, K., Matsuzaki, Y., Okano, H. & Itoh, H., 2013 6月 3, In: PloS one. 8, 6, e64843.

研究成果: Article › 査読

37 被引用数 (Scopus)

Kosaki overgrowth syndrome: A newly identified entity caused by pathogenic variants in platelet-derived growth factor receptor-beta

Takenouchi, T., Okuno, H. & Kosaki, K., 2019 12月 1, In: American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 181, 4, p. 650-657 8 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Large-area fluorescence and electron microscopic correlative imaging with multibeam scanning electron microscopy

Shibata, S., Iseda, T., Mitsuhashi, T., Oka, A., Shindo, T., Moritoki, N., Nagai, T., Otsubo, S., Inoue, T., Sasaki, E., Akazawa, C., Takahashi, T., Schalek, R., Lichtman, J. W. & Okano, H., 2019 4月 24, In: Frontiers in Neural Circuits. 13, 29.

研究成果: Article › 査読

Open Access

12 被引用数 (Scopus)

Laser-induced stress wave-assisted gene transfection with cationic liposome

Terakawa, M., Otsuka, R., Sato, S., Satoh, Y., Takishima, K., Ashida, H., Okano, H. & Obara, M., 2007 12月 14, In: Japanese Journal of Applied Physics, Part 2: Letters. 46, 45-49, p. L1243-L1245

研究成果: Article › 査読

3 被引用数 (Scopus)

Lecithinized brain-derived neurotrophic factor promotes the differentiation of embryonic stem cells in vitro and in vivo

Kitagawa, A., Nakayama, T., Takenaga, M., Matsumoto, K., Tokura, Y., Ohta, Y., Ichinohe, M., Yamaguchi, Y., Suzuki, N., Okano, H. & Igarashi, R., 2005 3月 25, In: Biochemical and Biophysical Research Communications. 328, 4, p. 1051-1057 7 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Lecithinized superoxide dismutase (PC-SOD) improved spinal cord injury-induced motor dysfunction through suppression of oxidative stress and enhancement of neurotrophic factor production

Takenaga, M., Ohta, Y., Tokura, Y., Hamaguchi, A., Nakamura, M., Okano, H. & Igarashi, R., 2006 1月 10, In: Journal of Controlled Release. 110, 2, p. 283-289 7 p.

研究成果: Article › 査読

33 被引用数 (Scopus)

Lefschetz-thimble inspired analysis of the Dykhne–Davis–Pechukas method and an application for the Schwinger Mechanism

Fukushima, K. & Shimazaki, T., 2020 4月, In: Annals of Physics. 415, 168111.

研究成果: Article › 査読

6 被引用数 (Scopus)

Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway

Kohno, D., Nakata, M., Maekawa, F., Fujiwara, K., Maejima, Y., Kuramochi, M., Shimazaki, T., Okano, H., Onaka, T. & Yada, T., 2007 5月, In: Endocrinology. 148, 5, p. 2251-2263 13 p.

研究成果: Article › 査読

117 被引用数 (Scopus)

Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16

Hishikawa, K., Marumo, T., Miura, S., Nakanishi, A., Matsuzaki, Y., Shibata, K., Kohike, H., Komori, T., Hayashi, M., Nakaki, T., Nakauchi, H., Okano, H. & Fujita, T., 2005 3月 4, In: Biochemical and Biophysical Research Communications. 328, 1, p. 288-291 4 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking

Ojima, K., Shiraiwa, K., Soga, K., Doura, T., Takato, M., Komatsu, K., Yuzaki, M., Hamachi, I. & Kiyonaka, S., 2021 12月, In: Nature communications. 12, 1, 831.

研究成果: Article › 査読

Open Access

14 被引用数 (Scopus)

LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop

Tomioka, T., Shimazaki, T., Yamauchi, T., Oki, T., Ohgoh, M. & Okano, H., 2014 1月 10, In: Journal of Biological Chemistry. 289, 2, p. 1000-1010 11 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

LNGFR⁺THY-1⁺ human pluripotent stem cell-derived neural crest-like cells have the potential to develop into mesenchymal stem cells

Ouchi, T., Morikawa, S., Shibata, S., Fukuda, K., Okuno, H., Fujimura, T., Kuroda, T., Ohyama, M., Akamatsu, W., Nakagawa, T. & Okano, H., 2016 12月 1, In: Differentiation. 92, 5, p. 270-280 11 p.

研究成果: Article › 査読

Open Access

16 被引用数 (Scopus)

LNGFR⁺THY-1⁺VCAM-1^hi+ cells reveal functionally distinct subpopulations in mesenchymal stem cells

Mabuchi, Y., Morikawa, S., Harada, S., Niibe, K., Suzuki, S., Renault-Mihara, F., Houlihan, D. D., Akazawa, C., Okano, H. & Matsuzaki, Y., 2013, In: Stem cell reports. 1, 2, p. 152-165 14 p.

研究成果: Article › 査読

143 被引用数 (Scopus)

Long Preservation of AAV-Transduced Fluorescence by a Modified Organic Solvent-Based Clearing Method

Lu, T., Shinozaki, M., Nagoshi, N., Nakamura, M. & Okano, H., 2022 9月, In: International journal of molecular sciences. 23, 17, 9637.

研究成果: Article › 査読

Open Access

Long-Range Interhemispheric Projection Neurons Show Biased Response Properties and Fine-Scale Local Subnetworks in Mouse Visual Cortex

Hagihara, K. M., Ishikawa, A. W., Yoshimura, Y., Tagawa, Y. & Ohki, K., 2021 2月 1, In: Cerebral Cortex. 31, 2, p. 1307-1315 9 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: Oncogenic transformation with epithelial-mesenchymal transition

Nori, S., Okada, Y., Nishimura, S., Sasaki, T., Itakura, G., Kobayashi, Y., Renault-Mihara, F., Shimizu, A., Koya, I., Yoshida, R., Kudoh, J., Koike, M., Uchiyama, Y., Ikeda, E., Toyama, Y., Nakamura, M. & Okano, H., 2015 3月 10, In: Stem cell reports. 4, 3, p. 360-373 14 p.

研究成果: Article › 査読

147 被引用数 (Scopus)

Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function

Kawai, M., Imaizumi, K., Ishikawa, M., Shibata, S., Shinozaki, M., Shibata, T., Hashimoto, S., Kitagawa, T., Ago, K., Kajikawa, K., Shibata, R., Kamata, Y., Ushiba, J., Koga, K., Furue, H., Matsumoto, M., Nakamura, M., Nagoshi, N. & Okano, H., 2021 11月 23, In: Cell Reports. 37, 8, 110019.

研究成果: Article › 査読

Open Access

15 被引用数 (Scopus)

Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice

Sakatani, T., Kaneda, A., Iacobuzio-Donahue, C. A., Carter, M. G., De Boom Witzel, S., Okano, H., Ko, M. S. H., Ohlsson, R., Longo, D. L. & Feinberg, A. P., 2005 3月 25, In: Science. 307, 5717, p. 1976-1978 3 p.

研究成果: Article › 査読

284 被引用数 (Scopus)

Loss of MeCP2 Function Across Several Neuronal Populations Impairs Breathing Response to Acute Hypoxia

Ward, C. S., Huang, T. W., Herrera, J. A., Samaco, R. C., McGraw, C. M., Parra, D. E., Arvide, E. M., Ito-Ishida, A., Meng, X., Ure, K., Zoghbi, H. Y. & Neul, J. L., 2020 10月 30, In: Frontiers in Neurology. 11, 593554.

研究成果: Article › 査読

Open Access

6 被引用数 (Scopus)

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression

Nakatsukasa, H., Oda, M., Yin, J., Chikuma, S., Ito, M., Koga-Iizuka, M., Someya, K., Kitagawa, Y., Ohkura, N., Sakaguchi, S., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Yamanaka, S., Takamura-Enya, T., Lu, Q. & Yoshimura, A., 2019 4月 26, In: International immunology. 31, 5, p. 335-347 13 p.

研究成果: Article › 査読

38 被引用数 (Scopus)

LOTUS inhibits neuronal apoptosis and promotes tract regeneration in contusive spinal cord injury model mice

Ito, S., Nagoshi, N., Tsuji, O., Shibata, S., Shinozaki, M., Kawabata, S., Kojima, K., Yasutake, K., Hirokawa, T., Matsumoto, M., Takei, K., Nakamura, M. & Okano, H., 2018 9月 1, In: eNeuro. 5, 5, e0303.

研究成果: Article › 査読

Open Access

20 被引用数 (Scopus)

LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury

Ito, S., Nagoshi, N., Kamata, Y., Kojima, K., Nori, S., Matsumoto, M., Takei, K., Nakamura, M. & Okano, H., 2021 11月 9, In: Stem cell reports. 16, 11, p. 2703-2717 15 p.

研究成果: Article › 査読

Open Access

7 被引用数 (Scopus)

Low-dose rapamycin-induced autophagy in cochlear outer sulcus cells

Saegusa, C., Hosoya, M., Nishiyama, T., Saeki, T., Fujimoto, C., Okano, H., Fujioka, M. & Ogawa, K., 2020 6月 1, In: Laryngoscope investigative otolaryngology. 5, 3, p. 520-528 9 p.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Low immunogenicity of mouse induced pluripotent stem cell-derived neural stem/progenitor cells

Itakura, G., Ozaki, M., Nagoshi, N., Kawabata, S., Nishiyama, Y., Sugai, K., Iida, T., Kashiwagi, R., Ookubo, T., Yastake, K., Matsubayashi, K., Kohyama, J., Iwanami, A., Matsumoto, M., Nakamura, M. & Okano, H., 2017 12月 1, In: Scientific reports. 7, 1, 12996.

研究成果: Article › 査読

Open Access

14 被引用数 (Scopus)

Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells

Ota, S., Misawa, A., Fukaya, R., Inoue, S., Kanemura, Y., Okano, H., Kawakami, Y. & Toda, M., 2012 10月 1, In: Development (Cambridge). 139, 19

研究成果: Article › 査読

75 被引用数 (Scopus)

研究成果

検索結果