生理学

Mouse embryonic stem cells give rise to gut-like morphogenesis, including intestinal stem cells, in the embryoid body model

Konuma, N., Wakabayashi, K., Matsumoto, T., Kusumi, Y., Masuko, T., Iribe, Y., Mitsumata, M., Okano, H., Kusafuka, T. & Mugishima, H., 2009 1月 1, In: Stem Cells and Development. 18, 1, p. 113-126 14 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Molecular signatures to define spermatogenic cells in common marmoset (Callithrix jacchus)

Lin, Z. Y. C., Imamura, M., Sano, C., Nakajima, R., Suzuki, T., Yamadera, R., Takehara, Y., Okano, H. J., Sasaki, E. & Okano, H., 2012 5月, In: Reproduction. 143, 5, p. 597-609 13 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Molecular Mechanisms for Learning and Memory: What Happens at the Synapses?

Kakegawa, W. & Yuzaki, M., 2018 7月 1, In: Brain and nerve = Shinkei kenkyu no shinpo. 70, 7, p. 677-687 11 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Molecular identity of periglomerular and short axon cells

Kiyokage, E., Pan, Y. Z., Shao, Z., Kobayashi, K., Szabo, G., Yanagawa, Y., Obata, K., Okano, H., Toida, K., Puche, A. C. & Shipley, M. T., 2010 1月 20, In: Journal of Neuroscience. 30, 3, p. 1185-1196 12 p.

研究成果: Article › 査読

160 被引用数 (Scopus)

Molecular Genetic Analysis of Myelin‐Deficient Mice: Shiverer Mutant Mice Show Deletion in Gene(s) Coding for Myelin Basic Protein

Kimura, M., Inoko, H., Katsuki, M., Ando, A., Sato, T., Hirose, T., Takashima, H., Inayama, S., Okano, H., Takamatsu, K., Mikoshiba, K., Tsukada, Y. & Watanabe, I., 1985 3月, In: Journal of Neurochemistry. 44, 3, p. 692-696 5 p.

研究成果: Article › 査読

70 被引用数 (Scopus)

Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury

Kitagawa, T., Nagoshi, N., Kamata, Y., Kawai, M., Ago, K., Kajikawa, K., Shibata, R., Sato, Y., Imaizumi, K., Shindo, T., Shinozaki, M., Kohyama, J., Shibata, S., Matsumoto, M., Nakamura, M. & Okano, H., 2022 1月 11, In: Stem cell reports. 17, 1, p. 127-142 16 p.

研究成果: Article › 査読

Open Access

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

Fujimori, K., Ishikawa, M., Otomo, A., Atsuta, N., Nakamura, R., Akiyama, T., Hadano, S., Aoki, M., Saya, H., Sobue, G. & Okano, H., 2018 10月 1, In: Nature medicine. 24, 10, p. 1579-1589 11 p.

研究成果: Article › 査読

152 被引用数 (Scopus)

Modeling rett syndrome using human induced pluripotent stem cells

Andoh-Noda, T., Inouye, M. O., Miyake, K., Kubota, T., Okano, H. & Akamatsu, W., 2016 5月 1, In: CNS and Neurological Disorders - Drug Targets. 15, 5, p. 544-550 7 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines

Fujimori, K., Tezuka, T., Ishiura, H., Mitsui, J., Doi, K., Yoshimura, J., Tada, H., Matsumoto, T., Isoda, M., Hashimoto, R., Hattori, N., Takahashi, T., Morishita, S., Tsuji, S., Akamatsu, W. & Okano, H., 2016 10月 3, In: Molecular brain. 9, 1, p. 1-14 14 p.

研究成果: Article › 査読

Open Access

14 被引用数 (Scopus)

Modeling neurodevelopment in a dish with pluripotent stem cells

Imaizumi, K. & Okano, H., 2021 1月, In: Development Growth and Differentiation. 63, 1, p. 18-25 8 p.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

Modeling familial Alzheimer's disease with induced pluripotent stem cells

Yagi, T., Ito, D., Okada, Y., Akamatsu, W., Nihei, Y., Yoshizaki, T., Yamanaka, S., Okano, H. & Suzuki, N., 2011 12月, In: Human molecular genetics. 20, 23, p. 4530-4539 10 p., ddr394.

研究成果: Article › 査読

420 被引用数 (Scopus)

Modeling familial alzheimer's disease with induced pluripotent stem cells

Yagi, T., Ito, D., Okada, Y., Akamatsu, W., Nihei, Y., Okano, H. & Suzuki, N., 2012, In: Clinical Neurology. 52, 11, p. 1134-1136 3 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Mode decomposed chiral magnetic effect and rotating fermions

Fukushima, K., Shimazaki, T. & Wang, L., 2020 7月 1, In: Physical Review D. 102, 1, 014045.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

MKK7 deficiency in mature neurons impairs parental behavior in mice

Shin, T., Hiraoka, Y., Yamasaki, T., Marth, J. D., Penninger, J. M., Kanai-Azuma, M., Tanaka, K., Kofuji, S. & Nishina, H., 2021 1月, In: Genes to Cells. 26, 1, p. 5-17 13 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advancestowards Quick Screening for Neuronal Disease Phenotypes In Vitro

Ishikawa, M., Aoyama, T., Shibata, S., Sone, T., Miyoshi, H., Watanabe, H., Nakamura, M., Morota, S., Uchino, H., Yoo, A. S. & Okano, H., 2020 2月 25, In: Cells. 9, 3

研究成果: Article › 査読

Open Access

10 被引用数 (Scopus)

Mimicking the neurotrophic factor profile of embryonic spinal cord controls the differentiation potential of spinal progenitors into neuronal cells

Nakamura, M., Tsuji, O., Bregman, B. S., Toyama, Y. & Okano, H., 2011, In: PloS one. 6, 6, e20717.

研究成果: Article › 査読

8 被引用数 (Scopus)

Migration and differentiation of transplanted enteric neural crest-derived cells in murine model of Hirschsprung’s disease

Nishikawa, R., Hotta, R., Shimojima, N., Shibata, S., Nagoshi, N., Nakamura, M., Matsuzaki, Y., Okano, H. J., Kuroda, T., Okano, H. & Morikawa, Y., 2015 8月 23, In: Cytotechnology. 67, 4, p. 661-670 10 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

MIF maintains the tumorigenic capacity of brain tumor-initiating cells by directly inhibiting p53

Fukaya, R., Ohta, S., Yaguchi, T., Matsuzaki, Y., Sugihara, E., Okano, H., Saya, H., Kawakami, Y., Kawase, T., Yoshida, K. & Toda, M., 2016 5月 1, In: Cancer Research. 76, 9, p. 2813-2823 11 p.

研究成果: Article › 査読

Open Access

40 被引用数 (Scopus)

MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells

Tsuyama, J., Bunt, J., Richards, L. J., Iwanari, H., Mochizuki, Y., Hamakubo, T., Shimazaki, T. & Okano, H., 2015 9月 8, In: Stem cell reports. 5, 3, p. 365-377 13 p.

研究成果: Article › 査読

Open Access

34 被引用数 (Scopus)

Microduplication of Xq24 and Hartsfield syndrome with holoprosencephaly, ectrodactyly, and clefting

Takenouchi, T., Okuno, H., Kosaki, R., Ariyasu, D., Torii, C., Momoshima, S., Harada, N., Yoshihashi, H., Takahashi, T., Awazu, M. & Kosaki, K., 2012 10月, In: American Journal of Medical Genetics, Part A. 158 A, 10, p. 2537-2541 5 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions

Saegusa, S., Fukaya, M., Kakegawa, W., Tanaka, M., Katsumata, O., Sugawara, T., Hara, Y., Itakura, M., Okubo, T., Sato, T., Yuzaki, M. & Sakagami, H., 2019 5月, In: PloS one. 14, 5, e0216960.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model

Ogawa, Y., Morikawa, S., Okano, H., Mabuchi, Y., Suzuki, S., Yaguchi, T., Sato, Y., Mukai, S., Yaguchi, S., Inaba, T., Okamoto, S., Kawakami, Y., Tsubota, K., Matsuzaki, Y. & Shimmura, S., 2016 1月 26, In: eLife. 5, JANUARY2016, e09394.

研究成果: Article › 査読

24 被引用数 (Scopus)

Methylene blue inhibits formation of tau fibrils but not of granular tau oligomers: A plausible key to understanding failure of a clinical trial for Alzheimer's disease

Soeda, Y., Saito, M., Maeda, S., Ishida, K., Nakamura, A., Kojima, S. & Takashima, A., 2019, In: Journal of Alzheimer's Disease. 68, 4, p. 1677-1686 10 p.

研究成果: Article › 査読

33 被引用数 (Scopus)

Meteorin: A secreted protein that regulates glial cell differentiation and promotes axonal extension

Nishino, J., Yamashita, K., Hashiguchi, H., Fujii, H., Shimazaki, T. & Hamada, H., 2004 5月 5, In: EMBO Journal. 23, 9, p. 1998-2008 11 p.

研究成果: Article › 査読

82 被引用数 (Scopus)

MeCP2 levels regulate the 3d structure of heterochromatic foci in mouse neurons

Ito-Ishida, A., Baker, S. A., Sillitoe, R. V., Sun, Y., Zhou, J., Ono, Y., Iwakiri, J., Yuzaki, M. & Zoghbi, H. Y., 2020 11月 4, In: Journal of Neuroscience. 40, 45, p. 8746-8766 21 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling

Nakashima, H., Tsujimura, K., Irie, K., Imamura, T., Trujillo, C. A., Ishizu, M., Uesaka, M., Pan, M., Noguchi, H., Okada, K., Aoyagi, K., Andoh-Noda, T., Okano, H., Muotri, A. R. & Nakashima, K., 2021 5月 18, In: Cell Reports. 35, 7, 109124.

研究成果: Article › 査読

Open Access

5 被引用数 (Scopus)

Measurement of baseline locomotion and other behavioral traits in a common marmoset model of Parkinson's disease established by a single administration regimen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: providing reference data for efficacious preclinical evaluations

Ando, K., Inoue, T., Hikishima, K., Komaki, Y., Kawai, K., Inoue, R., Nishime, C., Nishinaka, E., Urano, K. & Okano, H., 2020, In: Behavioural pharmacology. 31, 1, p. 45-60 16 p.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

Mature adipocyte-derived cells, dedifferentiated fat cells (DFAT), promoted functional recovery from spinal cord injury-induced motor dysfunction in rats

Ohta, Y., Takenaga, M., Tokura, Y., Hamaguchi, A., Matsuraoto, T., Kano, K., Mugishima, H., Okano, H. & Igarashi, R., 2008, In: Cell Transplantation. 17, 8, p. 877-886 10 p.

研究成果: Article › 査読

65 被引用数 (Scopus)

Markerless analysis of hindlimb kinematics in spinal cord-injured mice through deep learning

Sato, Y., Kondo, T., Shinozaki, M., Shibata, R., Nagoshi, N., Ushiba, J., Nakamura, M. & Okano, H., 2022 3月, In: Neuroscience Research. 176, p. 49-56 8 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Mapping spatio-temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brain

Tokunaga, A., Kohyama, J., Yoshida, T., Nakao, K., Sawamoto, K. & Okano, H., 2004 7月, In: Journal of Neurochemistry. 90, 1, p. 142-154 13 p.

研究成果: Article › 査読

89 被引用数 (Scopus)

Mapping orbitofrontal-limbic maturation in non-human primates: A longitudinal magnetic resonance imaging study

Uematsu, A., Hata, J., Komaki, Y., Seki, F., Yamada, C., Okahara, N., Kurotaki, Y., Sasaki, E. & Okano, H., 2017 12月, In: NeuroImage. 163, p. 55-67 13 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

Mapping of Notch activation during cochlear development in mice: Implications for determination of prosensory domain and cell fate diversification

Murata, J., Tokunaga, A., Okano, H. & Kubo, T., 2006 7月 20, In: Journal of Comparative Neurology. 497, 3, p. 502-518 17 p.

研究成果: Article › 査読

56 被引用数 (Scopus)

Making and repairing the mammalian brain: Introduction.

Okano, H., 2003 6月, In: Seminars in cell & developmental biology. 14, 3, 1 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells

Ota, S., Misawa, A., Fukaya, R., Inoue, S., Kanemura, Y., Okano, H., Kawakami, Y. & Toda, M., 2012 10月 1, In: Development (Cambridge). 139, 19

研究成果: Article › 査読

69 被引用数 (Scopus)

Low immunogenicity of mouse induced pluripotent stem cell-derived neural stem/progenitor cells

Itakura, G., Ozaki, M., Nagoshi, N., Kawabata, S., Nishiyama, Y., Sugai, K., Iida, T., Kashiwagi, R., Ookubo, T., Yastake, K., Matsubayashi, K., Kohyama, J., Iwanami, A., Matsumoto, M., Nakamura, M. & Okano, H., 2017 12月 1, In: Scientific reports. 7, 1, 12996.

研究成果: Article › 査読

13 被引用数 (Scopus)

Low-dose rapamycin-induced autophagy in cochlear outer sulcus cells

Saegusa, C., Hosoya, M., Nishiyama, T., Saeki, T., Fujimoto, C., Okano, H., Fujioka, M. & Ogawa, K., 2020 6月 1, In: Laryngoscope investigative otolaryngology. 5, 3, p. 520-528 9 p.

研究成果: Article › 査読

Open Access

2 被引用数 (Scopus)

LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury

Ito, S., Nagoshi, N., Kamata, Y., Kojima, K., Nori, S., Matsumoto, M., Takei, K., Nakamura, M. & Okano, H., 2021 11月 9, In: Stem cell reports. 16, 11, p. 2703-2717 15 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

LOTUS inhibits neuronal apoptosis and promotes tract regeneration in contusive spinal cord injury model mice

Ito, S., Nagoshi, N., Tsuji, O., Shibata, S., Shinozaki, M., Kawabata, S., Kojima, K., Yasutake, K., Hirokawa, T., Matsumoto, M., Takei, K., Nakamura, M. & Okano, H., 2018 9月 1, In: eNeuro. 5, 5, e0303.

研究成果: Article › 査読

15 被引用数 (Scopus)

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression

Nakatsukasa, H., Oda, M., Yin, J., Chikuma, S., Ito, M., Koga-Iizuka, M., Someya, K., Kitagawa, Y., Ohkura, N., Sakaguchi, S., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Yamanaka, S., Takamura-Enya, T., Lu, Q. & Yoshimura, A., 2019 4月 26, In: International immunology. 31, 5, p. 335-347 13 p.

研究成果: Article › 査読

28 被引用数 (Scopus)

Loss of MeCP2 Function Across Several Neuronal Populations Impairs Breathing Response to Acute Hypoxia

Ward, C. S., Huang, T. W., Herrera, J. A., Samaco, R. C., McGraw, C. M., Parra, D. E., Arvide, E. M., Ito-Ishida, A., Meng, X., Ure, K., Zoghbi, H. Y. & Neul, J. L., 2020 10月 30, In: Frontiers in Neurology. 11, 593554.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice

Sakatani, T., Kaneda, A., Iacobuzio-Donahue, C. A., Carter, M. G., De Boom Witzel, S., Okano, H., Ko, M. S. H., Ohlsson, R., Longo, D. L. & Feinberg, A. P., 2005 3月 25, In: Science. 307, 5717, p. 1976-1978 3 p.

研究成果: Article › 査読

282 被引用数 (Scopus)

Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function

Kawai, M., Imaizumi, K., Ishikawa, M., Shibata, S., Shinozaki, M., Shibata, T., Hashimoto, S., Kitagawa, T., Ago, K., Kajikawa, K., Shibata, R., Kamata, Y., Ushiba, J., Koga, K., Furue, H., Matsumoto, M., Nakamura, M., Nagoshi, N. & Okano, H., 2021 11月 23, In: Cell Reports. 37, 8, 110019.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: Oncogenic transformation with epithelial-mesenchymal transition

Nori, S., Okada, Y., Nishimura, S., Sasaki, T., Itakura, G., Kobayashi, Y., Renault-Mihara, F., Shimizu, A., Koya, I., Yoshida, R., Kudoh, J., Koike, M., Uchiyama, Y., Ikeda, E., Toyama, Y., Nakamura, M. & Okano, H., 2015 3月 10, In: Stem cell reports. 4, 3, p. 360-373 14 p.

研究成果: Article › 査読

138 被引用数 (Scopus)

Long-Range Interhemispheric Projection Neurons Show Biased Response Properties and Fine-Scale Local Subnetworks in Mouse Visual Cortex

Hagihara, K. M., Ishikawa, A. W., Yoshimura, Y., Tagawa, Y. & Ohki, K., 2021 2月 1, In: Cerebral Cortex. 31, 2, p. 1307-1315 9 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

LNGFR⁺THY-1⁺ human pluripotent stem cell-derived neural crest-like cells have the potential to develop into mesenchymal stem cells

Ouchi, T., Morikawa, S., Shibata, S., Fukuda, K., Okuno, H., Fujimura, T., Kuroda, T., Ohyama, M., Akamatsu, W., Nakagawa, T. & Okano, H., 2016 12月 1, In: Differentiation. 92, 5, p. 270-280 11 p.

研究成果: Article › 査読

Open Access

14 被引用数 (Scopus)

LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop

Tomioka, T., Shimazaki, T., Yamauchi, T., Oki, T., Ohgoh, M. & Okano, H., 2014 1月 10, In: Journal of Biological Chemistry. 289, 2, p. 1000-1010 11 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking

Ojima, K., Shiraiwa, K., Soga, K., Doura, T., Takato, M., Komatsu, K., Yuzaki, M., Hamachi, I. & Kiyonaka, S., 2021 12月, In: Nature communications. 12, 1, 831.

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Open Access

5 被引用数 (Scopus)

Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16

Hishikawa, K., Marumo, T., Miura, S., Nakanishi, A., Matsuzaki, Y., Shibata, K., Kohike, H., Komori, T., Hayashi, M., Nakaki, T., Nakauchi, H., Okano, H. & Fujita, T., 2005 3月 4, In: Biochemical and Biophysical Research Communications. 328, 1, p. 288-291 4 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway

Kohno, D., Nakata, M., Maekawa, F., Fujiwara, K., Maejima, Y., Kuramochi, M., Shimazaki, T., Okano, H., Onaka, T. & Yada, T., 2007 5月, In: Endocrinology. 148, 5, p. 2251-2263 13 p.

研究成果: Article › 査読

114 被引用数 (Scopus)

Lefschetz-thimble inspired analysis of the Dykhne–Davis–Pechukas method and an application for the Schwinger Mechanism

Fukushima, K. & Shimazaki, T., 2020 4月, In: Annals of Physics. 415, 168111.

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5 被引用数 (Scopus)

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