研究成果

2020

Armitage determines Piwi−piRISC processing from precursor formation and quality control to inter-organelle translocation

Yamashiro, H., Negishi, M., Kinoshita, T., Ishizu, H., Ohtani, H. & Siomi, M. C., 2020 2 5, : : EMBO Reports. 21, 2, e48769.

研究成果: Article

1 引用 (Scopus)

Crystal structure of Drosophila Piwi

Yamaguchi, S., Oe, A., Nishida, K. M., Yamashita, K., Kajiya, A., Hirano, S., Matsumoto, N., Dohmae, N., Ishitani, R., Saito, K., Siomi, H., Nishimasu, H., Siomi, M. C. & Nureki, O., 2020 12 1, : : Nature communications. 11, 1, 858.

研究成果: Article

公開
2019

Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Yamanaka, S., Nishihara, H., Toh, H., Eijy Nagai, L. A., Hashimoto, K., Park, S. J., Shibuya, A., Suzuki, A. M., Tanaka, Y., Nakai, K., Carninci, P., Sasaki, H. & Siomi, H., 2019 10 7, : : Developmental Cell. 51, 1, p. 21-34.e5

研究成果: Article

3 引用 (Scopus)

Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing

Osumi, K., Sato, K., Murano, K., Siomi, H. & Siomi, M. C., 2019 1 1, (Accepted/In press) : : EMBO Reports. e48296.

研究成果: Article

4 引用 (Scopus)

Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing

Murano, K., Iwasaki, Y. W., Ishizu, H., Mashiko, A., Shibuya, A., Kondo, S., Adachi, S., Suzuki, S., Saito, K., Natsume, T., Siomi, M. C. & Siomi, H., 2019 9 2, : : EMBO Journal. 38, 17, e102870.

研究成果: Article

10 引用 (Scopus)

Requirements for multivalent Yb body assembly in transposon silencing in Drosophila

Hirakata, S., Ishizu, H., Fujita, A., Tomoe, Y. & Siomi, M. C., 2019 7, : : EMBO Reports. 20, 7, e47708.

研究成果: Article

5 引用 (Scopus)

Template Activating Factor-I α Regulates Retroviral Silencing during Reprogramming

Bui, P. L., Nishimura, K., Seminario Mondejar, G., Kumar, A., Aizawa, S., Murano, K., Nagata, K., Hayashi, Y., Fukuda, A., Onuma, Y., Ito, Y., Nakanishi, M. & Hisatake, K., 2019 11 12, : : Cell Reports. 29, 7, p. 1909-1922.e5

研究成果: Article

公開
2018

Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype

Hosoi, Y., Soma, M., Shiura, H., Sado, T., Hasuwa, H., Abe, K., Kohda, T., Ishino, F. & Kobayashi, S., 2018 12 1, : : Nature communications. 9, 1, 3829.

研究成果: Article

3 引用 (Scopus)

Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology

Zhang, C., Seo, J., Murakami, K., Salem, E. S. B., Bernhard, E., Borra, V. J., Choi, K., Yuan, C. L., Chan, C. C., Chen, X., Huang, T., Weirauch, M. T., Divanovic, S., Qi, N. R., Thomas, H. E., Mercer, C. A., Siomi, H. & Nakamura, T., 2018 12 1, : : Nature communications. 9, 1, 3658.

研究成果: Article

11 引用 (Scopus)

Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis

Nishida, K. M., Sakakibara, K., Iwasaki, Y., Yamada, H., Murakami, R., Murota, Y., Kawamura, T., Kodama, T., Siomi, H. & Siomi, M. C., 2018 3 8, : : Nature. 555, 7695, p. 260-264 5 p.

研究成果: Article

10 引用 (Scopus)

Piwi Nuclear Localization and Its Regulatory Mechanism in Drosophila Ovarian Somatic Cells

Yashiro, R., Murota, Y., Nishida, K. M., Yamashiro, H., Fujii, K., Ogai, A., Yamanaka, S., Negishi, L., Siomi, H. & Siomi, M. C., 2018 6 19, : : Cell Reports. 23, 12, p. 3647-3657 11 p.

研究成果: Article

15 引用 (Scopus)

Profiling open chromatin structure in the ovarian somatic cells using ATAC-seq

Murano, K., Iwasaki, Y. & Siomi, H., 2018, Methods in Molecular Biology. Humana Press Inc., 巻 1680. p. 165-177 13 p. (Methods in Molecular Biology; 巻数 1680).

研究成果: Chapter

Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification

Sadahiro, T., Isomi, M., Muraoka, N., Kojima, H., Haginiwa, S., Kurotsu, S., Tamura, F., Tani, H., Tohyama, S., Fujita, J., Miyoshi, H., Kawamura, Y., Goshima, N., Iwasaki, Y. W., Murano, K., Saito, K., Oda, M., Andersen, P., Kwon, C., Uosaki, H. および3人, Nishizono, H., Fukuda, K. & Ieda, M., 2018 9 6, : : Cell Stem Cell. 23, 3, p. 382-395 14 p.

研究成果: Article

11 引用 (Scopus)
2017

Deep sequencing and high-throughput analysis of PIWI-associated small RNAs

Iwasaki, Y., Ishino, K. & Siomi, H., 2017 3 28, (Accepted/In press) : : Methods.

研究成果: Article

3 引用 (Scopus)

Human PIWI (HIWI) is an azoospermia factor

Hasuwa, H., Ishino, K. & Siomi, H., 2017 8 10, (Accepted/In press) : : Science China Life Sciences. p. 1-3 3 p.

研究成果: Article

4 引用 (Scopus)

Identification of mouse piRNA pathway components using anti-MIWI2 antibodies

Hirano, T., Hasuwa, H. & Siomi, H., 2017, Methods in Molecular Biology. Humana Press Inc., 巻 1463. p. 205-216 12 p. (Methods in Molecular Biology; 巻数 1463).

研究成果: Chapter

2 引用 (Scopus)

Mitotic phosphorylation of CCCTC-binding factor (CTCF) reduces its DNA binding activity

Sekiya, T., Murano, K., Kato, K., Kawaguchi, A. & Nagata, K., 2017 3 1, : : FEBS Open Bio. 7, 3, p. 397-404 8 p.

研究成果: Article

12 引用 (Scopus)

Mobile elements control stem cell potency

Hasuwa, H. & Siomi, H., 2017 2 10, : : Science. 355, 6325, p. 581-582 2 p.

研究成果: Short survey

2016

Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA

Matsumoto, N., Nishimasu, H., Sakakibara, K., Nishida, K. M., Hirano, T., Ishitani, R., Siomi, H., Siomi, M. C. & Nureki, O., 2016 10 6, : : Cell. 167, 2, p. 484-497.e9

研究成果: Article

44 引用 (Scopus)

Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian

Shibata, N., Kashima, M., Ishiko, T., Nishimura, O., Rouhana, L., Misaki, K., Yonemura, S., Saito, K., Siomi, H., Siomi, M. C. & Agata, K., 2016 5 9, : : Developmental Cell. 37, 3, p. 226-237 12 p.

研究成果: Article

30 引用 (Scopus)

Loss of l(3)mbt leads to acquisition of the ping-pong cycle in Drosophila ovarian somatic cells

Sumiyoshi, T., Sato, K., Yamamoto, H., Iwasaki, Y. W., Siomi, H. & Siomi, M. C., 2016 7 15, : : Genes and Development. 30, 14, p. 1617-1622 6 p.

研究成果: Article

19 引用 (Scopus)

MIWI2 as an Effector of DNA Methylation and Gene Silencing in Embryonic Male Germ Cells

Kojima-Kita, K., Kuramochi-Miyagawa, S., Nagamori, I., Ogonuki, N., Ogura, A., Hasuwa, H., Akazawa, T., Inoue, N. & Nakano, T., 2016 9 13, : : Cell Reports. 16, 11, p. 2819-2828 10 p.

研究成果: Article

15 引用 (Scopus)

Sphere-formation culture of testicular germ cells in the common marmoset, a small New World monkey

Lin, Z. Y. C., Hikabe, O., Suzuki, S., Hirano, T., Siomi, H., Sasaki, E., Imamura, M. & Okano, H., 2016 1 1, : : Primates. 57, 1, p. 129-135 7 p.

研究成果: Article

2 引用 (Scopus)
2015

Crystal structure and activity of the endoribonuclease domain of the piRNA pathway factor maelstrom

Matsumoto, N., Sato, K., Nishimasu, H., Namba, Y., Miyakubi, K., Dohmae, N., Ishitani, R., Siomi, H., Siomi, M. C. & Nureki, O., 2015 4 21, : : Cell Reports. 11, 3, p. 366-375 10 p.

研究成果: Article

19 引用 (Scopus)

Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development

Lin, Z. Y. C., Hirano, T., Shibata, S., Seki, N. M., Kitajima, R., Sedohara, A., Siomi, M. C., Sasaki, E., Siomi, H., Imamura, M. & Okano, H., 2015 4 1, : : Developmental Biology. 400, 1, p. 43-58 16 p.

研究成果: Article

7 引用 (Scopus)

Identification of species and genotypic compositions of Cryptomonas (Cryptophyceae) populations in the eutrophic Lake Hira, Japan, using single-cell PCR

Nishino, H., Hodoki, Y., Thottathil, S. D., Ohbayashi, K., Takao, Y. & Nakano, S. I., 2015 9 28, : : Aquatic Ecology. 49, 3, p. 263-272 10 p.

研究成果: Article

2 引用 (Scopus)

Krimper Enforces an Antisense Bias on piRNA Pools by Binding AGO3 in the Drosophila Germline

Sato, K., Iwasaki, Y., Shibuya, A., Carninci, P., Tsuchizawa, Y., Ishizu, H., Siomi, M. C. & Siomi, H., 2015 8 20, : : Molecular Cell. 59, 4, p. 553-563 11 p.

研究成果: Article

30 引用 (Scopus)

Misprocessed tRNA response targets piRNA clusters

Yamanaka, S. & Siomi, H., 2015 12 14, : : EMBO Journal. 34, 24, p. 2988-2989 2 p.

研究成果: Article

4 引用 (Scopus)

Phased piRNAs tackle transposons

Siomi, H. & Siomi, M. C., 2015 5 15, : : Science. 348, 6236, p. 756-757 2 p.

研究成果: Review article

11 引用 (Scopus)

PiRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals

Parrish, N. F., Fujino, K., Shiromoto, Y., Iwasaki, Y. W., Ha, H., Xing, J., Makino, A., Kuramochi-Miyagawa, S., Nakano, T., Siomi, H., Honda, T. & Tomonaga, K., 2015 10 1, : : RNA. 21, 10, p. 1691-1703 13 p.

研究成果: Article

30 引用 (Scopus)

PIWI-interacting RNA: Its biogenesis and functions

Iwasaki, Y. W., Siomi, M. C. & Siomi, H., 2015 6 2, : : Annual Review of Biochemistry. 84, p. 405-433 29 p.

研究成果: Article

255 引用 (Scopus)

Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons

Iwasaki, Y., Murano, K., Ishizu, H., Shibuya, A., Iyoda, Y., Siomi, M. C., Siomi, H. & Saito, K., 2015 12 16, (Accepted/In press) : : Molecular Cell.

研究成果: Article

54 引用 (Scopus)

Respective functions of two distinct siwi complexes assembled during PIWI-interacting RNA biogenesis in bombyx germ cells

Nishida, K. M., Iwasaki, Y. W., Murota, Y., Nagao, A., Mannen, T., Kato, Y., Siomi, H. & Siomi, M. C., 2015 1 13, : : Cell Reports. 10, 2, p. 193-203 11 p.

研究成果: Article

48 引用 (Scopus)

Small RNAs: Artificial piRNAs for transcriptional silencing

Hirano, T. & Siomi, H., 2015 1 1, : : Current Biology. 25, 7, p. R280-R283

研究成果: Short survey

1 引用 (Scopus)

Somatic Primary piRNA Biogenesis Driven by cis-Acting RNA Elements and trans-Acting Yb

Ishizu, H., Iwasaki, Y., Hirakata, S., Ozaki, H., Iwasaki, W., Siomi, H. & Siomi, M. C., 2015 7 21, : : Cell Reports. 12, 3, p. 429-440 12 p.

研究成果: Article

36 引用 (Scopus)

Tudor-domain containing proteins act to make the piRNA pathways more robust in Drosophila

Sato, K., Iwasaki, Y. W., Siomi, H. & Siomi, M. C., 2015 1 1, : : Fly. 9, 2, p. 86-90 5 p.

研究成果: Article

3 引用 (Scopus)
2014

DiRNA-Ago2-RAD51 complexes at double-strand break sites

Yamanaka, S. & Siomi, H., 2014 5, : : Cell Research. 24, 5, p. 511-512 2 p.

研究成果: Short survey

8 引用 (Scopus)

Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection

Kiga, K., Mimuro, H., Suzuki, M., Shinozaki-Ushiku, A., Kobayashi, T., Sanada, T., Kim, M., Ogawa, M., Iwasaki, Y. W., Kayo, H., Fukuda-Yuzawa, Y., Yashiro, M., Fukayama, M., Fukao, T. & Sasakawa, C., 2014, : : Nature communications. 5, 4497.

研究成果: Article

78 引用 (Scopus)
1 引用 (Scopus)

miRNA regulatory ecosystem in early development

Iwasaki, Y. W. & Siomi, H., 2014 12 4, : : Molecular Cell. 56, 5, p. 615-616 2 p.

研究成果: Short survey

3 引用 (Scopus)

PiRNA clusters and open chromatin structure

Yamanaka, S., Siomi, M. C. & Siomi, H., 2014 8 1, : : Mobile DNA. 5, 1, 22.

研究成果: Article

34 引用 (Scopus)

RNAi and overexpression of genes in ovarian somatic cells

Saito, K., 2014, PIWI-Interacting RNAs: Methods and Protocols. Humana Press Inc., p. 25-33 9 p. (Methods in Molecular Biology; 巻数 1093).

研究成果: Chapter

5 引用 (Scopus)

RNAi and overexpression of genes in ovarian somatic cells

Saito, K., 2014, Methods in Molecular Biology. 巻 1093. p. 25-33 9 p. (Methods in Molecular Biology; 巻数 1093).

研究成果: Chapter

Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate

Hirano, T., Iwasaki, Y. W., Lin, Z. Y. C., Imamura, M., Seki, N. M., Sasaki, E., Saito, K., Okano, H., Siomi, M. C. & Siomi, H., 2014 8, : : RNA. 20, 8, p. 1223-1237 15 p.

研究成果: Article

49 引用 (Scopus)

Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly

Murota, Y., Ishizu, H., Nakagawa, S., Iwasaki, Y. W., Shibata, S., Kamatani, M. K., Saito, K., Okano, H., Siomi, H. & Siomi, M. C., 2014 7 10, : : Cell Reports. 8, 1, p. 103-113 11 p.

研究成果: Article

44 引用 (Scopus)
2013

DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary

Ohtani, H., Iwasaki, Y. W., Shibuya, A., Siomi, H., Siomi, M. C. & Saito, K., 2013 8 1, : : Genes and Development. 27, 15, p. 1656-1661 6 p.

研究成果: Article

70 引用 (Scopus)

Global microRNA elevation by inducible Exportin 5 regulates cell cycle entry

Iwasaki, Y. W., Kiga, K., Kayo, H., Fukuda-Yuzawa, Y., Weise, J., Inada, T., Tomita, M., Ishihama, Y. & Fukao, T., 2013 4, : : RNA. 19, 4, p. 490-497 8 p.

研究成果: Article

38 引用 (Scopus)

Purification of dFMR1-containing complexes using tandem affinity purification

Miyoshi, K., Ogino, A., Siomi, M. C. & Siomi, H., 2013 7 24, Trinucleotide Repeat Protocols. p. 111-121 11 p. (Methods in Molecular Biology; 巻数 1010).

研究成果: Chapter

2 引用 (Scopus)

RNAi triggered by specialized machinery silences developmental genes and retrotransposons

Yamanaka, S., Mehta, S., Reyes-Turcu, F. E., Zhuang, F., Fuchs, R. T., Rong, Y., Robb, G. B. & Grewal, S. I. S., 2013 1 24, : : Nature. 493, 7433, p. 557-560 4 p.

研究成果: Article

90 引用 (Scopus)