研究成果

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Article
2020

Armitage determines Piwi−piRISC processing from precursor formation and quality control to inter-organelle translocation

Yamashiro, H., Negishi, M., Kinoshita, T., Ishizu, H., Ohtani, H. & Siomi, M. C., 2020 2 5, : : EMBO Reports. 21, 2, e48769.

研究成果: Article

1 引用 (Scopus)

Crystal structure of Drosophila Piwi

Yamaguchi, S., Oe, A., Nishida, K. M., Yamashita, K., Kajiya, A., Hirano, S., Matsumoto, N., Dohmae, N., Ishitani, R., Saito, K., Siomi, H., Nishimasu, H., Siomi, M. C. & Nureki, O., 2020 12 1, : : Nature communications. 11, 1, 858.

研究成果: Article

公開
2019

Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Yamanaka, S., Nishihara, H., Toh, H., Eijy Nagai, L. A., Hashimoto, K., Park, S. J., Shibuya, A., Suzuki, A. M., Tanaka, Y., Nakai, K., Carninci, P., Sasaki, H. & Siomi, H., 2019 10 7, : : Developmental Cell. 51, 1, p. 21-34.e5

研究成果: Article

3 引用 (Scopus)

Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing

Osumi, K., Sato, K., Murano, K., Siomi, H. & Siomi, M. C., 2019 1 1, (Accepted/In press) : : EMBO Reports. e48296.

研究成果: Article

4 引用 (Scopus)

Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing

Murano, K., Iwasaki, Y. W., Ishizu, H., Mashiko, A., Shibuya, A., Kondo, S., Adachi, S., Suzuki, S., Saito, K., Natsume, T., Siomi, M. C. & Siomi, H., 2019 9 2, : : EMBO Journal. 38, 17, e102870.

研究成果: Article

10 引用 (Scopus)

Requirements for multivalent Yb body assembly in transposon silencing in Drosophila

Hirakata, S., Ishizu, H., Fujita, A., Tomoe, Y. & Siomi, M. C., 2019 7, : : EMBO Reports. 20, 7, e47708.

研究成果: Article

5 引用 (Scopus)

Template Activating Factor-I α Regulates Retroviral Silencing during Reprogramming

Bui, P. L., Nishimura, K., Seminario Mondejar, G., Kumar, A., Aizawa, S., Murano, K., Nagata, K., Hayashi, Y., Fukuda, A., Onuma, Y., Ito, Y., Nakanishi, M. & Hisatake, K., 2019 11 12, : : Cell Reports. 29, 7, p. 1909-1922.e5

研究成果: Article

公開
2018

Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype

Hosoi, Y., Soma, M., Shiura, H., Sado, T., Hasuwa, H., Abe, K., Kohda, T., Ishino, F. & Kobayashi, S., 2018 12 1, : : Nature communications. 9, 1, 3829.

研究成果: Article

3 引用 (Scopus)

Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology

Zhang, C., Seo, J., Murakami, K., Salem, E. S. B., Bernhard, E., Borra, V. J., Choi, K., Yuan, C. L., Chan, C. C., Chen, X., Huang, T., Weirauch, M. T., Divanovic, S., Qi, N. R., Thomas, H. E., Mercer, C. A., Siomi, H. & Nakamura, T., 2018 12 1, : : Nature communications. 9, 1, 3658.

研究成果: Article

11 引用 (Scopus)

Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis

Nishida, K. M., Sakakibara, K., Iwasaki, Y., Yamada, H., Murakami, R., Murota, Y., Kawamura, T., Kodama, T., Siomi, H. & Siomi, M. C., 2018 3 8, : : Nature. 555, 7695, p. 260-264 5 p.

研究成果: Article

10 引用 (Scopus)

Piwi Nuclear Localization and Its Regulatory Mechanism in Drosophila Ovarian Somatic Cells

Yashiro, R., Murota, Y., Nishida, K. M., Yamashiro, H., Fujii, K., Ogai, A., Yamanaka, S., Negishi, L., Siomi, H. & Siomi, M. C., 2018 6 19, : : Cell Reports. 23, 12, p. 3647-3657 11 p.

研究成果: Article

15 引用 (Scopus)

Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification

Sadahiro, T., Isomi, M., Muraoka, N., Kojima, H., Haginiwa, S., Kurotsu, S., Tamura, F., Tani, H., Tohyama, S., Fujita, J., Miyoshi, H., Kawamura, Y., Goshima, N., Iwasaki, Y. W., Murano, K., Saito, K., Oda, M., Andersen, P., Kwon, C., Uosaki, H. および3人, Nishizono, H., Fukuda, K. & Ieda, M., 2018 9 6, : : Cell Stem Cell. 23, 3, p. 382-395 14 p.

研究成果: Article

11 引用 (Scopus)
2017

Deep sequencing and high-throughput analysis of PIWI-associated small RNAs

Iwasaki, Y., Ishino, K. & Siomi, H., 2017 3 28, (Accepted/In press) : : Methods.

研究成果: Article

3 引用 (Scopus)

Human PIWI (HIWI) is an azoospermia factor

Hasuwa, H., Ishino, K. & Siomi, H., 2017 8 10, (Accepted/In press) : : Science China Life Sciences. p. 1-3 3 p.

研究成果: Article

4 引用 (Scopus)

Mitotic phosphorylation of CCCTC-binding factor (CTCF) reduces its DNA binding activity

Sekiya, T., Murano, K., Kato, K., Kawaguchi, A. & Nagata, K., 2017 3 1, : : FEBS Open Bio. 7, 3, p. 397-404 8 p.

研究成果: Article

12 引用 (Scopus)
2016

Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA

Matsumoto, N., Nishimasu, H., Sakakibara, K., Nishida, K. M., Hirano, T., Ishitani, R., Siomi, H., Siomi, M. C. & Nureki, O., 2016 10 6, : : Cell. 167, 2, p. 484-497.e9

研究成果: Article

44 引用 (Scopus)

Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian

Shibata, N., Kashima, M., Ishiko, T., Nishimura, O., Rouhana, L., Misaki, K., Yonemura, S., Saito, K., Siomi, H., Siomi, M. C. & Agata, K., 2016 5 9, : : Developmental Cell. 37, 3, p. 226-237 12 p.

研究成果: Article

30 引用 (Scopus)

Loss of l(3)mbt leads to acquisition of the ping-pong cycle in Drosophila ovarian somatic cells

Sumiyoshi, T., Sato, K., Yamamoto, H., Iwasaki, Y. W., Siomi, H. & Siomi, M. C., 2016 7 15, : : Genes and Development. 30, 14, p. 1617-1622 6 p.

研究成果: Article

19 引用 (Scopus)

MIWI2 as an Effector of DNA Methylation and Gene Silencing in Embryonic Male Germ Cells

Kojima-Kita, K., Kuramochi-Miyagawa, S., Nagamori, I., Ogonuki, N., Ogura, A., Hasuwa, H., Akazawa, T., Inoue, N. & Nakano, T., 2016 9 13, : : Cell Reports. 16, 11, p. 2819-2828 10 p.

研究成果: Article

15 引用 (Scopus)

Sphere-formation culture of testicular germ cells in the common marmoset, a small New World monkey

Lin, Z. Y. C., Hikabe, O., Suzuki, S., Hirano, T., Siomi, H., Sasaki, E., Imamura, M. & Okano, H., 2016 1 1, : : Primates. 57, 1, p. 129-135 7 p.

研究成果: Article

2 引用 (Scopus)
2015

Crystal structure and activity of the endoribonuclease domain of the piRNA pathway factor maelstrom

Matsumoto, N., Sato, K., Nishimasu, H., Namba, Y., Miyakubi, K., Dohmae, N., Ishitani, R., Siomi, H., Siomi, M. C. & Nureki, O., 2015 4 21, : : Cell Reports. 11, 3, p. 366-375 10 p.

研究成果: Article

19 引用 (Scopus)

Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development

Lin, Z. Y. C., Hirano, T., Shibata, S., Seki, N. M., Kitajima, R., Sedohara, A., Siomi, M. C., Sasaki, E., Siomi, H., Imamura, M. & Okano, H., 2015 4 1, : : Developmental Biology. 400, 1, p. 43-58 16 p.

研究成果: Article

7 引用 (Scopus)

Identification of species and genotypic compositions of Cryptomonas (Cryptophyceae) populations in the eutrophic Lake Hira, Japan, using single-cell PCR

Nishino, H., Hodoki, Y., Thottathil, S. D., Ohbayashi, K., Takao, Y. & Nakano, S. I., 2015 9 28, : : Aquatic Ecology. 49, 3, p. 263-272 10 p.

研究成果: Article

2 引用 (Scopus)

Krimper Enforces an Antisense Bias on piRNA Pools by Binding AGO3 in the Drosophila Germline

Sato, K., Iwasaki, Y., Shibuya, A., Carninci, P., Tsuchizawa, Y., Ishizu, H., Siomi, M. C. & Siomi, H., 2015 8 20, : : Molecular Cell. 59, 4, p. 553-563 11 p.

研究成果: Article

30 引用 (Scopus)

Misprocessed tRNA response targets piRNA clusters

Yamanaka, S. & Siomi, H., 2015 12 14, : : EMBO Journal. 34, 24, p. 2988-2989 2 p.

研究成果: Article

4 引用 (Scopus)

PiRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals

Parrish, N. F., Fujino, K., Shiromoto, Y., Iwasaki, Y. W., Ha, H., Xing, J., Makino, A., Kuramochi-Miyagawa, S., Nakano, T., Siomi, H., Honda, T. & Tomonaga, K., 2015 10 1, : : RNA. 21, 10, p. 1691-1703 13 p.

研究成果: Article

30 引用 (Scopus)

PIWI-interacting RNA: Its biogenesis and functions

Iwasaki, Y. W., Siomi, M. C. & Siomi, H., 2015 6 2, : : Annual Review of Biochemistry. 84, p. 405-433 29 p.

研究成果: Article

255 引用 (Scopus)

Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons

Iwasaki, Y., Murano, K., Ishizu, H., Shibuya, A., Iyoda, Y., Siomi, M. C., Siomi, H. & Saito, K., 2015 12 16, (Accepted/In press) : : Molecular Cell.

研究成果: Article

54 引用 (Scopus)

Respective functions of two distinct siwi complexes assembled during PIWI-interacting RNA biogenesis in bombyx germ cells

Nishida, K. M., Iwasaki, Y. W., Murota, Y., Nagao, A., Mannen, T., Kato, Y., Siomi, H. & Siomi, M. C., 2015 1 13, : : Cell Reports. 10, 2, p. 193-203 11 p.

研究成果: Article

48 引用 (Scopus)

Somatic Primary piRNA Biogenesis Driven by cis-Acting RNA Elements and trans-Acting Yb

Ishizu, H., Iwasaki, Y., Hirakata, S., Ozaki, H., Iwasaki, W., Siomi, H. & Siomi, M. C., 2015 7 21, : : Cell Reports. 12, 3, p. 429-440 12 p.

研究成果: Article

36 引用 (Scopus)

Tudor-domain containing proteins act to make the piRNA pathways more robust in Drosophila

Sato, K., Iwasaki, Y. W., Siomi, H. & Siomi, M. C., 2015 1 1, : : Fly. 9, 2, p. 86-90 5 p.

研究成果: Article

3 引用 (Scopus)
2014

Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection

Kiga, K., Mimuro, H., Suzuki, M., Shinozaki-Ushiku, A., Kobayashi, T., Sanada, T., Kim, M., Ogawa, M., Iwasaki, Y. W., Kayo, H., Fukuda-Yuzawa, Y., Yashiro, M., Fukayama, M., Fukao, T. & Sasakawa, C., 2014, : : Nature communications. 5, 4497.

研究成果: Article

78 引用 (Scopus)
1 引用 (Scopus)

PiRNA clusters and open chromatin structure

Yamanaka, S., Siomi, M. C. & Siomi, H., 2014 8 1, : : Mobile DNA. 5, 1, 22.

研究成果: Article

34 引用 (Scopus)

Small RNA profiling and characterization of piRNA clusters in the adult testes of the common marmoset, a model primate

Hirano, T., Iwasaki, Y. W., Lin, Z. Y. C., Imamura, M., Seki, N. M., Sasaki, E., Saito, K., Okano, H., Siomi, M. C. & Siomi, H., 2014 8, : : RNA. 20, 8, p. 1223-1237 15 p.

研究成果: Article

49 引用 (Scopus)

Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly

Murota, Y., Ishizu, H., Nakagawa, S., Iwasaki, Y. W., Shibata, S., Kamatani, M. K., Saito, K., Okano, H., Siomi, H. & Siomi, M. C., 2014 7 10, : : Cell Reports. 8, 1, p. 103-113 11 p.

研究成果: Article

44 引用 (Scopus)
2013

DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary

Ohtani, H., Iwasaki, Y. W., Shibuya, A., Siomi, H., Siomi, M. C. & Saito, K., 2013 8 1, : : Genes and Development. 27, 15, p. 1656-1661 6 p.

研究成果: Article

70 引用 (Scopus)

Global microRNA elevation by inducible Exportin 5 regulates cell cycle entry

Iwasaki, Y. W., Kiga, K., Kayo, H., Fukuda-Yuzawa, Y., Weise, J., Inada, T., Tomita, M., Ishihama, Y. & Fukao, T., 2013 4, : : RNA. 19, 4, p. 490-497 8 p.

研究成果: Article

38 引用 (Scopus)
2 引用 (Scopus)

RNAi triggered by specialized machinery silences developmental genes and retrotransposons

Yamanaka, S., Mehta, S., Reyes-Turcu, F. E., Zhuang, F., Fuchs, R. T., Rong, Y., Robb, G. B. & Grewal, S. I. S., 2013 1 24, : : Nature. 493, 7433, p. 557-560 4 p.

研究成果: Article

90 引用 (Scopus)

Roles of R2D2, a Cytoplasmic D2 Body Component, in the Endogenous siRNA Pathway in Drosophila

Nishida, K. M., Miyoshi, K., Ogino, A., Miyoshi, T., Siomi, H. & Siomi, M. C., 2013 2 21, : : Molecular Cell. 49, 4, p. 680-691 12 p.

研究成果: Article

35 引用 (Scopus)

XMtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance

Lee, N. N., Chalamcharla, V. R., Reyes-Turcu, F., Mehta, S., Zofall, M., Balachandran, V., Dhakshnamoorthy, J., Taneja, N., Yamanaka, S., Zhou, M. & Grewal, S. I. S., 2013 11 21, : : Cell. 155, 5, 1 p.

研究成果: Article

87 引用 (Scopus)
2012

Drpiwi-1 is essential for germline cell formation during sexualization of the planarian Dugesia ryukyuensis

Nakagawa, H., Ishizu, H., Hasegawa, R., Kobayashi, K. & Matsumoto, M., 2012 1 1, : : Developmental Biology. 361, 1, p. 167-176 10 p.

研究成果: Article

18 引用 (Scopus)

RNA elimination machinery targeting meiotic mRNAs promotes facultative heterochromatin formation

Zofall, M., Yamanaka, S., Reyes-Turcu, F. E., Zhang, K., Rubin, C. & Grewal, S. I. S., 2012 1 6, : : Science. 335, 6064, p. 96-100 5 p.

研究成果: Article

110 引用 (Scopus)

Structure and function of Zucchini endoribonuclease in piRNA biogenesis

Nishimasu, H., Ishizu, H., Saito, K., Fukuhara, S., Kamatani, M. K., Bonnefond, L., Matsumoto, N., Nishizawa, T., Nakanaga, K., Aoki, J., Ishitani, R., Siomi, H., Siomi, M. C. & Nureki, O., 2012 11 8, : : Nature. 491, 7423, p. 284-287 4 p.

研究成果: Article

178 引用 (Scopus)
14 引用 (Scopus)
2011
4 引用 (Scopus)

Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila

Cernilogar, F. M., Onorati, M. C., Kothe, G. O., Burroughs, A. M., Parsi, K. M., Breiling, A., Sardo, F. L., Saxena, A., Miyoshi, K., Siomi, H., Siomi, M. C., Carninci, P., Gilmour, D. S., Corona, D. F. V. & Orlando, V., 2011 12 15, : : Nature. 480, 7377, p. 391-395 5 p.

研究成果: Article

149 引用 (Scopus)

Gender-specific hierarchy in nuage localization of PIWI-interacting RNA factors in Drosophila

Nagao, A., Sato, K., Nishida, K. M., Siomi, H. & Siomi, M. C., 2011 12 1, : : Frontiers in Genetics. 2, AUG, Article 55.

研究成果: Article

18 引用 (Scopus)

Maelstrom coordinates microtubule organization during Drosophila oogenesis through interaction with components of the MTOC

Sato, K., Nishida, K. M., Shibuya, A., Siomi, M. C. & Siomi, H., 2011 11 15, : : Genes and Development. 25, 22, p. 2361-2373 13 p.

研究成果: Article

36 引用 (Scopus)