臨床薬剤学

Actual use of anti-MRSA drugs in Japan with the focus on arbekacin

Shimizu, K., Aikawa, N., Tanigawara, Y., Kaku, M., Imae, M., Nishizawa, N. & Nakamura, H., 2003 11月, In: Japanese Journal of Chemotherapy. 51, 11, p. 717-730 14 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese

Kiyotani, K., Mushiroda, T., Tsunoda, T., Morizono, T., Hosono, N., Kubo, M., Tanigawara, Y., Imamura, C. K., Flockhart, D. A., Aki, F., Hirata, K., Takatsuka, Y., Okazaki, M., Ohsumi, S., Yamakawa, T., Sasa, M., Nakamura, Y. & Zembutsu, H., 2012 4月, In: Human molecular genetics. 21, 7, p. 1665-1672 8 p., ddr597.

研究成果: Article › 査読

47 被引用数 (Scopus)

A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam

Kosaki, K., Tamura, K., Sato, R., Samejima, H., Tanigawara, Y. & Takahashi, T., 2004 12月, In: Brain and Development. 26, 8, p. 530-534 5 p.

研究成果: Article › 査読

68 被引用数 (Scopus)

A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures - A randomized, active comparator, double-blind study

Matsumoto, T., Ito, M., Hayashi, Y., Hirota, T., Tanigawara, Y., Sone, T., Fukunaga, M., Shiraki, M. & Nakamura, T., 2011 10月, In: Bone. 49, 4, p. 605-612 8 p.

研究成果: Article › 査読

132 被引用数 (Scopus)

An open clinical study of arbekacin 200 mg q.d. in patients infected with methicillin-resistant Staphylococcus aureus (MRSA) - A clinical pharmacology study

Aikawa, N., Kohno, S., Kaku, M., Watanabe, A., Yamaguchi, K. & Tanigawara, Y., 2008 5月, In: Japanese Journal of Chemotherapy. 56, 3, p. 299-312 14 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

A pharmacokinetic and dose escalation study of pegfilgrastim (KRN125) in lung cancer patients with chemotherapy-induced neutropenia

Yamamoto, N., Sekine, I., Nakagawa, K., Takada, M., Fukuoka, M., Tanigawara, Y. & Saijo, N., 2009, In: Japanese journal of clinical oncology. 39, 7, p. 425-430 6 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

A phase i escalating single-dose and weekly fixed-dose study of cetuximab pharmacokinetics in Japanese patients with solid tumors

Shirao, K., Yoshino, T., Boku, N., Kato, K., Hamaguchi, T., Yasui, H., Yamamoto, N., Tanigawara, Y., Nolting, A. & Yoshino, S., 2009 7月, In: Cancer Chemotherapy and Pharmacology. 64, 3, p. 557-564 8 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype-Guided Dosing of Tamoxifen

Nakamura, T., Toshimoto, K., Lee, W., Imamura, C. K., Tanigawara, Y. & Sugiyama, Y., 2018 7月, In: CPT: Pharmacometrics and Systems Pharmacology. 7, 7, p. 474-482 9 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Application of population pharmacokinetic approach to clinical evaluation of anticancer agents

Tanigawara, Y., 2001 5月, In: Gan to kagaku ryoho. Cancer & chemotherapy. 28, 5, p. 711-721 11 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Appropriate hemodialysis scheduling based on therapeutic drug monitoring of carboplatin in a patient with lung cancer and chronic renal failure

Kamata, H., Asano, K., Soejima, K., Shirahata, T., Nakatani, M., Inamoto, H., Iketani, O., Yamayoshi, Y., Tanigawara, Y. & Ishizaka, A., 2009 9月, In: Japanese Journal of Cancer and Chemotherapy. 36, 9, p. 1529-1532 4 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Blood-direct InvaderPlus® as a new method for genetic testing

Hirasawa, A., Akahane, T., Tanigawara, Y. & Aoki, D., 2012 8月, In: Personalized Medicine. 9, 6, p. 657-663 7 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs

Takara, K., Tanigawara, Y., Komada, F., Nishiguchi, K., Sakaeda, T. & Okumura, K., 1999 12月, In: Biological and Pharmaceutical Bulletin. 22, 12, p. 1355-1359 5 p.

研究成果: Article › 査読

Open Access

57 被引用数 (Scopus)

Cerebrospinal pharmacokinetic and pharmacodynamic analysis of efficacy of meropenem in paediatric patients with bacterial meningitis

Ohata, Y., Tomita, Y., Sunakawa, K., Drusano, G. L. & Tanigawara, Y., 2019 9月, In: International journal of antimicrobial agents. 54, 3, p. 292-300 9 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

Clinical and bacteriological efficacies of sitafloxacin against community-acquired pneumonia caused by Streptococcus pneumoniae: Nested cohort within a multicenter clinical trial

Fujita, J., Niki, Y., Kadota, J. I., Yanagihara, K., Kaku, M., Watanabe, A., Aoki, N., Hori, S., Tanigawara, Y., Cash, H. L. & Kohno, S., 2013 6月, In: Journal of Infection and Chemotherapy. 19, 3, p. 472-479 8 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Clinical dose findings of sitafloxacin treatment: Pharmacokinetic- pharmacodynamic analysis of two clinical trial results for community-acquired respiratory tract infections

Kohno, S., Niki, Y., Kadota, J. I., Yanagihara, K., Kaku, M., Watanabe, A., Aoki, N., Hori, S., Fujita, J. & Tanigawara, Y., 2013 6月, In: Journal of Infection and Chemotherapy. 19, 3, p. 486-494 9 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Clinical Factors Predicting Detection of T790M Mutation in Rebiopsy for EGFR-Mutant Non–small-cell Lung Cancer

Kawamura, T., Kenmotsu, H., Omori, S., Nakashima, K., Wakuda, K., Ono, A., Naito, T., Murakami, H., Omae, K., Mori, K., Tanigawara, Y., Nakajima, T., Ohde, Y., Endo, M. & Takahashi, T., 2018 3月, In: Clinical Lung Cancer. 19, 2, p. e247-e252

研究成果: Article › 査読

30 被引用数 (Scopus)

Comparison of the pharmaceutical properties of sustained-release gel beads prepared by alginate having different molecular size with commercial sustained-release tablet

Imai, T., Kawasaki, C., Nishiyama, T. & Otagiri, M., 2000 4月 27, In: Pharmazie. 55, 3, p. 218-222 5 p.

研究成果: Article › 査読

24 被引用数 (Scopus)

Comprehensive screening of the thiopurine methyltransferase polymorphisms by denaturing high-performance liquid chromatography

Udaka, T., Torii, C., Takahashi, D., Mori, T., Aramaki, M., Kosaki, R., Tanigawara, Y., Takahashi, T. & Kosaki, K., 2005 6月 1, In: Genetic Testing. 9, 2, p. 85-92 8 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Current status of monitoring in investigator-initiated trials with IND

Imamura, C. K., 2013 11月 4, In: Japanese Pharmacology and Therapeutics. 41, SUPPL. 2, p. S84-S87

研究成果: Article › 査読

CYP2C19 genotype related effect of omeprazole on intragastric pH and antimicrobial stability

Kita, T., Tanigawara, Y., Aoyama, N., Hohda, T., Saijoh, Y., Komada, F., Sakaeda, T., Okumura, K., Sakai, T. & Kasuga, M., 2001, In: Pharmaceutical research. 18, 5, p. 615-621 7 p.

研究成果: Article › 査読

47 被引用数 (Scopus)

CYP2D6 genotype-guided tamoxifen dosing in hormone receptor-positive metastatic breast cancer (TARGET-1): A randomized, open-label, Phase II study

Tamura, K., Imamura, C. K., Takano, T., Saji, S., Yamanaka, T., Yonemori, K., Takahashi, M., Tsurutani, J., Nishimura, R., Sato, K., Kitani, A., Ueno, N. T., Mushiroda, T., Kubo, M., Fujiwara, Y. & Tanigawara, Y., 2020 2月 20, In: Journal of Clinical Oncology. 38, 6, p. 558-566 9 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Development of an S-1 dosage formula based on renal function by a prospective pharmacokinetic study

Bouoka, E., Imamura, C., Takeuchi, H., Hamamoto, Y., Gomi, D., Mizukami, T., Ichiyama, T., Tateishi, K., Takahashi, T., Kawakubo, H., Soejima, K., Boku, N., Tanigawara, Y. & Kitagawa, Y., 2016 7月 1, In: Gastric Cancer. 19, 3, p. 876-886 11 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients

Kiyotani, K., Mushiroda, T., Imamura, C. K., Tanigawara, Y., Hosono, N., Kubo, M., Sasa, M., Nakamura, Y. & Zembutsu, H., 2012 1月, In: Breast Cancer Research and Treatment. 131, 1, p. 137-145 9 p.

研究成果: Article › 査読

80 被引用数 (Scopus)

Dose-escalation study for the targeting of CD44v⁺ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Shitara, K., Doi, T., Nagano, O., Imamura, C., Ozeki, T., Ishii, Y., Tsuchihashi, K., Takahashi, S., Nakajima, T. E., Hironaka, S., Fukutani, M., Hasegawa, H., Nomura, S., Sato, A., Einaga, Y., Kuwata, T., Saya, H. & Ohtsu, A., 2017 3月 1, In: Gastric Cancer. 20, 2, p. 341-349 9 p.

研究成果: Article › 査読

57 被引用数 (Scopus)

Dose-finding phase I study of simultaneous weekly infusion with doxorubicin and docetaxel in patients with advanced breast cancer

Ito, Y., Aiba, K., Horikoshi, N., Saotome, T., Irie, T., Sugiyama, K., Nakane, M., Hashimoto, D., Yoshida, N., Mizunuma, N., Takahashi, S. & Tanigawara, Y., 2001 1月 1, In: International Journal of Clinical Oncology. 6, 5, p. 242-247 6 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Dose optimization of anticancer drugs in the elderly

Imamura, C. K., 2015 1月 1, In: Japanese Journal of Cancer and Chemotherapy. 42, 1, p. 21-25 5 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer

Yamauchi, T., Fernandez, J. R. E., Imamura, C., Yamauchi, H., Jinno, H., Takahashi, M., Kitagawa, Y., Nakamura, S., Lim, B., Krishnamurthy, S., Reuben, J. M., Liu, D., Tripathy, D., Chen, H., Takebe, N., Saya, H. & Ueno, N. T., 2018, In: Oncotarget. 9, 6, p. 6872-6882 11 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Effect of everolimus on the glucose metabolic pathway in mouse skeletal muscle cells (C2C12)

Yoshida, K., Imamura, C. K., Hara, K., Mochizuki, M. & Tanigawara, Y., 2017 8月 1, In: Metabolomics. 13, 8, 98.

研究成果: Article › 査読

11 被引用数 (Scopus)

Effect of its demethylated metabolite on the: Pharmacokinetics of unchanged TAK-603, a new antirheumatic agent, in rats

Tagawa, Y., Miwa, K., Tsukuda, R., Yoshimura, Y., Tanayama, S. & Tanigawara, Y., 1999 4月 24, In: Drug Metabolism and Disposition. 27, 4, p. 495-501 7 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Effects of 12 Ca²⁺ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression

Takara, K., Sakaeda, T., Tanigawara, Y., Nishiguchi, K., Ohmoto, N., Horinouchi, M., Komada, F., Ohnishi, N., Yokoyama, T. & Okumura, K., 2002, In: European Journal of Pharmaceutical Sciences. 16, 3, p. 159-165 7 p.

研究成果: Article › 査読

52 被引用数 (Scopus)

Effects of Cu, Zn-superoxide dismutase delivered by genetically modified skin fibroblasts on cold-induced skin edema in rats

Nishiguchi, K., Komada, F., Tanigawara, Y., Sakai, Y., Iwakawa, S. & Okumura, K., 1998 1月 1, In: Biological and Pharmaceutical Bulletin. 21, 12, p. 1379-1381 3 p.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia or lymphoma

Shimasaki, N., Mori, T., Samejima, H., Sato, R., Shimada, H., Yahagi, N., Torii, C., Yoshihara, H., Tanigawara, Y., Takahashi, T. & Kosaki, K., 2006 2月 1, In: Journal of Pediatric Hematology/Oncology. 28, 2, p. 64-68 5 p.

研究成果: Article › 査読

86 被引用数 (Scopus)

Effects of secretable SOD delivered by genetically modified cells on xanthine/xanthine oxidase and paraquat-induced cytotoxicity in vitro

Komada, F., Nishiguchi, K., Tanigawara, Y., Iwakawa, S. & Okumura, K., 1999 8月, In: Biological and Pharmaceutical Bulletin. 22, 8, p. 846-853 8 p.

研究成果: Article › 査読

Open Access

14 被引用数 (Scopus)

Efficacy, safety and pharmacokinetics of micafungin in pediatric patients with deep mycoses

Sunakawa, K., Tsukimoto, I., Toyonaga, Y., Tsunematsu, Y., Iwai, N. & Tanigawara, Y., 2008 3月 1, In: Japanese Journal of Chemotherapy. 56, 2, p. 190-201 12 p.

研究成果: Article › 査読

Evaluation of clinical response in cancer drug therapy

Imamura, C. K., 2016, In: Japanese Journal of Clinical Pharmacology and Therapeutics. 47, 2, p. 62-67 6 p.

研究成果: Article › 査読

Open Access

Evaluation of gefitinib systemic exposure in EGFR-mutated non-small cell lung cancer patients with gefitinib-induced severe hepatotoxicity

Kawamura, T., Imamura, C. K., Kenmotsu, H., Taira, T., Omori, S., Nakashima, K., Wakuda, K., Ono, A., Naito, T., Murakami, H., Mushiroda, T., Takahashi, T. & Tanigawara, Y., 2020 3月 1, In: Cancer Chemotherapy and Pharmacology. 85, 3, p. 605-614 10 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Factors influencing the prediction of steady state concentrations of digoxin

Nakamura, T., Kakumoto, M., Yamashita, K., Takara, K., Tanigawara, Y., Sakaeda, T. & Okumura, K., 2001, In: Biological and Pharmaceutical Bulletin. 24, 4, p. 403-408 6 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Gefitinib exposure and occurrence of interstitial lung disease in Japanese patients with non-small-cell lung cancer

Kawata, T., Higashimori, M., Itoh, Y., Tomkinson, H., Johnson, M. G., Tang, W., Nyberg, F., Jiang, H. & Tanigawara, Y., 2019 5月 1, In: Cancer Chemotherapy and Pharmacology. 83, 5, p. 849-858 10 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Genetic Polymorphisms and Individual Variability in Drug Response

Yamayoshi, Y., Mihara, K. & Tanigawara, Y., 2004 3月 1, In: Respiration and Circulation. 52, 3, p. 293-300 8 p.

研究成果: Article › 査読

Greater impact of oral fluconazole on drug interaction with intravenous calcineurin inhibitors as compared with intravenous fluconazole

Mihara, A., Mori, T., Aisa, Y., Yamazaki, R., Iketani, O., Tanigawara, Y., Ikeda, Y. & Okamoto, S., 2008 1月, In: European Journal of Clinical Pharmacology. 64, 1, p. 89-91 3 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

How tightly can a drug be bound to a protein and still be removable by charcoal hemoperfusion in overdose cases?

Kawasaki, C. I., Nishi, R., Uekihara, S., Hayano, S., Kragh-Hansen, U. & Otagiri, M., 2005, In: Journal of Toxicology - Clinical Toxicology. 43, 2, p. 95-99 5 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole

Imamura, C. K., Furihata, K., Okamoto, S. & Tanigawara, Y., 2016 4月 1, In: Journal of Clinical Pharmacology. 56, 4, p. 408-413 6 p.

研究成果: Article › 査読

23 被引用数 (Scopus)

Individualized Dosing of Axitinib Based on First-Dose Area Under the Concentration–Time Curve for Metastatic Renal-Cell Carcinoma

Miura, Y., Imamura, C. K., Uchino, K., Kishida, T., Matsubara, N., Shinojima, T., Kondo, K., Hongo, F., Yoshimura, K., Tanigawara, Y. & Takano, T., 2019 2月, In: Clinical Genitourinary Cancer. 17, 1, p. e1-e11

研究成果: Article › 査読

5 被引用数 (Scopus)

Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma

Shimasaki, N., Mori, T., Torii, C., Sato, R., Shimada, H., Tanigawara, Y., Kosaki, K. & Takahashi, T., 2008 5月 1, In: Journal of Pediatric Hematology/Oncology. 30, 5, p. 347-352 6 p.

研究成果: Article › 査読

51 被引用数 (Scopus)

Influence of sugar chain on fibrin affinity of recombinant t-PA

Aoki, S., Shimizu, N., Shimonishi, M., Kitagawa, M., Okumura, K. & Tanigawara, Y., 2001, In: Biological and Pharmaceutical Bulletin. 24, 3, p. 295-298 4 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein

Kusunoki, N., Takara, K., Tanigawara, Y., Yamauchi, A., Ueda, K., Komada, F., Ku, Y., Kuroda, Y., Saitoh, Y. & Okumura, K., 1998, In: Japanese Journal of Cancer Research. 89, 11, p. 1220-1228 9 p.

研究成果: Article › 査読

50 被引用数 (Scopus)

Interaction of digoxin with antihypertensive drugs via MDR1

Takara, K., Kakumoto, M., Tanigawara, Y., Funakoshi, J., Sakaeda, T. & Okumura, K., 2002 2月 15, In: Life Sciences. 70, 13, p. 1491-1500 10 p.

研究成果: Article › 査読

50 被引用数 (Scopus)

Linear pharmacokinetics of micafungin and its active metabolites in Japanese pediatric patients with fungal infections

Tabata, K., Katashima, M., Kawamura, A., Tanigawara, Y. & Sunagawa, K., 2006, In: Biological and Pharmaceutical Bulletin. 29, 8, p. 1706-1711 6 p.

研究成果: Article › 査読

30 被引用数 (Scopus)

MDR1-mediated interaction of digoxin with antiarrhythmic or antianginal drugs

Kakumoto, M., Takara, K., Sakaeda, T., Tanigawara, Y., Kita, T. & Okumura, K., 2002 12月, In: Biological and Pharmaceutical Bulletin. 25, 12, p. 1604-1607 4 p.

研究成果: Article › 査読

42 被引用数 (Scopus)

Modeling and simulation of bone mineral density in Japanese osteoporosis patients treated with zoledronic acid using tartrate-resistant acid phosphatase 5b, a bone resorption marker

Mori, Y., Kasai, H., Ose, A., Serada, M., Ishiguro, M., Shiraki, M. & Tanigawara, Y., 2018 5月 1, In: Osteoporosis International. 29, 5, p. 1155-1163 9 p.

研究成果: Article › 査読

Open Access

14 被引用数 (Scopus)

臨床薬剤学

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