医学部輸血・細胞療法センター

研究成果

2020

Clinical characteristics of human herpesvirus-6 myelitis after allogeneic hematopoietic stem cell transplantation and its favorable outcome by early intervention

Shiroshita, K., Mori, T., Kato, J., Sakurai, M., Koda, Y., Abe, R., Murakami, K., Sumiya, C., Fujita, S., Yamaguchi, K., Yamazaki, R., Nakayama, H., Suzuki, S., Nakahara, J. & Okamoto, S., 2020 5 1, : : Bone Marrow Transplantation. 55, 5, p. 939-945 7 p.

研究成果: Article

Hematopoietic cell infusion-related adverse events in pediatric/small recipients in a prospective/multicenter study

Ikeda, K., Ohto, H., Yamada-Fujiwara, M., Okuyama, Y., Fujiwara, S. I., Muroi, K., Mori, T., Kasama, K., Kanamori, H., Iseki, T., Nagamura-Inoue, T., Kameda, K., Kanda, J., Nagai, K., Fujii, N., Ashida, T., Hirose, A., Takahashi, T., Minakawa, K. & Tanosaki, R., 2020 5 1, : : Transfusion. 60, 5, p. 1015-1023 9 p.

研究成果: Article

2019
1 引用 (Scopus)
1 引用 (Scopus)
2018

Adverse Events Associated With Infusion of Hematopoietic Stem Cell Products: A Prospective and Multicenter Surveillance Study

Ikeda, K., Ohto, H., Okuyama, Y., Yamada-Fujiwara, M., Kanamori, H., Fujiwara, S. I., Muroi, K., Mori, T., Kasama, K., Iseki, T., Nagamura-Inoue, T., Fujii, N., Ashida, T., Kameda, K., Kanda, J., Hirose, A., Takahashi, T., Nagai, K., Minakawa, K. & Tanosaki, R., 2018 7, : : Transfusion Medicine Reviews. 32, 3, p. 186-194 9 p.

研究成果: Review article

7 引用 (Scopus)

Prognostic importance of pretransplant disease status for posttransplant outcomes in patients with adult T cell leukemia/lymphoma

Inoue, Y., Fuji, S., Tanosaki, R., Inamoto, Y., Tanaka, T., Ito, A., Okinaka, K., Kurosawa, S., Kim, S. W., Nakagama, H. & Fukuda, T., 2018 9 1, : : Bone Marrow Transplantation. 53, 9, p. 1105-1115 11 p.

研究成果: Article

6 引用 (Scopus)

Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response

Sakamoto, K., Katayama, R., Asaka, R., Sakata, S., Baba, S., Nakasone, H., Koike, S., Tsuyama, N., Dobashi, A., Sasaki, M., Ichinohasama, R., Takakuwa, E., Yamazaki, R., Takizawa, J., Maeda, T., Narita, M., Izutsu, K., Kanda, Y., Ohshima, K. & Takeuchi, K., 2018 12 1, : : Leukemia. 32, 12, p. 2590-2603 14 p.

研究成果: Article

22 引用 (Scopus)
2 引用 (Scopus)
2017

Adult T-cell leukemia cell-induced uveitis: rapid increase in adult T-cell leukemia cells disrupts the blood–ocular barrier

Hirano, M., Ohno, N., Tanosaki, R., Mochizuki, M., Ohno-Matsui, K., Uchimaru, K., Tojo, A. & Kamoi, K., 2017 7 4, (Accepted/In press) : : International Journal of Hematology. p. 1-5 5 p.

研究成果: Article

2 引用 (Scopus)
1 引用 (Scopus)
7 引用 (Scopus)

Increased incidence of oral and gastrointestinal secondary cancer after allogeneic hematopoietic stem cell transplantation

Tanaka, Y., Kurosawa, S., Tajima, K., Tanaka, T., Ito, R., Inoue, Y., Okinaka, K., Inamoto, Y., Fuji, S., Kim, S. W., Tanosaki, R., Yamashita, T. & Fukuda, T., 2017 2 13, (Accepted/In press) : : Bone Marrow Transplantation.

研究成果: Article

4 引用 (Scopus)
4 引用 (Scopus)

Refined methods to evaluate the in vivo hemostatic function and viability of transfused human platelets in rabbit models

Watanabe, N., Nogawa, M., Ishiguro, M., Maruyama, H., Shiba, M., Satake, M., Eto, K. & Handa, M., 2017 8 1, : : Transfusion. 57, 8, p. 2035-2044 10 p.

研究成果: Article

1 引用 (Scopus)

Risk Assessment in Adult T Cell Leukemia/Lymphoma Treated with Allogeneic Hematopoietic Stem Cell Transplantation

Yoshimitsu, M., Tanosaki, R., Kato, K., Ishida, T., Choi, I., Takatsuka, Y., Fukuda, T., Eto, T., Hidaka, M., Uchida, N., Miyamoto, T., Nakashima, Y., Moriuchi, Y., Nagafuji, K., Miyazaki, Y., Ichinohe, T., Takanashi, M., Atsuta, Y. & Utsunomiya, A., 2017 1 1, (Accepted/In press) : : Biology of Blood and Marrow Transplantation.

研究成果: Article

6 引用 (Scopus)
2016

Fibrinogen γ-Chain Peptide–Coated Adenosine 5′ Diphosphate–Encapsulated Liposomes Rescue Mice From Lethal Blast Lung Injury via Adenosine Signaling

Hagisawa, K., Kinoshita, M., Miyawaki, H., Sato, S., Miyazaki, H., Takeoka, S., Suzuki, H., Iwaya, K., Seki, S., Shono, S., Saitoh, D., Nishida, Y. & Handa, M., 2016 4 6, (Accepted/In press) : : Critical Care Medicine.

研究成果: Article

4 引用 (Scopus)

Genetic basis of myeloid transformation in familial platelet disorder/acute myeloid leukemia patients with haploinsufficient RUNX1 allele

Sakurai, M., Kasahara, H., Yoshida, K., Yoshimi, A., Kunimoto, H., Watanabe, N., Shiraishi, Y., Chiba, K., Tanaka, H., Harada, Y., Harada, H., Kawakita, T., Kurokawa, M., Miyano, S., Takahashi, S., Ogawa, S., Okamoto, S. & Nakajima, H., 2016 2 5, : : Blood Cancer Journal. 6, e392.

研究成果: Article

16 引用 (Scopus)
2015

A retrospective observational study to assess adverse transfusion reactions of patients with and without prior transfusion history

Kato, H., Nakayama, T., Uruma, M., Okuyama, Y., Handa, M., Tomiyama, Y., Shimodaira, S. & Takamoto, S., 2015 4 1, : : Vox Sanguinis. 108, 3, p. 243-250 8 p.

研究成果: Article

14 引用 (Scopus)
2 引用 (Scopus)

Pharmacokinetic Properties of Single and Repeated Injection of Liposomal Platelet Substitute in a Rat Model of Red Blood Cell Transfusion-Induced Dilutional Thrombocytopenia

Hashimoto, M., Taguchi, K., Ogaki, S., Watanabe, H., Kinoshita, M., Nishikawa, K., Takeoka, S., Ikeda, Y., Handa, M., Otagiri, M. & Maruyama, T., 2015 11 1, : : Journal of Pharmaceutical Sciences. 104, 11, p. 3968-3976 9 p.

研究成果: Article

Pharmacokinetics study of once-daily intravenous busulfan in conditioning regimens for hematopoietic stem cell transplantation

Sato, M., Kako, S., Matsumoto, K., Oshima, K., Akahoshi, Y., Nakano, H., Ugai, T., Yamasaki, R., Wada, H., Ishihara, Y., Sakamoto, K., Kawamura, K., Ashizawa, M., Terasako-Saito, K., Kimura, S. I., Nakasone, H., Kikuchi, M., Tanihara, A., Yamazaki, R., Tanaka, Y. および4人, Kanda, J., Nishida, J., Morita, K. & Kanda, Y., 2015 5 1, : : International journal of hematology. 101, 5, p. 497-504 8 p.

研究成果: Article

6 引用 (Scopus)

Repeated exposure rather than the total volume of transfused components may influence the incidence of allergic transfusion reactions

Kato, H., Nakayama, T., Uruma, M., Okuyama, Y., Handa, M., Tomiyama, Y., Shimodaira, S. & Takamoto, S., 2015 11 1, : : Transfusion. 55, 11, p. 2576-2581 6 p.

研究成果: Article

5 引用 (Scopus)
1 引用 (Scopus)

Treatment with fibrinogen γ-chain peptide-coated, adenosine 5′-diphosphate-encapsulated liposomes as an infusible hemostatic agent against active liver bleeding in rabbits with acute thrombocytopenia

Hagisawa, K., Nishikawa, K., Yanagawa, R., Kinoshita, M., Doi, M., Suzuki, H., Iwaya, K., Saitoh, D., Seki, S., Takeoka, S., Handa, M. & Nishida, Y., 2015 2 1, : : Transfusion. 55, 2, p. 314-325 12 p.

研究成果: Article

8 引用 (Scopus)
2014

A case of post-transplant adult T-cell leukemia/lymphoma presenting myelopathy similar to but distinct from human T-cell leukemia virus type I (HTLV- I)-associated myelopathy

Kawamata, T., Ohno, N., Sato, K., Kobayashi, M., Jo, N., Yuji, K., Tanosaki, R., Yamano, Y., Tojo, A. & Uchimaru, K., 2014 12 30, : : SpringerPlus. 3, 1, 581.

研究成果: Article

3 引用 (Scopus)

Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients

Sakurai, M., Kunimoto, H., Watanabe, N., Fukuchi, Y., Yuasa, S., Yamazaki, S., Nishimura, T., Sadahira, K., Fukuda, K., Okano, H., Nakauchi, H., Morita, Y., Matsumura, I., Kudo, K., Ito, E., Ebihara, Y., Tsuji, K., Harada, Y., Harada, H., Okamoto, S. および1人, Nakajima, H., 2014 12 11, : : Leukemia. 28, 12, p. 2344-2354 11 p.

研究成果: Article

41 引用 (Scopus)

PBSC collection from family donors in Japan: A prospective survey

Kodera, Y., Yamamoto, K., Harada, M., Morishima, Y., Dohy, H., Asano, S., Ikeda, Y., Nakahata, T., Imamura, M., Kawa, K., Kato, S., Tanimoto, M., Kanda, Y., Tanosaki, R., Shiobara, S., Kim, S. W., Nagafuji, K., Hino, M., Miyamura, K., Suzuki, R. および7人, Hamajima, N., Fukushima, M., Tamakoshi, A., Halter, J., Schmitz, N., Niederwieser, D. & Gratwohl, A., 2014 2 1, : : Bone Marrow Transplantation. 49, 2, p. 195-200 6 p.

研究成果: Article

19 引用 (Scopus)
2013

Epitope Mapping for Monoclonal Antibody Reveals the Activation Mechanism for αVβ3 Integrin

Kamata, T., Handa, M., Takakuwa, S., Sato, Y., Kawai, Y., Ikeda, Y. & Aiso, S., 2013 6 20, : : PloS one. 8, 6, e66096.

研究成果: Article

5 引用 (Scopus)

Evaluation of the Validity of Preemptive Therapy against Cytomegalovirus Disease Based on Antigenemia Assay with a Cutoff of 20 Positive Cells per Two Slides

Sakamoto, K., Nakasone, H., Wada, H., Yamasaki, R., Ishihara, Y., Kawamura, K., Ashizawa, M., Sato, M., Terasako-Saito, K., Machishima, T., Kimura, S. I., Kikuchi, M., Kako, S., Kanda, J., Yamazaki, R., Tanihara, A., Nishida, J. & Kanda, Y., 2013 9 5, : : PloS one. 8, 9, e73754.

研究成果: Article

13 引用 (Scopus)

Incidence of transfusion-related adverse reactions per patient reflects the potential risk of transfusion therapy in Japan

Kato, H., Uruma, M., Okuyama, Y., Fujita, H., Handa, M., Tomiyama, Y., Shimodaira, S., Kurata, Y. & Takamoto, S., 2013 8 1, : : American Journal of Clinical Pathology. 140, 2, p. 219-224 6 p.

研究成果: Article

26 引用 (Scopus)
3 引用 (Scopus)

Pharmacokinetic Study of Adenosine Diphosphate-Encapsulated Liposomes Coated with Fibrinogen γ-Chain Dodecapeptide as a Synthetic Platelet Substitute in an Anticancer Drug-Induced Thrombocytopenia Rat Model

Taguchi, K., Ujihira, H., Watanabe, H., Fujiyama, A., Doi, M., Takeoka, S., Ikeda, Y., Handa, M., Otagiri, M. & Maruyama, T., 2013 10, : : Journal of Pharmaceutical Sciences. 102, 10, p. 3852-3859 8 p.

研究成果: Article

5 引用 (Scopus)

Pharmacokinetic study of the structural components of adenosine diphosphate-encapsulated liposomes coated with fibrinogen g-chain dodecapeptide as a synthetic platelet substitutes

Taguchi, K., Ujihira, H., Ogaki, S., Watanabe, H., Fujiyama, A., Doi, M., Okamura, Y., Takeoka, S., Ikeda, Y., Handa, M., Otagiri, M. & Maruyama, T., 2013 8 1, : : Drug Metabolism and Disposition. 41, 8, p. 1584-1591 8 p.

研究成果: Article

6 引用 (Scopus)

Potential contribution of a novel tax epitope-specific CD4+ T cells to graft-versus-tax effect in adult T cell leukemia patients after allogeneic hematopoietic stem cell transplantation

Tamai, Y., Hasegawa, A., Takamori, A., Sasada, A., Tanosaki, R., Choi, I., Utsunomiya, A., Maeda, Y., Yamano, Y., Eto, T., Koh, K. R., Nakamae, H., Suehiro, Y., Kato, K., Takemoto, S., Okamura, J., Uike, N. & Kannagi, M., 2013 4 15, : : Journal of Immunology. 190, 8, p. 4382-4392 11 p.

研究成果: Article

10 引用 (Scopus)
2012

Ability of fibrinogen γ-derived dodecapeptides with different sequences to bind to rat platelets

Tokutomi, K., Tagawa, T., Korenaga, M., Chiba, M., Asai, T., Watanabe, N., Takeoka, S., Handa, M., Ikeda, Y. & Oku, N., 2012 11 15, : : International Journal of Pharmaceutics. 438, 1-2, p. 296-301 6 p.

研究成果: Article

2 引用 (Scopus)

Allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia-lymphoma with special emphasis on preconditioning regimen: A nationwide retrospective study

Ishida, T., Hishizawa, M., Kato, K., Tanosaki, R., Fukuda, T., Taniguchi, S., Eto, T., Takatsuka, Y., Miyazaki, Y., Moriuchi, Y., Hidaka, M., Akashi, K., Uike, N., Sakamaki, H., Morishima, Y., Suzuki, R., Nishiyama, T. & Utsunomiya, A., 2012 8 23, : : Blood. 120, 8, p. 1734-1741 8 p.

研究成果: Article

105 引用 (Scopus)

Fibrinogen γ-chain peptide-coated, ADP-encapsulated liposomes rescue thrombocytopenic rabbits from non-compressible liver hemorrhage

Nishikawa, K., Hagisawa, K., Kinoshita, M., Shono, S., Katsuno, S., Doi, M., Yanagawa, R., Suzuki, H., Iwaya, K., Saitoh, D., Sakamoto, T., Seki, S., Takeoka, S. & Handa, M., 2012 10 1, : : Journal of Thrombosis and Haemostasis. 10, 10, p. 2137-2148 12 p.

研究成果: Article

20 引用 (Scopus)
2011

Decoration of fibrinogen γ-chain peptide on adenosine diphosphate-encapsulated liposomes enhances binding of the liposomes to activated platelets

Tokutomi, K., Tagawa, T., Korenaga, M., Chiba, M., Asai, T., Watanabe, N., Takeoka, S., Handa, M., Ikeda, Y. & Oku, N., 2011 4 4, : : International Journal of Pharmaceutics. 407, 1-2, p. 151-157 7 p.

研究成果: Article

12 引用 (Scopus)

Erythroid crisis caused by parvovirus B19 transmitted via red blood cell transfusion

Tsukada, Y., Yokoyama, K., Ishida, A., Handa, M., Mori, T., Kizaki, M. & Okamoto, S., 2011 10 24, : : Internal Medicine. 50, 20, p. 2379-2382 4 p.

研究成果: Article

11 引用 (Scopus)

Shear-dependent suppression of platelet thrombus formation by phosphodiesterase 3 inhibition requires low levels of concomitant Gs-coupled receptor stimulation

Yoshida, H., Okamura, Y., Watanabe, N., Ikeda, Y. & Handa, M., 2011 3 1, : : Thrombosis and Haemostasis. 105, 3, p. 487-495 9 p.

研究成果: Article

6 引用 (Scopus)
7 引用 (Scopus)
2010

[Anti-platelet autoantibodies].

Watanabe, N. & Handa, M., 2010 6, : : Nippon rinsho. Japanese journal of clinical medicine. 68 Suppl 6, p. 691-693 3 p.

研究成果: Article

[Red cell autoantibodies].

Watanabe, N. & Handa, M., 2010 6, : : Nippon rinsho. Japanese journal of clinical medicine. 68 Suppl 6, p. 687-690 4 p.

研究成果: Article

Non-tuberculous mycobacterial infection localized in small intestine developing after allogeneic bone marrow transplantation

Yamazaki, R., Mori, T., Nakazato, T., Aisa, Y., Imaeda, H., Hisamatsu, T., Hibi, T. & Okamoto, S., 2010 7 1, : : Internal Medicine. 49, 12, p. 1191-1193 3 p.

研究成果: Article

9 引用 (Scopus)

Release abilities of adenosine diphosphate from phospholipid vesicles with different membrane properties and their hemostatic effects as a platelet substitute

Okamura, Y., Katsuno, S., Suzuki, H., Maruyama, H., Handa, M., Ikeda, Y. & Takeoka, S., 2010 12 20, : : Journal of Controlled Release. 148, 3, p. 373-379 7 p.

研究成果: Article

16 引用 (Scopus)

RIAM: bridge between Rap1 and integrin

Watanabe, N., 2010 6 1, : : [Rinshō ketsueki] The Japanese journal of clinical hematology. 51, 6, p. 377-383 7 p.

研究成果: Review article

1 引用 (Scopus)

Structural requirements for activation in αIIbβ3 integrin

Kamata, T., Handa, M., Ito, S., Sato, Y., Ohtani, T., Kawai, Y., Ikeda, Y. & Aiso, S., 2010 12 3, : : Journal of Biological Chemistry. 285, 49, p. 38428-38437 10 p.

研究成果: Article

19 引用 (Scopus)

Visualization of liposomes carrying fibrinogen γ-chain dodecapeptide accumulated to sites of vascular injury using computed tomography

Okamura, Y., Eto, K., Maruyama, H., Handa, M., Ikeda, Y. & Takeoka, S., 2010 4 1, : : Nanomedicine: Nanotechnology, Biology, and Medicine. 6, 2, p. 391-396 6 p.

研究成果: Article

17 引用 (Scopus)