医学部輸血・細胞療法センター

研究成果 1981 2019

フィルター
Article
2019
Human Herpesvirus 6
Hematopoietic Stem Cell Transplantation
T-Lymphocytes
Polymerase Chain Reaction
Central Nervous System Diseases
Hematopoietic Stem Cell Transplantation
Bacterial Infections
Immunoglobulins
Immunoglobulin G
Bacterial Pneumonia
Mycoses
Hematology
Air
Japan
Air Filters
2018
6 引用 (Scopus)

Prognostic importance of pretransplant disease status for posttransplant outcomes in patients with adult T cell leukemia/lymphoma

Inoue, Y., Fuji, S., Tanosaki, R., Inamoto, Y., Tanaka, T., Ito, A., Okinaka, K., Kurosawa, S., Kim, S. W., Nakagama, H. & Fukuda, T., 2018 3 9, (Accepted/In press) : : Bone Marrow Transplantation. p. 1-11 11 p.

研究成果: Article

Adult T Cell Leukemia Lymphoma
Hematopoietic Stem Cell Transplantation
Recurrence
Lymphoma
T-Cell Lymphoma
12 引用 (Scopus)

Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response

Sakamoto, K., Katayama, R., Asaka, R., Sakata, S., Baba, S., Nakasone, H., Koike, S., Tsuyama, N., Dobashi, A., Sasaki, M., Ichinohasama, R., Takakuwa, E., Yamazaki, R., Takizawa, J., Maeda, T., Narita, M., Izutsu, K., Kanda, Y., Ohshima, K. & Takeuchi, K., 2018 5 23, (Accepted/In press) : : Leukemia. p. 1-14 14 p.

研究成果: Article

Dendritic Cells
Pharmaceutical Preparations
Neoplasms
Aurora Kinases
Precision Medicine
2 引用 (Scopus)
Bacterial Pneumonia
Hematopoietic Stem Cell Transplantation
Immunoglobulins
Pneumonia
Immunoglobulin G
2017
1 引用 (Scopus)

Adult T-cell leukemia cell-induced uveitis: rapid increase in adult T-cell leukemia cells disrupts the blood–ocular barrier

Hirano, M., Ohno, N., Tanosaki, R., Mochizuki, M., Ohno-Matsui, K., Uchimaru, K., Tojo, A. & Kamoi, K., 2017 7 4, (Accepted/In press) : : International Journal of Hematology. p. 1-5 5 p.

研究成果: Article

Adult T Cell Leukemia Lymphoma
Uveitis
T-Lymphocytes
Eye Manifestations
Deltaretrovirus
1 引用 (Scopus)
Gallium
Lymphoma, Large B-Cell, Diffuse
Fluorodeoxyglucose F18
Radionuclide Imaging
Positron-Emission Tomography
4 引用 (Scopus)
Myelitis
Human Herpesvirus 6
Hyponatremia
Hematopoietic Stem Cell Transplantation
Encephalitis
3 引用 (Scopus)

Increased incidence of oral and gastrointestinal secondary cancer after allogeneic hematopoietic stem cell transplantation

Tanaka, Y., Kurosawa, S., Tajima, K., Tanaka, T., Ito, R., Inoue, Y., Okinaka, K., Inamoto, Y., Fuji, S., Kim, S. W., Tanosaki, R., Yamashita, T. & Fukuda, T., 2017 2 13, (Accepted/In press) : : Bone Marrow Transplantation.

研究成果: Article

4 引用 (Scopus)
Polyomavirus Infections
BK Virus
Cystitis
Hematopoietic Stem Cell Transplantation
Hematologic Neoplasms
1 引用 (Scopus)

Refined methods to evaluate the in vivo hemostatic function and viability of transfused human platelets in rabbit models

Watanabe, N., Nogawa, M., Ishiguro, M., Maruyama, H., Shiba, M., Satake, M., Eto, K. & Handa, M., 2017 8 1, : : Transfusion. 57, 8, p. 2035-2044 10 p.

研究成果: Article

Hemostatics
Blood Platelets
Rabbits
Bleeding Time
Survival
6 引用 (Scopus)

Risk Assessment in Adult T Cell Leukemia/Lymphoma Treated with Allogeneic Hematopoietic Stem Cell Transplantation

Yoshimitsu, M., Tanosaki, R., Kato, K., Ishida, T., Choi, I., Takatsuka, Y., Fukuda, T., Eto, T., Hidaka, M., Uchida, N., Miyamoto, T., Nakashima, Y., Moriuchi, Y., Nagafuji, K., Miyazaki, Y., Ichinohe, T., Takanashi, M., Atsuta, Y. & Utsunomiya, A., 2017 1 1, (Accepted/In press) : : Biology of Blood and Marrow Transplantation.

研究成果: Article

Adult T Cell Leukemia Lymphoma
Hematopoietic Stem Cell Transplantation
Cell Transplantation
Mortality
Comorbidity
2016
4 引用 (Scopus)

Fibrinogen γ-Chain Peptide–Coated Adenosine 5′ Diphosphate–Encapsulated Liposomes Rescue Mice From Lethal Blast Lung Injury via Adenosine Signaling

Hagisawa, K., Kinoshita, M., Miyawaki, H., Sato, S., Miyazaki, H., Takeoka, S., Suzuki, H., Iwaya, K., Seki, S., Shono, S., Saitoh, D., Nishida, Y. & Handa, M., 2016 4 6, (Accepted/In press) : : Critical Care Medicine.

研究成果: Article

Blast Injuries
Lung Injury
Liposomes
Adenosine
Fibrinogen
15 引用 (Scopus)

Genetic basis of myeloid transformation in familial platelet disorder/acute myeloid leukemia patients with haploinsufficient RUNX1 allele

Sakurai, M., Kasahara, H., Yoshida, K., Yoshimi, A., Kunimoto, H., Watanabe, N., Shiraishi, Y., Chiba, K., Tanaka, H., Harada, Y., Harada, H., Kawakita, T., Kurokawa, M., Miyano, S., Takahashi, S., Ogawa, S., Okamoto, S. & Nakajima, H., 2016 2 5, : : Blood Cancer Journal. 6, e392.

研究成果: Article

Core Binding Factor Alpha 2 Subunit
Blood Platelet Disorders
Neoplastic Cell Transformation
Haploinsufficiency
Genetic Association Studies
2015
11 引用 (Scopus)

A retrospective observational study to assess adverse transfusion reactions of patients with and without prior transfusion history

Kato, H., Nakayama, T., Uruma, M., Okuyama, Y., Handa, M., Tomiyama, Y., Shimodaira, S. & Takamoto, S., 2015 4 1, : : Vox Sanguinis. 108, 3, p. 243-250 8 p.

研究成果: Article

Observational Studies
Retrospective Studies
History
Erythrocytes
Blood Platelets
1 引用 (Scopus)
Liposomes
Thrombocytopenia
Adenosine Diphosphate
Fibrinogen
Blood Platelets

Pharmacokinetic Properties of Single and Repeated Injection of Liposomal Platelet Substitute in a Rat Model of Red Blood Cell Transfusion-Induced Dilutional Thrombocytopenia

Hashimoto, M., Taguchi, K., Ogaki, S., Watanabe, H., Kinoshita, M., Nishikawa, K., Takeoka, S., Ikeda, Y., Handa, M., Otagiri, M. & Maruyama, T., 2015 11 1, : : Journal of Pharmaceutical Sciences. 104, 11, p. 3968-3976 9 p.

研究成果: Article

Erythrocyte Transfusion
Thrombocytopenia
Adenosine Diphosphate
Blood Platelets
Pharmacokinetics
5 引用 (Scopus)

Repeated exposure rather than the total volume of transfused components may influence the incidence of allergic transfusion reactions

Kato, H., Nakayama, T., Uruma, M., Okuyama, Y., Handa, M., Tomiyama, Y., Shimodaira, S. & Takamoto, S., 2015 11 1, : : Transfusion. 55, 11, p. 2576-2581 6 p.

研究成果: Article

Hypersensitivity
Blood Platelets
Incidence
Transfusion Reaction
History
Blood Transfusion
Blood Component Transfusion
Donor Selection
Acute Lung Injury
Decision Making
8 引用 (Scopus)

Treatment with fibrinogen γ-chain peptide-coated, adenosine 5′-diphosphate-encapsulated liposomes as an infusible hemostatic agent against active liver bleeding in rabbits with acute thrombocytopenia

Hagisawa, K., Nishikawa, K., Yanagawa, R., Kinoshita, M., Doi, M., Suzuki, H., Iwaya, K., Saitoh, D., Seki, S., Takeoka, S., Handa, M. & Nishida, Y., 2015 2 1, : : Transfusion. 55, 2, p. 314-325 12 p.

研究成果: Article

Hemostatics
Liposomes
Thrombocytopenia
Adenosine Diphosphate
Fibrinogen
2014
40 引用 (Scopus)

Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients

Sakurai, M., Kunimoto, H., Watanabe, N., Fukuchi, Y., Yuasa, S., Yamazaki, S., Nishimura, T., Sadahira, K., Fukuda, K., Okano, H., Nakauchi, H., Morita, Y., Matsumura, I., Kudo, K., Ito, E., Ebihara, Y., Tsuji, K., Harada, Y., Harada, H., Okamoto, S. および1人, Nakajima, H., 2014 12 11, : : Leukemia. 28, 12, p. 2344-2354 11 p.

研究成果: Article

Induced Pluripotent Stem Cells
Acute Myeloid Leukemia
Blood Platelets
Hematopoiesis
Megakaryocyte Progenitor Cells
2013
5 引用 (Scopus)

Epitope Mapping for Monoclonal Antibody Reveals the Activation Mechanism for αVβ3 Integrin

Kamata, T., Handa, M., Takakuwa, S., Sato, Y., Kawai, Y., Ikeda, Y. & Aiso, S., 2013 6 20, : : PLoS One. 8, 6, e66096.

研究成果: Article

Epitope Mapping
integrins
Integrins
Epitopes
monoclonal antibodies
22 引用 (Scopus)

Incidence of transfusion-related adverse reactions per patient reflects the potential risk of transfusion therapy in Japan

Kato, H., Uruma, M., Okuyama, Y., Fujita, H., Handa, M., Tomiyama, Y., Shimodaira, S., Kurata, Y. & Takamoto, S., 2013 8, : : American Journal of Clinical Pathology. 140, 2, p. 219-224 6 p.

研究成果: Article

Japan
Blood Platelets
Incidence
Hypersensitivity
Blood Component Transfusion
3 引用 (Scopus)
Parvoviridae Infections
Parvovirus
Hematopoietic Stem Cell Transplantation
Transplantation
Viremia
5 引用 (Scopus)

Pharmacokinetic Study of Adenosine Diphosphate-Encapsulated Liposomes Coated with Fibrinogen γ-Chain Dodecapeptide as a Synthetic Platelet Substitute in an Anticancer Drug-Induced Thrombocytopenia Rat Model

Taguchi, K., Ujihira, H., Watanabe, H., Fujiyama, A., Doi, M., Takeoka, S., Ikeda, Y., Handa, M., Otagiri, M. & Maruyama, T., 2013 10, : : Journal of Pharmaceutical Sciences. 102, 10, p. 3852-3859 8 p.

研究成果: Article

Liposomes
Thrombocytopenia
Adenosine Diphosphate
Fibrinogen
Blood Platelets
6 引用 (Scopus)

Pharmacokinetic study of the structural components of adenosine diphosphate-encapsulated liposomes coated with fibrinogen g-chain dodecapeptide as a synthetic platelet substitutes

Taguchi, K., Ujihira, H., Ogaki, S., Watanabe, H., Fujiyama, A., Doi, M., Okamura, Y., Takeoka, S., Ikeda, Y., Handa, M., Otagiri, M. & Maruyama, T., 2013 8, : : Drug Metabolism and Disposition. 41, 8, p. 1584-1591 8 p.

研究成果: Article

Liposomes
Adenosine Diphosphate
Fibrinogen
Blood Platelets
Pharmacokinetics
2012
2 引用 (Scopus)

Ability of fibrinogen γ-derived dodecapeptides with different sequences to bind to rat platelets

Tokutomi, K., Tagawa, T., Korenaga, M., Chiba, M., Asai, T., Watanabe, N., Takeoka, S., Handa, M., Ikeda, Y. & Oku, N., 2012 11 15, : : International Journal of Pharmaceutics. 438, 1-2, p. 296-301 6 p.

研究成果: Article

Fibrinogen
Blood Platelets
Amino Acid Sequence
Platelet-Rich Plasma
Hemostasis
18 引用 (Scopus)

Fibrinogen γ-chain peptide-coated, ADP-encapsulated liposomes rescue thrombocytopenic rabbits from non-compressible liver hemorrhage

Nishikawa, K., Hagisawa, K., Kinoshita, M., Shono, S., Katsuno, S., Doi, M., Yanagawa, R., Suzuki, H., Iwaya, K., Saitoh, D., Sakamoto, T., Seki, S., Takeoka, S. & Handa, M., 2012 10, : : Journal of Thrombosis and Haemostasis. 10, 10, p. 2137-2148 12 p.

研究成果: Article

Liposomes
Adenosine Diphosphate
Fibrinogen
Hemorrhage
Rabbits
2011
11 引用 (Scopus)

Decoration of fibrinogen γ-chain peptide on adenosine diphosphate-encapsulated liposomes enhances binding of the liposomes to activated platelets

Tokutomi, K., Tagawa, T., Korenaga, M., Chiba, M., Asai, T., Watanabe, N., Takeoka, S., Handa, M., Ikeda, Y. & Oku, N., 2011 4 4, : : International Journal of Pharmaceutics. 407, 1-2, p. 151-157 7 p.

研究成果: Article

Liposomes
Adenosine Diphosphate
Fibrinogen
Blood Platelets
Peptides
10 引用 (Scopus)

Erythroid crisis caused by parvovirus B19 transmitted via red blood cell transfusion

Tsukada, Y., Yokoyama, K., Ishida, A., Handa, M., Mori, T., Kizaki, M. & Okamoto, S., 2011, : : Internal Medicine. 50, 20, p. 2379-2382 4 p.

研究成果: Article

Erythrocyte Transfusion
Parvovirus
Human Parvovirus B19
Parvoviridae Infections
Hairy Cell Leukemia
6 引用 (Scopus)
tirofiban
Phosphoric Diester Hydrolases
Phosphodiesterase 3 Inhibitors
Thrombosis
Blood Platelets
7 引用 (Scopus)
Liposomes
Thrombin
Fibrinogen
Blood Platelets
Electron Microscopy
2010

[Anti-platelet autoantibodies].

Watanabe, N. & Handa, M., 2010 6, : : Nippon rinsho. Japanese journal of clinical medicine. 68 Suppl 6, p. 691-693 3 p.

研究成果: Article

Specimen Handling
Hemagglutination Tests
Platelet Transfusion
Purpura
Idiopathic Thrombocytopenic Purpura

[Red cell autoantibodies].

Watanabe, N. & Handa, M., 2010 6, : : Nippon rinsho. Japanese journal of clinical medicine. 68 Suppl 6, p. 687-690 4 p.

研究成果: Article

Specimen Handling
Coombs Test
Autoimmune Hemolytic Anemia
Autoantibodies
Reference Values
9 引用 (Scopus)

Non-tuberculous mycobacterial infection localized in small intestine developing after allogeneic bone marrow transplantation

Yamazaki, R., Mori, T., Nakazato, T., Aisa, Y., Imaeda, H., Hisamatsu, T., Hibi, T. & Okamoto, S., 2010, : : Internal Medicine. 49, 12, p. 1191-1193 3 p.

研究成果: Article

Homologous Transplantation
Bone Marrow Transplantation
Myelodysplastic-Myeloproliferative Diseases
Small Intestine
Double-Balloon Enteroscopy
16 引用 (Scopus)

Release abilities of adenosine diphosphate from phospholipid vesicles with different membrane properties and their hemostatic effects as a platelet substitute

Okamura, Y., Katsuno, S., Suzuki, H., Maruyama, H., Handa, M., Ikeda, Y. & Takeoka, S., 2010 12 20, : : Journal of Controlled Release. 148, 3, p. 373-379 7 p.

研究成果: Article

Hemostatics
Adenosine Diphosphate
Phospholipids
Blood Platelets
Membranes
18 引用 (Scopus)

Structural requirements for activation in αIIbβ3 integrin

Kamata, T., Handa, M., Ito, S., Sato, Y., Ohtani, T., Kawai, Y., Ikeda, Y. & Aiso, S., 2010 12 3, : : Journal of Biological Chemistry. 285, 49, p. 38428-38437 10 p.

研究成果: Article

Integrins
Chemical activation
Glycosylation
Disulfides
Fibrinogen
17 引用 (Scopus)

Visualization of liposomes carrying fibrinogen γ-chain dodecapeptide accumulated to sites of vascular injury using computed tomography

Okamura, Y., Eto, K., Maruyama, H., Handa, M., Ikeda, Y. & Takeoka, S., 2010 4, : : Nanomedicine: Nanotechnology, Biology, and Medicine. 6, 2, p. 391-396 6 p.

研究成果: Article

Liposomes
Vascular System Injuries
Fibrinogen
Tomography
Visualization
2009
2 引用 (Scopus)
Drug Dose Response Relationship
Piperazines
Pyrimidines
Intestinal Absorption
Jejunum
46 引用 (Scopus)

Development of fibrinogen γ-chain peptide-coated, adenosine diphosphate-encapsulated liposomes as a synthetic platelet substitute

Okamura, Y., Takeoka, S., Eto, K., Maekawa, I., Fujie, T., Maruyama, H., Ikeda, Y. & Handa, M., 2009, : : Journal of Thrombosis and Haemostasis. 7, 3, p. 470-477 8 p.

研究成果: Article

Liposomes
Adenosine Diphosphate
Fibrinogen
Blood Platelets
Peptides
1 引用 (Scopus)

Emergency compatible, ABO-different blood group transfusion in the operating theater: A survey in Regional Japanese Society of Anesthesiologists- Certified Training Hospitals in 2006

Irita, K., Inada, E., Tsuzaki, K., Inaba, S., Handa, M., Kino, S., Mashiko, K., Kubo, T. & Morita, K., 2009 8, : : Japanese Journal of Anesthesiology. 58, 8, p. 1045-1054 10 p.

研究成果: Article

Blood Group Antigens
Blood Transfusion
Emergencies
Blood Platelets
Mortality
1 引用 (Scopus)
Tacrolimus
Oral Administration
Transplants
Area Under Curve
Pharmacokinetics
5 引用 (Scopus)
Gram-Positive Bacterial Infections
Leuconostoc
Peripheral Blood Stem Cell Transplantation
Bacteremia
Neutropenia
27 引用 (Scopus)

Novel platelet substitutes: Disk-shaped biodegradable nanosheets and their enhanced effects on platelet aggregation

Okamura, Y., Fukui, Y., Kabata, K., Suzuki, H., Handa, M., Ikeda, Y. & Takeoka, S., 2009 10 21, : : Bioconjugate Chemistry. 20, 10, p. 1958-1965 8 p.

研究成果: Article

Nanosheets
Platelets
Platelet Aggregation
Blood Platelets
Agglomeration
5 引用 (Scopus)

Present status of preparatory measures for massive hemorrhage and emergency blood transfusion in regional hospitals with an accredited department of anesthesiology in 2006

Irita, K., Inada, E., Yoshimura, H., Warabi, K., Tsuzaki, K., Inaba, S., Handa, M., Uemura, T., Kino, S., Mashiko, K., Yano, T., Kamei, Y. & Kubo, T., 2009 1, : : Japanese Journal of Anesthesiology. 58, 1, p. 109-123 15 p.

研究成果: Article

Anesthesiology
Blood Transfusion
Emergencies
Blood Group Antigens
Hemorrhage
3 引用 (Scopus)

SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription

Nakajima, H., Tamura, T., Ito, M., Shibata, F., Kuroda, K., Fukuchi, Y., Watanabe, N., Kitamura, T., Ikeda, Y. & Handa, M., 2009 1 29, : : Blood. 113, 5, p. 1027-1036 10 p.

研究成果: Article

Transcription
STAT5 Transcription Factor
Cytokines
Feedback
Genes
25 引用 (Scopus)
Human Herpesvirus 6
Diagnostic Errors
Hematopoietic Stem Cell Transplantation
Infection
Mouth Mucosa
2008
10 引用 (Scopus)

Evaluating efficacy of plasmapheresis for patients with pemphigus using desmoglein enzyme-linked immunosorbent assay

Nagasaka, T., Fujii, Y., Ishida, A., Handa, M., Tanikawa, A., Amagai, M. & Nishikawa, T., 2008 4, : : British Journal of Dermatology. 158, 4, p. 685-690 6 p.

研究成果: Article

Desmogleins
Pemphigus
Plasmapheresis
Enzyme-Linked Immunosorbent Assay
Autoantibodies
23 引用 (Scopus)
Fluconazole
Drug Interactions
Tacrolimus
Cyclosporine
Calcineurin Inhibitors