医学部輸血・細胞療法センター

研究成果

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Article
2020

Clinical characteristics of human herpesvirus-6 myelitis after allogeneic hematopoietic stem cell transplantation and its favorable outcome by early intervention

Shiroshita, K., Mori, T., Kato, J., Sakurai, M., Koda, Y., Abe, R., Murakami, K., Sumiya, C., Fujita, S., Yamaguchi, K., Yamazaki, R., Nakayama, H., Suzuki, S., Nakahara, J. & Okamoto, S., 2020 5 1, : : Bone Marrow Transplantation. 55, 5, p. 939-945 7 p.

研究成果: Article

2019
1 引用 (Scopus)
2 引用 (Scopus)
2018

Prognostic importance of pretransplant disease status for posttransplant outcomes in patients with adult T cell leukemia/lymphoma

Inoue, Y., Fuji, S., Tanosaki, R., Inamoto, Y., Tanaka, T., Ito, A., Okinaka, K., Kurosawa, S., Kim, S. W., Nakagama, H. & Fukuda, T., 2018 9 1, : : Bone Marrow Transplantation. 53, 9, p. 1105-1115 11 p.

研究成果: Article

7 引用 (Scopus)

Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response

Sakamoto, K., Katayama, R., Asaka, R., Sakata, S., Baba, S., Nakasone, H., Koike, S., Tsuyama, N., Dobashi, A., Sasaki, M., Ichinohasama, R., Takakuwa, E., Yamazaki, R., Takizawa, J., Maeda, T., Narita, M., Izutsu, K., Kanda, Y., Ohshima, K. & Takeuchi, K., 2018 12 1, : : Leukemia. 32, 12, p. 2590-2603 14 p.

研究成果: Article

23 引用 (Scopus)
3 引用 (Scopus)
2017

Adult T-cell leukemia cell-induced uveitis: rapid increase in adult T-cell leukemia cells disrupts the blood–ocular barrier

Hirano, M., Ohno, N., Tanosaki, R., Mochizuki, M., Ohno-Matsui, K., Uchimaru, K., Tojo, A. & Kamoi, K., 2017 7 4, (Accepted/In press) : : International Journal of Hematology. p. 1-5 5 p.

研究成果: Article

2 引用 (Scopus)
1 引用 (Scopus)
7 引用 (Scopus)

Increased incidence of oral and gastrointestinal secondary cancer after allogeneic hematopoietic stem cell transplantation

Tanaka, Y., Kurosawa, S., Tajima, K., Tanaka, T., Ito, R., Inoue, Y., Okinaka, K., Inamoto, Y., Fuji, S., Kim, S. W., Tanosaki, R., Yamashita, T. & Fukuda, T., 2017 2 13, (Accepted/In press) : : Bone Marrow Transplantation.

研究成果: Article

4 引用 (Scopus)
4 引用 (Scopus)

Refined methods to evaluate the in vivo hemostatic function and viability of transfused human platelets in rabbit models

Watanabe, N., Nogawa, M., Ishiguro, M., Maruyama, H., Shiba, M., Satake, M., Eto, K. & Handa, M., 2017 8 1, : : Transfusion. 57, 8, p. 2035-2044 10 p.

研究成果: Article

1 引用 (Scopus)

Risk Assessment in Adult T Cell Leukemia/Lymphoma Treated with Allogeneic Hematopoietic Stem Cell Transplantation

Yoshimitsu, M., Tanosaki, R., Kato, K., Ishida, T., Choi, I., Takatsuka, Y., Fukuda, T., Eto, T., Hidaka, M., Uchida, N., Miyamoto, T., Nakashima, Y., Moriuchi, Y., Nagafuji, K., Miyazaki, Y., Ichinohe, T., Takanashi, M., Atsuta, Y. & Utsunomiya, A., 2017 1 1, (Accepted/In press) : : Biology of Blood and Marrow Transplantation.

研究成果: Article

6 引用 (Scopus)
2016

Eltrombopag for Treatment of Thrombocytopenia after Allogeneic Hematopoietic Cell Transplantation

Tanaka, T., Inamoto, Y., Yamashita, T., Fuji, S., Okinaka, K., Kurosawa, S., Kim, S. W., Tanosaki, R. & Fukuda, T., 2016 5 1, : : Biology of Blood and Marrow Transplantation. 22, 5, p. 919-924 6 p.

研究成果: Article

25 引用 (Scopus)

Fibrinogen γ-Chain Peptide–Coated Adenosine 5′ Diphosphate–Encapsulated Liposomes Rescue Mice From Lethal Blast Lung Injury via Adenosine Signaling

Hagisawa, K., Kinoshita, M., Miyawaki, H., Sato, S., Miyazaki, H., Takeoka, S., Suzuki, H., Iwaya, K., Seki, S., Shono, S., Saitoh, D., Nishida, Y. & Handa, M., 2016 4 6, (Accepted/In press) : : Critical Care Medicine.

研究成果: Article

4 引用 (Scopus)

Genetic basis of myeloid transformation in familial platelet disorder/acute myeloid leukemia patients with haploinsufficient RUNX1 allele

Sakurai, M., Kasahara, H., Yoshida, K., Yoshimi, A., Kunimoto, H., Watanabe, N., Shiraishi, Y., Chiba, K., Tanaka, H., Harada, Y., Harada, H., Kawakita, T., Kurokawa, M., Miyano, S., Takahashi, S., Ogawa, S., Okamoto, S. & Nakajima, H., 2016 2 5, : : Blood Cancer Journal. 6, e392.

研究成果: Article

16 引用 (Scopus)
2015

A retrospective observational study to assess adverse transfusion reactions of patients with and without prior transfusion history

Kato, H., Nakayama, T., Uruma, M., Okuyama, Y., Handa, M., Tomiyama, Y., Shimodaira, S. & Takamoto, S., 2015 4 1, : : Vox Sanguinis. 108, 3, p. 243-250 8 p.

研究成果: Article

14 引用 (Scopus)
2 引用 (Scopus)

Pharmacokinetic Properties of Single and Repeated Injection of Liposomal Platelet Substitute in a Rat Model of Red Blood Cell Transfusion-Induced Dilutional Thrombocytopenia

Hashimoto, M., Taguchi, K., Ogaki, S., Watanabe, H., Kinoshita, M., Nishikawa, K., Takeoka, S., Ikeda, Y., Handa, M., Otagiri, M. & Maruyama, T., 2015 11 1, : : Journal of Pharmaceutical Sciences. 104, 11, p. 3968-3976 9 p.

研究成果: Article

Repeated exposure rather than the total volume of transfused components may influence the incidence of allergic transfusion reactions

Kato, H., Nakayama, T., Uruma, M., Okuyama, Y., Handa, M., Tomiyama, Y., Shimodaira, S. & Takamoto, S., 2015 11 1, : : Transfusion. 55, 11, p. 2576-2581 6 p.

研究成果: Article

5 引用 (Scopus)
1 引用 (Scopus)

Treatment with fibrinogen γ-chain peptide-coated, adenosine 5′-diphosphate-encapsulated liposomes as an infusible hemostatic agent against active liver bleeding in rabbits with acute thrombocytopenia

Hagisawa, K., Nishikawa, K., Yanagawa, R., Kinoshita, M., Doi, M., Suzuki, H., Iwaya, K., Saitoh, D., Seki, S., Takeoka, S., Handa, M. & Nishida, Y., 2015 2 1, : : Transfusion. 55, 2, p. 314-325 12 p.

研究成果: Article

8 引用 (Scopus)
2014

Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients

Sakurai, M., Kunimoto, H., Watanabe, N., Fukuchi, Y., Yuasa, S., Yamazaki, S., Nishimura, T., Sadahira, K., Fukuda, K., Okano, H., Nakauchi, H., Morita, Y., Matsumura, I., Kudo, K., Ito, E., Ebihara, Y., Tsuji, K., Harada, Y., Harada, H., Okamoto, S. および1人, Nakajima, H., 2014 12 11, : : Leukemia. 28, 12, p. 2344-2354 11 p.

研究成果: Article

42 引用 (Scopus)

PBSC collection from family donors in Japan: A prospective survey

Kodera, Y., Yamamoto, K., Harada, M., Morishima, Y., Dohy, H., Asano, S., Ikeda, Y., Nakahata, T., Imamura, M., Kawa, K., Kato, S., Tanimoto, M., Kanda, Y., Tanosaki, R., Shiobara, S., Kim, S. W., Nagafuji, K., Hino, M., Miyamura, K., Suzuki, R. および7人, Hamajima, N., Fukushima, M., Tamakoshi, A., Halter, J., Schmitz, N., Niederwieser, D. & Gratwohl, A., 2014 2, : : Bone Marrow Transplantation. 49, 2, p. 195-200 6 p.

研究成果: Article

19 引用 (Scopus)
2013

Epitope Mapping for Monoclonal Antibody Reveals the Activation Mechanism for αVβ3 Integrin

Kamata, T., Handa, M., Takakuwa, S., Sato, Y., Kawai, Y., Ikeda, Y. & Aiso, S., 2013 6 20, : : PloS one. 8, 6, e66096.

研究成果: Article

5 引用 (Scopus)

Incidence of transfusion-related adverse reactions per patient reflects the potential risk of transfusion therapy in Japan

Kato, H., Uruma, M., Okuyama, Y., Fujita, H., Handa, M., Tomiyama, Y., Shimodaira, S., Kurata, Y. & Takamoto, S., 2013 8 1, : : American Journal of Clinical Pathology. 140, 2, p. 219-224 6 p.

研究成果: Article

27 引用 (Scopus)
3 引用 (Scopus)

Pharmacokinetic Study of Adenosine Diphosphate-Encapsulated Liposomes Coated with Fibrinogen γ-Chain Dodecapeptide as a Synthetic Platelet Substitute in an Anticancer Drug-Induced Thrombocytopenia Rat Model

Taguchi, K., Ujihira, H., Watanabe, H., Fujiyama, A., Doi, M., Takeoka, S., Ikeda, Y., Handa, M., Otagiri, M. & Maruyama, T., 2013 10, : : Journal of Pharmaceutical Sciences. 102, 10, p. 3852-3859 8 p.

研究成果: Article

5 引用 (Scopus)

Pharmacokinetic study of the structural components of adenosine diphosphate-encapsulated liposomes coated with fibrinogen g-chain dodecapeptide as a synthetic platelet substitutes

Taguchi, K., Ujihira, H., Ogaki, S., Watanabe, H., Fujiyama, A., Doi, M., Okamura, Y., Takeoka, S., Ikeda, Y., Handa, M., Otagiri, M. & Maruyama, T., 2013 8, : : Drug Metabolism and Disposition. 41, 8, p. 1584-1591 8 p.

研究成果: Article

6 引用 (Scopus)
2012

Ability of fibrinogen γ-derived dodecapeptides with different sequences to bind to rat platelets

Tokutomi, K., Tagawa, T., Korenaga, M., Chiba, M., Asai, T., Watanabe, N., Takeoka, S., Handa, M., Ikeda, Y. & Oku, N., 2012 11 15, : : International Journal of Pharmaceutics. 438, 1-2, p. 296-301 6 p.

研究成果: Article

2 引用 (Scopus)

Comparison of outcomes after allogeneic hematopoietic stem cell transplantation in patients with follicular lymphoma, diffuse large B-cell lymphoma associated with follicular lymphoma, or de novo diffuse large B-cell lymphoma

Tada, K., Kim, S. W., Asakura, Y., Hiramoto, N., Yakushijin, K., Kurosawa, S., Tajima, K., Mori, S. I., Heike, Y., Tanosaki, R., Maeshima, A. M., Taniguchi, H., Furuta, K., Kagami, Y., Matsuno, Y., Tobinai, K., Takaue, Y. & Fukuda, T., 2012 8, : : American journal of hematology. 87, 8, p. 770-775 6 p.

研究成果: Article

11 引用 (Scopus)

Fibrinogen γ-chain peptide-coated, ADP-encapsulated liposomes rescue thrombocytopenic rabbits from non-compressible liver hemorrhage

Nishikawa, K., Hagisawa, K., Kinoshita, M., Shono, S., Katsuno, S., Doi, M., Yanagawa, R., Suzuki, H., Iwaya, K., Saitoh, D., Sakamoto, T., Seki, S., Takeoka, S. & Handa, M., 2012 10 1, : : Journal of Thrombosis and Haemostasis. 10, 10, p. 2137-2148 12 p.

研究成果: Article

20 引用 (Scopus)
2011

Decoration of fibrinogen γ-chain peptide on adenosine diphosphate-encapsulated liposomes enhances binding of the liposomes to activated platelets

Tokutomi, K., Tagawa, T., Korenaga, M., Chiba, M., Asai, T., Watanabe, N., Takeoka, S., Handa, M., Ikeda, Y. & Oku, N., 2011 4 4, : : International Journal of Pharmaceutics. 407, 1-2, p. 151-157 7 p.

研究成果: Article

12 引用 (Scopus)

Erythroid crisis caused by parvovirus B19 transmitted via red blood cell transfusion

Tsukada, Y., Yokoyama, K., Ishida, A., Handa, M., Mori, T., Kizaki, M. & Okamoto, S., 2011, : : Internal Medicine. 50, 20, p. 2379-2382 4 p.

研究成果: Article

11 引用 (Scopus)

Shear-dependent suppression of platelet thrombus formation by phosphodiesterase 3 inhibition requires low levels of concomitant Gs-coupled receptor stimulation

Yoshida, H., Okamura, Y., Watanabe, N., Ikeda, Y. & Handa, M., 2011 3 1, : : Thrombosis and Haemostasis. 105, 3, p. 487-495 9 p.

研究成果: Article

6 引用 (Scopus)
7 引用 (Scopus)
2010

[Anti-platelet autoantibodies].

Watanabe, N. & Handa, M., 2010 6, : : Nippon rinsho. Japanese journal of clinical medicine. 68 Suppl 6, p. 691-693 3 p.

研究成果: Article

[Red cell autoantibodies].

Watanabe, N. & Handa, M., 2010 6, : : Nippon rinsho. Japanese journal of clinical medicine. 68 Suppl 6, p. 687-690 4 p.

研究成果: Article

Non-tuberculous mycobacterial infection localized in small intestine developing after allogeneic bone marrow transplantation

Yamazaki, R., Mori, T., Nakazato, T., Aisa, Y., Imaeda, H., Hisamatsu, T., Hibi, T. & Okamoto, S., 2010 7 1, : : Internal Medicine. 49, 12, p. 1191-1193 3 p.

研究成果: Article

9 引用 (Scopus)

Release abilities of adenosine diphosphate from phospholipid vesicles with different membrane properties and their hemostatic effects as a platelet substitute

Okamura, Y., Katsuno, S., Suzuki, H., Maruyama, H., Handa, M., Ikeda, Y. & Takeoka, S., 2010 12 20, : : Journal of Controlled Release. 148, 3, p. 373-379 7 p.

研究成果: Article

16 引用 (Scopus)

Structural requirements for activation in αIIbβ3 integrin

Kamata, T., Handa, M., Ito, S., Sato, Y., Ohtani, T., Kawai, Y., Ikeda, Y. & Aiso, S., 2010 12 3, : : Journal of Biological Chemistry. 285, 49, p. 38428-38437 10 p.

研究成果: Article

19 引用 (Scopus)

Visualization of liposomes carrying fibrinogen γ-chain dodecapeptide accumulated to sites of vascular injury using computed tomography

Okamura, Y., Eto, K., Maruyama, H., Handa, M., Ikeda, Y. & Takeoka, S., 2010 4 1, : : Nanomedicine: Nanotechnology, Biology, and Medicine. 6, 2, p. 391-396 6 p.

研究成果: Article

17 引用 (Scopus)
2009

Administration of imatinib mesylate in patients with chronic myeloid leukemia with short bowel

Yamazaki, R., Aisa, Y., Mori, T., Iketani, O., Ikeda, Y. & Okamoto, S., 2009 8 17, : : Leukemia and Lymphoma. 50, 4, p. 670-672 3 p.

研究成果: Article

2 引用 (Scopus)

Busulfex (i.v. BU) and CY regimen before SCT: Japanese-targeted phase II pharmacokinetics combined study

Kim, S. W., Mori, S. J., Tanosaki, R., Fukuda, T., Kami, M., Sakamaki, H., Yamashita, T., Kodera, Y., Terakura, S., Taniguchi, S., Miyakoshi, S., Usui, N., Yano, S., Kawano, Y., Nagatoshi, Y., Harada, M., Morishima, Y., Okamoto, S., Saito, A. M., Ohashi, Y. および2人, Ueda, R. & Takaue, Y., 2009 1 1, : : Bone Marrow Transplantation. 43, 8, p. 611-617 7 p.

研究成果: Article

7 引用 (Scopus)

Development of fibrinogen γ-chain peptide-coated, adenosine diphosphate-encapsulated liposomes as a synthetic platelet substitute

Okamura, Y., Takeoka, S., Eto, K., Maekawa, I., Fujie, T., Maruyama, H., Ikeda, Y. & Handa, M., 2009 2 16, : : Journal of Thrombosis and Haemostasis. 7, 3, p. 470-477 8 p.

研究成果: Article

47 引用 (Scopus)

Generation of megakaryocytes and platelets from human subcutaneous adipose tissues

Matsubara, Y., Saito, E., Suzuki, H., Watanabe, N., Murata, M. & Ikeda, Y., 2009 1 23, : : Biochemical and Biophysical Research Communications. 378, 4, p. 716-720 5 p.

研究成果: Article

21 引用 (Scopus)

Interindividual Variation of Maximal Blood Levels of Tacrolimus After Its Oral Administration in Hematopoietic Cell Transplant Recipients

Yamazaki, R., Mori, T., Aisa, Y., Kato, J., Nakamura, Y., Nakazato, T., Mihara, A., Ikeda, Y. & Okamoto, S., 2009 6 1, : : Transplantation Proceedings. 41, 5, p. 1831-1833 3 p.

研究成果: Article

1 引用 (Scopus)

Novel platelet substitutes: Disk-shaped biodegradable nanosheets and their enhanced effects on platelet aggregation

Okamura, Y., Fukui, Y., Kabata, K., Suzuki, H., Handa, M., Ikeda, Y. & Takeoka, S., 2009 10 21, : : Bioconjugate Chemistry. 20, 10, p. 1958-1965 8 p.

研究成果: Article

27 引用 (Scopus)