先端医科学研究所

研究成果 1984 2020

2020

Identification of kit-ligand a as the gene responsible for the medaka pigment cell mutant few melanophore

Otsuki, Y., Okuda, Y., Naruse, K. & Saya, H., 2020 1 1, : : G3: Genes, Genomes, Genetics. 10, 1, p. 311-319 9 p.

研究成果: Article

公開
Melanophores
Oryzias
Stem Cell Factor
Genes
Piebaldism

Immune-resistant mechanisms in cancer immunotherapy

Kawakami, Y., Ohta, S., Sayem, M. A., Tsukamoto, N. & Yaguchi, T., 2020 1 1, (Accepted/In press) : : International Journal of Clinical Oncology.

研究成果: Review article

Immunotherapy
Neoplasms
T-Lymphocytes
Antibodies
Immunosuppressive Agents
2019
74 引用 (Scopus)

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., Shiota, A., Takeshita, K., Yasuma-Mitobe, K., Riethmacher, D., Kaisho, T., Norman, J. M., Mucida, D., Suematsu, M., Yaguchi, T., Bucci, V. および8人, Inoue, T., Kawakami, Y., Olle, B., Roberts, B., Hattori, M., Xavier, R. J., Atarashi, K. & Honda, K., 2019 1 31, : : Nature. 565, 7741, p. 600-605 6 p.

研究成果: Article

Immunity
T-Lymphocytes
Listeriosis
Histocompatibility
Microbiota
2 引用 (Scopus)

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M. & Suzuki, H., 2019 1 1, : : CMGH. 8, 3, p. 319-334 16 p.

研究成果: Article

公開
Helicobacter
Neoplastic Stem Cells
Catenins
Protein Splicing
Histones
2 引用 (Scopus)
Extramammary Paget's Disease
Epirubicin
Anthracyclines
Breast Neoplasms
Cytotoxins
2 引用 (Scopus)

Endothelial-mesenchymal transition drives expression of CD44 variant and xCT in pulmonary hypertension

Isobe, S., Kataoka, M., Endo, J., Moriyama, H., Okazaki, S., Tsuchihashi, K., Katsumata, Y., Yamamoto, T., Shirakawa, K., Yoshida, N., Shimoda, M., Chiba, T., Masuko, T., Hakamata, Y., Kobayashi, E., Saya, H., Fukuda, K. & Sano, M., 2019 1 1, : : American journal of respiratory cell and molecular biology. 61, 3, p. 367-379 13 p.

研究成果: Article

Sulfasalazine
Pulmonary Hypertension
Glutathione
Antioxidants
Chemotherapy
5 引用 (Scopus)

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors

Suzuki, K., Miura, Y., Mochida, Y., Miyazaki, T., Toh, K., Anraku, Y., Melo, V., Liu, X., Ishii, T., Nagano, O., Saya, H., Cabral, H. & Kataoka, K., 2019 5 10, : : Journal of Controlled Release. 301, p. 28-41 14 p.

研究成果: Article

Nanomedicine
Facilitative Glucose Transport Proteins
Blood Vessels
Micelles
Neoplasms
1 引用 (Scopus)

Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma

Okazaki, S., Umene, K., Yamasaki, J., Suina, K., Otsuki, Y., Yoshikawa, M., Minami, Y., Masuko, T., Kawaguchi, S., Nakayama, H., Banno, K., Aoki, D., Saya, H. & Nagano, O., 2019 11 1, : : Cancer science. 110, 11, p. 3453-3463 11 p.

研究成果: Article

公開
Sulfasalazine
Glutamate Dehydrogenase
Glutamine
Genes
Neoplasms

Identification of KLRC2 as a candidate marker for brain tumor-initiating cells

Ishihara, E., Takahashi, S., Fukaya, R., Ohta, S., Yoshida, K. & Toda, M., 2019 11 2, : : Neurological Research. 41, 11, p. 1043-1049 7 p.

研究成果: Article

Neoplastic Stem Cells
Brain Neoplasms
Glioma
Neural Stem Cells
Brain
6 引用 (Scopus)

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Kofuji, S., Hirayama, A., Eberhardt, A. O., Kawaguchi, R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yoshino, H., Yamashita, D., Sumita, K., Wolfe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S. および37人, Ban, Y., Asano, M., Flanary, V. L., Ramkissoon, A., Chow, L. M. L., Kiyokawa, J., Mashimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E. P., Anastasiou, D., Wakimoto, H., Holland, E. C., Yong, W. H., Horbinski, C., Nakano, I., DeBerardinis, R. J., Bachoo, R. M., Mischel, P. S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H. & Sasaki, A. T., 2019 8 1, : : Nature Cell Biology. 21, 8, p. 1003-1014 12 p.

研究成果: Article

IMP Dehydrogenase
Glioblastoma
Carcinogenesis
Transfer RNA
Guanine Nucleotides
1 引用 (Scopus)

Neuroprotective effects of memantine via enhancement of autophagy

Hirano, K., Fujimaki, M., Sasazawa, Y., Yamaguchi, A., Ishikawa, K. I., Miyamoto, K., Souma, S., Furuya, N., Imamichi, Y., Yamada, D., Saya, H., Akamatsu, W., Saiki, S. & Hattori, N., 2019 10 8, : : Biochemical and Biophysical Research Communications. 518, 1, p. 161-170 10 p.

研究成果: Article

Memantine
Autophagy
Neuroprotective Agents
Mitochondrial Degradation
N-Methyl-D-Aspartate Receptors
1 引用 (Scopus)

Programmed cell death ligand 1 (PD-L1) blockade attenuates metastatic colon cancer growth in cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin inhibitor-treated livers

Osawa, Y., Kojika, E., Nishikawa, K., Kimura, M., Osakaya, S., Miyauchi, H., Kanto, T., Kawakami, Y. & Kimura, K., 2019 4 30, : : Oncotarget. 10, 32, p. 3013-3026 14 p.

研究成果: Article

Catenins
Cyclic AMP Response Element-Binding Protein
Protein Binding
Colonic Neoplasms
Carrier Proteins
4 引用 (Scopus)

ROCK inhibition induces terminal adipocyte differentiation and suppresses tumorigenesis in chemoresistant osteosarcoma cells

Takahashi, N., Nobusue, H., Shimizu, T., Sugihara, E., Yamaguchi-Iwai, S., Onishi, N., Kunitomi, H., Kuroda, T. & Saya, H., 2019 6 15, : : Cancer Research. 79, 12, p. 3088-3099 12 p.

研究成果: Article

Osteosarcoma
Adipocytes
Carcinogenesis
Stem Cells
Neoplastic Stem Cells
2 引用 (Scopus)
公開
Clinical Trials, Phase I
Amyotrophic Lateral Sclerosis
Labels
Placebos
Stem cells

"Smart Eye Camera": An innovative technique to evaluate tear film breakup time in a murine dry eye disease model

Shimizu, E., Ogawa, Y., Yazu, H., Aketa, N., Yang, F., Yamane, M., Sato, Y., Kawakami, Y. & Tsubota, K., 2019 5 1, : : PloS one. 14, 5, e0215130.

研究成果: Article

eye diseases
Eye Diseases
disease models
Tears
cameras
公開
Sulfasalazine
Urinary Bladder Neoplasms
Cisplatin
p38 Mitogen-Activated Protein Kinases
Muscles

The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery

Yamamoto, K., Kokubun, T., Sato, K., Akaishi, T., Shimazaki, A., Nakamura, M., Shiga, Y., Tsuda, S., Omodaka, K., Saya, H. & Nakazawa, T., 2019 12 1, : : Scientific reports. 9, 1, 19288.

研究成果: Article

公開
Amsacrine
Filtering Surgery
Topoisomerase II Inhibitors
Trabeculectomy
Glaucoma
Homeobox Genes
Oncogenes
Uterine Cervical Neoplasms
Transcription Factors
Phenotype

Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy

Otsuki, Y., Yamasaki, J., Suina, K., Okazaki, S., Koike, N., Saya, H. & Nagano, O., 2019 1 1, (Accepted/In press) : : Cancer science.

研究成果: Article

公開
Oxyfedrine
Vasodilator Agents
Aldehydes
Sulfasalazine
Neoplasms
1 引用 (Scopus)

Visualization of spatiotemporal dynamics of human glioma stem cell invasion

Tamura, R., Miyoshi, H., Sampetrean, O., Shinozaki, M., Morimoto, Y., Iwasawa, C., Fukaya, R., Mine, Y., Masuda, H., Maruyama, T., Narita, M., Saya, H., Yoshida, K., Okano, H. & Toda, M., 2019 5 6, : : Molecular brain. 12, 1, 1 p.

研究成果: Article

公開
Glioma
Stem Cells
Glioblastoma
Axons
Time-Lapse Imaging
2018
6 引用 (Scopus)

An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment

Motohara, T., Masuda, K., Morotti, M., Zheng, Y., El-Sahhar, S., Chong, K. Y., Wietek, N., Alsaadi, A., Karaminejadranjbar, M., Hu, Z., Artibani, M., Gonzalez, L. S., Katabuchi, H., Saya, H. & Ahmed, A. A., 2018 1 1, (Accepted/In press) : : Oncogene.

研究成果: Article

Ovarian Neoplasms
Omentum
Tropism
Tumor Microenvironment
Stromal Cells
6 引用 (Scopus)

A pilot study of peptide vaccines for VEGF receptor 1 and 2 in patients with recurrent/progressive high grade glioma

Shibao, S., Ueda, R., Saito, K., Kikuchi, R., Nagashima, H., Kojima, A., Kagami, H., Pareira, E. S., Sasaki, H., Noji, S., Kawakami, Y., Yoshida, K. & Toda, M., 2018 4 20, : : Oncotarget. 9, 30, p. 21569-21579 11 p.

研究成果: Article

Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Subunit Vaccines
Glioma
Vascular Endothelial Growth Factor Receptor
2 引用 (Scopus)
Solitary Fibrous Tumors
Hemangiopericytoma
Cell Death
Neoplasm Metastasis
Ligands
3 引用 (Scopus)
Epirubicin
Carboplatin
Retrospective Studies
Carcinoma
Skin
3 引用 (Scopus)
Insulin
Amino Acids
Neutral Amino Acids
Antiporters
Amino Acid Transport Systems
5 引用 (Scopus)

Development of a functional thyroid model based on an organoid culture system

Saito, Y., Onishi, N., Takami, H., Seishima, R., Inoue, H., Hirata, Y., Kameyama, K., Tsuchihashi, K., Sugihara, E., Uchino, S., Ito, K., Kawakubo, H., Takeuchi, H., Kitagawa, Y., Saya, H. & Nagano, O., 2018 3 4, : : Biochemical and Biophysical Research Communications. 497, 2, p. 783-789 7 p.

研究成果: Article

Organoids
Thyroglobulin
Iodides
Cell culture
Thyroid Gland
1 引用 (Scopus)

Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer

Yamauchi, T., Fernandez, J. R. E., Imamura, C., Yamauchi, H., Jinno, H., Takahashi, M., Kitagawa, Y., Nakamura, S., Lim, B., Krishnamurthy, S., Reuben, J. M., Liu, D., Tripathy, D., Chen, H., Takebe, N., Saya, H. & Ueno, N. T., 2018 1 1, : : Oncotarget. 9, 6, p. 6872-6882 11 p.

研究成果: Article

Breast Neoplasms
Epithelial-Mesenchymal Transition
Neoplastic Stem Cells
Therapeutics
Biomarkers
1 引用 (Scopus)

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate–sensitive glutamate receptor signaling

Suina, K., Tsuchihashi, K., Yamasaki, J., Kamenori, S., Shintani, S., Hirata, Y., Okazaki, S., Sampetrean, O., Baba, E., Akashi, K., Mitsuishi, Y., Takahashi, F., Takahashi, K., Saya, H. & Nagano, O., 2018 1 1, (Accepted/In press) : : Cancer Science.

研究成果: Article

Glutamate Receptors
Epidermal Growth Factor Receptor
Glioma
Glutamic Acid
Epidermal Growth Factor
3 引用 (Scopus)

Functional Role of Lacrimal Gland Fibroblasts in a Mouse Model of Chronic Graft-Versus-Host Disease

Yamane, M., Ogawa, Y., Mukai, S., Yaguchi, S., Kamijuku, H., Inaba, T., Asai, K., Morikawa, S., Kawakami, Y., Shimmura, S. & Tsubota, K., 2018 1 1, : : Cornea. 37, 1, p. 102-108 7 p.

研究成果: Article

Lacrimal Apparatus
Graft vs Host Disease
Fibroblasts
Fibrosis
Immunohistochemistry
5 引用 (Scopus)

Generation of human immunosuppressive myeloid cell populations in human interleukin-6 transgenic NOG mice

Hanazawa, A., Ito, R., Katano, I., Kawai, K., Goto, M., Suemizu, H., Kawakami, Y., Ito, M. & Takahashi, T., 2018 2 2, : : Frontiers in Immunology. 9, FEB, 152.

研究成果: Article

Myeloid Cells
Immunosuppressive Agents
Transgenic Mice
Interleukin-6
Hematopoietic Stem Cells
22 引用 (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. および3人, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 12 1, : : Nature Communications. 9, 1, 1561.

研究成果: Article

Raman Spectrum Analysis
Oxidants
Gold
Raman spectroscopy
tumors
4 引用 (Scopus)

HER2 heterogeneity is associated with poor survival in HER2-positive breast cancer

Hosonaga, M., Arima, Y., Sampetrean, O., Komura, D., Koya, I., Sasaki, T., Sato, E., Okano, H., Kudo, J., Ishikawa, S., Saya, H. & Ishikawa, T., 2018 8 1, : : International Journal of Molecular Sciences. 19, 8, 2158.

研究成果: Article

breast
cancer
Breast Neoplasms
mice
RNA Sequence Analysis
4 引用 (Scopus)

Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

Yaguchi, T., Kobayashi, A., Inozume, T., Morii, K., Nagumo, H., Nishio, H., Iwata, T., Ka, Y., Katano, I., Ito, R., Ito, M. & Kawakami, Y., 2018 11 1, : : Cellular and Molecular Immunology. 15, 11, p. 953-962 10 p.

研究成果: Article

Blood Cells
T-Lymphocytes
Graft vs Host Disease
Cell- and Tissue-Based Therapy
Melanoma
2 引用 (Scopus)

IgG response to MHC class I epitope peptides is a quantitative predictive biomarker in the early course of treatment of colorectal cancer using therapeutic peptides

Kanekiyo, S., Hazama, S., Takenouchi, H., Nakajima, M., Shindo, Y., MATSuI, H., Tokumitsu, Y., Tomochika, S., Tsunedomi, R., Tokuhisa, Y., Iida, M., Sakamoto, K., SuzukI, N., Takeda, S., Yamamoto, S., Yoshino, S., Okuno, K., Udaka, K., Kawakami, Y., Matsueda, S. および2人, Ito, K. & Nagano, H., 2018 5 1, : : Oncology Reports. 39, 5, p. 2385-2392 8 p.

研究成果: Article

Epitopes
Colorectal Neoplasms
Immunoglobulin G
Biomarkers
Peptides
4 引用 (Scopus)

Inhibiting xCT improves 5-fluorouracil resistance of gastric cancer induced by CD44 variant 9 expression

Miyoshi, S., Tsugawa, H., Matsuzaki, J., Hirata, K., Mori, H., Saya, H., Kanai, T. & Suzuki, H., 2018 11 1, : : Anticancer Research. 38, 11, p. 6163-6170 8 p.

研究成果: Article

Fluorouracil
Stomach Neoplasms
Neoplastic Stem Cells
Antiporters
Drug Therapy
3 引用 (Scopus)

Inhibition of Vascular Adhesion Protein-1 for Treatment of Graft-Versus-Host Disease in Mice

Mukai, S., Ogawa, Y., Kawakami, Y., Mashima, Y. & Tsubota, K., 2018 8 1, : : FASEB Journal. 32, 8, p. 4085-4095 11 p.

研究成果: Article

Graft vs Host Disease
Grafts
Blood Vessels
Adhesion
Proteins
253 引用 (Scopus)

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

Pagès, F., Mlecnik, B., Marliot, F., Bindea, G., Ou, F. S., Bifulco, C., Lugli, A., Zlobec, I., Rau, T. T., Berger, M. D., Nagtegaal, I. D., Vink-Börger, E., Hartmann, A., Geppert, C., Kolwelter, J., Merkel, S., Grützmann, R., Van den Eynde, M., Jouret-Mourin, A., Kartheuser, A. および79人, Léonard, D., Remue, C., Wang, J. Y., Bavi, P., Roehrl, M. H. A., Ohashi, P. S., Nguyen, L. T., Han, S. J., MacGregor, H. L., Hafezi-Bakhtiari, S., Wouters, B. G., Masucci, G. V., Andersson, E. K., Zavadova, E., Vocka, M., Spacek, J., Petruzelka, L., Konopasek, B., Dundr, P., Skalova, H., Nemejcova, K., Botti, G., Tatangelo, F., Delrio, P., Ciliberto, G., Maio, M., Laghi, L., Grizzi, F., Fredriksen, T., Buttard, B., Angelova, M., Vasaturo, A., Maby, P., Church, S. E., Angell, H. K., Lafontaine, L., Bruni, D., El Sissy, C., Haicheur, N., Kirilovsky, A., Berger, A., Lagorce, C., Meyers, J. P., Paustian, C., Feng, Z., Ballesteros-Merino, C., Dijkstra, J., van de Water, C., van Lent-van Vliet, S., Knijn, N., Mușină, A. M., Scripcariu, D. V., Popivanova, B., Xu, M., Fujita, T., Hazama, S., Suzuki, N., Nagano, H., Okuno, K., Torigoe, T., Sato, N., Furuhata, T., Takemasa, I., Itoh, K., Patel, P. S., Vora, H. H., Shah, B., Patel, J. B., Rajvik, K. N., Pandya, S. J., Shukla, S. N., Wang, Y., Zhang, G., Kawakami, Y., Marincola, F. M., Ascierto, P. A., Sargent, D. J., Fox, B. A. & Galon, J., 2018 5 26, : : The Lancet. 391, 10135, p. 2128-2139 12 p.

研究成果: Article

Colonic Neoplasms
Neoplasms
Recurrence
Colon
Neoplasm Staging
10 引用 (Scopus)

Involvement of local renin-angiotensin system in immunosuppression of tumor microenvironment

Nakamura, K., Yaguchi, T., Ohmura, G., Kobayashi, A., Kawamura, N., Iwata, T., Kiniwa, Y., Okuyama, R. & Kawakami, Y., 2018 1 1, : : Cancer Science. 109, 1, p. 54-64 11 p.

研究成果: Article

Tumor Microenvironment
Angiotensin Receptor Antagonists
Immunosuppressive Agents
Renin-Angiotensin System
Immunosuppression
6 引用 (Scopus)

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model

Shibao, S., Minami, N., Koike, N., Fukui, N., Yoshida, K., Saya, H. & Sampetrean, O., 2018 2 19, : : Neuro-Oncology. 20, 3, p. 343-354 12 p.

研究成果: Article

Glioblastoma
Glioma
Stem Cells
Lactic Acid
Oxidative Phosphorylation
3 引用 (Scopus)

Modeling phenotypes of malignant gliomas

Sampetrean, O. & Saya, H., 2018 1 1, : : Cancer Science. 109, 1, p. 6-14 9 p.

研究成果: Review article

Glioma
Phenotype
Central Nervous System Neoplasms
Genetic Heterogeneity
Theoretical Models
23 引用 (Scopus)

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

Fujimori, K., Ishikawa, M., Otomo, A., Atsuta, N., Nakamura, R., Akiyama, T., Hadano, S., Aoki, M., Saya, H., Sobue, G. & Okano, H., 2018 1 1, (Accepted/In press) : : Nature Medicine.

研究成果: Article

Induced Pluripotent Stem Cells
Amyotrophic Lateral Sclerosis
Motor Neurons
Stem cells
Neurons

Novel elucidation and treatment of pancreatic chronic graft-versus-host disease in mice

Mukai, S., Ogawa, Y., Urano, F., Kawakami, Y. & Tsubota, K., 2018 10 1, : : Royal Society Open Science. 5, 10, 181067.

研究成果: Article

Graft vs Host Disease
Endoplasmic Reticulum Stress
Pancreas
Epithelial-Mesenchymal Transition
Therapeutics
3 引用 (Scopus)

Ocular Surface and Tear Film Characteristics in a Sclerodermatous Chronic Graft-Versus-Host Disease Mouse Model

He, J., Yamane, M., Shibata, S., Fukui, M., Shimizu, E., Yano, T., Mukai, S., Kawakami, Y., Li, S., Tsubota, K. & Ogawa, Y., 2018 4 1, : : Cornea. 37, 4, p. 486-494 9 p.

研究成果: Article

Graft vs Host Disease
Tears
Conjunctiva
Eyelids
Microvilli
3 引用 (Scopus)

Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma

Semba, T., Sugihara, E., Kamoshita, N., Ueno, S., Fukuda, K., Yoshino, M., Takao, K., Yoshikawa, K., Izuhara, K., Arima, Y., Suzuki, M. & Saya, H., 2018 1 1, (Accepted/In press) : : Cancer Science.

研究成果: Article

Antisense Oligonucleotides
Bleomycin
Melanoma
Lung
Neoplasm Metastasis
1 引用 (Scopus)

Pilot study of WT1 peptide-pulsed dendritic cell vaccination with docetaxel in esophageal cancer

Matsuda, T., Takeuchi, H., Sakurai, T., Mayanagi, S., Booka, E., Fujita, T., Higuchi, H., Taguchi, J., Hamamoto, Y., Takaishi, H., Kawakubo, H., Okamoto, M., Sunamura, M., Kawakami, Y. & Kitagawa, Y., 2018 7 1, : : Oncology Letters. 16, 1, p. 1348-1356 9 p.

研究成果: Article

docetaxel
Wilms' Tumor Genes
Wilms Tumor
Esophageal Neoplasms
Dendritic Cells
24 引用 (Scopus)

Prospects for new lung cancer treatments that target EMT signaling

Otsuki, Y., Saya, H. & Arima, Y., 2018 3 1, : : Developmental Dynamics. 247, 3, p. 462-472 11 p.

研究成果: Review article

Epithelial-Mesenchymal Transition
Lung Neoplasms
Neoplasms
Therapeutics
Epidermal Growth Factor Receptor

Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells

Ouchi, T., Morikawa, S., Shibata, S., Takahashi, M., Yoshikawa, M., Soma, T., Miyashita, H., Muraoka, W., Kameyama, K., Kawana, H., Arima, Y., Saya, H., Okano, H., Nakagawa, T. & Asoda, S., 2018 2 1, (Accepted/In press) : : Journal of Dental Research.

研究成果: Article

Mesenchymal Stromal Cells
Carcinoma
Cell Death
Platelet-Derived Growth Factor Receptors
Drug Therapy
7 引用 (Scopus)

Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells

Okazaki, S., Shintani, S., Hirata, Y., Suina, K., Semba, T., Yamasaki, J., Umene, K., Ishikawa, M., Saya, H. & Nagano, O., 2018 9 1, : : Oncotarget. 9, 73, p. 33832-33843 12 p.

研究成果: Article

Sulfasalazine
Glutathione
Neoplasms
Antiporters
Aldehyde Dehydrogenase
1 引用 (Scopus)

Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice

Mukai, S., Ogawa, Y., Saya, H., Kawakami, Y. & Tsubota, K., 2018 10 1, : : PLoS One. 13, 10, e0203742.

研究成果: Article

Graft vs Host Disease
Grafts
therapeutics
mice
bone marrow transplant
4 引用 (Scopus)
Neurofibromin 1
Neurofibromatosis 1
Epithelial-Mesenchymal Transition
Neurofibroma
Gene Expression