先端医科学研究所

研究成果

2020

2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche

Koike, N., Kota, R., Naito, Y., Hayakawa, N., Matsuura, T., Hishiki, T., Onishi, N., Fukada, J., Suematsu, M., Shigematsu, N., Saya, H. & Sampetrean, O., 2020 12 1, : : Communications biology. 3, 1, 450.

研究成果: Article

公開

A potent blood–brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model

Machida, Y., Nakagawa, M., Matsunaga, H., Yamaguchi, M., Ogawara, Y., Shima, Y., Yamagata, K., Katsumoto, T., Hattori, A., Itoh, M., Seki, T., Nishiya, Y., Nakamura, K., Suzuki, K., Imaoka, T., Baba, D., Suzuki, M., Sampetrean, O., Saya, H., Ichimura, K. および1人, Kitabayashi, I., 2020 2, : : Molecular cancer therapeutics. 19, 2, p. 375-383 9 p.

研究成果: Article

3 引用 (Scopus)

Author Correction: A VEGF receptor vaccine demonstrates preliminary efficacy in neurofibromatosis type 2 (Nature Communications, (2019), 10, 1, (5758), 10.1038/s41467-019-13640-1)

Tamura, R., Fujioka, M., Morimoto, Y., Ohara, K., Kosugi, K., Oishi, Y., Sato, M., Ueda, R., Fujiwara, H., Hikichi, T., Noji, S., Oishi, N., Ogawa, K., Kawakami, Y., Ohira, T., Yoshida, K. & Toda, M., 2020 12 1, : : Nature communications. 11, 1, 2028.

研究成果: Comment/debate

公開
1 引用 (Scopus)

Clinical and histopathological analyses of VEGF receptors peptide vaccine in patients with primary glioblastoma - A case series

Tamura, R., Morimoto, Y., Kosugi, K., Sato, M., Oishi, Y., Ueda, R., Kikuchi, R., Nagashima, H., Noji, S., Kawakami, Y., Sasaki, H., Yoshida, K. & Toda, M., 2020 3 12, : : BMC cancer. 20, 1, 196.

研究成果: Article

公開
2 引用 (Scopus)

Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma

Shono, K., Yamaguchi, I., Mizobuchi, Y., Kagusa, H., Sumi, A., Fujihara, T., Nakajima, K., Kitazato, K. T., Matsuzaki, K., Saya, H. & Takagi, Y., 2020 12 1, : : Scientific reports. 10, 1, 15286.

研究成果: Article

公開
1 引用 (Scopus)

Erratum: Clinical and histopathological analyses of VEGF receptors peptide vaccine in patients with primary glioblastoma-a case series (BMC Cancer (2020) 20 (196) DOI: 10.1186/s12885-020-6589-x)

Tamura, R., Morimoto, Y., Kosugi, K., Sato, M., Oishi, Y., Ueda, R., Kikuchi, R., Nagashima, H., Hikichi, T., Noji, S., Kawakami, Y., Sasaki, H., Yoshida, K. & Toda, M., 2020 4 14, : : BMC cancer. 20, 1, 301.

研究成果: Comment/debate

公開
公開

GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 ab

Kato, D., Yaguchi, T., Iwata, T., Katoh, Y., Morii, K., Tsubota, K., Takise, Y., Tamiya, M., Kamada, H., Akiba, H., Tsumoto, K., Serada, S., Naka, T., Nishimura, R., Nakagawa, T. & Kawakami, Y., 2020 3, : : eLife. 9, e49392.

研究成果: Article

公開
3 引用 (Scopus)

Identification of kit-ligand a as the gene responsible for the medaka pigment cell mutant few melanophore

Otsuki, Y., Okuda, Y., Naruse, K. & Saya, H., 2020 1 1, : : G3: Genes, Genomes, Genetics. 10, 1, p. 311-319 9 p.

研究成果: Article

公開

Immune-resistant mechanisms in cancer immunotherapy

Kawakami, Y., Ohta, S., Sayem, M. A., Tsukamoto, N. & Yaguchi, T., 2020 5 1, : : International Journal of Clinical Oncology. 25, 5, p. 810-817 8 p.

研究成果: Review article

1 引用 (Scopus)

In Vitro Blood-Brain Barrier Permeability and Cytotoxicity of an Atorvastatin-Loaded Nanoformulation against Glioblastoma in 2D and 3D Models

Lübtow, M. M., Oerter, S., Quader, S., Jeanclos, E., Jeanclos, E., Cubukova, A., Krafft, M., Haider, M. S., Schulte, C., Meier, L., Rist, M., Sampetrean, O., Kinoh, H., Gohla, A., Kataoka, K., Kataoka, K., Appelt-Menzel, A., Appelt-Menzel, A., Luxenhofer, R. & Luxenhofer, R., 2020 6 1, : : Molecular Pharmaceutics. 17, 6, p. 1835-1847 13 p.

研究成果: Article

1 引用 (Scopus)

Molecular and cellular mechanisms underlying brain metastasis of breast cancer

Hosonaga, M., Saya, H. & Arima, Y., 2020 9 1, : : Cancer and Metastasis Reviews. 39, 3, p. 711-720 10 p.

研究成果: Review article

公開

NUAK2 localization in normal skin and its expression in a variety of skin tumors with YAP

Al-Busani, H., Al-Sobaihi, S., Nojima, K., Tanemura, A., Yaguchi, T., Kawakami, Y., Matsumura, H., Nishimura, E. K., Yokozeki, H. & Namiki, T., 2020 2, : : Journal of Dermatological Science. 97, 2, p. 143-151 9 p.

研究成果: Article

Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma

Padthaisong, S., Thanee, M., Namwat, N., Phetcharaburanin, J., Klanrit, P., Khuntikeo, N., Titapun, A., Sungkhamanon, S., Saya, H. & Loilome, W., 2020 2 10, : : Journal of Translational Medicine. 18, 1, 64.

研究成果: Article

公開

Phosphorylation of the Anaphase Promoting Complex activator FZR1/CDH1 is required for Meiosis II entry in mouse male germ cell

Tanno, N., Kuninaka, S., Fujimura, S., Takemoto, K., Okamura, K., Takeda, N., Araki, K., Araki, M., Saya, H. & Ishiguro, K. I., 2020 12 1, : : Scientific reports. 10, 1, 10094.

研究成果: Article

公開

Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans

Yamane, M., Sato, S., Shimizu, E., Shibata, S., Hayano, M., Yaguchi, T., Kamijuku, H., Ogawa, M., Suzuki, T., Mukai, S., Shimmura, S., Okano, H., Takeuchi, T., Kawakami, Y., Ogawa, Y. & Tsubota, K., 2020 8 1, : : FASEB Journal. 34, 8, p. 10778-10800 23 p.

研究成果: Article

Targeting of cancer stem cells by differentiation therapy

Arima, Y., Nobusue, H. & Saya, H., 2020 8 1, : : Cancer science. 111, 8, p. 2689-2695 7 p.

研究成果: Article

公開

The insulin-PI3K-Rac1 axis contributes to terminal adipocyte differentiation through regulation of actin cytoskeleton dynamics

Kunitomi, H., Oki, Y., Onishi, N., Kano, K., Banno, K., Aoki, D., Saya, H. & Nobusue, H., 2020 3 1, : : Genes to Cells. 25, 3, p. 165-174 10 p.

研究成果: Article

1 引用 (Scopus)

Tumor-infiltrating lymphocytes predict survival outcomes in patients with cervical cancer treated with concurrent chemoradiotherapy

Ohno, A., Iwata, T., Katoh, Y., Taniguchi, S., Tanaka, K., Nishio, H., Nakamura, M., Morisada, T., Chen, G., Saito, M., Yaguchi, T., Kawakami, Y. & Aoki, D., 2020, (Accepted/In press) : : Gynecologic Oncology.

研究成果: Article

Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy

Otsuki, Y., Yamasaki, J., Suina, K., Okazaki, S., Koike, N., Saya, H. & Nagano, O., 2020 1 1, : : Cancer science. 111, 1, p. 127-136 10 p.

研究成果: Article

公開
4 引用 (Scopus)
2019

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., Shiota, A., Takeshita, K., Yasuma-Mitobe, K., Riethmacher, D., Kaisho, T., Norman, J. M., Mucida, D., Suematsu, M., Yaguchi, T., Bucci, V. および8人, Inoue, T., Kawakami, Y., Olle, B., Roberts, B., Hattori, M., Xavier, R. J., Atarashi, K. & Honda, K., 2019 1 31, : : Nature. 565, 7741, p. 600-605 6 p.

研究成果: Article

161 引用 (Scopus)

Analysis of the Tumor Reactivity of Tumor-Infiltrating Lymphocytes in a Metastatic Melanoma Lesion that Lost Major Histocompatibility Complex Class I Expression after Anti–PD-1 Therapy

Inozume, T., Yaguchi, T., Ariyasu, R., Togashi, Y., Ohnuma, T., Honobe, A., Nishikawa, H., Kawakami, Y. & Kawamura, T., 2019 7, : : Journal of Investigative Dermatology. 139, 7, p. 1490-1496 7 p.

研究成果: Article

3 引用 (Scopus)

An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment

Motohara, T., Masuda, K., Morotti, M., Zheng, Y., El-Sahhar, S., Chong, K. Y., Wietek, N., Alsaadi, A., Karaminejadranjbar, M., Hu, Z., Artibani, M., Gonzalez, L. S., Katabuchi, H., Saya, H. & Ahmed, A. A., 2019 4 18, : : Oncogene. 38, 16, p. 2885-2898 14 p.

研究成果: Review article

15 引用 (Scopus)

A VEGF receptor vaccine demonstrates preliminary efficacy in neurofibromatosis type 2

Tamura, R., Fujioka, M., Morimoto, Y., Ohara, K., Kosugi, K., Oishi, Y., Sato, M., Ueda, R., Fujiwara, H., Noji, S., Oishi, N., Ogawa, K., Kawakami, Y., Ohira, T., Yoshida, K. & Toda, M., 2019 12 1, : : Nature communications. 10, 1, 5758.

研究成果: Article

公開
5 引用 (Scopus)

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M. & Suzuki, H., 2019, : : CMGH. 8, 3, p. 319-334 16 p.

研究成果: Article

公開
4 引用 (Scopus)

Cluster of differentiation 30 expression in lacrimal gland and conjunctival tissues in patients with Sjögren's syndrome: Case series

Ogawa, A., Ogawa, Y., Mukai, S., Shimizu, E., Kuwana, M., Kawakami, Y. & Tsubota, K., 2019 7 1, : : Medicine. 98, 29, p. e16390

研究成果: Article

公開
1 引用 (Scopus)

Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease

Hirai, I., Tanese, K., Nakamura, Y., Ishii, M., Kawakami, Y. & Funakoshi, T., 2019 6, : : Oncologist. 24, 6, p. e394-e396

研究成果: Article

4 引用 (Scopus)

Endothelial-mesenchymal transition drives expression of CD44 variant and xCT in pulmonary hypertension

Isobe, S., Kataoka, M., Endo, J., Moriyama, H., Okazaki, S., Tsuchihashi, K., Katsumata, Y., Yamamoto, T., Shirakawa, K., Yoshida, N., Shimoda, M., Chiba, T., Masuko, T., Hakamata, Y., Kobayashi, E., Saya, H., Fukuda, K. & Sano, M., 2019 1 1, : : American journal of respiratory cell and molecular biology. 61, 3, p. 367-379 13 p.

研究成果: Article

5 引用 (Scopus)

Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma

Sato, T., Yoo, S., Kong, R., Sinha, A., Chandramani-Shivalingappa, P., Patel, A., Fridrikh, M., Nagano, O., Masuko, T., Beasley, M. B., Powell, C. A., Zhu, J. & Watanabe, H., 2019 12 15, : : Cancer Research. 79, 24, p. 6084-6100 17 p.

研究成果: Article

公開
4 引用 (Scopus)

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors

Suzuki, K., Miura, Y., Mochida, Y., Miyazaki, T., Toh, K., Anraku, Y., Melo, V., Liu, X., Ishii, T., Nagano, O., Saya, H., Cabral, H. & Kataoka, K., 2019 5 10, : : Journal of Controlled Release. 301, p. 28-41 14 p.

研究成果: Article

9 引用 (Scopus)

Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma

Okazaki, S., Umene, K., Yamasaki, J., Suina, K., Otsuki, Y., Yoshikawa, M., Minami, Y., Masuko, T., Kawaguchi, S., Nakayama, H., Banno, K., Aoki, D., Saya, H. & Nagano, O., 2019 11 1, : : Cancer science. 110, 11, p. 3453-3463 11 p.

研究成果: Article

公開
7 引用 (Scopus)

Identification of KLRC2 as a candidate marker for brain tumor-initiating cells

Ishihara, E., Takahashi, S., Fukaya, R., Ohta, S., Yoshida, K. & Toda, M., 2019 11 2, : : Neurological Research. 41, 11, p. 1043-1049 7 p.

研究成果: Article

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Kofuji, S., Hirayama, A., Eberhardt, A. O., Kawaguchi, R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yoshino, H., Yamashita, D., Sumita, K., Wolfe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S. および37人, Ban, Y., Asano, M., Flanary, V. L., Ramkissoon, A., Chow, L. M. L., Kiyokawa, J., Mashimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E. P., Anastasiou, D., Wakimoto, H., Holland, E. C., Yong, W. H., Horbinski, C., Nakano, I., DeBerardinis, R. J., Bachoo, R. M., Mischel, P. S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H. & Sasaki, A. T., 2019 8 1, : : Nature Cell Biology. 21, 8, p. 1003-1014 12 p.

研究成果: Article

15 引用 (Scopus)

Neuroprotective effects of memantine via enhancement of autophagy

Hirano, K., Fujimaki, M., Sasazawa, Y., Yamaguchi, A., Ishikawa, K. I., Miyamoto, K., Souma, S., Furuya, N., Imamichi, Y., Yamada, D., Saya, H., Akamatsu, W., Saiki, S. & Hattori, N., 2019 10 8, : : Biochemical and Biophysical Research Communications. 518, 1, p. 161-170 10 p.

研究成果: Article

7 引用 (Scopus)

Programmed cell death ligand 1 (PD-L1) blockade attenuates metastatic colon cancer growth in cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin inhibitor-treated livers

Osawa, Y., Kojika, E., Nishikawa, K., Kimura, M., Osakaya, S., Miyauchi, H., Kanto, T., Kawakami, Y. & Kimura, K., 2019 4 30, : : Oncotarget. 10, 32, p. 3013-3026 14 p.

研究成果: Article

3 引用 (Scopus)

ROCK inhibition induces terminal adipocyte differentiation and suppresses tumorigenesis in chemoresistant osteosarcoma cells

Takahashi, N., Nobusue, H., Shimizu, T., Sugihara, E., Yamaguchi-Iwai, S., Onishi, N., Kunitomi, H., Kuroda, T. & Saya, H., 2019 6 15, : : Cancer Research. 79, 12, p. 3088-3099 12 p.

研究成果: Article

11 引用 (Scopus)
公開
3 引用 (Scopus)

"Smart Eye Camera": An innovative technique to evaluate tear film breakup time in a murine dry eye disease model

Shimizu, E., Ogawa, Y., Yazu, H., Aketa, N., Yang, F., Yamane, M., Sato, Y., Kawakami, Y. & Tsubota, K., 2019 5, : : PloS one. 14, 5, e0215130.

研究成果: Article

2 引用 (Scopus)
公開
5 引用 (Scopus)

The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery

Yamamoto, K., Kokubun, T., Sato, K., Akaishi, T., Shimazaki, A., Nakamura, M., Shiga, Y., Tsuda, S., Omodaka, K., Saya, H. & Nakazawa, T., 2019 12 1, : : Scientific reports. 9, 1, 19288.

研究成果: Article

公開
1 引用 (Scopus)

Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter

Hirao, N., Iwata, T., Tanaka, K., Nishio, H., Nakamura, M., Morisada, T., Morii, K., Maruyama, N., Katoh, Y., Yaguchi, T., Ohta, S., Kukimoto, I., Aoki, D. & Kawakami, Y., 2019 11, : : Gynecologic Oncology. 155, 2, p. 340-348 9 p.

研究成果: Article

3 引用 (Scopus)

Visualization of spatiotemporal dynamics of human glioma stem cell invasion

Tamura, R., Miyoshi, H., Sampetrean, O., Shinozaki, M., Morimoto, Y., Iwasawa, C., Fukaya, R., Mine, Y., Masuda, H., Maruyama, T., Narita, M., Saya, H., Yoshida, K., Okano, H. & Toda, M., 2019 5 6, : : Molecular brain. 12, 1, 45.

研究成果: Article

公開
7 引用 (Scopus)
2018

A pilot study of peptide vaccines for VEGF receptor 1 and 2 in patients with recurrent/progressive high grade glioma

Shibao, S., Ueda, R., Saito, K., Kikuchi, R., Nagashima, H., Kojima, A., Kagami, H., Pareira, E. S., Sasaki, H., Noji, S., Kawakami, Y., Yoshida, K. & Toda, M., 2018 4 20, : : Oncotarget. 9, 30, p. 21569-21579 11 p.

研究成果: Article

9 引用 (Scopus)

Association between programmed cell death ligand-1 expression and extracranial metastasis in intracranial solitary fibrous tumor/hemangiopericytoma

Kamamoto, D., Ohara, K., Kitamura, Y., Yoshida, K., Kawakami, Y. & Sasaki, H., 2018 4 19, (Accepted/In press) : : Journal of Neuro-Oncology. p. 1-9 9 p.

研究成果: Article

4 引用 (Scopus)
4 引用 (Scopus)

Convection-enhanced delivery of sulfasalazine prolongs survival in a glioma stem cell brain tumor model

Haryu, S., Saito, R., Jia, W., Shoji, T., Mano, Y., Sato, A., Kanamori, M., Sonoda, Y., Sampetrean, O., Saya, H. & Tominaga, T., 2018 1 1, : : Journal of Neuro-Oncology. 136, 1, p. 23-31 9 p.

研究成果: Article

5 引用 (Scopus)

Development of a functional thyroid model based on an organoid culture system

Saito, Y., Onishi, N., Takami, H., Seishima, R., Inoue, H., Hirata, Y., Kameyama, K., Tsuchihashi, K., Sugihara, E., Uchino, S., Ito, K., Kawakubo, H., Takeuchi, H., Kitagawa, Y., Saya, H. & Nagano, O., 2018 3 4, : : Biochemical and Biophysical Research Communications. 497, 2, p. 783-789 7 p.

研究成果: Article

10 引用 (Scopus)