先端医科学研究所

研究成果

年別の研究成果 1984 2013 2014 2016 2017 2018 2019 2020 2021 2022

• 488 Article
• 42 Review article
• 8 Comment/debate
• 7 Chapter
• 11 その他
  • 3 Conference contribution
  • 3 Letter
  • 3 Short survey
  • 2 Editorial

年別の研究成果

年別の研究成果

検索結果

• 2004

  Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells

  Miyagishi, M., Sumimoto, H., Miyoshi, H., Kawakami, Y. & Taira, K., 2004 7月, In: Journal of Gene Medicine. 6, 7, p. 715-723 9 p.

  研究成果: Article › 査読

  • Small Interfering RNA 100%
  • Mammalian Cell 74%
  • Mutation 61%
  • Double-Stranded RNA 51%
  • Length 42%
  145 被引用数 (Scopus)

• Oxidative stress induces insulin resistance by activating the nuclear factor-κB pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase

  Ogihara, T., Asano, T., Katagiri, H., Sakoda, H., Anai, M., Shojima, N., Ono, H., Fujishiro, M., Kushiyama, A., Fukushima, Y., Kikuchi, M., Noguchi, N., Aburatani, H., Gotoh, Y., Komuro, I. & Fujita, T., 2004 5月, In: Diabetologia. 47, 5, p. 794-805 12 p.

  研究成果: Article › 査読

  • Buthionine Sulfoximine 100%
  • Normal Distribution 83%
  • 3T3-L1 Cells 71%
  • Phosphatidylinositol 3-Kinase 71%
  • Adipocytes 67%
  118 被引用数 (Scopus)

• Quantitative analysis of PRAME for detection of minimal residual disease in leukemia.

  Matsushita, M., Yamazaki, R. & Kawakami, Y., 2004, In: Methods in molecular medicine. 97, p. 267-275 9 p.

  研究成果: Article › 査読
  7 被引用数 (Scopus)

• Single nucleotide polymorphisms of the inflammatory cytokine genes in adults with chronic immune thrombocytopenic purpura

  Satoh, T., Pandey, J. P., Okazaki, Y., Yasuoka, H., Kawakami, Y., Ikeda, Y. & Kuwana, M., 2004 3月, In: British Journal of Haematology. 124, 6, p. 796-801 6 p.

  研究成果: Article › 査読

  • Idiopathic Thrombocytopenic Purpura 100%
  • Single Nucleotide Polymorphism 70%
  • Tumor Necrosis Factor-alpha 59%
  • Cytokines 52%
  • Genes 33%
  42 被引用数 (Scopus)
• 2005

  Cardiomyogenic potential of mesenchymal progenitors derived from human circulating CD14⁺ monocytes

  Kodama, H., Inoue, T., Watanabe, R., Yasuoka, H., Kawakami, Y., Ogawa, S., Ikeda, Y., Mikoshiba, K. & Kuwana, M., 2005 12月 1, In: Stem Cells and Development. 14, 6, p. 676-686 11 p.

  研究成果: Article › 査読

  • Monocytes 100%
  • Cardiac Myocytes 87%
  • Green Fluorescent Proteins 28%
  • GATA4 Transcription Factor 22%
  • Actinin 18%
  46 被引用数 (Scopus)

• Donor fibroblast chimerism in the pathogenic fibrotic lesion of human chronic graft-versus-host disease

  Ogawa, Y., Kodama, H., Kameyama, K., Yamazaki, K., Yasuoka, H., Okamoto, S., Inoko, H., Kawakami, Y. & Kuwana, M., 2005 12月, In: Investigative Ophthalmology and Visual Science. 46, 12, p. 4519-4527 9 p.

  研究成果: Article › 査読

  • Chimerism 100%
  • Graft vs Host Disease 84%
  • Lacrimal Apparatus 64%
  • Tissue Donors 62%
  • Fibroblasts 59%
  38 被引用数 (Scopus)

• Evaluation of cytomegalovirus-specific T-cell reconstitution in patients after various allogeneic haematopoietic stem cell transplantation using interferon-γ-enzyme-linked immunospot and human leucocyte antigen tetramer assays with an immunodominant T-cell epitope

  Ohnishi, M., Sakurai, T., Heike, Y., Yamazaki, R., Kanda, Y., Takaue, Y., Mizoguchi, H. & Kawakami, Y., 2005 11月 1, In: British Journal of Haematology. 131, 4, p. 472-479 8 p.

  研究成果: Article › 査読

  • Immunodominant Epitopes 100%
  • T-Lymphocyte Epitopes 92%
  • Hematopoietic Stem Cell Transplantation 81%
  • HLA Antigens 78%
  • Cytomegalovirus 76%
  39 被引用数 (Scopus)

• Frequent immune responses to a cancer/testis antigen, CAGE, in patients with microsatellite instability - Positive endometrial cancer

  Iwata, T., Fujita, T., Hirao, N., Matsuzaki, Y., Okada, T., Mochimaru, H., Susumu, N., Matsumoto, E., Sugano, K., Yamashita, N., Nozawa, S. & Kawakami, Y., 2005 5月 15, In: Clinical Cancer Research. 11, 10, p. 3949-3957 9 p.

  研究成果: Article › 査読

  • Microsatellite Instability 100%
  • Testicular Neoplasms 92%
  • Endometrial Neoplasms 83%
  • Antigens 51%
  • Colonic Neoplasms 36%
  30 被引用数 (Scopus)

• IgA nephropathy associated with polycythemia vera

  Yaguchi, T., Takimoto, C., Uchimura, H., Konishi, K., Ichihara, A., Hayashi, K., Saruta, T. & Hashiguchi, A., 2005 8月 10, In: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine. 94, 8, p. 1612-1614 3 p.

  研究成果: Article › 査読

  Open Access
  2 被引用数 (Scopus)

• Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis

  Okada, T., Noji, S., Goto, Y., Iwata, T., Fujita, T., Okada, T., Matsuzaki, Y., Kuwana, M., Hirakata, M., Horii, A., Matsuno, S., Sunamura, M. & Kawakami, Y., 2005 10月 10, In: International Journal of Cancer. 116, 6, p. 925-933 9 p.

  研究成果: Article › 査読

  • DNA Repair Enzymes 100%
  • Dermatomyositis 87%
  • DNA Mismatch Repair 84%
  • Pancreatic Neoplasms 67%
  • Adenocarcinoma 44%
  26 被引用数 (Scopus)

• Immunological detection of altered signaling molecules involved in melanoma development

  Kawakami, Y., Sumimoto, H., Fujita, T. & Matsuzaki, Y., 2005 6月, In: Cancer and Metastasis Reviews. 24, 2, p. 357-366 10 p.

  研究成果: Article › 査読

  • Melanoma 100%
  • Neoplasm Antigens 96%
  • Neoplasms 38%
  • Catenins 38%
  • Survivin 36%
  9 被引用数 (Scopus)

• Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip Are immunogenic in multiple melanoma patients

  Inozume, T., Matsuzaki, Y., Kurihara, S., Fujita, T., Yamamoto, A., Aburatani, H., Shimada, S. & Kawakami, Y., 2005 3月 20, In: International Journal of Cancer. 114, 2, p. 283-290 8 p.

  研究成果: Article › 査読

  • Melanoma-Specific Antigens 100%
  • Oligonucleotide Array Sequence Analysis 74%
  • Melanocytes 60%
  • Melanoma 59%
  • Complementary DNA 57%
  20 被引用数 (Scopus)

• Systematic identification of human melanoma antigens using Serial Analysis of Gene Expression (SAGE)

  Matsuzaki, Y., Hashimoto, S. I., Fujita, T., Suzuki, T., Sakurai, T., Matsushima, K. & Kawakami, Y., 2005, In: Journal of Immunotherapy. 28, 1, p. 10-19 10 p.

  研究成果: Article › 査読

  • Melanoma-Specific Antigens 100%
  • Forensic Anthropology 92%
  • Melanocytes 60%
  • Melanoma 59%
  • Gene Expression 42%
  26 被引用数 (Scopus)
• 2006

  A new melanoma antigen fatty acid-binding protein 7, involved in proliferation and invasion, is a potential target for immunotherapy and molecular target therapy

  Goto, Y., Matsuzaki, Y., Kurihara, S., Shimizu, A., Okada, T., Yamamoto, K., Murata, H., Takata, M., Aburatani, H., Hoon, D. S. B., Saida, T. & Kawakami, Y., 2006 4月 15, In: Cancer Research. 66, 8, p. 4443-4449 7 p.

  研究成果: Article › 査読

  • Fatty Acid-Binding Protein 7 100%
  • Melanoma-Specific Antigens 79%
  • Immunotherapy 50%
  • Melanoma 38%
  • Cell Line 12%
  49 被引用数 (Scopus)

• A novel cancer testis antigen that is frequently expressed in pancreatic, lung, and endometrial cancers

  Okada, T., Akada, M., Fujita, T., Iwata, T., Goto, Y., Kido, K., Okada, T., Matsuzaki, Y., Kobayashi, K., Matsuno, S., Sunamura, M. & Kawakami, Y., 2006 1月 1, In: Clinical Cancer Research. 12, 1, p. 191-197 7 p.

  研究成果: Article › 査読

  • Testicular Neoplasms 100%
  • Endometrial Neoplasms 90%
  • Pancreatic Neoplasms 83%
  • Lung Neoplasms 69%
  • Antigens 55%
  34 被引用数 (Scopus)

• Effects of a Helicobacter pylori eradication regimen on anti-platelet autoantibody response in infected and uninfected patients with idiopathic thrombocytopenic purpura

  Asahi, A., Kuwana, M., Suzuki, H., Hibi, T., Kawakami, Y. & Ikeda, Y., 2006 10月 1, In: Haematologica. 91, 10, p. 1436-1437 2 p.

  研究成果: Article › 査読

  • Idiopathic Thrombocytopenic Purpura 100%
  • Helicobacter pylori 81%
  • Autoantibodies 77%
  • Blood Platelets 65%
  • Helicobacter Infections 29%
  46 被引用数 (Scopus)

• Frequent immune response to a melanocyte specific protein KU-MEL-1 in patients with Vogt-Koyanagi-Harada disease

  Otani, S., Sakurai, T., Yamamoto, K., Fujita, T., Matsuzaki, Y., Goto, Y., Ando, Y., Suzuki, S., Usui, M., Takeuchi, M. & Kawakami, Y., 2006 6月, In: British Journal of Ophthalmology. 90, 6, p. 773-777 5 p.

  研究成果: Article › 査読

  • Uveomeningoencephalitic Syndrome 100%
  • Melanocytes 75%
  • Immunoglobulin G 31%
  • HLA-DRB1*04:05 antigen 31%
  • Autoantigens 27%
  26 被引用数 (Scopus)

• Identification of a glioma antigen, GARC-1, using cytotoxic T lymphocytes induced by HSV cancer vaccine

  Iizuka, Y., Kojima, H., Kobata, T., Kawase, T., Kawakami, Y. & Toda, M., 2006 2月 15, In: International Journal of Cancer. 118, 4, p. 942-949 8 p.

  研究成果: Article › 査読

  • Herpes Simplex Virus Vaccines 100%
  • Cancer Vaccines 70%
  • Cytotoxic T-Lymphocytes 63%
  • Glioma 54%
  • Antigens 37%
  26 被引用数 (Scopus)

• Increase in circulating endothelial precursors by atorvastatin in patients with systemic sclerosis

  Kuwana, M., Kaburaki, J., Okazaki, Y., Yasuoka, H., Kawakami, Y. & Ikeda, Y., 2006 6月, In: Arthritis and Rheumatism. 54, 6, p. 1946-1951 6 p.

  研究成果: Article › 査読

  • Atorvastatin 100%
  • Systemic Scleroderma 94%
  • Raynaud Disease 45%
  • Angiogenesis Inducing Agents 26%
  • Blood Vessels 13%
  78 被引用数 (Scopus)

• Neurogenic potential of progenitors derived from human circulating CD14⁺ monocytes

  Kodama, H., Inoue, T., Watanabe, R., Yasutomi, D., Kawakami, Y., Ogawa, S., Mikoshiba, K., Ikeda, Y. & Kuwana, M., 2006 4月 1, In: Immunology and Cell Biology. 84, 2, p. 209-217 9 p.

  研究成果: Article › 査読

  • Monocytes 100%
  • Neurons 30%
  • Microtubule-Associated Proteins 23%
  • Intermediate Filaments 22%
  • Coculture Techniques 20%
  39 被引用数 (Scopus)

• Pituitary adenylate cyclase-activating polypeptide regulates forebrain neural stem cells and neurogenesis in vitro and in vivo

  Ohta, S., Gregg, C. & Weiss, S., 2006 11月 1, In: Journal of neuroscience research. 84, 6, p. 1177-1186 10 p.

  研究成果: Article › 査読

  • Pituitary Adenylate Cyclase-Activating Polypeptide 100%
  • Neural Stem Cells 80%
  • Prosencephalon 77%
  • Neurogenesis 76%
  • In Vitro Techniques 31%
  43 被引用数 (Scopus)

• Possible involvement of allogeneic antigens recognised by donor-derived CD4 ⁺ cytotoxic T cells in selective GVL effects after stem cell transplantation of patients with haematological malignancy

  Matsushita, M., Yamazaki, R., Ikeda, H., Mori, T., Sumimoto, H., Fujita, T., Okamoto, S., Ikeda, Y. & Kawakami, Y., 2006 1月 1, In: British Journal of Haematology. 132, 1, p. 56-65 10 p.

  研究成果: Article › 査読

  • Stem Cell Transplantation 100%
  • HLA Antigens 98%
  • Hematologic Neoplasms 96%
  • Cytotoxic T-Lymphocytes 88%
  • Tissue Donors 74%
  11 被引用数 (Scopus)

• Translational research for cancer vaccine therapy with poxviral vectors expressing TAA and costimulatory molecules

  Kudo-Saito, C., 2006 11月 1, In: Biotherapy. 20, 6, p. 535-540 6 p.

  研究成果: Article › 査読

  • Active Immunotherapy 100%
  • Cancer Vaccines 92%
  • Translational Medical Research 86%
  • Neoplasm Antigens 81%
  • Neoplasms 24%
• 2007

  Clinical significance of serum p53 antibodies in patients with ulcerative colitis and its carcinogenesis

  Yoshizawa, S., Matsuoka, K., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y., Mukai, M., Fujita, T., Kawakami, Y. & Hibi, T., 2007 7月 1, In: Inflammatory bowel diseases. 13, 7, p. 865-873 9 p.

  研究成果: Article › 査読

  • Ulcerative Colitis 100%
  • Carcinogenesis 77%
  • Antibodies 56%
  • Serum 46%
  • Colorectal Neoplasms 35%
  21 被引用数 (Scopus)

• Evaluation of platelet kinetics in patients with liver cirrhosis: Similarity to idiopathic thrombocytopenic purpura

  Kajihara, M., Okazaki, Y., Kato, S., Ishii, H., Kawakami, Y., Ikeda, Y. & Kuwana, M., 2007 1月, In: Journal of Gastroenterology and Hepatology (Australia). 22, 1, p. 112-118 7 p.

  研究成果: Article › 査読

  • Idiopathic Thrombocytopenic Purpura 100%
  • Liver Cirrhosis 77%
  • Blood Platelets 65%
  • Kinetics 60%
  • glycocalicin 50%
  56 被引用数 (Scopus)

• Identification of a novel cancer-testis antigen CRT2 frequently expressed in various cancers using representational differential analysis

  Hayashi, E., Matsuzaki, Y., Hasegawa, G., Yaguchi, T., Kurihara, S., Fujita, T., Kageshita, T., Sano, M. & Kawakami, Y., 2007 11月 1, In: Clinical Cancer Research. 13, 21, p. 6267-6274 8 p.

  研究成果: Article › 査読

  • Testicular Neoplasms 100%
  • Antigens 55%
  • HLA-A24 Antigen 39%
  • Neoplasms 28%
  • Testis 21%
  12 被引用数 (Scopus)

• Intratumoral delivery of vector mediated IL-2 in combination with vaccine results in enhanced T cell avidity and anti-tumor activity

  Kudo-Saito, C., Garnett, C. T., Wansley, E. K., Schlom, J. & Hodge, J. W., 2007 12月, In: Cancer Immunology, Immunotherapy. 56, 12, p. 1897-1910 14 p.

  研究成果: Article › 査読

  • Combined Vaccines 100%
  • Fowlpox 97%
  • Interleukin-2 65%
  • T-Lymphocytes 45%
  • Neoplasms 23%
  15 被引用数 (Scopus)

• Role of heat shock protein 47, a collagen-binding chaperone, in lacrimal gland pathology in patients with cGVHD

  Ogawa, Y., Razzaque, M. S., Kameyama, K., Hasegawa, G., Shimmura, S., Kawai, M., Okamoto, S., Ikeda, Y., Tsubota, K., Kawakami, Y. & Kuwana, M., 2007 3月, In: Investigative Ophthalmology and Visual Science. 48, 3, p. 1079-1086 8 p.

  研究成果: Article › 査読

  • HSP47 Heat-Shock Proteins 100%
  • Lacrimal Apparatus 71%
  • Graft vs Host Disease 61%
  • Collagen 44%
  • Fibroblasts 39%
  32 被引用数 (Scopus)

• Visualizing the dynamics of p21^Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals

  Ohtani, N., Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru, N., Takahashi, A., Hirao, A., Shimizu, T., Mann, D. J., Saya, H., Hayashi, Y., Arase, S., Matsumoto, M., Nakao, K. & Hara, E., 2007 9月 18, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 38, p. 15034-15039 6 p.

  研究成果: Article › 査読

  • Cyclin-Dependent Kinases 100%
  • Gene Expression 51%
  • Animals 42%
  • Hair 21%
  • Skin 17%
  54 被引用数 (Scopus)

• Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells

  Iguchi, T., Miyakawa, Y., Saito, K., Nakabayashi, C., Nakanishi, M., Saya, H., Ikeda, Y. & Kizaki, M., 2007 8月, In: International journal of oncology. 31, 2, p. 285-291 7 p.

  研究成果: Article › 査読

  Open Access

  • Zoledronic Acid 100%
  • Osteosarcoma 79%
  • S Phase 75%
  • DNA Damage 66%
  • Apoptosis 46%
  46 被引用数 (Scopus)
• 2008

  Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells

  Oguma, K., Oshima, H., Aoki, M., Uchio, R., Naka, K., Nakamura, S., Hirao, A., Saya, H., Taketo, M. M. & Oshima, M., 2008 6月 18, In: EMBO Journal. 27, 12, p. 1671-1681 11 p.

  研究成果: Article › 査読

  • Catenins 100%
  • Glycogen 94%
  • Conditioned Culture Medium 59%
  • Stomach 56%
  • Tumor Necrosis Factor-alpha 56%
  238 被引用数 (Scopus)

• Autoreactive T-cell responses to myeloperoxidase in patients with antineutrophil cytoplasmic antibody-associated vasculitis and in healthy individuals

  Seta, N., Tajima, M., Kobayashi, S., Kawakami, Y., Hashimoto, H. & Kuwana, M., 2008, In: Modern rheumatology. 18, 6, p. 593-600 8 p.

  研究成果: Article › 査読

  • Antineutrophil Cytoplasmic Antibodies 100%
  • Vasculitis 81%
  • Peroxidase 76%
  • T-Lymphocytes 49%
  • Amino Acids 13%
  11 被引用数 (Scopus)

• EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding, internalization and motogenic effect of CD44

  Pályi-Krekk, Z., Barok, M., Kovács, T., Saya, H., Nagano, O., Szöllosi, J. & Nagy, P., 2008 5月 18, In: Cancer Letters. 263, 2, p. 231-242 12 p.

  研究成果: Article › 査読

  • Trastuzumab 100%
  • Neuregulin-1 71%
  • pertuzumab 52%
  • ErbB Receptors 48%
  • Oligosaccharides 37%
  33 被引用数 (Scopus)

• Functional recovery after spinal cord injury in mice through activation of microglia and dendritic cells after IL-12 administration

  Yaguchi, M., Ohta, S., Toyama, Y., Kawakami, Y. & Toda, M., 2008 7月 1, In: Journal of neuroscience research. 86, 9, p. 1972-1980 9 p.

  研究成果: Article › 査読

  • Interleukin-12 100%
  • Microglia 98%
  • Spinal Cord Injuries 93%
  • Dendritic Cells 87%
  • Macrophages 27%
  37 被引用数 (Scopus)

• Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen, SOX6

  Ueda, R., Kinoshita, E., Ito, R., Kawase, T., Kawakami, Y. & Toda, M., 2008 5月 15, In: International Journal of Cancer. 122, 10, p. 2274-2279 6 p.

  研究成果: Article › 査読

  • DNA Vaccines 100%
  • Glioma 75%
  • Immunity 67%
  • Antigens 52%
  • Vaccination 28%
  16 被引用数 (Scopus)

• Novel system evaluating in vivo pathogenicity of desmoglein 3-reactive T cell clones using murine pemphigus vulgaris

  Takahashi, H., Amagai, M., Nishikawa, T., Fujii, Y., Kawakami, Y. & Kuwana, M., 2008 7月 15, In: Journal of Immunology. 181, 2, p. 1526-1535 10 p.

  研究成果: Article › 査読

  Open Access

  • Desmoglein 3 100%
  • Pemphigus 79%
  • Virulence 54%
  • Clone Cells 50%
  • T-Lymphocytes 38%
  63 被引用数 (Scopus)

• p53 regulates toll-like receptor 3 expression and function in human epithelial cell lines

  Taura, M., Eguma, A., Suico, M. A., Shuto, T., Koga, T., Komatsu, K., Komune, T., Sato, T., Saya, H., Li, J. D. & Kai, H., 2008 11月, In: Molecular and cellular biology. 28, 21, p. 6557-6567 11 p.

  研究成果: Article › 査読

  • Toll-Like Receptor 3 100%
  • HCT116 Cells 90%
  • Poly I-C 66%
  • Epithelial Cells 49%
  • Cell Line 41%
  90 被引用数 (Scopus)

• Preferential activation of circulating CD8⁺ and γδ T cells in patients with active Behçet's disease and HLA-B51

  Yasuoka, H., Yamaguchi, Y., Mizuki, N., Nishida, T., Kawakami, Y. & Kuwana, M., 2008 7月 1, In: Clinical and experimental rheumatology. 26, 4 SUPPL. 50, p. S59-S63

  研究成果: Article › 査読

  • HLA-B51 Antigen 100%
  • T-Lymphocytes 36%
  27 被引用数 (Scopus)

• Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to- mesenchymal transition

  Arima, Y., Inoue, Y., Shibata, T., Hayashi, H., Nagano, O., Saya, H. & Taya, Y., 2008 7月 1, In: Cancer Research. 68, 13, p. 5104-5112 9 p.

  研究成果: Article › 査読

  • Epithelial-Mesenchymal Transition 100%
  • Cadherins 97%
  • Breast Neoplasms 36%
  • Cell Adhesion 36%
  • Neoplasms 31%
  131 被引用数 (Scopus)

• Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2

  Mochimaru, H., Usui, T., Yaguchi, T., Nagahama, Y., Hasegawa, G., Usui, Y., Shimmura, S., Tsubota, K., Amano, S., Kawakami, Y. & Ishida, S., 2008 4月, In: Investigative Ophthalmology and Visual Science. 49, 5, p. 2172-2177 6 p.

  研究成果: Article › 査読

  • Corneal Neovascularization 100%
  • Alkalies 85%
  • Vascular Endothelial Growth Factor Receptor 84%
  • Burns 71%
  • Dendritic Cells 62%
  19 被引用数 (Scopus)

• The ERK-RSK1 activation by growth factors at G2 phase delays cell cycle progression and reduces mitotic aberrations

  Nam, H. J., Kim, S., Lee, M. W., Lee, B. S., Hara, T., Saya, H., Cho, H. & Lee, J. H., 2008 7月, In: Cellular Signalling. 20, 7, p. 1349-1358 10 p.

  研究成果: Article › 査読

  • Hepatocyte Growth Factor 100%
  • G2 Phase 92%
  • Protein Kinases 77%
  • Intercellular Signaling Peptides and Proteins 68%
  • Cell Cycle 66%
  26 被引用数 (Scopus)
• 2009

  An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics

  Mori, D., Yamada, M., Mimori-Kiyosue, Y., Shirai, Y., Suzuki, A., Ohno, S., Saya, H., Wynshaw-Boris, A. & Hirotsune, S., 2009, In: Nature Cell Biology. 11, 9, p. 1057-1068 12 p.

  研究成果: Article › 査読

  • PKC-3 protein 100%
  • Neurites 71%
  • Microtubules 62%
  • Microtubule-Organizing Center 15%
  • Actin Cytoskeleton 10%
  101 被引用数 (Scopus)

• Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin

  Tamase, A., Muraguchi, T., Naka, K., Tanaka, S., Kinoshita, M., Hoshii, T., Ohmura, M., Shugo, H., Ooshio, T., Nakada, M., Sawamoto, K., Onodera, M., Matsumoto, K., Oshima, M., Asano, M., Saya, H., Okano, H., Suda, T., Hamada, J. I. & Hirao, A., 2009 10月 6, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 40, p. 17163-17168 6 p.

  研究成果: Article › 査読

  • Neoplastic Stem Cells 100%
  • Carcinogens 90%
  • Brain Neoplasms 87%
  • Neoplasms 21%
  • Proto-Oncogene Proteins c-met 18%
  72 被引用数 (Scopus)

• Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization

  Mochimaru, H., Takahashi, E., Tsukamoto, N., Miyazaki, J., Yaguchi, T., Koto, T., Kurihara, T., Noda, K., Ozawa, Y., Ishimoto, T., Kawakami, Y., Tanihara, H., Saya, H., Ishida, S. & Tsubota, K., 2009, In: Investigative Ophthalmology and Visual Science. 50, 9, p. 4410-4415 6 p.

  研究成果: Article › 査読

  • Hyaluronan Receptors 100%
  • Choroidal Neovascularization 84%
  • Hyaluronic Acid 38%
  • Light Coagulation 21%
  • Hymecromone 20%
  24 被引用数 (Scopus)

• K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells

  Nakai, R., Iida, S. I., Takahashi, T., Tsujita, T., Okamoto, S., Takada, C., Akasaka, K., Ichikawa, S., Ishida, H., Kusaka, H., Akinaga, S., Murakata, C., Honda, S., Nitta, M., Saya, H. & Yamashita, Y., 2009 5月 1, In: Cancer Research. 69, 9, p. 3901-3909 9 p.

  研究成果: Article › 査読

  • Kinesin 100%
  • Antineoplastic Agents 74%
  • Cell Death 59%
  • Neoplasms 25%
  • Chromosome Structures 18%
  71 被引用数 (Scopus)

• Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model

  Kai, K., Nagano, O., Sugihara, E., Arima, Y., Sampetrean, O., Ishimoto, T., Nakanishi, M., Ueno, N. T., Iwase, H. & Saya, H., 2009 12月, In: Cancer science. 100, 12, p. 2275-2282 8 p.

  研究成果: Article › 査読

  • Neoplastic Stem Cells 100%
  • Colonic Neoplasms 85%
  • HCT116 Cells 69%
  • Maintenance 66%
  • Epithelial Cell Adhesion Molecule 55%
  39 被引用数 (Scopus)

• M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

  Kubota, Y., Takubo, K., Shimizu, T., Ohno, H., Kishi, K., Shibuya, M., Saya, H. & Suda, T., 2009 5月 11, In: Journal of Experimental Medicine. 206, 5, p. 1089-1102 14 p.

  研究成果: Article › 査読

  • Pathologic Neovascularization 100%
  • Lymphangiogenesis 96%
  • Macrophage Colony-Stimulating Factor 86%
  • Blood Vessels 15%
  • Eye Neoplasms 10%
  287 被引用数 (Scopus)

• Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress

  Inumaru, J., Nagano, O., Takahashi, E., Ishimoto, T., Nakamura, S., Suzuki, Y., Niwa, S. I., Umezawa, K., Tanihara, H. & Saya, H., 2009 6月 15, In: Genes to Cells. 14, 6, p. 703-716 14 p.

  研究成果: Article › 査読

  • Intercellular Junctions 100%
  • Oxidative Stress 61%
  • Epithelial Cells 60%
  • delta catenin 48%
  • Epithelial-Mesenchymal Transition 32%
  61 被引用数 (Scopus)

• Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-κB activity

  Tomita, M., Toyota, M., Ishikawa, C., Nakazato, T., Okudaira, T., Matsuda, T., Uchihara, J. N., Taira, N., Ohshiro, K., Senba, M., Tanaka, Y., Ohshima, K., Saya, H., Tokino, T. & Mori, N., 2009 6月 1, In: International Journal of Cancer. 124, 11, p. 2607-2615 9 p.

  研究成果: Article › 査読

  • Deltaretrovirus 100%
  • Adult T Cell Leukemia Lymphoma 53%
  • T-Lymphocytes 44%
  • Gene Expression 43%
  • Survival 39%
  10 被引用数 (Scopus)

• Real-time in vivo imaging of p16^Ink4a reveals cross talk with p53

  Yamakoshi, K., Takahashi, A., Hirota, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann, D. J., Ohmura, M., Hirao, A., Saya, H., Arase, S., Hayashi, Y., Nakao, K., Matsumoto, M., Ohtani, N. & Hara, E., 2009 8月 10, In: Journal of Cell Biology. 186, 3, p. 393-407 15 p.

  研究成果: Article › 査読

  • Social Conditions 100%
  • Transferases 88%
  • Tumor Suppressor Genes 85%
  • Epigenomics 75%
  • DNA Damage 75%
  97 被引用数 (Scopus)