坂口光洋記念講座

研究成果 1979 2020

2020
2 引用 (Scopus)

Somatic inflammatory gene mutations in human ulcerative colitis epithelium

Nanki, K., Fujii, M., Shimokawa, M., Matano, M., Nishikori, S., Date, S., Takano, A., Toshimitsu, K., Ohta, Y., Takahashi, S., Sugimoto, S., Ishimaru, K., Kawasaki, K., Nagai, Y., Ishii, R., Yoshida, K., Sasaki, N., Hibi, T., Ishihara, S., Kanai, T. および1人, Sato, T., 2020 1 9, : : Nature. 577, 7789, p. 254-259 6 p.

研究成果: Article

Ulcerative Colitis
Interleukin-17
Epithelium
Organoids
Colon
2019
1 引用 (Scopus)
Indigo Carmine
Ulcerative Colitis
Pulmonary Hypertension
Intussusception
Liver Diseases
1 引用 (Scopus)

Cnnm4 deficiency suppresses Ca 2+ signaling and promotes cell proliferation in the colon epithelia

Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 5 16, : : Oncogene. 38, 20, p. 3962-3969 8 p.

研究成果: Article

Colon
Epithelium
Cell Proliferation
Capsaicin
Epidermal Growth Factor Receptor
1 引用 (Scopus)

Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis

Yoshimatsu, Y., Naganuma, M., Sugimoto, S., Tanemoto, S., Umeda, S., Fukuda, T., Nomura, E., Yoshida, K., Ono, K., Mutaguchi, M., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Takabayashi, K., Ogata, H., Iwao, Y. & Kanai, T., 2019 1 1, : : Digestion.

研究成果: Article

Indigo Carmine
Suppositories
Ulcerative Colitis
Therapeutics
Rectum
1 引用 (Scopus)
Ulcerative Colitis
Recurrence
Colonoscopy
Therapeutics
Blood Vessels
19 引用 (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Cho, H., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. および2人, Sato, T. & Kanai, T., 2019 1 1, (Accepted/In press) : : Nature Microbiology.

研究成果: Article

Th17 Cells
Sclerosing Cholangitis
Liver Diseases
Microbiota
Bacterial Translocation
1 引用 (Scopus)
Indigo Carmine
Ulcerative Colitis
Steroids
Placebos
Leukocyte L1 Antigen Complex
1 引用 (Scopus)

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M., Tada, N., Okano, H. & Akamatsu, W., 2019 2 12, : : Stem Cell Reports. 12, 2, p. 305-318 14 p.

研究成果: Article

Induced Pluripotent Stem Cells
Stem cells
Pluripotent Stem Cells
Fibroblast Growth Factor 4
Stem Cells
2 引用 (Scopus)

Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors

Hiratsuka, K., Monkawa, T., Akiyama, T., Nakatake, Y., Oda, M., Goparaju, S. K., Kimura, H., Chikazawa-Nohtomi, N., Sato, S., Ishiguro, K., Yamaguchi, S., Suzuki, S., Morizane, R., Ko, S., Itoh, H. & Ko, M., 2019 12 1, : : Scientific Reports. 9, 1, 913.

研究成果: Article

Pluripotent Stem Cells
Organoids
Nephrons
Transcription Factors
Kidney
2 引用 (Scopus)

Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis

Matsui, S., Okabayashi, K., Tsuruta, M., Shigeta, K., Seishima, R., Ishida, T., Kondo, T., Suzuki, Y., Hasegawa, H., Shimoda, M., Sugimoto, S., Sato, T. & Kitagawa, Y., 2019 7 1, : : Cancer science. 110, 7, p. 2156-2165 10 p.

研究成果: Article

公開
Interleukin-13
Carcinogenesis
Obesity
Colorectal Neoplasms
Cytokines
Cellular Structures
Cadherins
Ulcerative Colitis
Colitis
Signet Ring Cell Carcinoma

In Vitro Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of PCDH15 and RELN

Ishii, T., Ishikawa, M., Fujimori, K., Maeda, T., Kushima, I., Arioka, Y., Mori, D., Nakatake, Y., Yamagata, B., Nio, S., Kato, T. A., Yang, N., Wernig, M., Kanba, S., Mimura, M., Ozaki, N. & Okano, H., 2019 9 1, : : eNeuro. 6, 5

研究成果: Article

公開
Induced Pluripotent Stem Cells
Bipolar Disorder
Schizophrenia
Neurons
Psychiatry
2 引用 (Scopus)

Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine

Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M. および5人, Ohtsuka, K., Mochizuki, M., Watanabe, M., Hashiguchi, M. & Kanai, T., 2019 1 1, : : Journal of Gastroenterology and Hepatology (Australia).

研究成果: Review article

Inflammatory Bowel Diseases
Erythrocyte Indices
Leukopenia
Leukocyte Count
Genotype
8 引用 (Scopus)

Modeling Human Digestive Diseases With CRISPR-Cas9–Modified Organoids

Fujii, M., Clevers, H. & Sato, T., 2019 2 1, : : Gastroenterology. 156, 3, p. 562-576 15 p.

研究成果: Review article

Clustered Regularly Interspaced Short Palindromic Repeats
Organoids
Technology
Digestive System Diseases
Stem Cell Niche
2018
25 引用 (Scopus)

Advancing Intestinal Organoid Technology Toward Regenerative Medicine

Nakamura, T. & Sato, T., 2018 1 1, : : CMGH. 5, 1, p. 51-60 10 p.

研究成果: Review article

Organoids
Regenerative Medicine
Technology
Intestines
Tissue Scaffolds
20 引用 (Scopus)

Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling

Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R. & Ohno, H., 2018 2 1, : : Journal of Experimental Medicine. 215, 2, p. 501-519 19 p.

研究成果: Article

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Peyer's Patches
Cell Differentiation
Epithelium
Organoids
27 引用 (Scopus)

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S. および3人, Koo, B. K., Kanai, T. & Sato, T., 2018 8 9, : : Cell. 174, 4, p. 856-869.e17

研究成果: Article

Stomach Neoplasms
Organoids
Stomach
Screening
Carcinogenesis
29 引用 (Scopus)
Indigo Carmine
Ulcerative Colitis
Randomized Controlled Trials
Placebos
Pulmonary Hypertension
3 引用 (Scopus)

Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing

Akiyama, T., Sato, S., Chikazawa-Nohtomi, N., Soma, A., Kimura, H., Wakabayashi, S., Ko, S. & Ko, M., 2018 12 1, : : Scientific Reports. 8, 1, 1189.

研究成果: Article

Pluripotent Stem Cells
Muscle Cells
Skeletal Muscle
RNA
Gene Knockdown Techniques
Organoids
Genetic engineering
Genetic Engineering
Electroporation
Plasmids
3 引用 (Scopus)
Endocrine Cells
Biotechnology
Stem cells
Transcription Factors
Cells
22 引用 (Scopus)

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

Loomans, C. J. M., Williams Giuliani, N., Balak, J., Ringnalda, F., van Gurp, L., Huch, M., Boj, S. F., Sato, T., Kester, L., de Sousa Lopes, S. M. C., Roost, M. S., Bonner-Weir, S., Engelse, M. A., Rabelink, T. J., Heimberg, H., Vries, R. G. J., van Oudenaarden, A., Carlotti, F., Clevers, H. & de Koning, E. J. P., 2018 3 13, : : Stem Cell Reports. 10, 3, p. 1088-1101 14 p.

研究成果: Article

Organoids
Stem Cells
Tissue
Medical problems
Insulin
1 引用 (Scopus)

Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2018 10 1, : : PLoS One. 13, 10, e0204632.

研究成果: Article

Crohn disease
Crohn Disease
tumor necrosis factors
therapeutics
Tumor Necrosis Factor-alpha
1 引用 (Scopus)

Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Nanki, K., Mizuno, S., Matsuoka, K., Ono, K., Sugimoto, S., Kiyohara, H., Arai, M., Nakashima, M., Takeshita, K., Saigusa, K., Senoh, M., Fukuda, T., Naganuma, M., Kato, H., Suda, W., Hattori, M. & Kanai, T., 2018 1 1, : : Intestinal Research. 16, 1, p. 142-146 5 p.

研究成果: Article

Clostridium Infections
Clostridium difficile
Ulcerative Colitis
Dysbiosis
Recurrence
6 引用 (Scopus)

Gastroenteropancreatic neuroendocrine neoplasms: genes, therapies and models

Kawasaki, K., Fujii, M. & Sato, T., 2018 2 26, : : Disease models & mechanisms. 11, 2

研究成果: Review article

Gene therapy
Neoplasm Genes
Genetic Therapy
Neoplasms
Organoids
15 引用 (Scopus)

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Fujii, M., Matano, M., Toshimitsu, K., Takano, A., Mikami, Y., Nishikori, S., Sugimoto, S. & Sato, T., 2018 12 6, : : Cell Stem Cell. 23, 6, p. 787-793.e6

研究成果: Article

Organoids
Small Cytoplasmic RNA
Stem Cells
Clustered Regularly Interspaced Short Palindromic Repeats
RNA Sequence Analysis
73 引用 (Scopus)

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Seino, T., Kawasaki, S., Shimokawa, M., Tamagawa, H., Toshimitsu, K., Fujii, M., Ohta, Y., Matano, M., Nanki, K., Kawasaki, K., Takahashi, S., Sugimoto, S., Iwasaki, E., Takagi, J., Itoi, T., Kitago, M., Kitagawa, Y., Kanai, T. & Sato, T., 2018 1 1, (Accepted/In press) : : Cell Stem Cell.

研究成果: Article

Organoids
Stem Cell Niche
Stem Cell Factor
Disease Progression
Adenocarcinoma
9 引用 (Scopus)

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 12 1, : : Scientific Reports. 8, 1, 2821.

研究成果: Article

Organoids
Cholangiocarcinoma
Hepatocytes
Intrahepatic Bile Ducts
Cytochrome P-450 CYP3A
3 引用 (Scopus)

Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites

Mito, A., Nakano, Y., Saitoh, T., Gouraud, S. S. S., Yamaguchi, Y., Sato, T., Sasaki, N. & Kojima-Aikawa, K., 2018 1 1, : : Glycobiology. 28, 1, p. 21-31 11 p.

研究成果: Article

Colorectal Neoplasms
Cell growth
Binding Sites
Cells
Carbohydrates
25 引用 (Scopus)

Reconstruction of the Human Colon Epithelium In Vivo

Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., Kanai, T. & Sato, T., 2018 2 1, : : Cell Stem Cell. 22, 2, p. 171-176.e5

研究成果: Article

Colon
Epithelium
Organoids
Stem Cells
Heterografts

Selective modulation of local linkages between active transcription and oxidative demethylation activity shapes cardiomyocyte-specific gene-body epigenetic status in mice

Oda, M., Wakabayashi, S., Ari Wijetunga, N., Yuasa, S., Enomoto, H., Kaneda, R., Yoon, S. H., Mittal, N., Jing, Q., Suzuki, M., Greally, J. M., Fukuda, K. & Makino, S., 2018 5 10, : : BMC Genomics. 19, 1, 349.

研究成果: Article

Cardiac Myocytes
Epigenomics
Genes
Body Regions
Histone Code
8 引用 (Scopus)

Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification

Sadahiro, T., Isomi, M., Muraoka, N., Kojima, H., Haginiwa, S., Kurotsu, S., Tamura, F., Tani, H., Tohyama, S., Fujita, J., Miyoshi, H., Kawamura, Y., Goshima, N., Iwasaki, Y., Murano, K., Saito, K., Oda, M., Andersen, P., Kwon, C., Uosaki, H. および3人, Nishizono, H., Fukuda, K. & Ieda, M., 2018 9 6, : : Cell Stem Cell. 23, 3, p. 382-395 14 p.

研究成果: Article

Somites
Pluripotent Stem Cells
Mesoderm
Clustered Regularly Interspaced Short Palindromic Repeats
Germ Layers
7 引用 (Scopus)

The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy

Nakamoto, F. K., Okamoto, S., Mitsui, J., Sone, T., Ishikawa, M., Yamamoto, Y., Kanegae, Y., Nakatake, Y., Imaizumi, K., Ishiura, H., Tsuji, S. & Okano, H., 2018 12 1, : : Scientific Reports. 8, 1, 14215.

研究成果: Article

coenzyme Q10
Multiple System Atrophy
Induced Pluripotent Stem Cells
Neurons
Clustered Regularly Interspaced Short Palindromic Repeats
2017
7 引用 (Scopus)

Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium

Yamaguchi, M., Steward, M. C., Smallbone, K., Sohma, Y., Yamamoto, A., Ko, S., Kondo, T. & Ishiguro, H., 2017, (Accepted/In press) : : Journal of Physiology.

研究成果: Article

Fluids and Secretions
Pancreatic Ducts
Chloride-Bicarbonate Antiporters
Bicarbonates
Cystic Fibrosis Transmembrane Conductance Regulator
37 引用 (Scopus)

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T. および19人, Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J. I., Duchen, M. R., Nam, J. M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. & Fujita, Y., 2017 5 1, : : Nature Cell Biology. 19, 5, p. 530-541 12 p.

研究成果: Article

Epithelial Cells
Filamins
Mitochondrial Membrane Potential
Intestinal Mucosa
Lactic Acid
2 引用 (Scopus)
Colorectal Neoplasms
Stem Cells
Research
Organoids
Intestinal Mucosa
11 引用 (Scopus)

Endocytoscopy can be used to assess histological healing in ulcerative colitis

Nakazato, Y., Naganuma, M., Sugimoto, S., Bessho, R., Arai, M., Kiyohara, H., Ono, K., Nanki, K., Mutaguchi, M., Mizuno, S., Kobayashi, T., Hosoe, N., Shimoda, M., Abe, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2017 3 13, (Accepted/In press) : : Endoscopy.

研究成果: Article

Ulcerative Colitis
Rectum
Biopsy
Light
13 引用 (Scopus)
Mucous Membrane
Sigmoid Colon
Colonoscopy
Ulcerative Colitis
Rectum

Epigenetic barrier against the propagation of fluctuating gene expression in embryonic stem cells

Saito, Y., Kunitomi, A., Seki, T., Tohyama, S., Kusumoto, D., Takei, M., Kashimura, S., Hashimoto, H., Yozu, G., Motoda, C., Shimojima, M., Egashira, T., Oda, M., Fukuda, K. & Yuasa, S., 2017 9 1, : : FEBS Letters. 591, 18, p. 2879-2889 11 p.

研究成果: Letter

Embryonic Stem Cells
Stem cells
Epigenomics
Gene expression
Gene Expression
1 引用 (Scopus)

Epigenetic Manipulation Facilitates the Generation of Skeletal Muscle Cells from Pluripotent Stem Cells

Akiyama, T., Wakabayashi, S., Soma, A., Sato, S., Nakatake, Y., Oda, M., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S. & Ko, M., 2017, : : Stem Cells International. 2017, 7215010.

研究成果: Review article

Pluripotent Stem Cells
Epigenomics
Muscle Cells
Skeletal Muscle
Transcription Factors
6 引用 (Scopus)

Establishment of 3D intestinal organoid cultures from intestinal stem cells

Sugimoto, S. & Sato, T., 2017, Methods in Molecular Biology. Humana Press Inc., 巻 1612. p. 97-105 9 p. (Methods in Molecular Biology; 巻数 1612).

研究成果: Chapter

Organoids
Intestinal Mucosa
Stem Cells
Genetic Models
Mammals
7 引用 (Scopus)
Lacrimal Apparatus
Pluripotent Stem Cells
Transcription Factors
Epithelium
Microarray Analysis
21 引用 (Scopus)

IL-22BP dictates characteristics of Peyer's patch follicleassociated epithelium for antigen uptake

Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H. & Ohno, H., 2017 6 1, : : Journal of Experimental Medicine. 214, 6, p. 1607-1618 12 p.

研究成果: Article

Peyer's Patches
Carrier Proteins
Epithelium
Antigens
interleukin-22
15 引用 (Scopus)

Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice

Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., Suda, W., Hattori, M., Amagai, M., Ohyama, M. & Kanai, T., 2017 8 15, : : Cell Reports. 20, 7, p. 1513-1524 12 p.

研究成果: Article

Dysbiosis
Alopecia
Lactobacillus
Biotin
Physiology
2 引用 (Scopus)

Intestinal Epithelial Lgr5+ Stem Cell Niche and Organoids

Sasaki, N., Sato, T. & Clevers, H., 2017 4 14, Biology and Engineering of Stem Cell Niches. Elsevier Inc., p. 111-125 15 p.

研究成果: Chapter

Organoids
Stem Cell Niche
Stem cells
Stem Cells
Precision Medicine
9 引用 (Scopus)

Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors

Matsushita, M., Nakatake, Y., Arai, I., Ibata, K., Kohda, K., Goparaju, S. K., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S., Kanai, T., Yuzaki, M. & Ko, M., 2017 5 31, (Accepted/In press) : : Biochemical and Biophysical Research Communications.

研究成果: Article

Stem cells
Transgenes
Transcription Factors
Neurons
Doxycycline
20 引用 (Scopus)

Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors

Goparaju, S. K., Kohda, K., Ibata, K., Soma, A., Nakatake, Y., Akiyama, T., Wakabayashi, S., Matsushita, M., Sakota, M., Kimura, H., Yuzaki, M., Ko, S. & Ko, M., 2017 2 13, : : Scientific Reports. 7, 42367.

研究成果: Article

Pluripotent Stem Cells
Transcription Factors
Neurons
Messenger RNA
Preclinical Drug Evaluations

Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells

Arai, Y., Takahashi, D., Asano, K., Tanaka, M., Oda, M., Ko, S., Ko, M., Mandai, S., Nomura, N., Rai, T., Uchida, S. & Sohara, E., 2017 1 1, : : Scientific Reports. 7, 46580.

研究成果: Article

Janus Kinase 1
C Chemokines
STAT1 Transcription Factor
Interferon-gamma
Salts
29 引用 (Scopus)

SCODE: An efficient regulatory network inference algorithm from single-cell RNA-Seq during differentiation

Matsumoto, H., Kiryu, H., Furusawa, C., Ko, M., Ko, S., Gouda, N., Hayashi, T. & Nikaido, I., 2017 8 1, : : Bioinformatics. 33, 15, p. 2314-2321 8 p.

研究成果: Article

Regulatory Networks
RNA
Cell
Genes
Ordinary differential equations