坂口光洋記念講座

研究成果

2020

Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine

Sato, T., Sase, M., Ishikawa, S., Kajita, M., Asano, J., Sato, T., Mori, Y. & Ohteki, T., 2020 12 1, : : Scientific reports. 10, 1, 8308.

研究成果: Article

公開

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., Kanai, T. & Sato, T., 2020 2, : : Gastroenterology. 158, 3, p. 638-651.e8

研究成果: Article

6 引用 (Scopus)

Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis

Yoshimatsu, Y., Naganuma, M., Sugimoto, S., Tanemoto, S., Umeda, S., Fukuda, T., Nomura, E., Yoshida, K., Ono, K., Mutaguchi, M., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Takabayashi, K., Ogata, H., Iwao, Y. & Kanai, T., 2020 7 1, : : Digestion. 101, 4, p. 492-498 7 p.

研究成果: Article

1 引用 (Scopus)

Development of a Scalable Coculture System for Gut Anaerobes and Human Colon Epithelium

Sasaki, N., Miyamoto, K., Maslowski, K. M., Ohno, H., Kanai, T. & Sato, T., 2020 7, : : Gastroenterology. 159, 1, p. 388-390.e5

研究成果: Article

公開
1 引用 (Scopus)

Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells

Tanosaki, S., Tohyama, S., Fujita, J., Someya, S., Hishiki, T., Matsuura, T., Nakanishi, H., Ohto-Nakanishi, T., Akiyama, T., Morita, Y., Kishino, Y., Okada, M., Tani, H., Soma, Y., Nakajima, K., Kanazawa, H., Sugimoto, M., Ko, M. S. H., Suematsu, M. & Fukuda, K., 2020 9 25, : : iScience. 23, 9, 101535.

研究成果: Article

公開

Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors

Nakatake, Y., Ko, S. B. H., Sharov, A. A., Wakabayashi, S., Murakami, M., Sakota, M., Chikazawa, N., Ookura, C., Sato, S., Ito, N., Ishikawa-Hirayama, M., Mak, S. S., Jakt, L. M., Ueno, T., Hiratsuka, K., Matsushita, M., Goparaju, S. K., Akiyama, T., Ishiguro, K. I., Oda, M. および7人, Gouda, N., Umezawa, A., Akutsu, H., Nishimura, K., Matoba, R., Ohara, O. & Ko, M. S. H., 2020 5 19, : : Cell Reports. 31, 7, 107655.

研究成果: Article

公開

Identification and local manipulation of bone marrow vasculature during intravital imaging

Morikawa, T., Tamaki, S., Fujita, S., Suematsu, M. & Takubo, K., 2020 12 1, : : Scientific reports. 10, 1, 6422.

研究成果: Article

公開
3 引用 (Scopus)

Linking human intestinal scaffolds and organoids to combat intestinal failure

Fujii, M., Sugimoto, S. & Sato, T., 2020 10 1, : : Nature medicine. 26, 10, p. 1517-1518 2 p.

研究成果: Comment/debate

MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells

Ishiguro, K. I., Matsuura, K., Tani, N., Takeda, N., Usuki, S., Yamane, M., Sugimoto, M., Fujimura, S., Hosokawa, M., Chuma, S., Ko, M. S. H., Araki, K. & Niwa, H., 2020 2 24, : : Developmental Cell. 52, 4, p. 429-445.e10

研究成果: Article

7 引用 (Scopus)

Mucosal concentrations of N-acetyl-5-aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine

Fukuda, T., Naganuma, M., Takabayashi, K., Hagihara, Y., Tanemoto, S., Nomura, E., Yoshimatsu, Y., Sugimoto, S., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Mutaguchi, M., Inoue, N., Ogata, H., Iwao, Y., Abe, T. & Kanai, T., 2020, (Accepted/In press) : : Journal of Gastroenterology and Hepatology (Australia).

研究成果: Article

公開
1 引用 (Scopus)

Of infliximab with long-term administration in Japanese patients with Crohn's disease: Analysis using population pharmacokinetics

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Nagauma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2020, : : International journal of clinical pharmacology and therapeutics. 58, 2, p. 89-102 14 p.

研究成果: Article

Organoid derivation and orthotopic xenotransplantation for studying human intestinal stem cell dynamics

Sugimoto, S., Fujii, M. & Sato, T., 2020, Methods in Molecular Biology. Humana Press Inc., p. 303-320 18 p. (Methods in Molecular Biology; 巻数 2171).

研究成果: Chapter

Racial disparities in COVID-19 deaths reveal harsh truths about structural inequality in America

Anyane-Yeboa, A., Sato, T. & Sakuraba, A., 2020 10 1, : : Journal of Internal Medicine. 288, 4, p. 479-480 2 p.

研究成果: Letter

公開
2 引用 (Scopus)

Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages

Sato, T., Ishikawa, S., Asano, J., Yamamoto, H., Fujii, M., Sato, T., Yamamoto, K., Kitagaki, K., Akashi, T., Okamoto, R. & Ohteki, T., 2020 8 1, : : Nature Cell Biology. 22, 8, p. 919-926 8 p.

研究成果: Article

1 引用 (Scopus)

Significance of Conducting 2 Types of Fecal Tests in Patients With Ulcerative Colitis

Naganuma, M., Kobayashi, T., Nasuno, M., Motoya, S., Kato, S., Matsuoka, K., Hokari, R., Watanabe, C., Sakamoto, H., Yamamoto, H., Sasaki, M., Watanabe, K., Iijima, H., Endo, Y., Ichikawa, H., Ozeki, K., Tanida, S., Ueno, N., Fujiya, M., Sako, M. および6人, Takeuchi, K., Sugimoto, S., Abe, T., Hibi, T., Suzuki, Y. & Kanai, T., 2020 5, : : Clinical Gastroenterology and Hepatology. 18, 5, p. 1102-1111.e5

研究成果: Article

公開
1 引用 (Scopus)
公開

Somatic inflammatory gene mutations in human ulcerative colitis epithelium

Nanki, K., Fujii, M., Shimokawa, M., Matano, M., Nishikori, S., Date, S., Takano, A., Toshimitsu, K., Ohta, Y., Takahashi, S., Sugimoto, S., Ishimaru, K., Kawasaki, K., Nagai, Y., Ishii, R., Yoshida, K., Sasaki, N., Hibi, T., Ishihara, S., Kanai, T. および1人, Sato, T., 2020 1 9, : : Nature. 577, 7789, p. 254-259 6 p.

研究成果: Article

16 引用 (Scopus)
2019
4 引用 (Scopus)

ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation

Watanuki, S., Kobayashi, H., Sorimachi, Y., Yamamoto, M., Okamoto, S. & Takubo, K., 2019 6 18, : : Biochemical and Biophysical Research Communications. 514, 1, p. 287-294 8 p.

研究成果: Article

Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia

Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 5 16, : : Oncogene. 38, 20, p. 3962-3969 8 p.

研究成果: Article

2 引用 (Scopus)

Efficacy of therapeutic intervention for patients with an ulcerative colitis mayo endoscopic score of 1

Fukuda, T., Naganuma, M., Sugimoto, S., Ono, K., Nanki, K., Mizuno, S., Kimura, K., Mutaguchi, M., Nakazato, Y., Takabayashi, K., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2019 3 14, : : Inflammatory bowel diseases. 25, 4, p. 782-788 7 p.

研究成果: Article

5 引用 (Scopus)

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate-Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., Suematsu, M., Shimizu, T. & Takubo, K., 2019 7 2, : : Cell Reports. 28, 1, p. 145-158.e9

研究成果: Article

公開
8 引用 (Scopus)

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

Nagai, M., Noguchi, R., Takahashi, D., Morikawa, T., Koshida, K., Komiyama, S., Ishihara, N., Yamada, T., Kawamura, Y. I., Muroi, K., Hattori, K., Kobayashi, N., Fujimura, Y., Hirota, M., Matsumoto, R., Aoki, R., Tamura-Nakano, M., Sugiyama, M., Katakai, T., Sato, S. および3人, Takubo, K., Dohi, T. & Hase, K., 2019 8 22, : : Cell. 178, 5, p. 1072-1087.e14

研究成果: Article

22 引用 (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P. S., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. および2人, Sato, T. & Kanai, T., 2019 3 1, : : Nature Microbiology. 4, 3, p. 492-503 12 p.

研究成果: Article

40 引用 (Scopus)

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M. S. H., Tada, N., Okano, H. & Akamatsu, W., 2019 2 12, : : Stem cell reports. 12, 2, p. 305-318 14 p.

研究成果: Article

5 引用 (Scopus)

Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors

Hiratsuka, K., Monkawa, T., Akiyama, T., Nakatake, Y., Oda, M., Goparaju, S. K., Kimura, H., Chikazawa-Nohtomi, N., Sato, S., Ishiguro, K., Yamaguchi, S., Suzuki, S., Morizane, R., Ko, S. B. H., Itoh, H. & Ko, M. S. H., 2019 12 1, : : Scientific reports. 9, 1, 913.

研究成果: Article

6 引用 (Scopus)

Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis

Matsui, S., Okabayashi, K., Tsuruta, M., Shigeta, K., Seishima, R., Ishida, T., Kondo, T., Suzuki, Y., Hasegawa, H., Shimoda, M., Sugimoto, S., Sato, T. & Kitagawa, Y., 2019 7, : : Cancer science. 110, 7, p. 2156-2165 10 p.

研究成果: Article

公開
5 引用 (Scopus)
1 引用 (Scopus)

In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN

Ishii, T., Ishikawa, M., Fujimori, K., Maeda, T., Kushima, I., Arioka, Y., Mori, D., Nakatake, Y., Yamagata, B., Nio, S., Kato, T. A., Yang, N., Wernig, M., Kanba, S., Mimura, M., Ozaki, N. & Okano, H., 2019, : : eNeuro. 6, 5, ENEURO.0403-18.2019.

研究成果: Article

公開
5 引用 (Scopus)

Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine

Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M. および5人, Ohtsuka, K., Mochizuki, M., Watanabe, M., Hashiguchi, M. & Kanai, T., 2019 10 1, : : Journal of Gastroenterology and Hepatology (Australia). 34, 10, p. 1751-1757 7 p.

研究成果: Article

5 引用 (Scopus)

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression

Nakatsukasa, H., Oda, M., Yin, J., Chikuma, S., Ito, M., Koga-Iizuka, M., Someya, K., Kitagawa, Y., Ohkura, N., Sakaguchi, S., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Yamanaka, S., Takamura-Enya, T., Lu, Q. & Yoshimura, A., 2019 1 1, : : International immunology. 31, 5, p. 335-347 13 p.

研究成果: Article

8 引用 (Scopus)

Modeling Human Digestive Diseases With CRISPR-Cas9–Modified Organoids

Fujii, M., Clevers, H. & Sato, T., 2019 2 1, : : Gastroenterology. 156, 3, p. 562-576 15 p.

研究成果: Review article

20 引用 (Scopus)

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients

Higashikuse, Y., Mittal, N., Arimura, T., Yoon, S. H., Oda, M., Enomoto, H., Kaneda, R., Hattori, F., Suzuki, T., Kawakami, A., Gasch, A., Furukawa, T., Labeit, S., Fukuda, K., Kimura, A. & Makino, S., 2019, : : DMM Disease Models and Mechanisms. 12, 11, dmm.041103.

研究成果: Article

公開
1 引用 (Scopus)

Potential involvement of semaphorin 3A in maintaining intervertebral disc tissue homeostasis

Mima, Y., Suzuki, S., Fujii, T., Morikawa, T., Tamaki, S., Takubo, K., Shimoda, M., Miyamoto, T., Watanabe, K., Matsumoto, M., Nakamura, M. & Fujita, N., 2019 4, : : Journal of Orthopaedic Research. 37, 4, p. 972-980 9 p.

研究成果: Article

1 引用 (Scopus)
2018

Advancing Intestinal Organoid Technology Toward Regenerative Medicine

Nakamura, T. & Sato, T., 2018, : : CMGH. 5, 1, p. 51-60 10 p.

研究成果: Review article

37 引用 (Scopus)

Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling

Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R. & Ohno, H., 2018 2 1, : : Journal of Experimental Medicine. 215, 2, p. 501-519 19 p.

研究成果: Article

26 引用 (Scopus)

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S. および3人, Koo, B. K., Kanai, T. & Sato, T., 2018 8 9, : : Cell. 174, 4, p. 856-869.e17

研究成果: Article

48 引用 (Scopus)
44 引用 (Scopus)

Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing

Akiyama, T., Sato, S., Chikazawa-Nohtomi, N., Soma, A., Kimura, H., Wakabayashi, S., Ko, S. B. H. & Ko, M. S. H., 2018 12 1, : : Scientific reports. 8, 1, 1189.

研究成果: Article

4 引用 (Scopus)

Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors 10 Technology 1004 Medical Biotechnology

Ida, H., Akiyama, T., Ishiguro, K., Goparaju, S. K., Nakatake, Y., Chikazawa-Nohtomi, N., Sato, S., Kimura, H., Yokoyama, Y., Nagino, M., Ko, M. S. H. & Ko, S. B. H., 2018 10 25, : : Stem Cell Research and Therapy. 9, 1, 277.

研究成果: Article

5 引用 (Scopus)

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

Loomans, C. J. M., Williams Giuliani, N., Balak, J., Ringnalda, F., van Gurp, L., Huch, M., Boj, S. F., Sato, T., Kester, L., de Sousa Lopes, S. M. C., Roost, M. S., Bonner-Weir, S., Engelse, M. A., Rabelink, T. J., Heimberg, H., Vries, R. G. J., van Oudenaarden, A., Carlotti, F., Clevers, H. & de Koning, E. J. P., 2018 3 13, : : Stem cell reports. 10, 3, p. 712-724 13 p.

研究成果: Article

36 引用 (Scopus)

Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2018 10, : : PloS one. 13, 10, e0204632.

研究成果: Article

2 引用 (Scopus)

Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Nanki, K., Mizuno, S., Matsuoka, K., Ono, K., Sugimoto, S., Kiyohara, H., Arai, M., Nakashima, M., Takeshita, K., Saigusa, K., Senoh, M., Fukuda, T., Naganuma, M., Kato, H., Suda, W., Hattori, M. & Kanai, T., 2018, : : Intestinal Research. 16, 1, p. 142-146 5 p.

研究成果: Article

2 引用 (Scopus)

Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation

Baba, M., Endoh, M., Ma, W., Toyama, H., Hirayama, A., Nishikawa, K., Takubo, K., Hano, H., Hasumi, H., Umemoto, T., Hashimoto, M., Irie, N., Esumi, C., Kataoka, M., Nakagata, N., Soga, T., Yao, M., Kamba, T., Minami, T., Ishii, M. および1人, Suda, T., 2018 10, : : Journal of Bone and Mineral Research. 33, 10, p. 1785-1798 14 p.

研究成果: Article

11 引用 (Scopus)
9 引用 (Scopus)

Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells

Si, S., Nakajima-Takagi, Y., Iga, T., Tsuji, M., Hou, L., Oshima, M., Koide, S., Saraya, A., Yamazaki, S., Takubo, K., Kubota, Y., Minamino, T. & Iwama, A., 2018 7, : : Experimental Hematology. 63, p. 41-51.e1

研究成果: Article

4 引用 (Scopus)