坂口光洋記念講座

研究成果

2020

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., Kanai, T. & Sato, T., 2020 2, : : Gastroenterology. 158, 3, p. 638-651.e8

研究成果: Article

4 引用 (Scopus)
1 引用 (Scopus)

MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells

Ishiguro, K. I., Matsuura, K., Tani, N., Takeda, N., Usuki, S., Yamane, M., Sugimoto, M., Fujimura, S., Hosokawa, M., Chuma, S., Ko, M. S. H., Araki, K. & Niwa, H., 2020 2 24, : : Developmental Cell. 52, 4, p. 429-445.e10

研究成果: Article

2 引用 (Scopus)

Mucosal concentrations of N-acetyl-5-aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine

Fukuda, T., Naganuma, M., Takabayashi, K., Hagihara, Y., Tanemoto, S., Nomura, E., Yoshimatsu, Y., Sugimoto, S., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Mutaguchi, M., Inoue, N., Ogata, H., Iwao, Y., Abe, T. & Kanai, T., 2020 1 1, (Accepted/In press) : : Journal of Gastroenterology and Hepatology (Australia).

研究成果: Article

公開

Of infliximab with long-term administration in Japanese patients with Crohn's disease: Analysis using population pharmacokinetics

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Nagauma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2020 1 1, : : International journal of clinical pharmacology and therapeutics. 58, 2, p. 89-102 14 p.

研究成果: Article

Somatic inflammatory gene mutations in human ulcerative colitis epithelium

Nanki, K., Fujii, M., Shimokawa, M., Matano, M., Nishikori, S., Date, S., Takano, A., Toshimitsu, K., Ohta, Y., Takahashi, S., Sugimoto, S., Ishimaru, K., Kawasaki, K., Nagai, Y., Ishii, R., Yoshida, K., Sasaki, N., Hibi, T., Ishihara, S., Kanai, T. および1人, Sato, T., 2020 1 9, : : Nature. 577, 7789, p. 254-259 6 p.

研究成果: Article

3 引用 (Scopus)
2019
2 引用 (Scopus)

Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia

Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 5 16, : : Oncogene. 38, 20, p. 3962-3969 8 p.

研究成果: Article

2 引用 (Scopus)

Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis

Yoshimatsu, Y., Naganuma, M., Sugimoto, S., Tanemoto, S., Umeda, S., Fukuda, T., Nomura, E., Yoshida, K., Ono, K., Mutaguchi, M., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Takabayashi, K., Ogata, H., Iwao, Y. & Kanai, T., 2019 1 1, : : Digestion.

研究成果: Article

1 引用 (Scopus)

Efficacy of therapeutic intervention for patients with an ulcerative colitis mayo endoscopic score of 1

Fukuda, T., Naganuma, M., Sugimoto, S., Ono, K., Nanki, K., Mizuno, S., Hukuhara, K., Mutaguchi, M., Nakazato, Y., Takabayashi, K., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2019 3 14, : : Inflammatory bowel diseases. 25, 4, p. 782-788 7 p.

研究成果: Article

4 引用 (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P. S., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. および2人, Sato, T. & Kanai, T., 2019 3 1, : : Nature Microbiology. 4, 3, p. 492-503 12 p.

研究成果: Article

25 引用 (Scopus)

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M., Tada, N., Okano, H. & Akamatsu, W., 2019 2 12, : : Stem Cell Reports. 12, 2, p. 305-318 14 p.

研究成果: Article

3 引用 (Scopus)

Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors

Hiratsuka, K., Monkawa, T., Akiyama, T., Nakatake, Y., Oda, M., Goparaju, S. K., Kimura, H., Chikazawa-Nohtomi, N., Sato, S., Ishiguro, K., Yamaguchi, S., Suzuki, S., Morizane, R., Ko, S., Itoh, H. & Ko, M. S. H., 2019 12 1, : : Scientific Reports. 9, 1, 913.

研究成果: Article

5 引用 (Scopus)

Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis

Matsui, S., Okabayashi, K., Tsuruta, M., Shigeta, K., Seishima, R., Ishida, T., Kondo, T., Suzuki, Y., Hasegawa, H., Shimoda, M., Sugimoto, S., Sato, T. & Kitagawa, Y., 2019 7 1, : : Cancer science. 110, 7, p. 2156-2165 10 p.

研究成果: Article

公開
4 引用 (Scopus)

In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN

Ishii, T., Ishikawa, M., Fujimori, K., Maeda, T., Kushima, I., Arioka, Y., Mori, D., Nakatake, Y., Yamagata, B., Nio, S., Kato, T. A., Yang, N., Wernig, M., Kanba, S., Mimura, M., Ozaki, N. & Okano, H., 2019 1 1, : : eNeuro. 6, 5, ENEURO.0403-18.2019.

研究成果: Article

公開
4 引用 (Scopus)

Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine

Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M. および5人, Ohtsuka, K., Mochizuki, M., Watanabe, M., Hashiguchi, M. & Kanai, T., 2019 1 1, : : Journal of Gastroenterology and Hepatology (Australia).

研究成果: Review article

3 引用 (Scopus)

Modeling Human Digestive Diseases With CRISPR-Cas9–Modified Organoids

Fujii, M., Clevers, H. & Sato, T., 2019 2 1, : : Gastroenterology. 156, 3, p. 562-576 15 p.

研究成果: Review article

14 引用 (Scopus)
2018

Advancing Intestinal Organoid Technology Toward Regenerative Medicine

Nakamura, T. & Sato, T., 2018 1 1, : : CMGH. 5, 1, p. 51-60 10 p.

研究成果: Review article

31 引用 (Scopus)

Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling

Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R. & Ohno, H., 2018 2 1, : : Journal of Experimental Medicine. 215, 2, p. 501-519 19 p.

研究成果: Article

23 引用 (Scopus)

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S. および3人, Koo, B. K., Kanai, T. & Sato, T., 2018 8 9, : : Cell. 174, 4, p. 856-869.e17

研究成果: Article

35 引用 (Scopus)
34 引用 (Scopus)

Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing

Akiyama, T., Sato, S., Chikazawa-Nohtomi, N., Soma, A., Kimura, H., Wakabayashi, S., Ko, S. & Ko, M., 2018 12 1, : : Scientific Reports. 8, 1, 1189.

研究成果: Article

3 引用 (Scopus)

Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors 10 Technology 1004 Medical Biotechnology

Ida, H., Akiyama, T., Ishiguro, K., Goparaju, S. K., Nakatake, Y., Chikazawa-Nohtomi, N., Sato, S., Kimura, H., Yokoyama, Y., Nagino, M., Ko, M. S. H. & Ko, S. B. H., 2018 10 25, : : Stem Cell Research and Therapy. 9, 1, 277.

研究成果: Article

3 引用 (Scopus)

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

Loomans, C. J. M., Williams Giuliani, N., Balak, J., Ringnalda, F., van Gurp, L., Huch, M., Boj, S. F., Sato, T., Kester, L., de Sousa Lopes, S. M. C., Roost, M. S., Bonner-Weir, S., Engelse, M. A., Rabelink, T. J., Heimberg, H., Vries, R. G. J., van Oudenaarden, A., Carlotti, F., Clevers, H. & de Koning, E. J. P., 2018 3 13, : : Stem cell reports. 10, 3, p. 712-724 13 p.

研究成果: Article

31 引用 (Scopus)

Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2018 10 1, : : PLoS One. 13, 10, e0204632.

研究成果: Article

1 引用 (Scopus)

Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Nanki, K., Mizuno, S., Matsuoka, K., Ono, K., Sugimoto, S., Kiyohara, H., Arai, M., Nakashima, M., Takeshita, K., Saigusa, K., Senoh, M., Fukuda, T., Naganuma, M., Kato, H., Suda, W., Hattori, M. & Kanai, T., 2018 1 1, : : Intestinal Research. 16, 1, p. 142-146 5 p.

研究成果: Article

2 引用 (Scopus)
9 引用 (Scopus)

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Fujii, M., Matano, M., Toshimitsu, K., Takano, A., Mikami, Y., Nishikori, S., Sugimoto, S. & Sato, T., 2018 12 6, : : Cell Stem Cell. 23, 6, p. 787-793.e6

研究成果: Article

25 引用 (Scopus)

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Seino, T., Kawasaki, S., Shimokawa, M., Tamagawa, H., Toshimitsu, K., Fujii, M., Ohta, Y., Matano, M., Nanki, K., Kawasaki, K., Takahashi, S., Sugimoto, S., Iwasaki, E., Takagi, J., Itoi, T., Kitago, M., Kitagawa, Y., Kanai, T. & Sato, T., 2018 1 1, (Accepted/In press) : : Cell Stem Cell.

研究成果: Article

96 引用 (Scopus)

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 12 1, : : Scientific Reports. 8, 1, 2821.

研究成果: Article

10 引用 (Scopus)

Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites

Mito, A., Nakano, Y., Saitoh, T., Gouraud, S. S. S., Yamaguchi, Y., Sato, T., Sasaki, N. & Kojima-Aikawa, K., 2018 1 1, : : Glycobiology. 28, 1, p. 21-31 11 p.

研究成果: Article

4 引用 (Scopus)

Reconstruction of the Human Colon Epithelium In Vivo

Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., Kanai, T. & Sato, T., 2018 2 1, : : Cell Stem Cell. 22, 2, p. 171-176.e5

研究成果: Article

32 引用 (Scopus)

Selective modulation of local linkages between active transcription and oxidative demethylation activity shapes cardiomyocyte-specific gene-body epigenetic status in mice

Oda, M., Wakabayashi, S., Ari Wijetunga, N., Yuasa, S., Enomoto, H., Kaneda, R., Yoon, S. H., Mittal, N., Jing, Q., Suzuki, M., Greally, J. M., Fukuda, K. & Makino, S., 2018 5 10, : : BMC Genomics. 19, 1, 349.

研究成果: Article

Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification

Sadahiro, T., Isomi, M., Muraoka, N., Kojima, H., Haginiwa, S., Kurotsu, S., Tamura, F., Tani, H., Tohyama, S., Fujita, J., Miyoshi, H., Kawamura, Y., Goshima, N., Iwasaki, Y., Murano, K., Saito, K., Oda, M., Andersen, P., Kwon, C., Uosaki, H. および3人, Nishizono, H., Fukuda, K. & Ieda, M., 2018 9 6, : : Cell Stem Cell. 23, 3, p. 382-395 14 p.

研究成果: Article

10 引用 (Scopus)

The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy

Nakamoto, F. K., Okamoto, S., Mitsui, J., Sone, T., Ishikawa, M., Yamamoto, Y., Kanegae, Y., Nakatake, Y., Imaizumi, K., Ishiura, H., Tsuji, S. & Okano, H., 2018 12 1, : : Scientific Reports. 8, 1, 14215.

研究成果: Article

8 引用 (Scopus)
2017

Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium

Yamaguchi, M., Steward, M. C., Smallbone, K., Sohma, Y., Yamamoto, A., Ko, S. B. H., Kondo, T. & Ishiguro, H., 2017 3 15, : : Journal of Physiology. 595, 6, p. 1947-1972 26 p.

研究成果: Article

8 引用 (Scopus)

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T. および19人, Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J. I., Duchen, M. R., Nam, J. M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. & Fujita, Y., 2017 5 1, : : Nature Cell Biology. 19, 5, p. 530-541 12 p.

研究成果: Article

46 引用 (Scopus)
2 引用 (Scopus)

Endocytoscopy can be used to assess histological healing in ulcerative colitis

Nakazato, Y., Naganuma, M., Sugimoto, S., Bessho, R., Arai, M., Kiyohara, H., Ono, K., Nanki, K., Mutaguchi, M., Mizuno, S., Kobayashi, T., Hosoe, N., Shimoda, M., Abe, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2017 3 13, (Accepted/In press) : : Endoscopy.

研究成果: Article

13 引用 (Scopus)
13 引用 (Scopus)

Epigenetic barrier against the propagation of fluctuating gene expression in embryonic stem cells

Saito, Y., Kunitomi, A., Seki, T., Tohyama, S., Kusumoto, D., Takei, M., Kashimura, S., Hashimoto, H., Yozu, G., Motoda, C., Shimojima, M., Egashira, T., Oda, M., Fukuda, K. & Yuasa, S., 2017 9 1, : : FEBS Letters. 591, 18, p. 2879-2889 11 p.

研究成果: Letter

Epigenetic Manipulation Facilitates the Generation of Skeletal Muscle Cells from Pluripotent Stem Cells

Akiyama, T., Wakabayashi, S., Soma, A., Sato, S., Nakatake, Y., Oda, M., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S. & Ko, M., 2017, : : Stem Cells International. 2017, 7215010.

研究成果: Review article

2 引用 (Scopus)

Establishment of 3D intestinal organoid cultures from intestinal stem cells

Sugimoto, S. & Sato, T., 2017, Methods in Molecular Biology. Humana Press Inc., 巻 1612. p. 97-105 9 p. (Methods in Molecular Biology; 巻数 1612).

研究成果: Chapter

9 引用 (Scopus)

Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos

Ishiguro, K. I., Nakatake, Y., Chikazawa-Nohtomi, N., Kimura, H., Akiyama, T., Oda, M., Ko, S. B. H. & Ko, M. S. H., 2017 2 1, : : In Vitro Cellular and Developmental Biology - Animal. 53, 2, p. 179-190 12 p.

研究成果: Article

1 引用 (Scopus)

Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells

Hirayama, M., Ko, S., Kawakita, T., Akiyama, T., Goparaju, S. K., Soma, A., Nakatake, Y., Sakota, M., Chikazawa-Nohtomi, N., Shimmura, S., Tsubota, K. & Ko, M., 2017 12 1, : : npj Aging and Mechanisms of Disease. 3, 1, 1.

研究成果: Article

9 引用 (Scopus)

IL-22BP dictates characteristics of Peyer's patch follicleassociated epithelium for antigen uptake

Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H. & Ohno, H., 2017 6 1, : : Journal of Experimental Medicine. 214, 6, p. 1607-1618 12 p.

研究成果: Article

23 引用 (Scopus)