坂口光洋記念講座

研究成果

2017

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T. および19人, Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J. I., Duchen, M. R., Nam, J. M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. & Fujita, Y., 2017 5 1, : : Nature Cell Biology. 19, 5, p. 530-541 12 p.

研究成果: Article

48 引用 (Scopus)
2 引用 (Scopus)

Endocytoscopy can be used to assess histological healing in ulcerative colitis

Nakazato, Y., Naganuma, M., Sugimoto, S., Bessho, R., Arai, M., Kiyohara, H., Ono, K., Nanki, K., Mutaguchi, M., Mizuno, S., Kobayashi, T., Hosoe, N., Shimoda, M., Abe, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2017 3 13, (Accepted/In press) : : Endoscopy.

研究成果: Article

13 引用 (Scopus)
13 引用 (Scopus)

Epigenetic barrier against the propagation of fluctuating gene expression in embryonic stem cells

Saito, Y., Kunitomi, A., Seki, T., Tohyama, S., Kusumoto, D., Takei, M., Kashimura, S., Hashimoto, H., Yozu, G., Motoda, C., Shimojima, M., Egashira, T., Oda, M., Fukuda, K. & Yuasa, S., 2017 9 1, : : FEBS Letters. 591, 18, p. 2879-2889 11 p.

研究成果: Letter

Epigenetic Manipulation Facilitates the Generation of Skeletal Muscle Cells from Pluripotent Stem Cells

Akiyama, T., Wakabayashi, S., Soma, A., Sato, S., Nakatake, Y., Oda, M., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S. B. H. & Ko, M. S. H., 2017, : : Stem Cells International. 2017, 7215010.

研究成果: Review article

2 引用 (Scopus)

Establishment of 3D intestinal organoid cultures from intestinal stem cells

Sugimoto, S. & Sato, T., 2017, Methods in Molecular Biology. Humana Press Inc., 巻 1612. p. 97-105 9 p. (Methods in Molecular Biology; 巻数 1612).

研究成果: Chapter

9 引用 (Scopus)

Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos

Ishiguro, K. I., Nakatake, Y., Chikazawa-Nohtomi, N., Kimura, H., Akiyama, T., Oda, M., Ko, S. B. H. & Ko, M. S. H., 2017 2 1, : : In Vitro Cellular and Developmental Biology - Animal. 53, 2, p. 179-190 12 p.

研究成果: Article

1 引用 (Scopus)

Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells

Hirayama, M., Ko, S., Kawakita, T., Akiyama, T., Goparaju, S. K., Soma, A., Nakatake, Y., Sakota, M., Chikazawa-Nohtomi, N., Shimmura, S., Tsubota, K. & Ko, M. S. H., 2017 12 1, : : npj Aging and Mechanisms of Disease. 3, 1, 1.

研究成果: Article

9 引用 (Scopus)

IL-22BP dictates characteristics of Peyer's patch follicleassociated epithelium for antigen uptake

Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H. & Ohno, H., 2017 6 1, : : Journal of Experimental Medicine. 214, 6, p. 1607-1618 12 p.

研究成果: Article

23 引用 (Scopus)

Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice

Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., Suda, W., Hattori, M., Amagai, M., Ohyama, M. & Kanai, T., 2017 8 15, : : Cell Reports. 20, 7, p. 1513-1524 12 p.

研究成果: Article

22 引用 (Scopus)

Intestinal Epithelial Lgr5+ Stem Cell Niche and Organoids

Sasaki, N., Sato, T. & Clevers, H., 2017 4 14, Biology and Engineering of Stem Cell Niches. Elsevier Inc., p. 111-125 15 p.

研究成果: Chapter

2 引用 (Scopus)

Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors

Matsushita, M., Nakatake, Y., Arai, I., Ibata, K., Kouda, K., Goparaju, S. K., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S., Kanai, T., Yuzaki, M. & Ko, M. S. H., 2017 5 31, (Accepted/In press) : : Biochemical and Biophysical Research Communications.

研究成果: Article

12 引用 (Scopus)

Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors

Goparaju, S. K., Kouda, K., Ibata, K., Soma, A., Nakatake, Y., Akiyama, T., Wakabayashi, S., Matsushita, M., Sakota, M., Kimura, H., Yuzaki, M., Ko, S. B. H. & Ko, M. S. H., 2017 2 13, : : Scientific reports. 7, 42367.

研究成果: Article

27 引用 (Scopus)

Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells

Arai, Y., Takahashi, D., Asano, K., Tanaka, M., Oda, M., Ko, S., Ko, M., Mandai, S., Nomura, N., Rai, T., Uchida, S. & Sohara, E., 2017 1 1, : : Scientific Reports. 7, 46580.

研究成果: Article

SCODE: An efficient regulatory network inference algorithm from single-cell RNA-Seq during differentiation

Matsumoto, H., Kiryu, H., Furusawa, C., Ko, M., Ko, S., Gouda, N., Hayashi, T. & Nikaido, I., 2017 8 1, : : Bioinformatics. 33, 15, p. 2314-2321 8 p.

研究成果: Article

39 引用 (Scopus)

Single fecal microbiota transplantation failed to change intestinal microbiota and had limited effectiveness against ulcerative colitis in Japanese patients

Mizuno, S., Nanki, K., Matsuoka, K., Saigusa, K., Ono, K., Arai, M., Sugimoto, S., Kiyohara, H., Nakashima, M., Takeshita, K., Naganuma, M., Suda, W., Hattori, M. & Kanai, T., 2017 1 1, : : Intestinal Research. 15, 1, p. 68-74 7 p.

研究成果: Article

16 引用 (Scopus)
7 引用 (Scopus)

Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression

Torii, H., Kurihara, T., Seko, Y., Negishi, K., Ohnuma, K., Inaba, T., Kawashima, M., Jiang, X., Kondo, S., Miyauchi, M., Miwa, Y., Katada, Y., Mori, K., Kato, K., Tsubota, K., Goto, H., Oda, M., Hatori, M. & Tsubota, K., 2017 2 1, : : EBioMedicine. 15, p. 210-219 10 p.

研究成果: Article

43 引用 (Scopus)

Visualization and targeting of LGR5 + human colon cancer stem cells

Shimokawa, M., Ohta, Y., Nishikori, S., Matano, M., Takano, A., Fujii, M., Date, S., Sugimoto, S., Kanai, T. & Sato, T., 2017 5 11, : : Nature. 545, 7653, p. 187-192 6 p.

研究成果: Article

194 引用 (Scopus)

Zscan4 is expressed specifically during late meiotic prophase in both spermatogenesis and oogenesis

Ishiguro, K. I., Monti, M., Akiyama, T., Kimura, H., Chikazawa-Nohtomi, N., Sakota, M., Sato, S., Redi, C. A., Ko, S. B. H. & Ko, M. S. H., 2017 2 1, : : In Vitro Cellular and Developmental Biology - Animal. 53, 2, p. 167-178 12 p.

研究成果: Article

6 引用 (Scopus)
2016

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Fujii, M., Shimokawa, M., Date, S., Takano, A., Matano, M., Nanki, K., Ohta, Y., Toshimitsu, K., Nakazato, Y., Kawasaki, K., Uraoka, T., Watanabe, T., Kanai, T. & Sato, T., 2016 6 2, : : Cell Stem Cell. 18, 6, p. 827-838 12 p.

研究成果: Article

195 引用 (Scopus)

Active and water-soluble form of lipidated wnt protein is maintained by a serum glycoprotein afamin/α-albumin

Mihara, E., Hirai, H., Yamamoto, H., Tamura-Kawakami, K., Matano, M., Kikuchi, A., Sato, T. & Takagi, J., 2016 2 23, : : eLife. 5, FEBRUARY2016, e11621.

研究成果: Article

53 引用 (Scopus)

Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study

Sugimoto, S., Naganuma, M., Kiyohara, H., Arai, M., Ono, K., Mori, K., Saigusa, K., Nanki, K., Takeshita, K., Takeshita, T., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hisamatsu, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2016 3 10, (Accepted/In press) : : Digestion. p. 193-201 9 p.

研究成果: Article

33 引用 (Scopus)

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways

Kikuchi, I., Takahashi-Kanemitsu, A., Sakiyama, N., Tang, C., Tang, P. J., Noda, S., Nakao, K., Kassai, H., Sato, T., Aiba, A. & Hatakeyama, M., 2016 9 21, : : Nature Communications. 7, 12887.

研究成果: Article

19 引用 (Scopus)

EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells

Nakajo, A., Yoshimura, S. I., Togawa, H., Kunii, M., Iwano, T., Izumi, A., Noguchi, Y., Watanabe, A., Goto, A., Sato, T. & Harada, A., 2016, : : Journal of Cell Biology. 212, 3, p. 297-306 10 p.

研究成果: Article

16 引用 (Scopus)

Emergence of undifferentiated colonies from mouse embryonic stem cells undergoing differentiation by retinoic acid treatment

Sharova, L. V., Sharov, A. A., Piao, Y., Stagg, C. A., Amano, T., Qian, Y., Dudekula, D., Schlessinger, D. & Ko, M., 2016 4 29, (Accepted/In press) : : In Vitro Cellular and Developmental Biology - Animal. p. 1-9 9 p.

研究成果: Article

6 引用 (Scopus)

Endoscopic Severity Predicts Long-Term Prognosis in Crohn's Disease Patients with Clinical Remission

Naganuma, M., Hisamatsu, T., Matsuoka, K., Kiyohara, H., Arai, M., Sugimoto, S., Mori, K., Nanki, K., Ohno, K., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hosoe, N., Inoue, N., Iwao, Y., Ogata, H. & Kanai, T., 2016 1 1, : : Digestion. 93, 1, p. 66-71 6 p.

研究成果: Article

2 引用 (Scopus)

Gene array analysis of neural crest cells identifies transcription factors necessary for direct conversion of embryonic fibroblasts into neural crest cells

Motohashi, T., Watanabe, N., Nishioka, M., Nakatake, Y., Yulan, P., Mochizuki, H., Kawamura, Y., Ko, M. S. H., Goshima, N. & Kunisada, T., 2016 3 15, : : Biology Open. 5, 3, p. 311-322 12 p.

研究成果: Article

5 引用 (Scopus)

Generation and gene expression profiling of 48 transcription-factor-inducible mouse embryonic stem cell lines

Yamamizu, K., Sharov, A. A., Piao, Y., Amano, M., Yu, H., Nishiyama, A., Dudekula, D. B., Schlessinger, D. & Ko, M., 2016 5 6, : : Scientific Reports. 6, 25667.

研究成果: Article

11 引用 (Scopus)

H1foo has a pivotal role in qualifying induced pluripotent stem cells

Kunitomi, A., Yuasa, S., Sugiyama, F., Saito, Y., Seki, T., Kusumoto, D., Kashimura, S., Takei, M., Tohyama, S., Hashimoto, H., Egashira, T., Tanimoto, Y., Mizuno, S., Tanaka, S., Okuno, H., Yamazawa, K., Watanabe, H., Oda, M., Kaneda, R., Matsuzaki, Y. および5人, Nagai, T., Okano, H., Yagami, K. I., Tanaka, M. & Fukuda, K., 2016 6 14, : : Stem cell reports. 6, 6, p. 825-833 9 p.

研究成果: Article

15 引用 (Scopus)

Indole compounds may be promising medicines for ulcerative colitis

Sugimoto, S., Naganuma, M. & Kanai, T., 2016 5 9, (Accepted/In press) : : Journal of Gastroenterology. p. 1-9 9 p.

研究成果: Article

48 引用 (Scopus)

Induction of specific neuron types by overexpression of single transcription factors

Teratani-Ota, Y., Yamamizu, K., Piao, Y., Sharova, L., Amano, M., Yu, H., Schlessinger, D., Ko, M. & Sharov, A. A., 2016 6 1, (Accepted/In press) : : In Vitro Cellular and Developmental Biology - Animal. p. 1-13 13 p.

研究成果: Article

3 引用 (Scopus)

Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response

Saito, Y., Nakaoka, T., Sakai, K., Muramatsu, T., Toshimitsu, K., Kimura, M., Kanai, T., Sato, T. & Saito, H., 2016 5 4, : : Scientific Reports. 6, 25311.

研究成果: Article

15 引用 (Scopus)

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

Dominguez-Brauer, C., Hao, Z., Elia, A. J., Fortin, J. M., Nechanitzky, R., Brauer, P. M., Sheng, Y., Mana, M. D., Chio, I. I. C., Haight, J., Pollett, A., Cairns, R., Tworzyanski, L., Inoue, S., Reardon, C., Marques, A., Silvester, J., Cox, M. A., Wakeham, A., Yilmaz, O. H. および5人, Sabatini, D. M., van Es, J. H., Clevers, H., Sato, T. & Mak, T. W., 2016 8 4, : : Cell stem cell. 19, 2, p. 205-216 12 p.

研究成果: Article

9 引用 (Scopus)

Osteoprotegerin regulates pancreatic β-cell homeostasis upon microbial invasion

Kuroda, Y., Maruyama, K., Fujii, H., Sugawara, I., Ko, S. B. H., Yasuda, H., Matsui, H. & Matsuo, K., 2016 1 11, : : PloS one. 11, 1, e0146544.

研究成果: Article

8 引用 (Scopus)

Recent trends and future directions for the medical treatment of ulcerative colitis

Naganuma, M., Mizuno, S., Nanki, K., Sugimoto, S. & Kanai, T., 2016 12 1, : : Clinical Journal of Gastroenterology. 9, 6, p. 329-336 8 p.

研究成果: Review article

17 引用 (Scopus)

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling

Oudhoff, M. J., Braam, M. J. S., Freeman, S. A., Wong, D., Rattray, D. G., Wang, J., Antignano, F., Snyder, K., Refaeli, I., Hughes, M. R., McNagny, K. M., Gold, M. R., Arrowsmith, C. H., Sato, T., Rossi, F. M. V., Tatlock, J. H., Owen, D. R., Brown, P. J. & Zaph, C., 2016 4 4, : : Developmental Cell. 37, 1, p. 47-57 11 p.

研究成果: Article

41 引用 (Scopus)

The ulcerative colitis endoscopic index of severity is useful to predict medium- to long-term prognosis in ulcerative colitis patients with clinical remission

Arai, M., Naganuma, M., Sugimoto, S., Kiyohara, H., Ono, K., Mori, K., Saigusa, K., Nanki, K., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hosoe, N., Matsuoka, K., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2016, : : Journal of Crohn's and Colitis. 10, 11, p. 1303-1309 7 p.

研究成果: Article

29 引用 (Scopus)

Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells

Akiyama, T., Wakabayashi, S., Soma, A., Sato, S., Nakatake, Y., Oda, M., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S. B. H. & Ko, M. S. H., 2016 10 15, : : Development (Cambridge). 143, 20, p. 3674-3685 12 p.

研究成果: Article

20 引用 (Scopus)

Ulcerative colitis endoscopic index of severity is associated with long-term prognosis in ulcerative colitis patients treated with infliximab

Saigusa, K., Matsuoka, K., Sugimoto, S., Arai, M., Kiyohara, H., Takeshita, K., Mizuno, S., Mori, K., Nanki, K., Takeshita, T., Nakazato, Y., Yajima, T., Naganuma, M., Hisamatsu, T., Ogata, H., Iwao, Y. & Kanai, T., 2016 9 1, : : Digestive Endoscopy. 28, 6, p. 665-670 6 p.

研究成果: Article

12 引用 (Scopus)

Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress

Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irié, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K. & Fukada, T., 2016 10, : : PLoS Genetics. 12, 10, e1006349.

研究成果: Article

35 引用 (Scopus)
23 引用 (Scopus)
2015

An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium

Pin, C., Parker, A., Gunning, A. P., Ohta, Y., Johnson, I. T., Carding, S. R. & Sato, T., 2015 2 1, : : Integrative Biology (United Kingdom). 7, 2, p. 213-228 16 p.

研究成果: Article

14 引用 (Scopus)

Back to 2D Culture for Ground State of Intestinal Stem Cells

Shimokawa, M. & Sato, T., 2015, : : Cell Stem Cell. 17, 1, p. 5-7 3 p.

研究成果: Review article

5 引用 (Scopus)

Combination therapy with infliximab and thiopurine compared to infliximab monotherapy in maintaining remission of postoperative crohn's disease

Sakuraba, A., Okamoto, S., Matsuoka, K., Sato, T., Naganuma, M., Hisamatsu, T., Iwao, Y., Ogata, H., Kanai, T. & Hibi, T., 2015 5 6, : : Digestion. 91, 3, p. 233-238 6 p.

研究成果: Article

7 引用 (Scopus)

Correction of Down syndrome and Edwards syndrome aneuploidies in human cell cultures

Amano, T., Jeffries, E., Amano, M., Ko, A. C., Yu, H. & Ko, M., 2015 5 6, : : DNA Research. 22, 5, p. 331-342 12 p.

研究成果: Article

12 引用 (Scopus)

Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes

Sakamoto, H., Takeda, N., Arai, F., Hosokawa, K., Garcia, P., Suda, T., Frampton, J. & Ogawa, M., 2015 2 1, : : Stem Cells. 33, 2, p. 479-490 12 p.

研究成果: Article

6 引用 (Scopus)

Diagnostic and therapeutic applications of water-immersion colonoscopy

Sugimoto, S. & Mizukami, T., 2015 6 7, : : World Journal of Gastroenterology. 21, 21, p. 6451-6459 9 p.

研究成果: Review article

公開
14 引用 (Scopus)