坂口光洋記念講座

研究成果

2014

Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Kinoshita, T., Nagamatsu, G., Saito, S., Takubo, K., Horimoto, K. & Suda, T., 2014 5 30, : : Journal of Biological Chemistry. 289, 22, p. 15776-15787 12 p.

研究成果: Article

10 引用 (Scopus)

The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells

Kobayashi, C. I., Takubo, K., Kobayashi, H., Nakamura-Ishizu, A., Honda, H., Kataoka, K., Kumano, K., Akiyama, H., Sudo, T., Kurokawa, M. & Suda, T., 2014 4 17, : : Blood. 123, 16, p. 2540-2549 10 p.

研究成果: Article

35 引用 (Scopus)

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2

Simmini, S., Bialecka, M., Huch, M., Kester, L., Van De Wetering, M., Sato, T., Beck, F., Van Oudenaarden, A., Clevers, H. & Deschamps, J., 2014, : : Nature communications. 5, 5728.

研究成果: Article

45 引用 (Scopus)

Unprecedented cell-selection using ultra-quick freezing combined with aquaporin expression

Kato, Y., Miyauchi, T., Abe, Y., Kojić, D., Tanaka, M., Chikazawa, N., Nakatake, Y., Ko, S. B. H., Kobayashi, D., Hazama, A., Fujiwara, S., Uchida, T. & Yasui, M., 2014 2 18, : : PloS one. 9, 2, e87644.

研究成果: Article

2 引用 (Scopus)

[Intestinal stem cells].

Sato, T., 2013 9, : : Seikagaku. The Journal of Japanese Biochemical Society. 85, 9, p. 743-748 6 p.

研究成果: Review article

A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance

Livigni, A., Peradziryi, H., Sharov, A. A., Chia, G., Hammachi, F., Migueles, R. P., Sukparangsi, W., Pernagallo, S., Bradley, M., Nichols, J., Ko, M. S. H. & Brickman, J. M., 2013 11 18, : : Current Biology. 23, 22, p. 2233-2244 12 p.

研究成果: Article

25 引用 (Scopus)

An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity

Shirakawa, T., Yaman-Deveci, R., Tomizawa, S. I., Kamizato, Y., Nakajima, K., Sone, H., Sato, Y., Sharif, J., Yamashita, A., Takada-Horisawa, Y., Yoshida, S., Ura, K., Muto, M., Koseki, H., Suda, T. & Ohbo, K., 2013 9 1, : : Development (Cambridge). 140, 17, p. 3565-3576 12 p.

研究成果: Article

40 引用 (Scopus)

Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy

Lee, J., Kim, K. E., Choi, D. K., Jang, J. Y., Jung, J. J., Kiyonari, H., Shioi, G., Chang, W., Suda, T., Mochizuki, N., Nakaoka, Y., Komuro, I., Yoo, O. J. & Koh, G. Y., 2013 9 18, : : Science translational medicine. 5, 203, 203ra127.

研究成果: Article

73 引用 (Scopus)

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice

Hayashi, A., Sato, T., Kamada, N., Mikami, Y., Matsuoka, K., Hisamatsu, T., Hibi, T., Roers, A., Yagita, H., Ohteki, T., Yoshimura, A. & Kanai, T., 2013 6 12, : : Cell Host and Microbe. 13, 6, p. 711-722 12 p.

研究成果: Article

118 引用 (Scopus)

Conversion of primordial germ cells to pluripotent stem cells: Methods for cell tracking and culture conditions

Nagamatsu, G. & Suda, T., 2013 9 4, Imaging and Tracking Stem Cells: Methods and Protocols. p. 49-56 8 p. (Methods in Molecular Biology; 巻数 1052).

研究成果: Chapter

4 引用 (Scopus)

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma

Mizuno, N., Yatabe, Y., Hara, K., Hijioka, S., Imaoka, H., Shimizu, Y., Ko, S. B. H. & Yamao, K., 2013 10 16, : : Frontiers in Physiology. 4 SEP, Article 269.

研究成果: Article

11 引用 (Scopus)

Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice

Handa, T., Kanai, T., Sato, T., Mikami, Y., Sujino, T., Hayashi, A., Mizuno, S., Matsumoto, A., Hisamatsu, T. & Hibi, T., 2013 2 1, : : Immunology Letters. 150, 1-2, p. 123-129 7 p.

研究成果: Article

Developmental arrest and mouse antral not-surrounded nucleolus oocytes

Monti, M., Zanoni, M., Calligaro, A., Ko, M. S. H., Mauri, P. & Redi, C. A., 2013 1, : : Biology of reproduction. 88, 1, 2.

研究成果: Article

40 引用 (Scopus)

Endoscopic detorsion for sigmoid volvulus using unsedated water-immersion colonoscopy

Sugimoto, S., Mizukami, T., Ito, T., Tsunoda, Y., Imamura, S., Tamura, T., Nagakubo, S., Morohoshi, Y., Koike, Y., Fujita, Y. & Komatsu, H., 2013, : : Endoscopy. 45, SUPPL2, p. E263-E264

研究成果: Comment/debate

公開
3 引用 (Scopus)

Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells

Ikushima, Y. M., Arai, F., Nakamura, Y., Hosokawa, K., Kubota, Y., Hirashima, M., Toyama, H. & Suda, T., 2013 1 4, : : Biochemical and Biophysical Research Communications. 430, 1, p. 20-25 6 p.

研究成果: Article

9 引用 (Scopus)

Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues

Miyake, M., Toguchi, H., Nishibayashi, T., Higaki, K., Sugita, A., Koganei, K., Kamada, N., Kitazume, M. T., Hisamatsu, T., Sato, T., Okamoto, S., Kanai, T. & Hibi, T., 2013 8, : : Journal of Pharmaceutical Sciences. 102, 8, p. 2564-2571 8 p.

研究成果: Article

14 引用 (Scopus)

Growing self-organizing mini-guts from a single intestinal stem cell: Mechanism and applications

Sato, T. & Clevers, H., 2013, : : Science. 340, 6137, p. 1190-1194 5 p.

研究成果: Review article

542 引用 (Scopus)

Haploinsufficiency of SAMD9L, an Endosome Fusion Facilitator, Causes Myeloid Malignancies in Mice Mimicking Human Diseases with Monosomy 7

Nagamachi, A., Matsui, H., Asou, H., Ozaki, Y., Aki, D., Kanai, A., Takubo, K., Suda, T., Nakamura, T., Wolff, L., Honda, H. & Inaba, T., 2013 9 9, : : Cancer Cell. 24, 3, p. 305-317 13 p.

研究成果: Article

65 引用 (Scopus)

Hematopoietic stem cell niche: An interplay among a repertoire of multiple functional niches

Nakamura-Ishizu, A. & Suda, T., 2013 2, : : Biochimica et Biophysica Acta - General Subjects. 1830, 2, p. 2404-2409 6 p.

研究成果: Article

30 引用 (Scopus)

Identification of transcription factors for lineage-specific ESC differentiation

Yamamizu, K., Piao, Y., Sharov, A. A., Zsiros, V., Yu, H., Nakazawa, K., Schlessinger, D. & Ko, M. S. H., 2013 12 17, : : Stem cell reports. 1, 6, p. 545-559 15 p.

研究成果: Article

42 引用 (Scopus)

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

Matsumoto, A., Kanai, T., Mikami, Y., Chu, P. S., Nakamoto, N., Ebinuma, H., Saito, H., Sato, T., Yagita, H. & Hibi, T., 2013 4 23, : : PloS one. 8, 4, e62853.

研究成果: Article

21 引用 (Scopus)

Induction of pluripotent stem cells from primordial germ cells by single reprogramming factors

Nagamatsu, G., Kosaka, T., Saito, S., Honda, H., Takubo, K., Kinoshita, T., Akiyama, H., Sudo, T., Horimoto, K., Oya, M. & Suda, T., 2013 3, : : Stem Cells. 31, 3, p. 479-487 9 p.

研究成果: Article

11 引用 (Scopus)

Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas

Ko, S. B. H., Azuma, S., Yokoyama, Y., Yamamoto, A., Kyokane, K., Niida, S., Ishiguro, H. & Ko, M. S. H., 2013 6 16, : : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 12, p. G1103-G1116

研究成果: Article

8 引用 (Scopus)

In vitro expansion of single Lgr5 + liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., Van Es, J. H., Li, V. S. W., Van De Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., Haft, A., Vries, R. G., Grompe, M. & Clevers, H., 2013 2 14, : : Nature. 494, 7436, p. 247-250 4 p.

研究成果: Article

681 引用 (Scopus)

Kinetics of drug selection systems in mouse embryonic stem cells

Nakatake, Y., Fujii, S., Masui, S., Sugimoto, T., Torikai-Nishikawa, S., Adachi, K. & Niwa, H., 2013 8 7, : : BMC Biotechnology. 13, 64.

研究成果: Article

13 引用 (Scopus)

Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients

Miyoshi, J., Matsuoka, K., Inoue, N., Hisamatsu, T., Ichikawa, R., Yajima, T., Okamoto, S., Naganuma, M., Sato, T., Kanai, T., Ogata, H., Iwao, Y. & Hibi, T., 2013 12 15, : : Journal of Crohn's and Colitis. 7, 12, p. e609-e614

研究成果: Article

37 引用 (Scopus)

No more sugar-coating it: Mucins and platelet biology

Matsubara, Y., 2013 8 29, : : Blood. 122, 9, p. 1537-1538 2 p.

研究成果: Review article

Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder

Sato, T., Ikeda, M., Yotsumoto, S., Shimada, Y., Higuchi, T., Kobayashi, H., Fukuda, T., Ohashi, T., Suda, T. & Ohteki, T., 2013, : : Blood. 121, 16, p. 3267-3273 7 p.

研究成果: Article

4 引用 (Scopus)

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells

Yamashita, M., Nitta, E., Nagamatsu, G., Ikushima, Y. M., Hosokawa, K., Arai, F. & Suda, T., 2013 11 8, : : Biochemical and Biophysical Research Communications. 441, 1, p. 196-201 6 p.

研究成果: Article

18 引用 (Scopus)

OP9 Bone Marrow Stroma Cells Differentiate into Megakaryocytes and Platelets

Matsubara, Y., Ono, Y., Suzuki, H., Arai, F., Suda, T., Murata, M. & Ikeda, Y., 2013 3 1, : : PloS one. 8, 3, e58123.

研究成果: Article

11 引用 (Scopus)

Primary mouse small intestinal epithelial cell cultures

Sato, T. & Clevers, H., 2013, Epithelial Cell Culture Protocols: Second Edition. Randell, S. & Fulcher, L. (版). p. 319-328 10 p. (Methods in Molecular Biology; 巻数 945).

研究成果: Chapter

134 引用 (Scopus)

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

Ikushima, Y. M., Arai, F., Hosokawa, K., Toyama, H., Takubo, K., Furuyashiki, T., Narumiya, S. & Suda, T., 2013, : : Blood. 121, 11, p. 1995-2007 13 p.

研究成果: Article

25 引用 (Scopus)

Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells

Takubo, K., Nagamatsu, G., Kobayashi, C. I., Nakamura-Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Rahimi, Y., Johnson, R. S., Soga, T., Hirao, A., Suematsu, M. & Suda, T., 2013 1 3, : : Cell stem cell. 12, 1, p. 49-61 13 p.

研究成果: Article

332 引用 (Scopus)
17 引用 (Scopus)

Role of iPSC-Producing Factors in Pre-Implantation Embryos

Amano, T. & Ko, M. S. H., 2013 10 1, Principles of Cloning: Second Edition. Elsevier Inc., p. 473-484 12 p.

研究成果: Chapter

Spur cell anemia associated with alcoholic cirrhosis

Sugimoto, S., Yamagishi, Y., Ebinuma, H. & Kanai, T., 2013 12 23, : : Internal Medicine. 52, 24, 1 p.

研究成果: Comment/debate

1 引用 (Scopus)

Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells

Nishiyama, A., Sharov, A. A., Piao, Y., Amano, M., Amano, T., Hoang, H. G., Binder, B. Y., Tapnio, R., Bassey, U., Malinou, J. N., Correa-Cerro, L. S., Yu, H., Xin, L., Meyers, E., Zalzman, M., Nakatake, Y., Stagg, C., Sharova, L., Qian, Y., Dudekula, D. および9人, Sheer, S., Cadet, J. S., Hirata, T., Yang, H. T., Goldberg, I., Evans, M. K., Longo, D. L., Schlessinger, D. & Ko, M. S. H., 2013 3 25, : : Scientific reports. 3, 1390.

研究成果: Article

38 引用 (Scopus)

TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease

Yoneno, K., Hisamatsu, T., Shimamura, K., Kamada, N., Ichikawa, R., Kitazume, M. T., Mori, M., Uo, M., Namikawa, Y., Matsuoka, K., Sato, T., Koganei, K., Sugita, A., Kanai, T. & Hibi, T., 2013 5 1, : : Immunology. 139, 1, p. 19-29 11 p.

研究成果: Article

71 引用 (Scopus)

Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation

Xu, D., Shen, W., Guo, R., Xue, Y., Peng, W., Sima, J., Yang, J., Sharov, A., Srikantan, S., Yang, J., Fox, D., Qian, Y., Martindale, J. L., Piao, Y., Machamer, J., Joshi, S. R., Mohanty, S., Shaw, A. C., Lloyd, T. E., Brown, G. W. および4人, Ko, M. S. H., Gorospe, M., Zou, S. & Wang, W., 2013 9, : : Nature Neuroscience. 16, 9, p. 1238-1247 10 p.

研究成果: Article

71 引用 (Scopus)

Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions

Morgani, S. M., Canham, M. A., Nichols, J., Sharov, A. A., Migueles, R. P., Ko, M. S. H. & Brickman, J. M., 2013 3 27, : : Cell Reports. 3, 6, p. 1945-1957 13 p.

研究成果: Article

131 引用 (Scopus)

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

Huch, M., Bonfanti, P., Boj, S. F., Sato, T., Loomans, C. J. M., Van De Wetering, M., Sojoodi, M., Li, V. S. W., Schuijers, J., Gracanin, A., Ringnalda, F., Begthel, H., Hamer, K., Mulder, J., Van Es, J. H., De Koning, E., Vries, R. G. J., Heimberg, H. & Clevers, H., 2013 10 16, : : EMBO Journal. 32, 20, p. 2708-2721 14 p.

研究成果: Article

308 引用 (Scopus)

Zscan4 restores the developmental potency of embryonic stem cells

Amano, T., Hirata, T., Falco, G., Monti, M., Sharova, L. V., Amano, M., Sheer, S., Hoang, H. G., Piao, Y., Stagg, C. A., Yamamizu, K., Akiyama, T. & Ko, M. S. H., 2013 6 6, : : Nature communications. 4, 1966.

研究成果: Article

公開
60 引用 (Scopus)
2012

[Regulation of hematopoietic stem cells in niche signaling].

Matsumoto, Y. & Suda, T., 2012 4, : : Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 2, p. 133-138 6 p.

研究成果: Article

1 引用 (Scopus)

Activation of JNK triggers release of Brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stress

Nishiyama, A., Dey, A., Tamura, T., Ko, M. & Ozato, K., 2012 5 2, : : PloS one. 7, 5, e34719.

研究成果: Article

4 引用 (Scopus)

A Meg by any other name

Matsubara, Y., 2012 9 6, : : Blood. 120, 10, p. 1970-1971 2 p.

研究成果: Comment/debate

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D. E., Schafer, Z. T., Evans, R. M., Suda, T., Lee, C. H. & Pandolfi, P. P., 2012 9, : : Nature medicine. 18, 9, p. 1350-1358 9 p.

研究成果: Article

351 引用 (Scopus)

CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis

Mizukami, T., Kanai, T., Mikami, Y., Hayashi, A., Doi, T., Handa, T., Matsumoto, A., Jun, L., Matsuoka, K., Sato, T., Hisamatsu, T. & Hibi, T., 2012 9 1, : : Immunology Letters. 147, 1-2, p. 75-79 5 p.

研究成果: Article

5 引用 (Scopus)

Cdx2 determines the fate of postnatal intestinal endoderm

Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, C. A., Winton, D. J., Wright, N. A., Freund, J. N., Deschamps, J. & Beck, F., 2012 2 1, : : Development. 139, 3, p. 465-474 10 p.

研究成果: Article

60 引用 (Scopus)

Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012

Ohara, H., Okazaki, K., Tsubouchi, H., Inui, K., Kawa, S., Kamisawa, T., Tazuma, S., Uchida, K., Hirano, K., Yoshida, H., Nishino, T., Ko, S. B. H., Mizuno, N., Hamano, H., Kanno, A., Notohara, K., Hasebe, O., Nakazawa, T., Nakanuma, Y. & Takikawa, H., 2012 9, : : Journal of Hepato-Biliary-Pancreatic Sciences. 19, 5, p. 536-542 7 p.

研究成果: Review article

223 引用 (Scopus)