坂口光洋記念講座

研究成果

2012

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B. K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., Van Es, J. H. & Clevers, H., 2012 1 1, : : Nature Methods. 9, 1, p. 81-83 3 p.

研究成果: Article

179 引用 (Scopus)

Culture of megakaryocytes and platelets from subcutaneous adipose tissue and a preadipocyte cell line

Matsubara, Y., Murata, M. & Ikeda, Y., 2012, Platelets and Megakaryocytes: Volume 3, Additional Protocols and Perspectives. Gibbins, J. & Mahaut-Smith, M. (版). p. 249-258 10 p. (Methods in Molecular Biology; 巻数 788).

研究成果: Chapter

14 引用 (Scopus)

Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO3- exchange in mouse pancreatic duct

Ishiguro, H., Song, Y., Yamamoto, A., Steward, M. C., Ko, S. B. H., Stewart, A. K., Soleimani, M., Liu, B. C., Kondo, T. & Jin, C. X., 2012 10 15, : : American Journal of Physiology - Cell Physiology. 303, 8, p. C815-C824

研究成果: Article

12 引用 (Scopus)

Detection of a large heterozygous deletion and a splicing defect in the CFTR transcripts from nasal swab of a Japanese case of cystic fibrosis

Nakakuki, M., Fujiki, K., Yamamoto, A., Ko, S. B., Yi, L., Ishiguro, M., Yamaguchi, M., Kondo, S., Maruyama, S., Yanagimoto, K., Naruse, S. & Ishiguro, H., 2012 7, : : Journal of Human Genetics. 57, 7, p. 427-433 7 p.

研究成果: Article

7 引用 (Scopus)

Dll1 + secretory progenitor cells revert to stem cells upon crypt damage

Van Es, J. H., Sato, T., Van De Wetering, M., Lyubimova, A., Yee Nee, A. N., Gregorieff, A., Sasaki, N., Zeinstra, L., Van Den Born, M., Korving, J., Martens, A. C. M., Barker, N., Van Oudenaarden, A. & Clevers, H., 2012 10, : : Nature Cell Biology. 14, 10, p. 1099-1104 6 p.

研究成果: Article

413 引用 (Scopus)

Dynamic regulation of T h17 differentiation by oxygen concentrations

Ikejiri, A., Nagai, S., Goda, N., Kurebayashi, Y., Osada-Oka, M., Takubo, K., Suda, T. & Koyasu, S., 2012, : : International immunology. 24, 3, p. 137-146 10 p.

研究成果: Article

43 引用 (Scopus)

Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration

Nakamura-Ishizu, A., Okuno, Y., Omatsu, Y., Okabe, K., Morimoto, J., Uede, T., Nagasawa, T., Suda, T. & Kubota, Y., 2012 6 7, : : Blood. 119, 23, p. 5429-5437 9 p.

研究成果: Article

83 引用 (Scopus)

Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice

Sano, K., Katsuta, O., Shirae, S., Kubota, Y., Ema, M., Suda, T., Nakamura, M. & Hirashima, M., 2012 4 6, : : Biochemical and Biophysical Research Communications. 420, 2, p. 422-427 6 p.

研究成果: Article

4 引用 (Scopus)

Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1

Cui, C. Y., Childress, V., Piao, Y., Michel, M., Johnson, A. A., Kunisada, M., Ko, M. S. H., Kaestner, K. H., Marmorstein, A. D. & Schlessinger, D., 2012 1 24, : : Proceedings of the National Academy of Sciences of the United States of America. 109, 4, p. 1199-1203 5 p.

研究成果: Article

47 引用 (Scopus)

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5 + stem cell

Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., Clevers, H. & Watanabe, M., 2012 4 1, : : Nature medicine. 18, 4, p. 618-623 6 p.

研究成果: Article

433 引用 (Scopus)

Gene expression profiling and regulatory networks in single cells

Arai, F., Hosokawa, K., Matsumoto, Y., Toyama, H. & Suda, T., 2012 2 1, New Frontiers of Network Analysis in Systems Biology. Springer Netherlands, p. 1-13 13 p.

研究成果: Chapter

Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects

Kodo, K., Nishizawa, T., Furutani, M., Arai, S., Ishihara, K., Oda, M., Makino, S., Fukuda, K., Takahashi, T., Matsuoka, R., Nakanishi, T. & Yamagishi, H., 2012 7 5, : : Circulation Journal. 76, 7, p. 1703-1711 9 p.

研究成果: Article

41 引用 (Scopus)

Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf

Ono, Y., Wang, Y., Suzuki, H., Okamoto, S., Ikeda, Y., Murata, M., Poncz, M. & Matsubara, Y., 2012 11 1, : : Blood. 120, 18, p. 3812-3821 10 p.

研究成果: Article

45 引用 (Scopus)

Intermittent Granulocyte and Monocyte Apheresis Versus Mercaptopurine for Maintaining Remission of Ulcerative Colitis: A Pilot Study

Sakuraba, A., Sato, T., Morohoshi, Y., Matsuoka, K., Okamoto, S., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2012 6 1, : : Therapeutic Apheresis and Dialysis. 16, 3, p. 213-218 6 p.

研究成果: Article

8 引用 (Scopus)

Molecular mechanisms of pancreatic stone formation in chronic pancreatitis

Ko, S. B. H., Azuma, S., Yoshikawa, T., Yamamoto, A., Kyokane, K., Ko, M. S. H. & Ishiguro, H., 2012, : : Frontiers in Physiology. 3 NOV, Article 415.

研究成果: Article

10 引用 (Scopus)

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs

Toyama, H., Arai, F., Hosokawa, K., Ikushima, Y. M. & Suda, T., 2012 11 23, : : Biochemical and Biophysical Research Communications. 428, 3, p. 354-359 6 p.

研究成果: Article

4 引用 (Scopus)

Neovascular niche for human myeloma cells in immunodeficient mouse bone

Iriuchishima, H., Takubo, K., Miyakawa, Y., Nakamura-Ishizu, A., Miyauchi, Y., Fujita, N., Miyamoto, K., Miyamoto, T., Ikeda, E., Kizaki, M., Nojima, Y. & Suda, T., 2012 2 7, : : PloS one. 7, 2, e30557.

研究成果: Article

15 引用 (Scopus)

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche

Sugimura, R., He, X. C., Venkatraman, A., Arai, F., Box, A., Semerad, C., Haug, J. S., Peng, L., Zhong, X. B., Suda, T. & Li, L., 2012 7 20, : : Cell. 150, 2, p. 351-365 15 p.

研究成果: Article

170 引用 (Scopus)

Nucleostemin in injury-induced liver regeneration

Shugo, H., Ooshio, T., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Muraguchi, T., Tamase, A., Uema, N., Yamashita, T., Nakamoto, Y., Suda, T., Kaneko, S. & Hirao, A., 2012 11 1, : : Stem Cells and Development. 21, 16, p. 3044-3054 11 p.

研究成果: Article

10 引用 (Scopus)

On the biomechanics of stem cell niche formation in the gut - Modelling growing organoids

Buske, P., Przybilla, J., Loeffler, M., Sachs, N., Sato, T., Clevers, H. & Galle, J., 2012 9, : : FEBS Journal. 279, 18, p. 3475-3487 13 p.

研究成果: Article

54 引用 (Scopus)

Optimal ratio of transcription factors for somatic cell reprogramming

Nagamatsu, G., Saito, S., Kosaka, T., Takubo, K., Kinoshita, T., Oya, M., Horimoto, K. & Suda, T., 2012 10 19, : : Journal of Biological Chemistry. 287, 43, p. 36273-36282 10 p.

研究成果: Article

22 引用 (Scopus)

Passing a baton to the next generation

Suda, T. & Kitamura, S., 2012 11 1, : : International journal of hematology. 96, 5, p. 529-530 2 p.

研究成果: Editorial

Pathological neoangiogenesis depends on oxidative stress regulation by ATM

Okuno, Y., Nakamura-Ishizu, A., Otsu, K., Suda, T. & Kubota, Y., 2012 8, : : Nature medicine. 18, 8, p. 1208-1216 9 p.

研究成果: Article

98 引用 (Scopus)

Prenatal arsenic exposure alters gene expression in the adult liver to a proinflammatory state contributing to accelerated atherosclerosis

States, J. C., Singh, A. V., Knudsen, T. B., Rouchka, E. C., Ngalame, N. O., Arteel, G. E., Piao, Y. & Ko, M. S. H., 2012 6 15, : : PloS one. 7, 6, e38713.

研究成果: Article

39 引用 (Scopus)

Regulation of reactive oxygen species in stem cells and cancer stem cells

Kobayashi, C. I. & Suda, T., 2012 1 1, : : Journal of Cellular Physiology. 227, 2, p. 421-430 10 p.

研究成果: Short survey

157 引用 (Scopus)

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Arai, F., Hosokawa, K., Toyama, H., Matsumoto, Y. & Suda, T., 2012 8, : : Annals of the New York Academy of Sciences. 1266, 1, p. 72-77 6 p.

研究成果: Article

32 引用 (Scopus)

Roles of the hypoxia response system in hematopoietic and leukemic stem cells

Takubo, K. & Suda, T., 2012 5 1, : : International journal of hematology. 95, 5, p. 478-483 6 p.

研究成果: Article

26 引用 (Scopus)

Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration

Xie, H., Sun, X., Piao, Y., Jegga, A. G., Handwerger, S., Ko, M. S. H. & Dey, S. K., 2012 9 14, : : Journal of Biological Chemistry. 287, 38, p. 32288-32297 10 p.

研究成果: Article

30 引用 (Scopus)
6 引用 (Scopus)

Structure and function of the pancreas in the polycystic kidney rat

Yi, L., Naruse, S., Furuya, S., Yamamoto, A., Nakakuki, M., Nagao, S., Yoshihara, D., Ko, S. B. H., Wei, M., Kondo, T. & Ishiguro, H., 2012 11, : : Pancreas. 41, 8, p. 1292-1298 7 p.

研究成果: Article

2 引用 (Scopus)

TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

Takaesu, G., Inagaki, M., Takubo, K., Mishina, Y., Hess, P. R., Dean, G. A., Yoshimura, A., Matsumoto, K., Suda, T. & Ninomiya-Tsuji, J., 2012 11 30, : : PloS one. 7, 11, e51073.

研究成果: Article

10 引用 (Scopus)

Three cases of bronchial asthma preceding IgG4-related autoimmune pancreatitis

Ito, S., Ko, S. B. H., Morioka, M., Imaizumi, K., Kondo, M., Mizuno, N. & Hasegawa, Y., 2012, : : Allergology International. 61, 1, p. 171-174 4 p.

研究成果: Article

19 引用 (Scopus)

Transcriptional Activation by Oct4 Is Sufficient for the Maintenance and Induction of Pluripotency

Hammachi, F., Morrison, G. M., Sharov, A. A., Livigni, A., Narayan, S., Papapetrou, E. P., O'Malley, J., Kaji, K., Ko, M. S. H., Ptashne, M. & Brickman, J. M., 2012 2 23, : : Cell Reports. 1, 2, p. 99-109 11 p.

研究成果: Article

42 引用 (Scopus)

Two anatomically distinct niches regulate stem cell activity

Ema, H. & Suda, T., 2012 9 13, : : Blood. 120, 11, p. 2174-2181 8 p.

研究成果: Review article

49 引用 (Scopus)

Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis

Mayumi, T., Inui, K., Maetani, I., Yokoe, M., Sakamoto, T., Yoshida, M., Ko, S., Hirata, K. & Takada, T., 2012 8, : : Pancreas. 41, 6, p. 869-875 7 p.

研究成果: Article

10 引用 (Scopus)

Zscan4 transiently reactivates early embryonic genes during the generation of induced pluripotent stem cells

Hirata, T., Amano, T., Nakatake, Y., Amano, M., Piao, Y., Hoang, H. G. & Ko, M. S. H., 2012, : : Scientific reports. 2, 208.

研究成果: Article

59 引用 (Scopus)
2011

A germ cell-specific gene, Prmt5, works in somatic cell reprogramming

Nagamatsu, G., Kosaka, T., Kawasumi, M., Kinoshita, T., Takubo, K., Akiyama, H., Sudo, T., Kobayashi, T., Oya, M. & Suda, T., 2011 3 25, : : Journal of Biological Chemistry. 286, 12, p. 10641-10648 8 p.

研究成果: Article

50 引用 (Scopus)

Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing

Okuno, Y., Nakamura-Ishizu, A., Kishi, K., Suda, T. & Kubota, Y., 2011 5 12, : : Blood. 117, 19, p. 5264-5272 9 p.

研究成果: Article

76 引用 (Scopus)

Dynamic replacement of histone H3 variants reprograms epigenetic marks in early mouse embryos

Akiyama, T., Suzuki, O., Matsuda, J. & Aoki, F., 2011 10, : : PLoS Genetics. 7, 10, e1002279.

研究成果: Article

公開
90 引用 (Scopus)

Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells

Ko, S. B. H., Yamamoto, A., Azuma, S., Song, H., Kamimura, K., Nakakuki, M., Gray, M. A., Becq, F., Ishiguro, H. & Goto, H., 2011 7 15, : : Biochemical and Biophysical Research Communications. 410, 4, p. 904-909 6 p.

研究成果: Article

6 引用 (Scopus)

Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression

Iriuchishima, H., Takubo, K., Matsuoka, S., Onoyama, I., Nakayama, K. I., Nojima, Y. & Suda, T., 2011 2 24, : : Blood. 117, 8, p. 2373-2377 5 p.

研究成果: Article

28 引用 (Scopus)

Generation of mouse ES cell lines engineered for the forced induction of transcription factors

Correa-Cerro, L. S., Piao, Y., Sharov, A. A., Nishiyama, A., Cadet, J. S., Yu, H., Sharova, L. V., Xin, L., Hoang, H. G., Thomas, M., Qian, Y., Dudekula, D. B., Meyers, E., Binder, B. Y., Mowrer, G., Bassey, U., Longo, D. L., Schlessinger, D. & Ko, M. S. H., 2011, : : Scientific reports. 1, 167.

研究成果: Article

31 引用 (Scopus)

GSK-3β negatively regulates megakaryocyte differentiation and platelet production from primary human bone marrow cells in vitro

Ono, M., Matsubara, Y., Shibano, T., Ikeda, Y. & Murata, M., 2011 5, : : Platelets. 22, 3, p. 196-203 8 p.

研究成果: Article

12 引用 (Scopus)

Hematopoiesis and bone remodeling

Suda, T., 2011 5 26, : : Blood. 117, 21, p. 5556-5557 2 p.

研究成果: Comment/debate

5 引用 (Scopus)

Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation

Honda, H., Takubo, K., Oda, H., Kosaki, K., Tazaki, T., Yamasaki, N., Miyazaki, K., Moore, K. A., Honda, Z. I., Suda, T. & Lemischka, I. R., 2011 2 8, : : Proceedings of the National Academy of Sciences of the United States of America. 108, 6, p. 2468-2473 6 p.

研究成果: Article

10 引用 (Scopus)

Intravenous fluid therapy successfully prevents renal injury by gemcitabine in patients with pancreatic cancer

Ko, S. B. H., Azuma, S., Kamimura, K., Goto, H., Anzai, N., Yamamoto, A., Ishiguro, H. & Mizuno, N., 2011 7, : : Pancreas. 40, 5, p. 784-787 4 p.

研究成果: Letter

1 引用 (Scopus)

Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero

Kubota, Y., Takubo, K., Hirashima, M., Nagoshi, N., Kishi, K., Okuno, Y., Nakamura-Ishizu, A., Sano, K., Murakami, M., Ema, M., Omatsu, Y., Takahashi, S., Nagasawa, T., Shibuya, M., Okano, H. & Suda, T., 2011 5, : : Journal of Experimental Medicine. 208, 5, p. 949-960 12 p.

研究成果: Article

25 引用 (Scopus)

Isolation and in vitro expansion of human colonic stem cells

Jung, P., Sato, T., Merlos-Suárez, A., Barriga, F. M., Iglesias, M., Rossell, D., Auer, H., Gallardo, M., Blasco, M. A., Sancho, E., Clevers, H. & Batlle, E., 2011 10 1, : : Nature medicine. 17, 10, p. 1225-1227 3 p.

研究成果: Article

380 引用 (Scopus)

Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome

Suzuki, M., Oda, M., Ramos, M. P., Pascual, M., Lau, K., Stasiek, E., Agyiri, F., Thompson, R. F., Glass, J. L., Jing, Q., Sandstrom, R., Fazzari, M. J., Hansen, R. S., Stamatoyannopoulos, J. A., McLellan, A. S. & Greally, J. M., 2011 11, : : Genome Research. 21, 11, p. 1833-1840 8 p.

研究成果: Article

25 引用 (Scopus)