坂口光洋記念講座

研究成果

2011

Metabolic regulation of hematopoietic stem cells in the hypoxic niche

Suda, T., Takubo, K. & Semenza, G. L., 2011 10 4, : : Cell stem cell. 9, 4, p. 298-310 13 p.

研究成果: Review article

429 引用 (Scopus)

Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells

Kim, Y., Sharov, A. A., McDole, K., Cheng, M., Hao, H., Fan, C. M., Gaiano, N., Ko, M. S. H. & Zheng, Y., 2011 12 23, : : Science. 334, 6063, p. 1706-1710 5 p.

研究成果: Article

153 引用 (Scopus)

New IJH guidelines highlight greater transparency

Sipp, D. & Suda, T., 2011 4 1, : : International journal of hematology. 93, 4, p. 411-412 2 p.

研究成果: Editorial

Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization

Miyamoto, K., Yoshida, S., Kawasumi, M., Hashimoto, K., Kimura, T., Sato, Y., Kobayashi, T., Miyauchi, Y., Hoshi, H., Iwasaki, R., Miyamoto, H., Hao, W., Morioka, H., Chiba, K., Kobayashi, T., Yasuda, H., Penninger, J. M., Toyama, Y., Suda, T. & Miyamoto, T., 2011 10 24, : : Journal of Experimental Medicine. 208, 11, p. 2175-2181 7 p.

研究成果: Article

57 引用 (Scopus)

P57 Kip2 and p27 Kip1 cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70

Zou, P., Yoshihara, H., Hosokawa, K., Tai, I., Shinmyozu, K., Tsukahara, F., Maru, Y., Nakayama, K., Nakayama, K. I. & Suda, T., 2011 9 2, : : Cell stem cell. 9, 3, p. 247-261 15 p.

研究成果: Article

170 引用 (Scopus)

Pancreatic stone protein/regenerating protein family in pancreatic and gastrointestinal diseases

Jin, C. X., Hayakawa, T., Ko, S. B. H., Ishiguro, H. & Kitagawa, M., 2011 8 11, : : Internal Medicine. 50, 15, p. 1507-1516 10 p.

研究成果: Review article

18 引用 (Scopus)

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Sato, T., Van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., Van Den Born, M., Barker, N., Shroyer, N. F., Van De Wetering, M. & Clevers, H., 2011 1 20, : : Nature. 469, 7330, p. 415-418 4 p.

研究成果: Article

1296 引用 (Scopus)

Responsiveness of genes to manipulation of transcription factors in ES cells is associated with histone modifications and tissue specificity

Sharov, A. A., Nishiyama, A., Piao, Y., Correa-Cerro, L. S., Amano, T., Thomas, M., Mehta, S. & Ko, M. S. H., 2011 2 9, : : BMC Genomics. 12, 102.

研究成果: Article

10 引用 (Scopus)

SLC26 anion exchangers of guinea pig pancreatic duct: Molecular cloning and functional characterization

Stewart, A. K., Shmukler, B. E., Vandorpe, D. H., Reimold, F., Heneghan, J. F., Nakakuki, M., Akhavein, A., Ko, S., Ishiguro, H. & Alper, S. L., 2011 8, : : American Journal of Physiology - Cell Physiology. 301, 2, p. C289-C303

研究成果: Article

31 引用 (Scopus)

Stem cell self-renewal: Lessons from bone marrow, gut and iPS toward clinical applications

Staal, F. J. T., Baum, C., Cowan, C., Dzierzak, E., Hacein-Bey-Abina, S., Karlsson, S., Lapidot, T., Lemischka, I., Mendez-Ferrer, S., Mikkers, H., Moore, K., Moreno, E., Mummery, C. L., Robin, C., Suda, T., Van Pel, M., Vanden Brink, G., Zwaginga, J. J. & Fibbe, W. E., 2011 7 1, : : Leukemia. 25, 7, p. 1095-1102 8 p.

研究成果: Review article

17 引用 (Scopus)

Telomerase reverse transcriptase protectsATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism

Nitta, E., Yamashita, M., Hosokawa, K., Xian, M. J., Takubo, K., Arai, F., Nakada, S. & Suda, T., 2011 4 21, : : Blood. 117, 16, p. 4169-4180 12 p.

研究成果: Article

45 引用 (Scopus)
2010

Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Hembree, M., Yin, T., Nakamura, Y., Gomei, Y., Takubo, K., Shiama, H., Matsuoka, S., Li, L. & Suda, T., 2010 3 5, : : Cell stem cell. 6, 3, p. 194-198 5 p.

研究成果: Letter

73 引用 (Scopus)

Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells

Kobayashi, I., Ono, H., Moritomo, T., Kano, K., Nakanishi, T. & Suda, T., 2010 1 14, : : Blood. 115, 2, p. e1-e9

研究成果: Article

23 引用 (Scopus)

Corticosteroids Correct Aberrant CFTR Localization in the Duct and Regenerate Acinar Cells in Autoimmune Pancreatitis

Ko, S. B. H., Mizuno, N., Yatabe, Y., Yoshikawa, T., Ishiguro, H., Yamamoto, A., Azuma, S., Naruse, S., Yamao, K., Muallem, S. & Goto, H., 2010 5, : : Gastroenterology. 138, 5, p. 1988-1996.e3

研究成果: Article

80 引用 (Scopus)

Dkk4 and eda regulate distinctive developmental mechanisms for subtypes of mouse hair

Cui, C. Y., Kunisada, M., Piao, Y., Childress, V., Ko, M. S. H. & Schlessinger, D., 2010, : : PloS one. 5, 4, e10009.

研究成果: Article

22 引用 (Scopus)

DOCK180 is a rac activator that regulates cardiovascular development by acting downstream of CXCR4

Sanematsu, F., Hirashima, M., Laurin, M., Takii, R., Nishikimi, A., Kitajima, K., Ding, G., Noda, M., Murata, Y., Tanaka, Y., Masuko, S., Suda, T., Meno, C., Côté, J. F., Nagasawa, T. & Fukui, Y., 2010 10 29, : : Circulation research. 107, 9, p. 1102-1105 4 p.

研究成果: Article

32 引用 (Scopus)

Erratum: Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells (Nature Medicine (2006)12 (446-451))

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y. & Suda, T., 2010 1 1, : : Nature medicine. 16, 1, 1 p.

研究成果: Comment/debate

2 引用 (Scopus)

Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells

Gomei, Y., Nakamura, Y., Yoshihara, H., Hosokawa, K., Iwasaki, H., Suda, T. & Arai, F., 2010 2, : : Experimental Hematology. 38, 2, p. 82-89.e1

研究成果: Article

25 引用 (Scopus)
173 引用 (Scopus)

Gene expression profiling of mouse embryos with microarrays

Sharov, A. A., Piao, Y. & Ko, M. S. H., 2010, Methods in Enzymology. C 版 Academic Press Inc., p. 511-541 31 p. (Methods in Enzymology; 巻数 477, 番号 C).

研究成果: Chapter

2 引用 (Scopus)

Generation of induced pluripotent stem cells from human terminally differentiated circulating t cells

Seki, T., Yuasa, S., Oda, M., Egashira, T., Yae, K., Kusumoto, D., Nakata, H., Tohyama, S., Hashimoto, H., Kodaira, M., Okada, Y., Seimiya, H., Fusaki, N., Hasegawa, M. & Fukuda, K., 2010 7, : : Cell stem cell. 7, 1, p. 11-14 4 p.

研究成果: Letter

374 引用 (Scopus)

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

Nakamura, Y., Arai, F., Iwasaki, H., Hosokawa, K., Kobayashi, I., Gomei, Y., Matsumoto, Y., Yoshihara, H. & Suda, T., 2010 9 2, : : Blood. 116, 9, p. 1422-1432 11 p.

研究成果: Article

140 引用 (Scopus)

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Nakamura, Y., Gomei, Y. & Suda, T., 2010 7 29, : : Blood. 116, 4, p. 554-563 10 p.

研究成果: Article

87 引用 (Scopus)

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Nakada, S., Tai, I., Panier, S., Al-Hakim, A., Iemura, S. I., Juang, Y. C., O'Donnell, L., Kumakubo, A., Munro, M., Sicheri, F., Gingras, A. C., Natsume, T., Suda, T. & Durocher, D., 2010 8 19, : : Nature. 466, 7309, p. 941-946 6 p.

研究成果: Article

226 引用 (Scopus)

The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis

Miyauchi, Y., Ninomiya, K., Miyamoto, H., Sakamoto, A., Iwasaki, R., Hoshi, H., Miyamoto, K., Hao, W., Yoshida, S., Morioka, H., Chiba, K., Kato, S., Tokuhisa, T., Saitou, M., Toyama, Y., Suda, T. & Miyamoto, T., 2010 4 12, : : Journal of Experimental Medicine. 207, 4, p. 751-762 12 p.

研究成果: Article

119 引用 (Scopus)

Trophoblast cell lineage in cloned mouse embryos

Oda, M., Shiota, K. & Tanaka, S., 2010 4 1, : : Development Growth and Differentiation. 52, 3, p. 285-291 7 p.

研究成果: Review article

12 引用 (Scopus)

Von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina

Kurihara, T., Kubota, Y., Ozawa, Y., Takubo, K., Noda, K., Simon, M. C., Johnson, R. S., Suematsu, M., Tsubota, K., Ishida, S., Goda, N., Suda, T. & Okano, H., 2010 5 1, : : Development. 137, 9, p. 1563-1571 9 p.

研究成果: Article

48 引用 (Scopus)

Zscan4 regulates telomere elongation and genomic stability in ES cells

Zalzman, M., Falco, G., Sharova, L. V., Nishiyama, A., Thomas, M., Lee, S. L., Stagg, C. A., Hoang, H. G., Yang, H. T., Indig, F. E., Wersto, R. P. & Ko, M. S. H., 2010 4 8, : : Nature. 464, 7290, p. 858-863 6 p.

研究成果: Article

221 引用 (Scopus)
2009

1-Alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression

Sakai, S., Takaishi, H., Matsuzaki, K., Kaneko, H., Furukawa, M., Miyauchi, Y., Shiraishi, A., Saito, K., Tanaka, A., Taniguchi, T., Suda, T., Miyamoto, T. & Toyama, Y., 2009 11, : : Journal of Bone and Mineral Metabolism. 27, 6, p. 643-652 10 p.

研究成果: Article

44 引用 (Scopus)

Aging and cancer in hematopoietic stem cells

Nitta, E. & Suda, T., 2009 5 1, : : Japanese Journal of Geriatrics. 46, 3, p. 195-199 5 p.

研究成果: Article

Angiopoietin-like Protein 2 Promotes Chronic Adipose Tissue Inflammation and Obesity-Related Systemic Insulin Resistance

Tabata, M., Kadomatsu, T., Fukuhara, S., Miyata, K., Ito, Y., Endo, M., Urano, T., Zhu, H. J., Tsukano, H., Tazume, H., Kaikita, K., Miyashita, K., Iwawaki, T., Shimabukuro, M., Sakaguchi, K., Ito, T., Nakagata, N., Yamada, T., Katagiri, H., Kasuga, M. および6人, Ando, Y., Ogawa, H., Mochizuki, N., Itoh, H., Suda, T. & Oike, Y., 2009 9 2, : : Cell Metabolism. 10, 3, p. 178-188 11 p.

研究成果: Article

218 引用 (Scopus)

Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis

Adachi, H., Fujiwara, Y., Kondo, T., Nishikawa, T., Ogawa, R., Matsumura, T., Ishii, N., Nagai, R., Miyata, K., Tabata, M., Motoshima, H., Furukawa, N., Tsuruzoe, K., Kawashima, J., Takeya, M., Yamashita, S., Koh, G. Y., Nagy, A., Suda, T., Oike, Y. および1人, Araki, E., 2009 2 20, : : Biochemical and Biophysical Research Communications. 379, 4, p. 806-811 6 p.

研究成果: Article

56 引用 (Scopus)

Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis

Ko, S. B. H., Mizuno, N., Yatabe, Y., Yoshikawa, T., Ishiguro, H., Yamamoto, A., Azuma, S., Naruse, S., Yamao, K., Muallem, S. & Goto, H., 2009, : : Journal of Medical Investigation. 56, SUPPL. 1, p. 318-321 4 p.

研究成果: Article

14 引用 (Scopus)

Bidirectional signaling through EphrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis

Irie, N., Takada, Y., Watanabe, Y., Matsuzaki, Y., Naruse, C., Asano, M., Iwakura, Y., Suda, T. & Matsuo, K., 2009 5 22, : : Journal of Biological Chemistry. 284, 21, p. 14637-14644 8 p.

研究成果: Article

112 引用 (Scopus)

Cancer stem cell concepts--lesson from leukemia

Nitta, E. & Suda, T., 2009 10, : : Nippon rinsho. Japanese journal of clinical medicine. 67, 10, p. 1863-1867 5 p.

研究成果: Review article

1 引用 (Scopus)

Cancer stem cells and their niche

Iwasaki, H. & Suda, T., 2009 6 23, : : Cancer science. 100, 7, p. 1166-1172 7 p.

研究成果: Review article

106 引用 (Scopus)

CFTR Functions as a bicarbonate channel in pancreatic duct cells

Ishiguro, H., Steward, M. C., Naruse, S., Shigeru, B. H. K., Goto, H., Case, R. M., Kondo, T. & Yamamoto, A., 2009 3, : : Journal of General Physiology. 133, 3, p. 315-326 12 p.

研究成果: Article

79 引用 (Scopus)

Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells

Sun, C., Nakatake, Y., Akagi, T., Ura, H., Matsuda, T., Nishiyama, A., Koide, H., Ko, M. S. H., Niwa, H. & Yokota, T., 2009 8, : : Molecular and cellular biology. 29, 16, p. 4574-4583 10 p.

研究成果: Article

57 引用 (Scopus)

Establishment of trophoblast stem cell lines from somatic cell nuclear-transferred embryos

Oda, M., Tanaka, S., Yamazaki, Y., Ohta, H., Iwatani, M., Suzuki, M., Ohgane, J., Hattori, N., Yanagimachi, R., Wakayama, T. & Shiota, K., 2009 9 22, : : Proceedings of the National Academy of Sciences of the United States of America. 106, 38, p. 16293-16297 5 p.

研究成果: Article

19 引用 (Scopus)

Exhaustive search for over-represented DNA sequence motifs with cisfinder

Sharov, A. A. & Ko, M. S. H., 2009 10, : : DNA Research. 16, 5, p. 261-273 13 p.

研究成果: Article

89 引用 (Scopus)

Glucose transport in interlobular ducts isolated from rat pancreas

Futakuchi, S., Ishiguro, H., Naruse, S., Ko, S. B. H., Fujiki, K., Yamamoto, A., Nakakuki, M., Song, Y., Steward, M. C., Kondo, T. & Goto, H., 2009, : : Journal of Medical Investigation. 56, SUPPL. 1, p. 308-311 4 p.

研究成果: Article

11 引用 (Scopus)

High glucose inhibits HCO3 and fluid secretion in rat pancreatic ducts

Futakuchi, S., Ishiguro, H., Naruse, S., Ko, S. B. H., Fujiki, K., Yamamoto, A., Nakakuki, M., Song, Y., Steward, M. C., Kondo, T. & Goto, H., 2009 11 1, : : Pflugers Archiv European Journal of Physiology. 459, 1, p. 215-226 12 p.

研究成果: Article

11 引用 (Scopus)

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers

Oda, M., Glass, J. L., Thompson, R. F., Mo, Y., Olivier, E. N., Figueroa, M. E., Selzer, R. R., Richmond, T. A., Zhang, X., Dannenberg, L., Green, R. D., Melnick, A., Hatchwell, E., Bouhassira, E. E., Verma, A., Suzuki, M. & Greally, J. M., 2009, : : Nucleic acids research. 37, 12, p. 3829-3839 11 p.

研究成果: Article

111 引用 (Scopus)

Histological diagnosis of autoimmune pancreatitis using EUS-guided trucut biopsy: A comparison study with EUS-FNA

Mizuno, N., Bhatia, V., Hosoda, W., Sawaki, A., Hoki, N., Hara, K., Takagi, T., Ko, S. B. H., Yatabe, Y., Goto, H. & Yamao, K., 2009 5 12, : : Journal of gastroenterology. 44, 7, p. 742-750 9 p.

研究成果: Article

148 引用 (Scopus)

Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: Functional roles of HoxD8 in lymphangiogenesis

Harada, K., Yamazaki, T., Iwata, C., Yoshimatsu, Y., Sase, H., Mishima, K., Morishita, Y., Hirashima, M., Oike, Y., Suda, T., Miura, N., Watabe, T. & Miyazono, K., 2009, : : Journal of Cell Science. 122, 21, p. 3923-3930 8 p.

研究成果: Article

24 引用 (Scopus)

Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin

Tamase, A., Muraguchi, T., Naka, K., Tanaka, S., Kinoshita, M., Hoshii, T., Ohmura, M., Shugo, H., Ooshio, T., Nakada, M., Sawamoto, K., Onodera, M., Matsumoto, K., Oshima, M., Asano, M., Saya, H., Okano, H., Suda, T., Hamada, J. I. & Hirao, A., 2009 10 6, : : Proceedings of the National Academy of Sciences of the United States of America. 106, 40, p. 17163-17168 6 p.

研究成果: Article

66 引用 (Scopus)

Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type i interferon-dependent exhaustion

Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T. & Ohteki, T., 2009 6 8, : : Nature medicine. 15, 6, p. 696-700 5 p.

研究成果: Article

249 引用 (Scopus)