坂口光洋記念講座

研究成果

Article

Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine

Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M. および5人, Ohtsuka, K., Mochizuki, M., Watanabe, M., Hashiguchi, M. & Kanai, T., 2019 10 1, : : Journal of Gastroenterology and Hepatology (Australia). 34, 10, p. 1751-1757 7 p.

研究成果: Article

5 引用 (Scopus)

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression

Nakatsukasa, H., Oda, M., Yin, J., Chikuma, S., Ito, M., Koga-Iizuka, M., Someya, K., Kitagawa, Y., Ohkura, N., Sakaguchi, S., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Yamanaka, S., Takamura-Enya, T., Lu, Q. & Yoshimura, A., 2019 1 1, : : International immunology. 31, 5, p. 335-347 13 p.

研究成果: Article

8 引用 (Scopus)

Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival

Hamaguchi, I., Morisada, T., Azuma, M., Murakami, K., Kuramitsu, M., Mizukami, T., Ohbo, K., Yamaguchi, K., Oike, Y., Dumont, D. J. & Suda, T., 2006 2 1, : : Blood. 107, 3, p. 1207-1213 7 p.

研究成果: Article

12 引用 (Scopus)

Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin-2 receptor γ chain-deficient mice

Ikebe, M., Miyakawa, K., Takahashi, K., Ohbo, K., Nakamura, M., Sugamura, K., Suda, T., Yamamura, K. I. & Tomita, K., 1997, : : International Journal of Experimental Pathology. 78, 3, p. 133-148 16 p.

研究成果: Article

17 引用 (Scopus)

Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn’s disease

Kanai, T., Watanabe, M., Okazawa, A., Sato, T., Yamazaki, M., Okamoto, S., Ishii, H., Totsuka, T., Iiyama, R., Okamoto, R., Ikeda, M., Kurimoto, M., Takeda, K., Akira, S. & Hibi, T., 2001 1 1, : : Gastroenterology. 121, 4, p. 875-888 14 p.

研究成果: Article

150 引用 (Scopus)

Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation

Mikami, Y., Mizuno, S., Nakamoto, N., Hayashi, A., Sujino, T., Sato, T., Kamada, N., Matsuoka, K., Hisamatsu, T., Ebinuma, H., Hibi, T., Yoshimura, A. & Kanai, T., 2014 1 2, : : PloS one. 9, 1, e84619.

研究成果: Article

9 引用 (Scopus)
22 引用 (Scopus)

Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells

Kurihara, N., Iwama, A., Tatsumi, J., Ikeda, K. & Suda, T., 1996 5 1, : : Blood. 87, 9, p. 3704-3710 7 p.

研究成果: Article

公開
75 引用 (Scopus)

Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes

Wang, M. H., Dlugosz, A. A., Sun, Y., Suda, T., Skeel, A. & Leonard, E. J., 1996 7 10, : : Experimental Cell Research. 226, 1, p. 39-46 8 p.

研究成果: Article

96 引用 (Scopus)

Maintenance of undifferentiated mouse embryonic stem cells in suspension by the serum- and feeder-free defined culture condition

Tsuji, Y., Yoshimura, N., Aoki, H., Sharov, A. A., Ko, M. S. H., Motohashi, T. & Kunisada, T., 2008 8, : : Developmental Dynamics. 237, 8, p. 2129-2138 10 p.

研究成果: Article

15 引用 (Scopus)

Maps from two interspecific backcross DNA panels available as a community genetic mapping resource

Rowe, L. B., Nadeau, J. H., Turner, R., Frankel, W. N., Letts, V. A., Eppig, J. T., Ko, M. S. H., Thurston, S. J. & Birkenmeier, E. H., 1994 5, : : Mammalian Genome. 5, 5, p. 253-274 22 p.

研究成果: Article

626 引用 (Scopus)

Maternal TET3 is dispensable for embryonic development but is required for neonatal growth

Tsukada, Y. I., Akiyama, T. & Nakayama, K. I., 2015 10 28, : : Scientific reports. 5, 15876.

研究成果: Article

公開
21 引用 (Scopus)

MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner

Miyamoto, K., Ninomiya, K., Sonoda, K. H., Miyauchi, Y., Hoshi, H., Iwasaki, R., Miyamoto, H., Yoshida, S., Sato, Y., Morioka, H., Chiba, K., Egashira, K., Suda, T., Toyama, Y. & Miyamoto, T., 2009 6 5, : : Biochemical and Biophysical Research Communications. 383, 3, p. 373-377 5 p.

研究成果: Article

58 引用 (Scopus)

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

Kubota, Y., Takubo, K., Shimizu, T., Ohno, H., Kishi, K., Shibuya, M., Saya, H. & Suda, T., 2009 5 11, : : Journal of Experimental Medicine. 206, 5, p. 1089-1102 14 p.

研究成果: Article

246 引用 (Scopus)

Mechanisms of transcription in eosinophils: GATA-1, but not GATA-2, transactivates the promoter of the eosinophil granule major basic protein gene

Yamaguchi, Y., Ackerman, S. J., Minegishi, N., Takiguchi, M., Yamamoto, M. & Suda, T., 1998 5 1, : : Blood. 91, 9, p. 3447-3458 12 p.

研究成果: Article

公開
57 引用 (Scopus)

Megakaryocytopoiesis in vitro of patients with essential thrombocythaemia: effect of plasma and serum on megakaryocyte colony formation

Komatsu, N., Suda, T., Sakata, Y., Eguchi, M., Kaji, K., Saito, M. & Miura, Y., 1986 10, : : British Journal of Haematology. 64, 2, p. 241-252 12 p.

研究成果: Article

37 引用 (Scopus)

Megaloblastic Anemia Associated with Psoriasis: Case Report and Review of the Literature

Iwama, A., Miwa, A., Suzuki, T., Ema, H., Suda, T., Sakamoto, S. & Miura, Y., 1992 1 1, : : Internal Medicine. 31, 1, p. 127-130 4 p.

研究成果: Article

公開
3 引用 (Scopus)

MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells

Ishiguro, K. I., Matsuura, K., Tani, N., Takeda, N., Usuki, S., Yamane, M., Sugimoto, M., Fujimura, S., Hosokawa, M., Chuma, S., Ko, M. S. H., Araki, K. & Niwa, H., 2020 2 24, : : Developmental Cell. 52, 4, p. 429-445.e10

研究成果: Article

6 引用 (Scopus)

Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation

Arai, F., Ohneda, O., Miyamoto, T., Zhang, X. Q. & Suda, T., 2002 6 17, : : Journal of Experimental Medicine. 195, 12, p. 1549-1563 15 p.

研究成果: Article

173 引用 (Scopus)
76 引用 (Scopus)

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids

Matano, M., Date, S., Shimokawa, M., Takano, A., Fujii, M., Ohta, Y., Watanabe, T., Kanai, T. & Sato, T., 2015 3, : : Nature medicine. 21, 3, p. 256-262 7 p.

研究成果: Article

430 引用 (Scopus)

Models of lineage switching in hematopoietic development: A new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential

Yamaguchi, Y., Nishio, H., Kasahara, T., Ackerman, S. J., Koyanagi, H. & Suda, T., 1998 1 1, : : Leukemia. 12, 9, p. 1430-1439 10 p.

研究成果: Article

公開
14 引用 (Scopus)

Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor γ chain

Ohbo, K., Suda, T., Hashiyama, M., Mantani, A., Ikebe, M., Miyakawa, K., Moriyama, M., Nakamura, M., Katsuki, M., Takahashi, K., Yamamura, K. I. & Sugamura, K., 1996 2 1, : : Blood. 87, 3, p. 956-967 12 p.

研究成果: Article

公開
196 引用 (Scopus)

Molecular cloning and characterization of a new member of the rat placental prolactin (PRL) family, PRL-like protein H

Iwatsuki, K., Oda, M., Sun, W., Tanaka, S., Ogawa, T. & Shiota, K., 1998 1 1, : : Endocrinology. 139, 12, p. 4976-4983 8 p.

研究成果: Article

公開
26 引用 (Scopus)

Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells

Iwama, A., Hamaguchi, I., Hashiyama, M., Murayama, Y., Yasunaga, K. & Suda, T., 1993 8 31, : : Biochemical and Biophysical Research Communications. 195, 1, p. 301-309 9 p.

研究成果: Article

186 引用 (Scopus)

Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase)

Sakano, S., Iwama, A., Inazawa, J., Ariyama, T., Ohno, M. & Suda, T., 1994 4 1, : : Oncogene. 9, 4, p. 1155-1161 7 p.

研究成果: Article

58 引用 (Scopus)

Molecular cloning of rat macrophage-stimulating protein and its involvement in the male reproductive system

Ohshiro, K., Iwama, A., Matsuno, K., Ezaki, T., Sakamoto, O., Hamaguchi, I., Takasu, N. & Suda, T., 1996 10 3, : : Biochemical and Biophysical Research Communications. 227, 1, p. 273-280 8 p.

研究成果: Article

18 引用 (Scopus)

Molecular mechanisms of pancreatic stone formation in chronic pancreatitis

Ko, S. B. H., Azuma, S., Yoshikawa, T., Yamamoto, A., Kyokane, K., Ko, M. S. H. & Ishiguro, H., 2012, : : Frontiers in Physiology. 3 NOV, Article 415.

研究成果: Article

10 引用 (Scopus)

Morphological examinations of murine granulocyte/macrophage colonies grown in serum-free cultures

Kubota, K., Motoyoshi, K., Kajigaya, S., Suda, T., Saito, M. & Miura, Y., 1983 7 29, : : Experimental Hematology. 11, 5, p. 364-370 7 p.

研究成果: Article

10 引用 (Scopus)

Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress

Tai-Nagara, I., Matsuoka, S., Ariga, H. & Suda, T., 2014 1 2, : : Blood. 123, 1, p. 41-50 10 p.

研究成果: Article

38 引用 (Scopus)

Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells

Kim, Y., Sharov, A. A., McDole, K., Cheng, M., Hao, H., Fan, C. M., Gaiano, N., Ko, M. S. H. & Zheng, Y., 2011 12 23, : : Science. 334, 6063, p. 1706-1710 5 p.

研究成果: Article

153 引用 (Scopus)

Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development

Tsunematsu, R., Nakayama, K., Oike, Y., Nishiyama, M., Ishida, N., Hatakeyama, S., Bessho, Y., Kageyama, R., Suda, T. & Nakayama, K. I., 2004 3 5, : : Journal of Biological Chemistry. 279, 10, p. 9417-9423 7 p.

研究成果: Article

197 引用 (Scopus)

Mucosal concentrations of N-acetyl-5-aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine

Fukuda, T., Naganuma, M., Takabayashi, K., Hagihara, Y., Tanemoto, S., Nomura, E., Yoshimatsu, Y., Sugimoto, S., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Mutaguchi, M., Inoue, N., Ogata, H., Iwao, Y., Abe, T. & Kanai, T., 2020, (Accepted/In press) : : Journal of Gastroenterology and Hepatology (Australia).

研究成果: Article

公開
1 引用 (Scopus)

Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients

Miyoshi, J., Matsuoka, K., Inoue, N., Hisamatsu, T., Ichikawa, R., Yajima, T., Okamoto, S., Naganuma, M., Sato, T., Kanai, T., Ogata, H., Iwao, Y. & Hibi, T., 2013 12 15, : : Journal of Crohn's and Colitis. 7, 12, p. e609-e614

研究成果: Article

37 引用 (Scopus)

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

Dominguez-Brauer, C., Hao, Z., Elia, A. J., Fortin, J. M., Nechanitzky, R., Brauer, P. M., Sheng, Y., Mana, M. D., Chio, I. I. C., Haight, J., Pollett, A., Cairns, R., Tworzyanski, L., Inoue, S., Reardon, C., Marques, A., Silvester, J., Cox, M. A., Wakeham, A., Yilmaz, O. H. および5人, Sabatini, D. M., van Es, J. H., Clevers, H., Sato, T. & Mak, T. W., 2016 8 4, : : Cell stem cell. 19, 2, p. 205-216 12 p.

研究成果: Article

9 引用 (Scopus)

Multiple myeloma with hemolytic anemia and thrombocytopenia

Muroi, K., Imagawa, S., Suda, T., Kajii, E., Otuka, Y., Sakurabayashi, I., Amemiya, Y., Sakamoto, S. & Miura, Y., 1991 8, : : [Rinshō ketsueki] The Japanese journal of clinical hematology. 32, 8, p. 909-911 3 p.

研究成果: Article

4 引用 (Scopus)

Multipotent and Committed CD34+ Cells in Bone Marrow Transplantation

Ema, H., Suda, T., Nakauchi, H., Nakamura, Y., Iwama, A., Imagawa, S., Akutsu, M., Kano, Y., Kato, S., Yabe, M., Yoshida, M., Sakamoto, S., Amemiya, Y. & Miura, Y., 1991 5, : : Japanese Journal of Cancer Research. 82, 5, p. 547-552 6 p.

研究成果: Article

4 引用 (Scopus)

Myeloid and erythroid lineage expression of haemopoietic progenitors derived from an abnormal clone in erythroleukaemia

Suda, T., Sato, Y., Furukawa, Y., Suda, J., Eguchi, M., Saito, M. & Miura, Y., 1986 12, : : British Journal of Haematology. 64, 4, p. 647-656 10 p.

研究成果: Article

6 引用 (Scopus)

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs

Toyama, H., Arai, F., Hosokawa, K., Ikushima, Y. M. & Suda, T., 2012 11 23, : : Biochemical and Biophysical Research Communications. 428, 3, p. 354-359 6 p.

研究成果: Article

4 引用 (Scopus)

Neovascular niche for human myeloma cells in immunodeficient mouse bone

Iriuchishima, H., Takubo, K., Miyakawa, Y., Nakamura-Ishizu, A., Miyauchi, Y., Fujita, N., Miyamoto, K., Miyamoto, T., Ikeda, E., Kizaki, M., Nojima, Y. & Suda, T., 2012 2 7, : : PloS one. 7, 2, e30557.

研究成果: Article

15 引用 (Scopus)

Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors

Matsushita, M., Nakatake, Y., Arai, I., Ibata, K., Kouda, K., Goparaju, S. K., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S., Kanai, T., Yuzaki, M. & Ko, M. S. H., 2017 5 31, (Accepted/In press) : : Biochemical and Biophysical Research Communications.

研究成果: Article

12 引用 (Scopus)

Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis

Yoshida, S., Takakura, A., Ohbo, K., Abe, K., Wakabayashi, J., Yamamoto, M., Suda, T. & Nabeshima, Y. I., 2004 5 15, : : Developmental Biology. 269, 2, p. 447-458 12 p.

研究成果: Article

201 引用 (Scopus)

Neuropilin-1 on hematopoietic cells as a source of vascular development

Yamada, Y., Oike, Y., Ogawa, H., Ito, Y., Fujisawa, H., Suda, T. & Takakura, N., 2003 3 1, : : Blood. 101, 5, p. 1801-1809 9 p.

研究成果: Article

36 引用 (Scopus)

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Nakada, S., Tai, I., Panier, S., Al-Hakim, A., Iemura, S. I., Juang, Y. C., O'Donnell, L., Kumakubo, A., Munro, M., Sicheri, F., Gingras, A. C., Natsume, T., Suda, T. & Durocher, D., 2010 8 19, : : Nature. 466, 7309, p. 941-946 6 p.

研究成果: Article

226 引用 (Scopus)

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche

Sugimura, R., He, X. C., Venkatraman, A., Arai, F., Box, A., Semerad, C., Haug, J. S., Peng, L., Zhong, X. B., Suda, T. & Li, L., 2012 7 20, : : Cell. 150, 2, p. 351-365 15 p.

研究成果: Article

170 引用 (Scopus)

Nonpathogenic Escherichia coli strain Nissle 1917 prevents murine acute and chronic colitis

Kamada, N., Inoue, N., Hisamatsu, T., Okamoto, S., Matsuoka, K., Sato, T., Chinen, H., Hong, K. S., Yamada, T., Suzuki, Y., Suzuki, T., Watanabe, N., Tsuchimoto, K. & Hibi, T., 2005 5 1, : : Inflammatory bowel diseases. 11, 5, p. 455-463 9 p.

研究成果: Article

52 引用 (Scopus)

Notch2 is required for formation of the placental circulatory system, but not for cell-type specification in the developing mouse placenta

Hamada, Y., Hiroe, T., Suzuki, Y., Oda, M., Tsujimoto, Y., Coleman, J. R. & Tanaka, S., 2007 3, : : Differentiation. 75, 3, p. 268-278 11 p.

研究成果: Article

19 引用 (Scopus)
44 引用 (Scopus)

Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder

Sato, T., Ikeda, M., Yotsumoto, S., Shimada, Y., Higuchi, T., Kobayashi, H., Fukuda, T., Ohashi, T., Suda, T. & Ohteki, T., 2013, : : Blood. 121, 16, p. 3267-3273 7 p.

研究成果: Article

4 引用 (Scopus)

Nucleostemin in injury-induced liver regeneration

Shugo, H., Ooshio, T., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Muraguchi, T., Tamase, A., Uema, N., Yamashita, T., Nakamoto, Y., Suda, T., Kaneko, S. & Hirao, A., 2012 11 1, : : Stem Cells and Development. 21, 16, p. 3044-3054 11 p.

研究成果: Article

10 引用 (Scopus)