坂口光洋記念講座

2023

CXCL16 inhibits epithelial regeneration and promotes fibrosis during the progression of radiation enteritis

Cui, Y., Wu, H., Liu, Z., Ma, T., Liang, W., Zeng, Q., Chen, D., Qin, Q., Huang, B., Wang, M. H., Huang, X., He, Y., Kuang, Y., Sugimoto, S., Sato, T. & Wang, L., 2023 2月, In: Journal of Pathology. 259, 2, p. 180-193 14 p.

研究成果: Article › 査読

Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma

Ebisudani, T., Hamamoto, J., Togasaki, K., Mitsuishi, A., Sugihara, K., Shinozaki, T., Fukushima, T., Kawasaki, K., Seino, T., Oda, M., Hanyu, H., Toshimitsu, K., Emoto, K., Hayashi, Y., Asakura, K., Johnson, T. A., Terai, H., Ikemura, S., Kawada, I., Ishii, M., & 8 othersHishida, T., Asamura, H., Soejima, K., Nakagawa, H., Fujii, M., Fukunaga, K., Yasuda, H. & Sato, T., 2023 3月 28, In: Cell Reports. 42, 3, 112212.

研究成果: Article › 査読

Open Access

2022

Cell–matrix interface regulates dormancy in human colon cancer stem cells

Ohta, Y., Fujii, M., Takahashi, S., Takano, A., Nanki, K., Matano, M., Hanyu, H., Saito, M., Shimokawa, M., Nishikori, S., Hatano, Y., Ishii, R., Sawada, K., Machinaga, A., Ikeda, W., Imamura, T. & Sato, T., 2022 8月 25, In: Nature. 608, 7924, p. 784-794 11 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

Schmitt, M., Ceteci, F., Gupta, J., Pesic, M., Böttger, T. W., Nicolas, A. M., Kennel, K. B., Engel, E., Schewe, M., Callak Kirisözü, A., Petrocelli, V., Dabiri, Y., Varga, J., Ramakrishnan, M., Karimova, M., Ablasser, A., Sato, T., Arkan, M. C., de Sauvage, F. J. & Greten, F. R., 2022 12月 8, In: Nature. 612, 7939, p. 347-353 7 p.

研究成果: Article › 査読

Identification of Quiescent LGR5⁺ Stem Cells in the Human Colon

Ishikawa, K., Sugimoto, S., Oda, M., Fujii, M., Takahashi, S., Ohta, Y., Takano, A., Ishimaru, K., Matano, M., Yoshida, K., Hanyu, H., Toshimitsu, K., Sawada, K., Shimokawa, M., Saito, M., Kawasaki, K., Ishii, R., Taniguchi, K., Imamura, T., Kanai, T., & 1 othersSato, T., 2022 11月, In: Gastroenterology. 163, 5, p. 1391-1406.e24

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

In Vivo Intestinal Research Using Organoid Transplantation

Sugimoto, S., Kobayashi, E., Kanai, T. & Sato, T., 2022, In: Keio Journal of Medicine. 71, 4, p. 73-81 9 p.

研究成果: Article › 査読

Open Access

Microfluidic Device to Manipulate 3D Human Epithelial Cell-Derived Intestinal Organoids

Matsumoto, M., Morimoto, Y., Sato, T. & Takeuchi, S., 2022 12月, In: Micromachines. 13, 12, 2082.

研究成果: Article › 査読

Open Access

Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer

Toshimitsu, K., Takano, A., Fujii, M., Togasaki, K., Matano, M., Takahashi, S., Kanai, T. & Sato, T., 2022 6月, In: Nature Chemical Biology. 18, 6, p. 605-614 10 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

2021

Analysis of risk factors for immune-related adverse events in various solid tumors using real-world data

Shimozaki, K., Sukawa, Y., Sato, Y., Horie, S., Chida, A., Tsugaru, K., Togasaki, K., Kawasaki, K., Hirata, K., Hayashi, H., Hamamoto, Y. & Kanai, T., 2021 7月, In: Future Oncology. 17, 20, p. 2593-2603 11 p.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

An organoid-based organ-repurposing approach to treat short bowel syndrome

Sugimoto, S., Kobayashi, E., Fujii, M., Ohta, Y., Arai, K., Matano, M., Ishikawa, K., Miyamoto, K., Toshimitsu, K., Takahashi, S., Nanki, K., Hakamata, Y., Kanai, T. & Sato, T., 2021 4月 1, In: Nature. 592, 7852, p. 99-104 6 p.

研究成果: Article › 査読

58 被引用数 (Scopus)

Demarcated redness associated with increased vascular density/size: A useful marker of flat-type dysplasia in patients with ulcerative colitis

Ikebata, A., Shimoda, M., Okabayashi, K., Uraoka, T., Maehata, T., Sugimoto, S., Mutaguchi, M., Naganuma, M., Kameyama, K., Yahagi, N., Kanai, T., Kitagawa, Y., Kanai, Y. & Iwao, Y., 2021 4月 1, In: Endoscopy International Open. 9, 4, p. E552-E561

研究成果: Article › 査読

Open Access

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps

Chen, B., Scurrah, C. R., McKinley, E. T., Simmons, A. J., Ramirez-Solano, M. A., Zhu, X., Markham, N. O., Heiser, C. N., Vega, P. N., Rolong, A., Kim, H., Sheng, Q., Drewes, J. L., Zhou, Y., Southard-Smith, A. N., Xu, Y., Ro, J., Jones, A. L., Revetta, F., Berry, L. D., & 32 othersNiitsu, H., Islam, M., Pelka, K., Hofree, M., Chen, J. H., Sarkizova, S., Ng, K., Giannakis, M., Boland, G. M., Aguirre, A. J., Anderson, A. C., Rozenblatt-Rosen, O., Regev, A., Hacohen, N., Kawasaki, K., Sato, T., Goettel, J. A., Grady, W. M., Zheng, W., Washington, M. K., Cai, Q., Sears, C. L., Goldenring, J. R., Franklin, J. L., Su, T., Huh, W. J., Vandekar, S., Roland, J. T., Liu, Q., Coffey, R. J., Shrubsole, M. J. & Lau, K. S., 2021 12月 22, In: Cell. 184, 26, p. 6262-6280.e26

研究成果: Article › 査読

Open Access

47 被引用数 (Scopus)

Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis

Horisawa-Takada, Y., Kodera, C., Takemoto, K., Sakashita, A., Horisawa, K., Maeda, R., Shimada, R., Usuki, S., Fujimura, S., Tani, N., Matsuura, K., Akiyama, T., Suzuki, A., Niwa, H., Tachibana, M., Ohba, T., Katabuchi, H., Namekawa, S. H., Araki, K. & Ishiguro, K. I., 2021 12月 1, In: Nature communications. 12, 1, 3184.

研究成果: Article › 査読

Open Access

9 被引用数 (Scopus)

S100P Expression via DNA Hypomethylation Promotes Cell Growth in the Sessile Serrated Adenoma/Polyp-Cancer Sequence

Takahashi, S., Okamoto, K., Tanahashi, T., Fujimoto, S., Nakagawa, T., Bando, M., Ma, B., Kawaguchi, T., Fujino, Y., Mitsui, Y., Kitamura, S., Miyamoto, H., Sato, Y., Muguruma, N., Bando, Y., Sato, T., Fujimori, T. & Takayama, T., 2021 9月 1, In: Digestion. 102, 5, p. 789-802 14 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Synthetic mRNA-based differentiation method enables early detection of Parkinson's phenotypes in neurons derived from Gaucher disease-induced pluripotent stem cells

Akiyama, T., Sato, S., Ko, S. B. H., Sano, O., Sato, S., Saito, M., Nagai, H., Ko, M. S. H. & Iwata, H., 2021 4月, In: Stem Cells Translational Medicine. 10, 4, p. 572-581 10 p.

研究成果: Article › 査読

Open Access

5 被引用数 (Scopus)

Unbiased, comprehensive analysis of Japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function

Makino, K., Shimizu-Hirota, R., Goda, N., Hashimoto, M., Kawada, I., Kashiwagi, K., Hirota, Y., Itoh, H., Jinzaki, M., Iwao, Y., Ko, M., Ko, S. & Takaishi, H., 2021 12月, In: Scientific reports. 11, 1, 15954.

研究成果: Article › 査読

Open Access

2020

Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine

Sato, T., Sase, M., Ishikawa, S., Kajita, M., Asano, J., Sato, T., Mori, Y. & Ohteki, T., 2020 12月 1, In: Scientific reports. 10, 1, 8308.

研究成果: Article › 査読

Open Access

10 被引用数 (Scopus)

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., Kanai, T. & Sato, T., 2020 2月, In: Gastroenterology. 158, 3, p. 638-651.e8

研究成果: Article › 査読

42 被引用数 (Scopus)

Development of a Scalable Coculture System for Gut Anaerobes and Human Colon Epithelium

Sasaki, N., Miyamoto, K., Maslowski, K. M., Ohno, H., Kanai, T. & Sato, T., 2020 7月, In: Gastroenterology. 159, 1, p. 388-390.e5

研究成果: Article › 査読

Open Access

38 被引用数 (Scopus)

Efficacy of apheresis as maintenance therapy for patients with ulcerative colitis in an open-label prospective multicenter randomised controlled trial

for the CAPTAIN study Group, 2020 4月 1, In: Journal of gastroenterology. 55, 4, p. 390-400 11 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells

Tanosaki, S., Tohyama, S., Fujita, J., Someya, S., Hishiki, T., Matsuura, T., Nakanishi, H., Ohto-Nakanishi, T., Akiyama, T., Morita, Y., Kishino, Y., Okada, M., Tani, H., Soma, Y., Nakajima, K., Kanazawa, H., Sugimoto, M., Ko, M., Suematsu, M. & Fukuda, K., 2020 9月 25, In: iScience. 23, 9, 101535.

研究成果: Article › 査読

Open Access

33 被引用数 (Scopus)

Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors

Nakatake, Y., Ko, S., Sharov, A. A., Wakabayashi, S., Murakami, M., Sakota, M., Chikazawa, N., Ookura, C., Sato, S., Ito, N., Ishikawa-Hirayama, M., Mak, S. S., Jakt, L. M., Ueno, T., Hiratsuka, K., Matsushita, M., Goparaju, S. K., Akiyama, T., Ishiguro, K. I., Oda, M., & 7 othersGouda, N., Umezawa, A., Akutsu, H., Nishimura, K., Matoba, R., Ohara, O. & Ko, M. S. H., 2020 5月 19, In: Cell Reports. 31, 7, 107655.

研究成果: Article › 査読

Open Access

14 被引用数 (Scopus)

MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells

Ishiguro, K. I., Matsuura, K., Tani, N., Takeda, N., Usuki, S., Yamane, M., Sugimoto, M., Fujimura, S., Hosokawa, M., Chuma, S., Ko, M. S. H., Araki, K. & Niwa, H., 2020 2月 24, In: Developmental Cell. 52, 4, p. 429-445.e10

研究成果: Article › 査読

74 被引用数 (Scopus)

Multiple immune-related adverse events and anti-tumor efficacy: Real-world data on various solid tumors

Shimozaki, K., Sukawa, Y., Beppu, N., Kurihara, I., Suzuki, S., Mizuno, R., Funakoshi, T., Ikemura, S., Tsugaru, K., Togasaki, K., Kawasaki, K., Hirata, K., Hayashi, H., Hamamoto, Y., Takaishi, H. & Kanai, T., 2020, In: Cancer Management and Research. 12, p. 4585-4593 9 p.

研究成果: Article › 査読

Open Access

25 被引用数 (Scopus)

Of infliximab with long-term administration in Japanese patients with Crohn's disease: Analysis using population pharmacokinetics

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Nagauma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2020, In: International journal of clinical pharmacology and therapeutics. 58, 2, p. 89-102 14 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages

Sato, T., Ishikawa, S., Asano, J., Yamamoto, H., Fujii, M., Sato, T., Yamamoto, K., Kitagaki, K., Akashi, T., Okamoto, R. & Ohteki, T., 2020 8月 1, In: Nature Cell Biology. 22, 8, p. 919-926 8 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Somatic inflammatory gene mutations in human ulcerative colitis epithelium

Nanki, K., Fujii, M., Shimokawa, M., Matano, M., Nishikori, S., Date, S., Takano, A., Toshimitsu, K., Ohta, Y., Takahashi, S., Sugimoto, S., Ishimaru, K., Kawasaki, K., Nagai, Y., Ishii, R., Yoshida, K., Sasaki, N., Hibi, T., Ishihara, S., Kanai, T., & 1 othersSato, T., 2020 1月 9, In: Nature. 577, 7789, p. 254-259 6 p.

研究成果: Article › 査読

134 被引用数 (Scopus)

2019

Cnnm4 deficiency suppresses Ca²⁺ signaling and promotes cell proliferation in the colon epithelia

Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 5月 16, In: Oncogene. 38, 20, p. 3962-3969 8 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Difference in the clinical characteristic and prognosis of colitis-associated cancer and sporadic neoplasia in ulcerative colitis patients

Mutaguchi, M., Naganuma, M., Sugimoto, S., Fukuda, T., Nanki, K., Mizuno, S., Hosoe, N., Shimoda, M., Ogata, H., Iwao, Y. & Kanai, T., 2019 9月, In: Digestive and Liver Disease. 51, 9, p. 1257-1264 8 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P. S., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K., & 2 othersSato, T. & Kanai, T., 2019 3月 1, In: Nature Microbiology. 4, 3, p. 492-503 12 p.

研究成果: Article › 査読

190 被引用数 (Scopus)

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M. S. H., Tada, N., Okano, H. & Akamatsu, W., 2019 2月 12, In: Stem cell reports. 12, 2, p. 305-318 14 p.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors

Hiratsuka, K., Monkawa, T., Akiyama, T., Nakatake, Y., Oda, M., Goparaju, S. K., Kimura, H., Chikazawa-Nohtomi, N., Sato, S., Ishiguro, K., Yamaguchi, S., Suzuki, S., Morizane, R., Ko, S. B. H., Itoh, H. & Ko, M. S. H., 2019 12月 1, In: Scientific reports. 9, 1, 913.

研究成果: Article › 査読

Open Access

32 被引用数 (Scopus)

Intramucosal poorly differentiated and signet-ring cell components in patients with ulcerative colitis-associated high-grade dysplasia

Sugimoto, S., Shimoda, M., Iwao, Y., Mutaguchi, M., Nanki, K., Mizuno, S., Kameyama, K., Ogata, H., Naganuma, M. & Kanai, T., 2019 11月 1, In: Digestive Endoscopy. 31, 6, p. 706-711 6 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN

Ishii, T., Ishikawa, M., Fujimori, K., Maeda, T., Kushima, I., Arioka, Y., Mori, D., Nakatake, Y., Yamagata, B., Nio, S., Kato, T. A., Yang, N., Wernig, M., Kanba, S., Mimura, M., Ozaki, N. & Okano, H., 2019, In: eNeuro. 6, 5, ENEURO.0403-18.2019.

研究成果: Article › 査読

Open Access

37 被引用数 (Scopus)

Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine

Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M., & 5 othersOhtsuka, K., Mochizuki, M., Watanabe, M., Hashiguchi, M. & Kanai, T., 2019 10月 1, In: Journal of Gastroenterology and Hepatology (Australia). 34, 10, p. 1751-1757 7 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients

Higashikuse, Y., Mittal, N., Arimura, T., Yoon, S. H., Oda, M., Enomoto, H., Kaneda, R., Hattori, F., Suzuki, T., Kawakami, A., Gasch, A., Furukawa, T., Labeit, S., Fukuda, K., Kimura, A. & Makino, S., 2019, In: DMM Disease Models and Mechanisms. 12, 11, dmm.041103.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

2018

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S., & 3 othersKoo, B. K., Kanai, T. & Sato, T., 2018 8月 9, In: Cell. 174, 4, p. 856-869.e17

研究成果: Article › 査読

Open Access

174 被引用数 (Scopus)

Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing

Akiyama, T., Sato, S., Chikazawa-Nohtomi, N., Soma, A., Kimura, H., Wakabayashi, S., Ko, S. B. H. & Ko, M. S. H., 2018 12月 1, In: Scientific reports. 8, 1, 1189.

研究成果: Article › 査読

Open Access

18 被引用数 (Scopus)

Erratum to: Efficient genetic engineering of human intestinal organoids using electroporation (Nature Protocols, (2015), 10, 10, (1474-1485), 10.1038/nprot.2015.088)

Fujii, M., Matano, M., Nanki, K. & Sato, T., 2018 1月 1, (Accepted/In press) In: Nature Protocols.

研究成果: Article › 査読

2 被引用数 (Scopus)

Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors 10 Technology 1004 Medical Biotechnology

Ida, H., Akiyama, T., Ishiguro, K., Goparaju, S. K., Nakatake, Y., Chikazawa-Nohtomi, N., Sato, S., Kimura, H., Yokoyama, Y., Nagino, M., Ko, M. S. H. & Ko, S. B. H., 2018 10月 25, In: Stem Cell Research and Therapy. 9, 1, 277.

研究成果: Article › 査読

Open Access

9 被引用数 (Scopus)

Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2018 10月, In: PloS one. 13, 10, e0204632.

研究成果: Article › 査読

13 被引用数 (Scopus)

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Fujii, M., Matano, M., Toshimitsu, K., Takano, A., Mikami, Y., Nishikori, S., Sugimoto, S. & Sato, T., 2018 12月 6, In: Cell stem cell. 23, 6, p. 787-793.e6

研究成果: Article › 査読

Open Access

226 被引用数 (Scopus)

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Seino, T., Kawasaki, S., Shimokawa, M., Tamagawa, H., Toshimitsu, K., Fujii, M., Ohta, Y., Matano, M., Nanki, K., Kawasaki, K., Takahashi, S., Sugimoto, S., Iwasaki, E., Takagi, J., Itoi, T., Kitago, M., Kitagawa, Y., Kanai, T. & Sato, T., 2018 3月 1, In: Cell stem cell. 22, 3, p. 454-467.e6

研究成果: Article › 査読

Open Access

343 被引用数 (Scopus)

Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites

Mito, A., Nakano, Y., Saitoh, T., Gouraud, S. S. S., Yamaguchi, Y., Sato, T., Sasaki, N. & Kojima-Aikawa, K., 2018 1月 1, In: Glycobiology. 28, 1, p. 21-31 11 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Reconstruction of the Human Colon Epithelium In Vivo

Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., Kanai, T. & Sato, T., 2018 2月 1, In: Cell stem cell. 22, 2, p. 171-176.e5

研究成果: Article › 査読

118 被引用数 (Scopus)

The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy

Nakamoto, F. K., Okamoto, S., Mitsui, J., Sone, T., Ishikawa, M., Yamamoto, Y., Kanegae, Y., Nakatake, Y., Imaizumi, K., Ishiura, H., Tsuji, S. & Okano, H., 2018 12月 1, In: Scientific reports. 8, 1, 14215.

研究成果: Article › 査読

Open Access

39 被引用数 (Scopus)

2017

Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium

Yamaguchi, M., Steward, M. C., Smallbone, K., Sohma, Y., Yamamoto, A., Ko, S. B. H., Kondo, T. & Ishiguro, H., 2017 3月 15, In: Journal of Physiology. 595, 6, p. 1947-1972 26 p.

研究成果: Article › 査読

Open Access

19 被引用数 (Scopus)

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., & 19 othersSasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J. I., Duchen, M. R., Nam, J. M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. & Fujita, Y., 2017 5月 1, In: Nature Cell Biology. 19, 5, p. 530-541 12 p.

研究成果: Article › 査読

134 被引用数 (Scopus)

Endoscopic morphologic features of ulcerative colitis–associated dysplasia classified according to the SCENIC consensus statement

Sugimoto, S., Naganuma, M., Iwao, Y., Matsuoka, K., Shimoda, M., Mikami, S., Mizuno, S., Nakazato, Y., Nanki, K., Inoue, N., Ogata, H. & Kanai, T., 2017 3月 1, In: Gastrointestinal Endoscopy. 85, 3, p. 639-646.e2

研究成果: Article › 査読

30 被引用数 (Scopus)

Epigenetic barrier against the propagation of fluctuating gene expression in embryonic stem cells

Saito, Y., Kunitomi, A., Seki, T., Tohyama, S., Kusumoto, D., Takei, M., Kashimura, S., Hashimoto, H., Yozu, G., Motoda, C., Shimojima, M., Egashira, T., Oda, M., Fukuda, K. & Yuasa, S., 2017 9月, In: FEBS Letters. 591, 18, p. 2879-2889 11 p.

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坂口光洋記念講座

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