医学教育統轄センター

研究成果

年別の研究成果 1986 2004 2005 2016 2023

• 405 Article
• 53 Review article
• 9 Chapter
• 9 Letter
• 14 その他
  • 6 Editorial
  • 4 Comment/debate
  • 2 Short survey
  • 1 Book
  • 1 Foreword/postscript

年別の研究成果

年別の研究成果

検索結果

• 1996

  Mutational analysis of the ligand binding site of the inositol 1,4,5- trisphosphate receptor

  Yoshikawa, F., Morita, M., Monkawa, T., Michikawa, T., Furuichi, T. & Mikoshiba, K., 1996, In: Journal of Biological Chemistry. 271, 30, p. 18277-18284 8 p.

  研究成果: Article › 査読

  • Inositol 1,4,5-Trisphosphate Receptors 100%
  • Inositol 89%
  • Amines 79%
  • Binding Sites 58%
  • Acids 56%
  166 被引用数 (Scopus)

• Regulation of obese mRNA expression by hormonal factors in primary cultures of rat adipocytes

  Yoshida, T., Hayashi, M., Monkawa, T. & Saruta, T., 1996 11月, In: European journal of endocrinology. 135, 5, p. 619-625 7 p.

  研究成果: Article › 査読

  • Adipocytes 100%
  • Messenger RNA 59%
  • Insulin 47%
  • Dexamethasone 42%
  • 8-bromocyclic GMP 34%
  8 被引用数 (Scopus)

• Role of vasopressin V2 receptor in acute regulation of aquaporin-2

  Hayashi, M., Sasaki, S., Tsuganezawa, H., Monkawa, T., Kitajima, W., Fushimi, K., Marumo, F. & Saruta, T., 1996 1月 1, In: Kidney and Blood Pressure Research. 19, 1, p. 32-37 6 p.

  研究成果: Article › 査読

  • Aquaporin 2 100%
  • Vasopressin Receptors 87%
  • Vasopressins 54%
  • Antidiuretic Hormone Receptor Antagonists 21%
  • Confocal Microscopy 14%
  18 被引用数 (Scopus)

• Two cases of interstitial pneumonia with anti-PL-12 (alanyl tRNA synthetase) antibodies

  Satoh, S., Hirakata, M., Suwa, A., Mimori, T., Inada, S. & Akizuki, M., 1996 12月 1, In: Ryumachi. 36, 6, p. 862-868 7 p.

  研究成果: Article › 査読

  • Alanine-tRNA Ligase 100%
  • Interstitial Lung Diseases 59%
  • Myositis 37%
  • Antibodies 30%
  • Arthritis 27%
  4 被引用数 (Scopus)
• 1995

  A case of rheumatoid arthritis complicated with salazosulfapyridine-induced aplastic anemia

  Suwa, A., Inada, S., Kawai, S., Hirakata, M. & Nakamura, A., 1995, In: Japanese Journal of Clinical Immunology. 18, 1, p. 116-122 7 p.

  研究成果: Article › 査読

  Open Access

  • Sulfasalazine 100%
  • Aplastic Anaemia 92%
  • Rheumatoid Arthritis 63%
  • Blood Cell Count 58%
  • Testosterone Congeners 33%

• Heterotetrameric complex formation of inositol 1,4,5-trisphosphate receptor subunits

  Monkawa, T., Miyawaki, A., Sugiyama, T., Yoneshima, H., Yamamoto-Hino, M., Furuichi, T., Saruta, T., Hasegawa, M. & Mikoshiba, K., 1995 6月 16, In: Journal of Biological Chemistry. 270, 24, p. 14700-14704 5 p.

  研究成果: Article › 査読

  • Inositol 1,4,5-Trisphosphate Receptors 100%
  • CHO Cells 90%
  • Inositol 89%
  • Inositol 1,4,5-Trisphosphate 47%
  • Cell Line 44%
  35 被引用数 (Scopus)

• Immunohistochemical study of rat Peyer's patches in peptidoglycan- polysaccharide complex-induced chronic enteritis

  Tanaka, S., Miura, S., Suzuki, H., Ohkubo, N., Imaeda, H., Shiozaki, H., Tashiro, H., Serizawa, H. & Tsuchiya, M., 1995 1月 1, In: Advances in experimental medicine and biology. 371, B, p. 1395-1398 4 p.

  研究成果: Article › 査読

• Interstitial lung disease in patients with connective tissue diseases

  Hirakata, M., Nakamura, K., Kaburaki, J., Suwa, A., Mimori, T., Kanazawa, M. & Akizuki, M., 1995 12月, In: Nihon Kyōbu Shikkan Gakkai zasshi. 33 Suppl, p. 268-276 9 p.

  研究成果: Article › 査読

  • Connective Tissue Diseases 100%
  • Interstitial Lung Diseases 91%
  • Dermatomyositis 63%
  • Amino Acyl-tRNA Synthetases 43%
  • Systemic Lupus Erythematosus 39%
  1 被引用数 (Scopus)

• In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats: Hydroethidine microfluorography

  Suzuki, H., Swei, A., Zweifach, B. W. & Schmid-Schönbein, G. W., 1995 5月, In: Hypertension. 25, 5, p. 1083-1089 7 p.

  研究成果: Article › 査読

  • hydroethidine 100%
  • Inbred SHR Rats 63%
  • Ethidium 62%
  • Oxidative Stress 42%
  • Glucocorticoids 35%
  313 被引用数 (Scopus)

• Involvement of an AP-1 complex in zone-specific expression of the CYP11B1 gene in the rat adrenal cortex

  Mukai, K., Mitani, F., Shimada, H. & Ishimura, Y., 1995 11月, In: Molecular and cellular biology. 15, 11, p. 6003-6012 10 p.

  研究成果: Article › 査読

  • Steroid 11-beta-Hydroxylase 100%
  • Adrenal Cortex 75%
  • Transcription Factor AP-1 69%
  • Steroidogenic Factor 1 47%
  • Zona Fasciculata 46%
  15 被引用数 (Scopus)

• Massive pericardial effusion in scleroderma: A review of five cases

  Satoh, M., Tokuhira, M., Hama, N., Hirakata, M., Kuwana, M., Akizuki, M., Ichikawa, Y., Ogawa, S. & Homma, M., 1995 6月, In: Rheumatology. 34, 6, p. 564-567 4 p.

  研究成果: Article › 査読

  • Pericarditis 100%
  • Pericardial Effusion 94%
  • Type I DNA Topoisomerase 52%
  • Renal Insufficiency 35%
  • Pericardial Fluid 29%
  26 被引用数 (Scopus)

• Substance P induces degranulation of mast cells and leukocyte adhesion to venular endothelium

  Suzuki, H., Miura, S., Liu, Y. Y., Tsuchiya, M. & Ishii, H., 1995, In: Peptides. 16, 8, p. 1447-1452 6 p.

  研究成果: Article › 査読

  • Substance P 100%
  • Mast Cells 72%
  • Cell Adhesion 69%
  • Endothelium 65%
  • Leukocytes 58%
  29 被引用数 (Scopus)

• Three cases with systemic rheumatic diseases who developed pulmonary lesions suggestive of bronchiolitis obliterans organizing pneumonia

  Nakamura, K., Hirakata, M., Fujii, T., Yoshida, T., Mimori, T., Mukai, M. & Akizuki, M., 1995, In: Ryumachi. 35, 1, p. 9-14 6 p.

  研究成果: Article › 査読

  • Cryptogenic Organizing Pneumonia 100%
  • Rheumatic Diseases 71%
  • Lung 35%
  • Lung Diseases 23%
  • Prednisolone 13%
  4 被引用数 (Scopus)

• Vasodilator response of mesenteric arterioles to histamine in spontaneously hypertensive rats

  Suzuki, H., Zweifach, B. W. & Schmid-Schönbein, G. W., 1995 9月, In: Hypertension. 26, 3, p. 397-400 4 p.

  研究成果: Article › 査読

  • Arterioles 100%
  • Inbred SHR Rats 99%
  • Vasodilator Agents 92%
  • Histamine 88%
  • Nitroprusside 29%
  3 被引用数 (Scopus)
• 1994

  Autoantibodies to RNA polymerase II are common in systemic lupus erythematosus and overlap syndrome. Specific recognition of the phosphorylated (IIO) form by a subset of human sera

  Satoh, M., Ajmani, A. K., Ogasawara, T., Langdon, J. J., Hirakata, M., Wang, J. & Reeves, W. H., 1994, In: Journal of Clinical Investigation. 94, 5, p. 1981-1989 9 p.

  研究成果: Article › 査読

  Open Access

  • RNA Polymerase II 100%
  • Systemic Lupus Erythematosus 80%
  • Autoantibodies 79%
  • Systemic Scleroderma 68%
  • RNA Polymerase I 61%
  19 被引用数 (Scopus)

• Cloning and expression of a protein kinase C-regulated chloride channel abundantly expressed in rat brain neuronal cells

  Kawasaki, M., Uchida, S., Monkawa, T., Miyawaki, A., Mikoshiba, K., Marumo, F. & Sasaki, S., 1994 3月, In: Neuron. 12, 3, p. 597-604 8 p.

  研究成果: Article › 査読

  • Chloride Channels 100%
  • Protein Kinase C 75%
  • Organism Cloning 73%
  • Brain 39%
  • Amino Acids 37%
  218 被引用数 (Scopus)

• DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA

  Suwa, A., Hirakata, M., Takeda, Y., Jesch, S. A., Mimori, T. & Hardin, J. A., 1994 7月 19, In: Proceedings of the National Academy of Sciences of the United States of America. 91, 15, p. 6904-6908 5 p.

  研究成果: Article › 査読

  • Ku Autoantigen 100%
  • DNA-Activated Protein Kinase 91%
  • DNA 35%
  • Holoenzymes 20%
  • Autoantigens 17%
  169 被引用数 (Scopus)

• Expression and distribution of aquaporin of collecting duct are regulated by vasopressin V₂ receptor in rat kidney

  Hayashi, M., Sasaki, S., Tsuganezawa, H., Monkawa, T., Kitajima, W., Konishi, K., Fushimi, K., Marumo, F. & Saruta, T., 1994 11月, In: Journal of Clinical Investigation. 94, 5, p. 1778-1783 6 p.

  研究成果: Article › 査読

  Open Access

  • rat V2 vasopressin receptor 100%
  • Vasopressin Receptors 58%
  • Aquaporins 57%
  • Kidney 24%
  • Dehydration 21%
  64 被引用数 (Scopus)

• In Vivo visualization of oxygen radical-dependent photoemission

  Tsuchiya, M., Suematsu, M. & Suzuki, H., 1994 1月 1, In: Methods in Enzymology. 233, C, p. 128-140 13 p.

  研究成果: Article › 査読

  • Photoemission 100%
  • Oxidative Stress 81%
  • Reactive Oxygen Species 66%
  • Oxidants 51%
  • Oxygen Radical 50%
  44 被引用数 (Scopus)

• Reactivity against the epitope region 4 (ER 4) on the DNA topoisomerase I molecule as a new predictor for progressive restrictive pulmonary function abnormality in patients with systemic sclerosis

  Kaburaki, J., Kuwana, M., Ikeda, Y., Hirakata, M., Okano, Y. & Tojo, T., 1994, In: Japanese Journal of Clinical Immunology. 17, 5, p. 547-551 5 p.

  研究成果: Article › 査読

  • Type I DNA Topoisomerase 100%
  • Systemic Scleroderma 87%
  • Epitopes 65%
  • Lung 41%
  • Observation 9%

• Verotoxin induces hemorrhagic lesions in rat small intestine - Temporal alteration of vasoactive substances

  Tashiro, H., Miura, S., Kurose, I., Fukumura, D., Suzuki, H., Suematsu, M., Yoshioka, M., Tsuchiya, M., Kai, A. & Kudoh, Y., 1994 6月 1, In: Digestive Diseases and Sciences. 39, 6, p. 1230-1238 9 p.

  研究成果: Article › 査読

  • Shiga Toxins 100%
  • Platelet Activating Factor 82%
  • Small Intestine 62%
  • Escherichia coli O157 35%
  • Neutrophils 32%
  3 被引用数 (Scopus)
• 1993

  Helicobacter pylori elicits gastric mucosal cell damage associated with neutrophil-derived toxic oxidants

  Suzuki, M., Miura, S., Suematsu, M., Fukumura, D., Suzuki, H., Kai, A. & Tsuchiya, M., 1993 1月 1, In: European Journal of Gastroenterology and Hepatology. 5, SUPPL. 1, p. S35-S39

  研究成果: Article › 査読

  • Oxidants 100%
  • Helicobacter pylori 92%
  • Neutrophils 75%
  • Poisons 71%
  • Stomach 68%

• Isolation and characterization of rat CYP11B genes involved in late steps of mineralo- and glucocorticoid syntheses

  Mukai, K., Imai, M., Shimada, H. & Ishimura, Y., 1993, In: Journal of Biological Chemistry. 268, 12, p. 9130-9137 8 p.

  研究成果: Article › 査読

  • Steroid 11-beta-Hydroxylase 100%
  • Mineralocorticoids 80%
  • Glucocorticoid 80%
  • Nucleotide Sequence 76%
  • Glucocorticoids 56%
  13 被引用数 (Scopus)

• Xanthine oxidase-mediated intracellular oxidative stress in response to cerulein in rat pancreatic acinar cells

  Suzuki, H., Suematsu, M., Miura, S., Asako, H., Kurose, I., Ishii, H., Houzawa, S. & Tsuchiya, M., 1993 7月, In: Pancreas. 8, 4, p. 465-470 6 p.

  研究成果: Article › 査読

  • Ceruletide 100%
  • Xanthine Oxidase 89%
  • Acinar Cells 86%
  • Fluorescence 59%
  • Oxidative Stress 53%
  7 被引用数 (Scopus)
• 1992

  A 75-year-old woman with longstanding hypertension, resulting in congestive heart failure and renal failure.

  Handa, S., Yoshikawa, T., Kondoh, T., Wakui, M., Suzuki, H., Yuasa, Y., Kameyama, K. & Hata, J., 1992 3月, In: The Keio Journal of Medicine. 41, 1, p. 33-39 7 p.

  研究成果: Article › 査読

• Autoantibodies to small nuclear and cytoplasmic ribonucleoproteins in japanese patients with inflammatory muscle disease

  Hirakata, M., Mimori, T., Akizuki, M., Craft, J., Hardin, J. A. & Homma, M., 1992 4月, In: Arthritis & Rheumatism. 35, 4, p. 449-456 8 p.

  研究成果: Article › 査読

  Open Access

  • Small Cytoplasmic Ribonucleoproteins 100%
  • Small Nuclear Ribonucleoproteins 67%
  • Myositis 56%
  • Autoantibodies 42%
  • Dermatomyositis 28%
  120 被引用数 (Scopus)

• Early midzonal oxidative stress preceding cell death in hypoperfused rat liver

  Suematsu, M., Suzuki, H., Ishii, H., Kato, S., Yanagisawa, T., Asako, H., Suzuki, M. & Tsuchiya, M., 1992 9月, In: Gastroenterology. 103, 3, p. 994-1001 8 p.

  研究成果: Article › 査読

  • 2',7'-dichlorofluorescein 100%
  • Cell Death 94%
  • Oxidative Stress 91%
  • Hypoxia 73%
  • Propidium 71%
  5 被引用数 (Scopus)

• Effect of rat CINC/gro, a member of the interleukin-8 family, on leukocytes in microcirculation of the rat mesentery

  Watanabe, K., Suematsu, M., Iida, M., Takaishi, K., Iizuka, Y., Suzuki, H., Suzuki, M., Tsuchiya, M. & Tsurufuji, S., 1992 2月, In: Experimental and Molecular Pathology. 56, 1, p. 60-69 10 p.

  研究成果: Article › 査読

  • Chemoattractant 100%
  • Mesentery 83%
  • Chemotactic Factors 76%
  • Microcirculation 72%
  • Interleukin-8 65%
  55 被引用数 (Scopus)

• Enzyme-linked immunosorbent assay of anti-Ku antibodies using purified recombinant Ku antigens

  Suwa, A., Mimori, T., Hama, N., Fujii, T., Hirakata, M., Ohosone, Y., Akizuki, M. & Homma, M., 1992, In: Japanese Journal of Clinical Immunology. 15, 4, p. 337-345 9 p.

  研究成果: Article › 査読

  • Ku Autoantigen 100%
  • Anti-Idiotypic Antibodies 52%
  • Enzyme-Linked Immunosorbent Assay 44%
  • Galactosidases 41%
  • Polymyositis 28%

• Helicobacter pylori-associated ammonia production enhances neutrophil- dependent gastric mucosal cell injury

  Suzuki, M., Miura, S., Suematsu, M., Fukumura, D., Kurose, I., Suzuki, H., Kai, A., Kudoh, Y., Ohashi, M. & Tsuchiya, M., 1992, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 263, 5 26-5, p. G719-G725

  研究成果: Article › 査読

  • Ammonia 100%
  • Helicobacter pylori 85%
  • Neutrophils 69%
  • Stomach 63%
  • Wounds and Injuries 42%
  87 被引用数 (Scopus)

• Quantitative Analysis of Mesenteric Microcirculatory Disturbances Induced by Autonomic Nervous Irritation

  Liu, Y. Y., Miura, S., Suzuki, H., Kurose, I., Fukumura, D., Suzuki, M., Suematsu, M. & Tsuchiya, M., 1992, In: Keio Journal of Medicine. 41, 3, p. 128-133 6 p.

  研究成果: Article › 査読

  Open Access

  • Venules 100%
  • Arterioles 68%
  • pontamine sky blue 39%
  • Electric Stimulation 38%
  • Permeability 35%
  7 被引用数 (Scopus)

• Spontaneous remission of dermatomyositis which developed one month after normal delivery

  Suwa, A., Hirakata, M., Tsuzaka, K., Hama, N., Fujii, T., Mimori, T. & Akizuki, M., 1992 5月 4, In: Ryumachi. 32, 1, p. 73-79 7 p.

  研究成果: Article › 査読
  2 被引用数 (Scopus)

• The use of digital imaging photonic microscopy to investigate oxygen-derived free radicals in microcirculatory disturbances

  Tsuchiya, M., Suzuki, H. & Suematsu, M., 1992 1月 1, In: Japanese Journal of Plastic and Reconstructive Surgery. 35, 10, p. 1059-1065 7 p.

  研究成果: Article › 査読
• 1991

  Analysis of free radical production by fluorescent probes in CCL₄-induced liver injury

  Kato, S., Suematsu, M., Suzuki, H., Ishii, H. & Tsuchiya, M., 1991, In: Journal of Toxicological Sciences. 16, SUPPL. 2, p. 79-82 4 p.

  研究成果: Article › 査読

  Open Access

• Repeated intestinal ulcerations in a patient with systemic lupus erythematosus and high serum antiphospholipid antibody levels

  Sasamura, H., Nakamoto, H., Ryuzaki, M., Kumagai, K., Abe, S., Suzuki, H., Hirakata, M., Tojo, T., Handa, M., Yamamoto, M., Teramoto, T., Hosoda, Y. & Saruta, T., 1991 4月, In: Southern Medical Journal. 84, 4, p. 515-517 3 p.

  研究成果: Article › 査読
  4 被引用数 (Scopus)

• Structural differences in 5′-flanking regions of rat cytochrome P-450aldo and P-45011β genes

  Mukai, K., Imai, M., Shimada, H., Okada, Y., Ogishima, T. & Ishimura, Y., 1991 11月 14, In: Biochemical and Biophysical Research Communications. 180, 3, p. 1187-1193 7 p.

  研究成果: Article › 査読

  • 5' Flanking Region 100%
  • Cytochromes 95%
  • Cytochrome 72%
  • Protein 34%
  • Genes 33%
  17 被引用数 (Scopus)
• 1990

  Isolation and phosphorylation of the Bacillus subtilis degS and degU gene products

  Mukai, K., Kawata, M. & Tanaka, T., 1990, In: Journal of Biological Chemistry. 265, 32, p. 20000-20006 7 p.

  研究成果: Article › 査読

  • Phosphoryl 100%
  • Bacillus subtilis 97%
  • alkaline protease 93%
  • Phosphorylation 61%
  • Phosphates 51%
  28 被引用数 (Scopus)
• 1988

  Coexistence of CREST syndrome and primary biliary cirrhosis. Serological studies of two cases

  Hirakata, M., Akizuki, M., Miyachi, K., Matsushima, H., Okano, T. & Homma, M., 1988 1月 1, In: Journal of Rheumatology. 15, 7, p. 1166-1170 5 p.

  研究成果: Article › 査読

  • CREST Syndrome 100%
  • Biliary Liver Cirrhosis 72%
  • Immunodiffusion 18%
  • Centromere 18%
  • Antibody Specificity 18%
  4 被引用数 (Scopus)

• Pyloric stenosis in a patient with progressive systemic sclerosis

  Hirakata, M., Akizuki, M., Okano, Y., Hama, N., Tojo, T., Asakura, H., Kumai, K., Ishibiki, K., Hosoda, Y. & Homma, M., 1988 9月, In: Clinical Rheumatology. 7, 3, p. 394-397 4 p.

  研究成果: Article › 査読

  • Pyloric Stenosis 100%
  • Diffuse Scleroderma 89%
  • Duodenum 33%
  • Conservative Treatment 29%
  • Edema 27%
  2 被引用数 (Scopus)
• 1986

  IN vitro production of autoantibodies to u1 ribonucleoproteins by peripheral blood mononuclear cells from patients with connective tissue diseases

  Ohosone, Y., Akizuki, M., Hirakata, M., Satoh, M., Yamagata, H. & Homma, M., 1986 11月, In: Arthritis & Rheumatism. 29, 11, p. 1343-1350 8 p.

  研究成果: Article › 査読

  • Ribonucleoproteins 100%
  • Connective Tissue Diseases 97%
  • Autoantibodies 74%
  • Blood Cells 66%
  • Antibodies 44%
  4 被引用数 (Scopus)