総合医科学研究センター

研究成果 2001 2019

  • 27 Article
  • 1 Conference contribution
2019
公開
Workplace
Health Status
Odds Ratio
Confidence Intervals
Health
1 引用 (Scopus)

Innervation of the tibial epiphysis through the intercondylar foramen

Matsuo, K., Ji, S., Miya, A., Yoda, M., Hamada, Y., Tanaka, T., Takao-Kawabata, R., Kawaai, K., Kuroda, Y. & Shibata, S., 2019 3 1, : : Bone. 120, p. 297-304 8 p.

研究成果: Article

Venus
Epiphyses
Schwann Cells
Sensory Receptor Cells
Knee Joint
公開
Skull Base
Osteoclasts
Osteoblasts
Posterior Cranial Fossa
Bone and Bones
2018

Granulocyte-colony stimulating factor enhances load-induced muscle hypertrophy in mice

Ohashi, M., Okubo, K., Mizuno, S., Yoda, M., Shirasawa, H., Chiba, K., Horiuchi, K., Matsumoto, M. & Nakamura, M., 2018 1 1, (Accepted/In press) : : Biochemical and Biophysical Research Communications.

研究成果: Article

Granulocyte Colony-Stimulating Factor
Hypertrophy
Muscle
Muscles
Granulocyte Colony-Stimulating Factor Receptors

Inhibition of ADAM10 in satellite cells accelerates muscle regeneration following muscle injury

Mizuno, S., Yoda, M., Shimoda, M., Chiba, K., Nakamura, M. & Horiuchi, K., 2018 1 1, (Accepted/In press) : : Journal of Orthopaedic Research.

研究成果: Article

Muscle Cells
Regeneration
Muscles
Wounds and Injuries
Cell Differentiation
2 引用 (Scopus)

Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy

Yuasa, K., Okubo, K., Yoda, M., Otsu, K., Ishii, Y., Nakamura, M., Itoh, Y. & Horiuchi, K., 2018 12 1, : : Scientific Reports. 8, 1, 9037.

研究成果: Article

Muscular Atrophy
Denervation
p38 Mitogen-Activated Protein Kinases
Cell Aging
Cell Differentiation
2017
10 引用 (Scopus)

Inhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice

Shirasawa, H., Matsumura, N., Shimoda, M., Oki, S., Yoda, M., Tohmonda, T., Kanai, Y., Matsumoto, M., Nakamura, M. & Horiuchi, K., 2017 1 31, : : Scientific Reports. 7, 41552.

研究成果: Article

Platelet-Derived Growth Factor Receptors
Mesenchymal Stromal Cells
Humeral Head
Muscles
Rotator Cuff
2016
2 引用 (Scopus)
Ataxia Telangiectasia
Osteoclasts
Bone and Bones
DNA Damage
Bone Resorption
2015
14 引用 (Scopus)

ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface

Uchikawa, S., Yoda, M., Tohmonda, T., Kanaji, A., Matsumoto, M., Toyama, Y. & Horiuchi, K., 2015 2 1, : : Cytokine. 71, 2, p. 238-245 8 p.

研究成果: Article

Interleukin-1 Type II Receptors
Interleukins
Interleukin-1
Interleukin Receptors
Interleukin-1 Receptors
7 引用 (Scopus)

A disintegrin and metalloprotease 10 (ADAM10) is indispensable for maintenance of the muscle satellite cell pool

Mizuno, S., Yoda, M., Shimoda, M., Tohmonda, T., Okada, Y., Toyama, Y., Takeda, SI., Nakamura, M., Matsumoto, M. & Horiuchi, K., 2015 11 20, : : Journal of Biological Chemistry. 290, 47, p. 28456-28464 9 p.

研究成果: Article

Disintegrins
Metalloproteases
Muscle Cells
Muscle
Maintenance
2 引用 (Scopus)

Generation and characterization of a novel shoulder contracture mouse model

Oki, S., Shirasawa, H., Yoda, M., Matsumura, N., Tohmonda, T., Yuasa, K., Nakamura, M., Matsumoto, M. & Horiuchi, K., 2015 11 1, : : Journal of Orthopaedic Research. 33, 11, p. 1732-1738 7 p.

研究成果: Article

Bursitis
Contracture
Shoulder Joint
Gene Expression
Animal Models
17 引用 (Scopus)

IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis

Tohmonda, T., Yoda, M., Iwawaki, T., Matsumoto, M., Nakamura, M., Mikoshiba, K., Toyama, Y. & Horiuchi, K., 2015 8 3, : : Journal of Clinical Investigation. 125, 8, p. 3269-3279 11 p.

研究成果: Article

Unfolded Protein Response
Osteoclasts
Osteogenesis
Endoplasmic Reticulum
NFATC Transcription Factors
2013
13 引用 (Scopus)

Conditional Inactivation of TNFα-Converting Enzyme in Chondrocytes Results in an Elongated Growth Plate and Shorter Long Bones

Saito, K., Horiuchi, K., Kimura, T., Mizuno, S., Yoda, M., Morioka, H., Akiyama, H., Threadgill, D., Okada, Y., Toyama, Y. & Satou, K., 2013 1 18, : : PLoS One. 8, 1, e54853.

研究成果: Article

growth plate
Growth Plate
chondrocytes
Chondrocytes
Epidermal Growth Factor Receptor
26 引用 (Scopus)

Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Activity In Vivo

Yoda, M., Kimura, T., Tohmonda, T., Morioka, H., Matsumoto, M., Okada, Y., Toyama, Y. & Horiuchi, K., 2013 1 14, : : PLoS One. 8, 1, e54412.

研究成果: Article

Transgenic Mice
Genes
genetically modified organisms
Defects
mice
11 引用 (Scopus)

The IRE1α-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in PTH-induced osteoclastogenesis

Tohmonda, T., Yoda, M., Mizuochi, H., Morioka, H., Matsumoto, M., Urano, F., Toyama, Y. & Horiuchi, K., 2013 1 18, : : Journal of Biological Chemistry. 288, 3, p. 1691-1695 5 p.

研究成果: Article

Parathyroid Hormone Receptor Type 1
Parathyroid Hormone
Osteogenesis
Osteoblasts
Transcription
2012
22 引用 (Scopus)

A novel multi-kinase inhibitor pazopanib suppresses growth of synovial sarcoma cells through inhibition of the PI3K-AKT pathway

Hosaka, S., Horiuchi, K., Yoda, M., Nakayama, T. R., Tohmonda, T., Susa, M., Nakamura, M., Chiba, K., Toyama, Y. & Morioka, H., 2012 9, : : Journal of Orthopaedic Research. 30, 9, p. 1493-1498 6 p.

研究成果: Article

Synovial Sarcoma
Phosphatidylinositol 3-Kinases
Phosphotransferases
Growth
Cytotoxins
22 引用 (Scopus)

The transient appearance of zipper-like actin superstructures during the fusion of osteoclasts

Takito, J., Nakamura, M., Yoda, M., Tohmonda, T., Uchikawa, S., Horiuchi, K., Toyama, Y. & Chiba, K., 2012 2 1, : : Journal of Cell Science. 125, 3, p. 662-672 11 p.

研究成果: Article

Osteoclasts
Actins
Bone Diseases
Giant Cells
Cherubism
2011
29 引用 (Scopus)

Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis

Yoda, M., Kimura, T., Tohmonda, T., Uchikawa, S., Koba, T., Takito, J., Morioka, H., Matsumoto, M., Link, D. C., Chiba, K., Okada, Y., Toyama, Y. & Horiuchi, K., 2011 12 22, : : Blood. 118, 26, p. 6939-6942 4 p.

研究成果: Article

Myeloproliferative Disorders
Cells
Hematopoiesis
Granulocyte Colony-Stimulating Factor
Stem cells
68 引用 (Scopus)

The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix

Tohmonda, T., Miyauchi, Y., Ghosh, R., Yoda, M., Uchikawa, S., Takito, J., Morioka, H., Nakamura, M., Iwawaki, T., Chiba, K., Toyama, Y., Urano, F. & Horiuchi, K., 2011 5 1, : : EMBO Reports. 12, 5, p. 451-457 7 p.

研究成果: Article

Osteoblasts
Inositol
Transcription
Carrier Proteins
Unfolded Protein Response
20 引用 (Scopus)

VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage raw 264.7 cells

Shirakabe, K., Hattori, S., Seiki, M., Koyasu, S. & Okada, Y., 2011 12 16, : : Journal of Biological Chemistry. 286, 50, p. 43154-43163 10 p.

研究成果: Article

Macrophages
Metalloproteases
Phagocytosis
Membrane Proteins
Disintegrins
2010
12 引用 (Scopus)

GRIP1 enhances estrogen receptor α-dependent extracellular matrix gene expression in chondrogenic cells

Kato, M., Takaishi, H., Yoda, M., Tohmonda, T., Takito, J., Fujita, N., Hosogane, N., Horiuchi, K., Kimura, T., Okada, Y., Saito, T., Kawaguchi, H., Kikuchi, T., Matsumoto, M., Toyama, Y. & Chiba, K., 2010 7, : : Osteoarthritis and Cartilage. 18, 7, p. 934-941 8 p.

研究成果: Article

Nuclear Receptor Coactivator 2
Gene expression
Estrogen Receptors
Extracellular Matrix
Proteins
29 引用 (Scopus)

Inhibition of STAT1 accelerates bone fracture healing

Tajima, K., Takaishi, H., Takito, J., Tohmonda, T., Yoda, M., Ota, N., Kosaki, N., Matsumoto, M., Ikegami, H., Nakamura, T., Kimura, T., Okada, Y., Horiuchi, K., Chiba, K. & Toyama, Y., 2010 7, : : Journal of Orthopaedic Research. 28, 7, p. 937-941 5 p.

研究成果: Article

STAT1 Transcription Factor
Fracture Healing
Bone Fractures
Osteogenesis
Osteoblasts
13 引用 (Scopus)

Receptor activator of NF-κB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages

Hakozaki, A., Yoda, M., Tohmonda, T., Furukawa, M., Hikata, T., Uchikawa, S., Takaishi, H., Matsumoto, M., Chiba, K., Horiuchi, K. & Toyama, Y., 2010 3 1, : : Journal of Immunology. 184, 5, p. 2442-2448 7 p.

研究成果: Article

RANK Ligand
Osteogenesis
Macrophages
Membrane Proteins
Osteoclasts
2009
28 引用 (Scopus)

Accelerated cartilage resorption by chondroclasts during bone fracture healing in osteoprotegerin-deficient mice

Ota, N., Takaishi, H., Kosaki, N., Takito, J., Yoda, M., Tohmonda, T., Kimura, T., Okada, Y., Yasuda, H., Kawaguchi, H., Matsumoto, M., Chiba, K., Ikegami, H. & Toyama, Y., 2009 11, : : Endocrinology. 150, 11, p. 4823-4834 12 p.

研究成果: Article

Osteoprotegerin
Fracture Healing
Bone Fractures
Chondrocytes
Cartilage
41 引用 (Scopus)

IL-27 abrogates receptor activator of NF-κB ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos

Furukawa, M., Takaishi, H., Takito, J., Yoda, M., Sakai, S., Hikata, T., Hakozaki, A., Uchikawa, S., Matsumoto, M., Chiba, K., Kimura, T., Okada, Y., Matsuo, K., Yoshida, H. & Toyama, Y., 2009 8 15, : : Journal of Immunology. 183, 4, p. 2397-2406 10 p.

研究成果: Article

Interleukin-27
Granulocyte-Macrophage Progenitor Cells
Osteogenesis
Ligands
Osteoclasts
2008
30 引用 (Scopus)

Transmission of force sensation by micro-macro bilateral control with scaling of control gains

Susa, S., Shimono, T., Takei, T., Atsuta, K., Shimojima, N., Ozawa, S., Morikawa, Y. & Ohnishi, K., 2008, International Workshop on Advanced Motion Control, AMC. 巻 1. p. 532-537 6 p. 4516123

研究成果: Conference contribution

Gain control
Macros
Scaling Factor
Reproducibility
Scaling
2002

Detection of stimulants from charred bodies killed by a traffic accident: Distribution in the bodies

Nakajima, R., Shinozuka, T., Takei, S., Ohue, O., Baba, M., Ro, A., Yanagida, J. & Murai, T., 2002, : : Japanese Journal of Forensic Toxicology. 20, 1, p. 49-55 7 p.

研究成果: Article

Methamphetamine
Highway accidents
Traffic Accidents
Urine
Gas chromatography
2001
34 引用 (Scopus)

Sudden death due to cardiovascular disorders: A review of the studies on the medico-legal cases in Tokyo

Murai, T., Baba, M., Ro, A., Murai, N., Matsuo, Y., Takada, A. & Saito, K., 2001 9, : : Keio Journal of Medicine. 50, 3, p. 175-181 7 p.

研究成果: Article

Coroners and Medical Examiners
Tokyo
Sudden Death
Myocardial Ischemia
Cause of Death