生命情報学科

研究成果

Enhancement or induction of neurite formation by a protein tyrosine phosphatase inhibitor, 3,4-dephostatin, in growth factor-treated PC12h cells

Fujiwara, S., Watanabe, T., Nagatsu, T., Gohda, J., Imoto, M. & Umezawa, K., 1997 9 8, : : Biochemical and Biophysical Research Communications. 238, 1, p. 213-217 5 p.

研究成果: Article

25 引用 (Scopus)

Induction of apoptotic cell death by tyrosine kinase inhibitor

Imoto, M., Simizu, S. & Umezawa, K., 1997 1 1, : : nippon nogeikagaku kaishi. 71, 5, p. 523-526 4 p.

研究成果: Article

公開
2 引用 (Scopus)

Pholipeptin, a novel cyclic lipoundecapeptide from Pseudomonas fluorescens

Ui, H., Miyake, T., Iinuma, H., Imoto, M., Naganawa, H., Hattori, S., Hamada, M., Takeuchi, T., Umezawa, S. & Umezawa, K., 1997 1 1, : : Journal of Organic Chemistry. 62, 1, p. 103-108 6 p.

研究成果: Article

25 引用 (Scopus)

Preparation and characterization of liposomes containing magnetic particles for magnetic targeting

Tokiwa, Y., Ohta, E., Sato, T., Kasamo, K. & Oka, K., 1997 1 1, : : Drug Delivery System. 12, 1, p. 43-48 6 p.

研究成果: Article

2 引用 (Scopus)

Screening of phosphatidylinositol turnover inhibitors and regulation of cell cycle progression

Umezawa, K., Deguchi, A. & Imoto, M., 1997 11 7, : : Japanese Journal of Cancer and Chemotherapy. 24, 11, p. 1578-1584 7 p.

研究成果: Article

1 引用 (Scopus)

Shear stress induced intracellular calcium response in endothelial cells

Abe, T., Oka, K., Matsumura, S., Ikeda, M. & Tanisita, K., 1997 12 1, : : American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 35, p. 543-544 2 p.

研究成果: Article

1996

Compliant effect on the axial gas transport in model airway

Inaba, Y., Fujioka, H., Oka, K. & Tanishita, K., 1996 12 1, : : American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 33, p. 177-178 2 p.

研究成果: Article

20 引用 (Scopus)

Dendritic Ca2+ response in cereal sensory interneurons of the cricket Gryllus bimaculatus

Ogawa, H., Baba, Y. & Kotaro, O., 1996 11 15, : : Neuroscience Letters. 219, 1, p. 21-24 4 p.

研究成果: Article

8 引用 (Scopus)

Effect of shear stress on albumin uptake into cultured endothelial cells

Kudo, S., Ikezawa, K., Matsumura, S., Ikeda, M., Oka, K. & Tanishita, K., 1996 12 1, : : American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 33, p. 209-210 2 p.

研究成果: Article

4 引用 (Scopus)

Inhibition of G1 cyclin expression in normal rat kidney cells by inostamycin, a phosphatidylinositol synthesis inhibitor

Deguchi, A., Imoto, M. & Umezawa, K., 1996 12, : : Journal of biochemistry. 120, 6, p. 1118-1122 5 p.

研究成果: Article

17 引用 (Scopus)

Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells

Simizu, S., Imoto, M., Masuda, N., Takada, M. & Umezawa, K., 1996 11 1, : : Cancer Research. 56, 21, p. 4978-4982 5 p.

研究成果: Article

47 引用 (Scopus)
3 引用 (Scopus)

Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase

Sanpei, K., Saito, Y., Imoto, M., Umezawa, K. & Kato, K., 1996 11 5, : : Bioorganic and Medicinal Chemistry Letters. 6, 21, p. 2487-2490 4 p.

研究成果: Article

3 引用 (Scopus)
2 引用 (Scopus)
1995

A novel cyclic lipoundecapeptide, pholipeptin, isolated from Pseudomonas sp.

Ui, H., Miyake, T., Iinuma, H., Imoto, M., Hattori, S., Hamada, M., Takeuchi, T., Umezawa, S. & Umezawa, K., 1995 10 9, : : Tetrahedron Letters. 36, 41, p. 7479-7480 2 p.

研究成果: Article

7 引用 (Scopus)

Induction of erythroid differentiation in leukemic K562 cells by an S-adenosylhomocysteine hydrolase inhibitor, aristeromycin

Mizutani, Y., Masuoka, S., Imoto, M., Kawada, M. & Umezawa, K., 1995 2 6, : : Biochemical and Biophysical Research Communications. 207, 1, p. 69-74 6 p.

研究成果: Article

6 引用 (Scopus)

Inhibition of Phosphatidylinositol-specific Phospholipase C Activity by Fluvirucin B2

Ui, H., Imoto, M. & Umezawa, K., 1995 1 1, : : The Journal of Antibiotics. 48, 5, p. 387-390 4 p.

研究成果: Article

公開
17 引用 (Scopus)
1994

Antitumor effect of piericidin B1 N-oxide

Nishioka, H., Sawa, T., Takeuchi, T., Imoto, M., Imaoka, T. & Umezawa, K., 1994 1 1, : : The Journal of Antibiotics. 47, 4, p. 447-452 6 p.

研究成果: Article

公開
16 引用 (Scopus)
14 引用 (Scopus)

Enhancement of CDP-DG:inositol transferase activity in src- and erbB2- transformed cells

Imoto, M., Taniguchi, Y., Fujiwara, H. & Umezawa, K., 1994 1 1, : : Experimental Cell Research. 212, 1, p. 151-154 4 p.

研究成果: Article

8 引用 (Scopus)

Induction of Apoptosis by Erbstatin in Mouse Leukemia L1210 Cells

Simizu, S., Imoto, M. & Umezawa, K., 1994, : : Bioscience, biotechnology, and biochemistry. 58, 9, p. 1549-1552 4 p.

研究成果: Article

9 引用 (Scopus)

Inhibition of T Cell Receptor-mediated Signal Transduction by Erbstatin

Imoto, M., Nakamura, T., Tanaka, S. I. & Umezawa, K., 1994, : : Bioscience, biotechnology, and biochemistry. 58, 9, p. 1700-1701 2 p.

研究成果: Article

3 引用 (Scopus)

Involvement of phosphatidylinositol synthesis in the regulation of S phase induction

Imoto, M., Morii, T., Deguchi, A. & Umezawa, K., 1994 11, : : Experimental Cell Research. 215, 1, p. 228-233 6 p.

研究成果: Article

20 引用 (Scopus)

Learning languages by collecting cases and tuning parameters

Sakakibara, Y., Jantke, K. P. & Lange, S., 1994, Algorithmic Learning Theory - 4th International Workshop on Analogical and Inductive Inference, AII 1994 and 5th International Workshop on Algorithmic Learning Theory, ALT 1994, Proceedings. Arikawa, S. & Jantke, K. P. (版). Springer Verlag, p. 532-546 15 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); 巻数 872 LNAI).

研究成果: Conference contribution

4 引用 (Scopus)

Recent methods for rna modeling using stochastic context-free grammars

Sakakibara, Y., Brown, M., Hughey, R., Mian, S., Sjölander, K., Underwood, R. C. & Haussler, D., 1994 1 1, Combinatorial Pattern Matching - 5th Annual Symposium, CPM 1994, Proceedings. Crochemore, M. & Gusfield, D. (版). Springer Verlag, p. 290-306 17 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); 巻数 807 LNCS).

研究成果: Conference contribution

16 引用 (Scopus)
1993

Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces: Structure determination

Kakeya, H., Imoto, M., Takahashil, Y., Naganawa, H., Takeuchi, T. & Umezawa, K., 1993 7, : : Journal of Antibiotics. 46, 11, p. 1716-1719 4 p.

研究成果: Article

公開
30 引用 (Scopus)

Dephostatin, A Novel Protein Tyrosine Phosphatase Inhibitor Produced By Streptomyces I Taxonomy, Isolation, And Characterization

Masaya, I., Hldeaki, K., Tsutomu, S., Cfflgusa, H., Masa, H., Tomio, T. & Kazuo, U., 1993 5, : : The Journal of Antibiotics. 46, 9, p. 1342-1346 5 p.

研究成果: Article

85 引用 (Scopus)

Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia

Hiramatsu, T., Imoto, M., Koyano, T. & Umezawa, K., 1993 9 30, : : Cancer Letters. 73, 2-3, p. 161-166 6 p.

研究成果: Article

83 引用 (Scopus)

Involvement of tyrosine kinase in growth factor-induced phospholipase C activation in NIH3T3 cells

Imoto, M., Sujikai, I., Ui, H. & Umezawa, K., 1993 2 24, : : Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism. 1166, 2-3, p. 188-192 5 p.

研究成果: Article

8 引用 (Scopus)

Isolation of a novel substrate-competitive tyrosine kinase inhibitor, desmal, from the plant Desmos chinensis

Kakeya, H., Imoto, M., Tabata, Y., Iwami, J., Matsumoto, H., Nakamura, K., Koyano, T., Tadano, K. I. & Umezawa, K., 1993 4 5, : : FEBS Letters. 320, 2, p. 169-172 4 p.

研究成果: Article

27 引用 (Scopus)
1992

Biosynthetic preparation of radioactively labeled erbstatin

Tabata, Y., Imoto, M. & Umezawa, K., 1992 1 1, : : The Journal of Antibiotics. 45, 8, p. 1382-1384 3 p.

研究成果: Article

公開
2 引用 (Scopus)
29 引用 (Scopus)

Development of liposome for targeting therapy against brain tumor.

Shibata, S., Ryu, N., Ochi, A., Jinnouchi, T., Sato, T., Sunamoto, J., Hirai, M. & Matsuyama, K., 1992 1 1, : : Drug Delivery System. 7, 2, p. 109-114 6 p.

研究成果: Article

1 引用 (Scopus)

Direct transfer of tumor surface antigenic protein (TSAP) from tumor cell to liposome for making liposomal vaccine

Junzo, S., Tetsurou, N., Toshinori, S., Kazunari, A., Ryujiro, S., Ei-ichi, N. & Hiroshi, S., 1992 6, : : Journal of Controlled Release. 20, 2, p. 143-153 11 p.

研究成果: Article

11 引用 (Scopus)
24 引用 (Scopus)
44 引用 (Scopus)

Inhibition of CDP-DG:iNositol transferase by inostamycin

Imoto, M., Taniguchi, Y. & Umezawa, K., 1992 8, : : Journal of biochemistry. 112, 2, p. 299-302 4 p.

研究成果: Article

22 引用 (Scopus)

Inhibition of tyrosine kinase and src oncogene functions by stable erbstatin analogues

Hori, T., Kondo, T., Tsuji, T., Imoto, M. & Umezawa, K., 1992 1 1, : : The Journal of Antibiotics. 45, 2, p. 280-282 3 p.

研究成果: Article

公開
10 引用 (Scopus)
26 引用 (Scopus)
51 引用 (Scopus)
33 引用 (Scopus)