生命情報学科

研究成果

年別の研究成果 1985 2005 2006 2007 2008 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 799 Article
• 58 Conference contribution
• 35 Review article
• 16 Chapter
• 45 その他
  • 12 Paper
  • 12 Comment/debate
  • 12 Editorial
  • 3 Conference article
  • 3 Letter
  • 3 Short survey

年別の研究成果

年別の研究成果

検索結果

• 1997

  Numerical analysis of oscillatory flow and gas transport through a bifurcating airway model

  Fujioka, H., Oka, K. & Tanishita, K., 1997 12月 1, In: American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 36, p. 43-44 2 p.

  研究成果: Article › 査読

• Preparation and characterization of liposomes containing magnetic particles for magnetic targeting

  Tokiwa, Y., Ohta, E., Sato, T., Kasamo, K. & Oka, K., 1997, In: Drug Delivery System. 12, 1, p. 43-48 6 p.

  研究成果: Article › 査読

  • Magnetic Particle 100%
  • Liposomes 81%
  • Liposome 75%
  • Ferrosoferric Oxide 55%
  • Magnetite 37%
  2 被引用数 (Scopus)

• Screening of phosphatidylinositol turnover inhibitors and regulation of cell cycle progression

  Umezawa, K., Deguchi, A. & Imoto, M., 1997 11月 7, In: Japanese Journal of Cancer and Chemotherapy. 24, 11, p. 1578-1584 7 p.

  研究成果: Article › 査読

  • inostamycin 100%
  • Phosphatidylinositols 49%
  • CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase 43%
  • Cell Cycle 36%
  • akaterpin 28%
  1 被引用数 (Scopus)

• Shear stress induced intracellular calcium response in endothelial cells

  Abe, T., Oka, K., Matsumura, S., Ikeda, M. & Tanisita, K., 1997, In: American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 35, p. 543-544 2 p.

  研究成果: Article › 査読
• 1996

  Compliant effect on the axial gas transport in model airway

  Inaba, Y., Fujioka, H., Oka, K. & Tanishita, K., 1996 12月 1, In: American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 33, p. 177-178 2 p.

  研究成果: Article › 査読

• Dendritic Ca²⁺ response in cereal sensory interneurons of the cricket Gryllus bimaculatus

  Ogawa, H., Baba, Y. & Kotaro, O., 1996 11月 15, In: Neuroscience Letters. 219, 1, p. 21-24 4 p.

  研究成果: Article › 査読

  • Gryllidae 100%
  • Edible Grain 81%
  • Interneurons 70%
  • calcium green 58%
  • Dendrites 34%
  8 被引用数 (Scopus)

• Effect of shear stress on albumin uptake into cultured endothelial cells

  Kudo, S., Ikezawa, K., Matsumura, S., Ikeda, M., Oka, K. & Tanishita, K., 1996 12月 1, In: American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 33, p. 209-210 2 p.

  研究成果: Article › 査読

  • Endothelial cells 100%
  • Shear stress 61%
  • Macromolecules 46%
  • Monolayers 29%
  • Microscopes 10%
  5 被引用数 (Scopus)

• Fault tolerance of the TBSF (Tandem Banyan Switching Fabrics) and PBSF (Piled Banyan Switching Fabrics)

  Funahashi, A., Hanawa, T. & Amano, H., 1996 1月 1, In: IEICE Transactions on Information and Systems. E79-D, 8, p. 1180-1189 10 p.

  研究成果: Article › 査読

  • Fault tolerance 100%
  • Degradation 35%
  • Recovery 34%
  • Bandwidth 31%
  • Telecommunication links 23%

• Inhibition of G1 cyclin expression in normal rat kidney cells by inostamycin, a phosphatidylinositol synthesis inhibitor

  Deguchi, A., Imoto, M. & Umezawa, K., 1996 12月, In: Journal of biochemistry. 120, 6, p. 1118-1122 5 p.

  研究成果: Article › 査読

  • inostamycin 100%
  • Cyclin G1 71%
  • Phosphatidylinositol 55%
  • Phosphatidylinositols 49%
  • Cyclin-Dependent Kinase 2 28%
  17 被引用数 (Scopus)

• Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells

  Simizu, S., Imoto, M., Masuda, N., Takada, M. & Umezawa, K., 1996 11月 1, In: Cancer Research. 56, 21, p. 4978-4982 5 p.

  研究成果: Article › 査読

  • erbstatin 100%
  • Small Cell Lung Carcinoma 61%
  • Hydrogen Peroxide 55%
  • DNA Fragmentation 35%
  • Apoptosis 33%
  53 被引用数 (Scopus)

• Local gas transport rate in oscillatory flow in a model human central airways

  Tanaka, G., Ito, J., Oka, K. & Tanishita, K., 1996 12月 1, In: American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 33, p. 179-180 2 p.

  研究成果: Article › 査読

  • Gases 100%
  • Bifurcation (mathematics) 72%
  • Tracers 67%
  • Geometry 35%
  4 被引用数 (Scopus)

• Oscillatory flow in a flexible curved tube

  Fujioka, H., Oka, K. & Tanishita, K., 1996 12月 1, In: American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 33, p. 75-76 2 p.

  研究成果: Article › 査読

• Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase

  Sanpei, K., Saito, Y., Imoto, M., Umezawa, K. & Kato, K., 1996 11月 5, In: Bioorganic and Medicinal Chemistry Letters. 6, 21, p. 2487-2490 4 p.

  研究成果: Article › 査読

  • 1-Phosphatidylinositol 4-Kinase 100%
  • Phosphatidylinositol 80%
  • Glycosides 80%
  • Glycoside 63%
  • Pyrimidine 59%
  3 被引用数 (Scopus)

• Transition to turbulence in a bifurcating airway model

  Ueda, Y., Okaniwa, T., Oka, K. & Tanishita, K., 1996, In: American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 33, p. 181-182 2 p.

  研究成果: Article › 査読

  • Turbulence 100%
  • Laser Doppler velocimeters 56%
  • Color 26%
  3 被引用数 (Scopus)

• Transition to turbulence in physiologically intermittent flow in an aortic arch model

  Sato, Y., Koshiba, J., Oka, K. & Tanishita, K., 1996 12月 1, In: American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. 33, p. 409-410 2 p.

  研究成果: Article › 査読

  • Arches 100%
  • Turbulence 81%
  • Laser Doppler velocimeters 34%
  • Axial flow 27%
  • Secondary flow 26%
• 1995

  A novel cyclic lipoundecapeptide, pholipeptin, isolated from Pseudomonas sp.

  Ui, H., Miyake, T., Iinuma, H., Imoto, M., Hattori, S., Hamada, M., Takeuchi, T., Umezawa, S. & Umezawa, K., 1995 10月 9, In: Tetrahedron Letters. 36, 41, p. 7479-7480 2 p.

  研究成果: Article › 査読

  • myrmicacin 100%
  • 3-Hydroxydecanoic Acid 88%
  • Trifluoroacetic Acid 74%
  • Phosphoinositide Phospholipase C 65%
  • Pseudomonas 51%
  7 被引用数 (Scopus)

• Induction of erythroid differentiation in leukemic K562 cells by an S-adenosylhomocysteine hydrolase inhibitor, aristeromycin

  Mizutani, Y., Masuoka, S., Imoto, M., Kawada, M. & Umezawa, K., 1995 2月 6, In: Biochemical and Biophysical Research Communications. 207, 1, p. 69-74 6 p.

  研究成果: Article › 査読

  • aristeromycin 100%
  • Adenosylhomocysteinase 83%
  • Hydrolase Inhibitor 79%
  • K562 Cells 59%
  • Phosphatidylethanolamine 28%
  6 被引用数 (Scopus)

• Inhibition of Phosphatidylinositol-specific Phospholipase C Activity by Fluvirucin B₂

  Ui, H., Imoto, M. & Umezawa, K., 1995 1月 1, In: The Journal of Antibiotics. 48, 5, p. 387-390 4 p.

  研究成果: Article › 査読

  Open Access

  • fluvirucin B2 100%
  • Phosphoinositide Phospholipase C 58%
  • Phosphatidylinositol 49%
  • Streptomyces 16%
  • Phosphatidylinositols 14%
  17 被引用数 (Scopus)
• 1994

  Antitumor effect of piericidin B₁ N-oxide

  Nishioka, H., Sawa, T., Takeuchi, T., Imoto, M., Imaoka, T. & Umezawa, K., 1994 1月 1, In: The Journal of Antibiotics. 47, 4, p. 447-452 6 p.

  研究成果: Article › 査読

  Open Access

  • piericidin B1 N-oxide 100%
  • Antitumor 35%
  • Phosphatidylinositol 31%
  • Phosphatidylinositols 27%
  • Phosphatidic Acids 8%
  19 被引用数 (Scopus)

• Effect of conformation of the substrate on enzymatic eecarboxylation of α-Arylmalonic Acid

  Miyamoto, K., Ohta, H. & Osamura, Y., 1994 6月, In: Bioorganic and Medicinal Chemistry. 2, 6, p. 469-475 7 p.

  研究成果: Article › 査読

  • Malonic Acid 100%
  • Decarboxylation 84%
  • Potential Energy Surface 78%
  • Acids 62%
  • Enzymes 45%
  15 被引用数 (Scopus)

• Enhancement of CDP-DG:inositol transferase activity in src- and erbB2- transformed cells

  Imoto, M., Taniguchi, Y., Fujiwara, H. & Umezawa, K., 1994 1月 1, In: Experimental Cell Research. 212, 1, p. 151-154 4 p.

  研究成果: Article › 査読

  • CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase 100%
  • Phosphatidylinositols 42%
  • Protein-Tyrosine Kinases 24%
  • erbstatin 23%
  • Rous sarcoma virus 18%
  8 被引用数 (Scopus)

• Involvement of phosphatidylinositol synthesis in the regulation of S phase induction

  Imoto, M., Morii, T., Deguchi, A. & Umezawa, K., 1994 11月, In: Experimental Cell Research. 215, 1, p. 228-233 6 p.

  研究成果: Article › 査読

  • inostamycin 100%
  • Phosphatidylinositols 49%
  • S Phase 45%
  • CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase 21%
  • G1 Phase 12%
  20 被引用数 (Scopus)
• 1993

  Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces: Structure determination

  Kakeya, H., Imoto, M., Takahashil, Y., Naganawa, H., Takeuchi, T. & Umezawa, K., 1993 7月, In: Journal of Antibiotics. 46, 11, p. 1716-1719 4 p.

  研究成果: Article › 査読

  Open Access

  • dephostatin 100%
  • Protein Tyrosine Phosphatase Inhibitor 84%
  • Protein Tyrosine Phosphatases 60%
  • Streptomyces 60%
  • Hydroquinone 50%
  32 被引用数 (Scopus)

• Dephostatin, A Novel Protein Tyrosine Phosphatase Inhibitor Produced By Streptomyces I Taxonomy, Isolation, And Characterization

  Masaya, I., Hldeaki, K., Tsutomu, S., Cfflgusa, H., Masa, H., Tomio, T. & Kazuo, U., 1993 5月, In: The Journal of Antibiotics. 46, 9, p. 1342-1346 5 p.

  研究成果: Article › 査読
  90 被引用数 (Scopus)

• Involvement of tyrosine kinase in growth factor-induced phospholipase C activation in NIH3T3 cells

  Imoto, M., Sujikai, I., Ui, H. & Umezawa, K., 1993 2月 24, In: Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism. 1166, 2-3, p. 188-192 5 p.

  研究成果: Article › 査読

  • Tyrosine Kinase Inhibitor 100%
  • Bombesin 96%
  • Type C Phospholipases 79%
  • Tyrosine 65%
  • Protein-Tyrosine Kinases 65%
  9 被引用数 (Scopus)
• 1992

  Biosynthetic preparation of radioactively labeled erbstatin

  Tabata, Y., Imoto, M. & Umezawa, K., 1992 1月 1, In: The Journal of Antibiotics. 45, 8, p. 1382-1384 3 p.

  研究成果: Article › 査読

  Open Access
  2 被引用数 (Scopus)

• Cloning and heterologous expression of a novel arylmalonate decarboxylase gene from Alcaligenes bronchisepticus KU 1201

  Miyamoto, K. & Ohta, H., 1992 11月 1, In: Applied Microbiology and Biotechnology. 38, 2, p. 234-238 5 p.

  研究成果: Article › 査読

  • malonate decarboxylase 100%
  • Alcaligenes 73%
  • Organism Cloning 42%
  • Genes 18%
  • Amino Acid Sequence 17%
  31 被引用数 (Scopus)

• Enantioselective oxidation of mandelic acid using a phenylmalonate metabolizing pathway of a soil bacterium Alcaligenesbronchisepticus KU 1201

  Miyamoto, K. & Ohta, H., 1992 5月 1, In: Biotechnology Letters. 14, 5, p. 363-366 4 p.

  研究成果: Article › 査読

  • mandelic acid 100%
  • Mandelic Acid 80%
  • Bacteria 67%
  • Soil 64%
  • Mandelic Acids 63%
  26 被引用数 (Scopus)

• Highly efficient conversion of (±)-mandelic acid to its (R)-(-)-enantiomer by combination of enzyme-mediated oxidation and reduction

  Tsuchiya, S., Miyamoto, K. & Ohta, H., 1992 12月 1, In: Biotechnology Letters. 14, 12, p. 1137-1142 6 p.

  研究成果: Article › 査読

  • Enantiomers 100%
  • mandelic acid 95%
  • (R)-Mandelic Acid 93%
  • (S)-Mandelic Acid 92%
  • Mandelic Acid 76%
  44 被引用数 (Scopus)

• Inhibition of CDP-DG:iNositol transferase by inostamycin

  Imoto, M., Taniguchi, Y. & Umezawa, K., 1992 8月, In: Journal of biochemistry. 112, 2, p. 299-302 4 p.

  研究成果: Article › 査読

  • inostamycin 100%
  • CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase 87%
  • Inositol 55%
  • Phosphatidylinositols 49%
  • Phosphatidylinositol 44%
  23 被引用数 (Scopus)

• Inhibition of tyrosine kinase and src oncogene functions by stable erbstatin analogues

  Hori, T., Kondo, T., Tsuji, T., Imoto, M. & Umezawa, K., 1992, In: The Journal of Antibiotics. 45, 2, p. 280-282 3 p.

  研究成果: Article › 査読

  Open Access
  11 被引用数 (Scopus)

• Microbial asymmetric decarboxylation of fluorine-containing arylmalonic acid derivatives

  Miyamoto, K., Tsuchiya, S. & Ohta, H., 1992 11月, In: Journal of Fluorine Chemistry. 59, 2, p. 225-232 8 p.

  研究成果: Article › 査読

  • decarboxylation 100%
  • Alcaligenes 92%
  • malonic acid 89%
  • phenylacetic acid 88%
  • Fluorine 80%
  28 被引用数 (Scopus)

• Purification and properties of a novel arylmalonate decarboxylase from Alcaligenes bronchisepticus KU 1201

  MIYAMOTO, K. & OHTA, H., 1992 12月, In: European Journal of Biochemistry. 210, 2, p. 475-481 7 p.

  研究成果: Article › 査読

  • malonate decarboxylase 100%
  • Alcaligenes 73%
  • Decarboxylation 47%
  • Purification 31%
  • Enzyme Activity 25%
  57 被引用数 (Scopus)

• Stereochemistry of Enzyme-Catalyzed Decarboxylation of α-Methyl-α-phenylmalonic Acid

  Miyamoto, K., Tsuchiya, S. & Ohta, H., 1992 7月 1, In: Journal of the American Chemical Society. 114, 15, p. 6256-6257 2 p.

  研究成果: Article › 査読
  34 被引用数 (Scopus)
• 1991

  Asymmetric decarboxylation of disubstituted malonic acid by alcaligenes bronchisepticus KU 1201

  Miyamoto, K. & Ohta, H., 1991, In: Biocatalysis and Biotransformation. 5, 1, p. 49-60 12 p.

  研究成果: Article › 査読

  • Decarboxylation 100%
  • Alcaligenes 93%
  • malonic acid 90%
  • Malonic Acid 70%
  • Acids 52%
  41 被引用数 (Scopus)

• Induction of morphological change by tyrosine kinase inhibitors in Rous sarcoma virus-transformed rat kidney cells

  Umezawa, K., Tanaka, K., Hori, T., Abe, S., Sekizawa, R. & Imoto, M., 1991 2月 11, In: FEBS Letters. 279, 1, p. 132-136 5 p.

  研究成果: Article › 査読

  • Tyrosine Kinase Inhibitor 100%
  • Rous sarcoma virus 98%
  • erbstatin 80%
  • Protein-Tyrosine Kinases 65%
  • Fiber 45%
  16 被引用数 (Scopus)

• Inhibition of epidermal growth factor-induced activation of phospholipase c by psi-tectorigenin

  Imoto, M., Shimura, N. & Umezawa, K., 1991, In: Journal of Antibiotics. 44, 8, p. 915-917 3 p.

  研究成果: Article › 査読

  Open Access
  8 被引用数 (Scopus)
• 1990

  Enzyme-Mediated Asymmetric Decarboxylation of Disubstituted Malonic Acids

  Miyamoto, K. & Ohta, H., 1990 1月 1, In: Journal of the American Chemical Society. 112, 10, p. 4077-4078 2 p.

  研究成果: Article › 査読
  90 被引用数 (Scopus)

• Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors

  Umezawa, K., Hori, T., Tajima, H., Imoto, M., Isshiki, K. & Takeuchi, T., 1990, In: FEBS Letters. 260, 2, p. 198-200 3 p.

  研究成果: Article › 査読

  • erbstatin 100%
  • Tyrosine Kinase Inhibitor 77%
  • methyl 2,5-dihydroxycinnamate 71%
  • Epidermal Growth Factor 54%
  • Protein-Tyrosine Kinases 50%
  128 被引用数 (Scopus)

• Inhibition of phosphatidylinositol kinase by toyocamycin

  Nishioka, H., Sawa, T., Hamada, M., Shimura, N., Imoto, M. & Umezawa, K., 1990, In: The Journal of Antibiotics. 43, 12, p. 1586-1589 4 p.

  研究成果: Article › 査読

  Open Access

  • Toyocamycin 100%
  • Phosphatidylinositol 62%
  • Phosphatidylinositols 54%
  • Phosphotransferases 39%
  • 2,3-dihydroxybenzaldehyde 38%
  27 被引用数 (Scopus)
• 1989

  Modification of Cellular Membrane Functions by Pendolmycin

  Umezawa, K., Imoto, M., Yamashita, T., Sawa, T. & Takeuchi, T., 1989 1月, In: Japanese Journal of Cancer Research. 80, 1, p. 15-18 4 p.

  研究成果: Article › 査読

  • pendolmycin 100%
  • teleocidins 43%
  • Membranes 24%
  • Phosphatidylinositols 17%
  • lyngbyatoxin A 16%
  6 被引用数 (Scopus)
• 1988

  Asymmetric Hydrolysis of 1-Cyanoalkyl Acetates

  Ohta, H., Hiraga, S., Miyamoto, K. & Tsuchihashi, G. I., 1988, In: Agricultural and biological chemistry. 52, 12, p. 3023-3027 5 p.

  研究成果: Article › 査読

  • Acetates 100%
  • Hydrolysis 93%
  • acetates 78%
  • hydrolysis 74%
  • Acetate 70%

• Asymmetric hydrolysis of l-Cyanoalkyl acetates

  Ohta, H., Hiraga, S., Miyamoto, K. & Tsuchihashi, G. I., 1988 12月, In: Agricultural and biological chemistry. 52, 12, p. 3023-3027 5 p.

  研究成果: Article › 査読

  • Acetates 100%
  • Hydrolysis 93%
  • acetates 78%
  • hydrolysis 74%
  • Acetate 70%
  20 被引用数 (Scopus)

• New potent anthracyclines, Barminomycins I and II

  Uchida, T., Imoto, M., Takahashi, Y., Sawa, T., Naganawa, H., Hamada, M., Takeuchi, T., Umezawa, H., Odagawa, A. & Tatsuta, K., 1988, In: The Journal of Antibiotics. 41, 3, p. 404-408 5 p.

  研究成果: Article › 査読

  Open Access
  25 被引用数 (Scopus)

• Surface charge density estimation of vigna mungo protoplasts using a fluorescent dye, 9-aminoacridine

  Oka, K., Ikeshima, H., Ishikawa, H., Ohta, E. & Sakata, M., 1988 7月, In: Plant and Cell Physiology. 29, 5, p. 771-775 5 p.

  研究成果: Article › 査読

  • Aminacrine 100%
  • Vigna 91%
  • Protoplasts 82%
  • Vigna mungo 79%
  • fluorescent dyes 62%
  14 被引用数 (Scopus)
• 1987

  Effects of external Ca²⁺ on K⁺ permeability of the elongating region of mung bean roots under high KCl stress

  Oka, K., Ishikawa, H., Ohta, E. & Sakata, M., 1987 6月, In: Plant and Cell Physiology. 28, 4, p. 581-586 6 p.

  研究成果: Article › 査読

  • Vigna 100%
  • mung beans 68%
  • Permeability 54%
  • permeability 53%
  • Vigna mungo 43%
  2 被引用数 (Scopus)

• Membrane potential measurement of protoplasts isolated from vigna mungo hypocotyl using a fluorescent probe, diS-C₃-(5)

  Oka, K., Naitou, S., Yoshida, M., Ishikawa, H., Ohta, E. & Sakata, M., 1987 7月, In: Plant and Cell Physiology. 28, 5, p. 843-849 7 p.

  研究成果: Article › 査読

  • 3,3'-dipropyl-2,2'-thiadicarbocyanine 100%
  • Hypocotyl 94%
  • Vigna 83%
  • Protoplasts 75%
  • Vigna mungo 72%
  5 被引用数 (Scopus)
• 1985

  Saquayamycins, new aquayamycin-group antibiotics

  Uchida, T., Imoto, M., Watanabe, Y., Miura, K., Dobashi, T., Matsuda, N., Sawa, T., Naganawa, H., Hamada, M., Takeuchi, T. & Umezawa, H., 1985, In: The Journal of Antibiotics. 38, 9, p. 1171-1181 11 p.

  研究成果: Article › 査読

  Open Access

  • saquayamycin 100%
  • aquayamycin 98%
  • vineomycin A1 95%
  • saquayamycin D 52%
  • Aquayamycin 40%
  72 被引用数 (Scopus)