研究成果 1975 2020

フィルター
Article
2020
Paclitaxel
Liposomes
Bovine Serum Albumin
Breast Neoplasms
Neoplasms

Thermoresponsive anionic copolymer brush-grafted surfaces for cell separation

Nagase, K., Uchikawa, N., Hirotani, T., Akimoto, A. M. & Kanazawa, H., 2020 1 1, : : Colloids and Surfaces B: Biointerfaces. 185, 110565.

研究成果: Article

Cell Separation
brushes
Brushes
copolymers
Polymers
2019
4 引用 (Scopus)

Adsorption-Desorption Control of Fibronectin in Real Time at the Liquid/Polymer Interface on a Quartz Crystal Microbalance by Thermoresponsivity

Li, J., Kaku, T., Tokura, Y., Matsukawa, K., Homma, K., Nishimoto, T., Hiruta, Y., Akimoto, A. M., Nagase, K., Kanazawa, H. & Shiratori, S., 2019 1 1, : : Biomacromolecules.

研究成果: Article

Quartz crystal microbalances
Fibronectins
Desorption
Polymers
Adsorption
公開
Theophylline
Acids
Serum
1,3-dimethyluric acid
Aptitude

Age-Related Trends in Home Blood Pressure, Home Pulse Rate, and Day-to-Day Blood Pressure and Pulse Rate Variability Based on Longitudinal Cohort Data: The Ohasama Study

Satoh, M., Metoki, H., Asayama, K., Murakami, T., Inoue, R., Tsubota-Utsugi, M., Matsuda, A., Hirose, T., Hara, A., Obara, T., Kikuya, M., Nomura, K., Hozawa, A., Imai, Y. & Ohkubo, T., 2019 8 6, : : Journal of the American Heart Association. 8, 15, e012121.

研究成果: Article

公開
Heart Rate
Blood Pressure
Sex Characteristics
Linear Models
Japan
2 引用 (Scopus)

Airway M Cells arise in the lower airway due to RANKL signaling and reside in the bronchiolar epithelium associated with iBALT in murine models of respiratory disease

Kimura, S., Mutoh, M., Hisamoto, M., Saito, H., Takahashi, S., Asakura, T., Ishii, M., Nakamura, Y., Iida, J., Hase, K. & Iwanaga, T., 2019 1 1, : : Frontiers in Immunology. 10, JUN, 1323.

研究成果: Article

公開
Lymphoid Tissue
Bronchi
Epithelium
Respiratory System
Glycoproteins
Japan
Costs and Cost Analysis
Pharmaceutical Preparations
Health Expenditures
Drug Costs
1 引用 (Scopus)

A Nationwide, Multicenter Registry Study of Antiemesis for Carboplatin-Based Chemotherapy-Induced Nausea and Vomiting in Japan

Iihara, H., Shimokawa, M., Hayashi, T., Kawazoe, H., Saeki, T., Aiba, K. & Tamura, K., 2019 1 1, (Accepted/In press) : : Oncologist.

研究成果: Article

公開
Carboplatin
Nausea
Multicenter Studies
Vomiting
Registries
2 引用 (Scopus)

A partial agonist for retinoid X receptor mitigates experimental colitis

Masayoshi, O., Masaki, W., Narumi, I., Koichiro, S., Kei, T., Masato, H., Takahiro, Y., Aiko, E., Osamu, S., Midori, N., Michiko, F., Makoto, M., Takahashi, D., Yukihiro, F., Hiroki, K. & Koji, H., 2019 2 19, : : International Immunology. 31, 4, p. 251-262 12 p.

研究成果: Article

Retinoid X Receptors
Colitis
Cytoplasmic and Nuclear Receptors
Ulcerative Colitis
Peroxisome Proliferator-Activated Receptors
Multiple Myeloma
Apoptosis
Derivatives
Degradation
Caspase 9

Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation

Watanabe, Y., Nagai, Y., Honda, H., Okamoto, N., Yanagibashi, T., Ogasawara, M., Yamamoto, S., Imamura, R., Takasaki, I., Hara, H., Sasahara, M., Arita, M., Hida, S., Taniguchi, S., Suda, T. & Takatsu, K., 2019 11 1, : : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 11821-11835 15 p.

研究成果: Article

Crosstalk
Adipocytes
Adipose Tissue
White Adipose Tissue
Interleukin-1

Cardiac Pacemaker Cells Generate Cardiomyocytes from Fibroblasts in Long-Term Cultures

Kiuchi, S., Usami, A., Shimoyama, T., Otsuka, F., Yamaguchi, S., Nakamura, T., Suzuki, S. & Ono, K., 2019 12 1, : : Scientific reports. 9, 1, 15174.

研究成果: Article

公開
Cardiac Myocytes
Sinoatrial Node
Fibroblasts
Guinea
Coculture Techniques

CD44-targeting nanocarriers for cancer treatment

Yamanouchi, T. & Kanazawa, H., 2019 1 1, : : Drug Delivery System. 34, 1, p. 38-45 8 p.

研究成果: Article

公開
Hyaluronic Acid
Research
CD44 Antigens
Neoplasms
Neoplastic Stem Cells
1 引用 (Scopus)
公開
Stem cells
Mesenchymal Stromal Cells
Tissue
Cell culture
Cell Culture Techniques
公開
Unsaturated Fatty Acids
Lipids
Arachidonic Acid
Tissue
Eicosapentaenoic Acid
2 引用 (Scopus)
Lipopolysaccharides
Nitric Oxide
Acylation
Hydroxylation
Butyrates
2 引用 (Scopus)

Circulating microRNA-1246 as a possible biomarker for early tumor recurrence of hepatocellular carcinoma

Chuma, M., Toyoda, H., Matsuzaki, J., Saito, Y., Kumada, T., Tada, T., Kaneoka, Y., Maeda, A., Yokoo, H., Ogawa, K., Kamiyama, T., Taketomi, A., Matsuno, Y., Yazawa, K., Takeda, K., Kunisaki, C., Ogushi, K., Moriya, S., Hara, K., Nozaki, A. および6人, Kondo, M., Fukuda, H., Numata, K., Tanaka, K., Maeda, S. & Sakamoto, N., 2019 7 1, : : Hepatology Research. 49, 7, p. 810-822 13 p.

研究成果: Article

Tumor Biomarkers
MicroRNAs
Hepatocellular Carcinoma
Recurrence
Neoplasms
1 引用 (Scopus)

Collateral sensitivity of drug-resistant ABCB5- and mutation-activated EGFR overexpressing cells towards resveratrol due to modulation of SIRT1 expression

Saeed, M. E. M., Rahama, M., Kuete, V., Dawood, M., Elbadawi, M., Sugimoto, Y. & Efferth, T., 2019 6 1, : : Phytomedicine. 59, 152890.

研究成果: Article

Sirtuin 1
Mutation
Pharmaceutical Preparations
Multiple Drug Resistance
Cluster Analysis

Combination with l-menthol enhances transdermal penetration of indomethacin solid nanoparticles

Nagai, N., Ogata, F., Yamaguchi, M., Fukuoka, Y., Otake, H., Nakazawa, Y. & Kawasaki, N., 2019 8 1, : : International journal of molecular sciences. 20, 15, 3644.

研究成果: Article

公開
menthol
Menthol
Indomethacin
Nanoparticles
Gels

Crosslinked Poly(N-Isopropylacrylamide)-Based Microfibers as Cell Manipulation Materials with Prompt Cell Detachment

Konishi, T., Mizutani Akimoto, A., Nishimoto, T., Tokura, Y., Tenjimbayashi, M., Homma, K., Matsukawa, K., Kaku, T., Hiruta, Y., Nagase, K., Kanazawa, H. & Shiratori, S., 2019 1 1, (Accepted/In press) : : Macromolecular Rapid Communications. 1900464.

研究成果: Article

Cell adhesion
Temperature
Intelligent materials
Fibers
Swelling
2 引用 (Scopus)

Cytotoxicity of 40 Egyptian plant extracts targeting mechanisms of drug-resistant cancer cells

Hegazy, M. E. F., Abdelfatah, S., Hamed, A. R., Mohamed, T. A., Elshamy, A. A., Saleh, I. A., Reda, E. H., Abdel-Azim, N. S., Shams, K. A., Sakr, M., Sugimoto, Y., Paré, P. W. & Efferth, T., 2019 6 1, : : Phytomedicine. 59, 152771.

研究成果: Article

Plant Extracts
Drug Delivery Systems
Centaurea
Multiple Drug Resistance
Pulicaria
2 引用 (Scopus)

Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells

Saeed, M. E. M., Boulos, J. C., Elhaboub, G., Rigano, D., Saab, A., Loizzo, M. R., Hassan, L. E. A., Sugimoto, Y., Piacente, S., Tundis, R., Yagi, S., Khalid, H. & Efferth, T., 2019 9 1, : : Phytomedicine. 62, 152945.

研究成果: Article

Neoplasms
P-Glycoprotein
Cucurbitacins
Epidermal Growth Factor Receptor
Breast Neoplasms
公開
Electronic medical equipment
Stevens-Johnson Syndrome
Electronic Health Records
Poisons
electronics
1 引用 (Scopus)

Distinct roles of α7 nAChRs in antigen-presenting cells and CD4+ T cells in the regulation of T cell differentiation

Mashimo, M., Komori, M., Matsui, Y. Y., Murase, M. X., Fujii, T., Takeshima, S., Okuyama, H., Ono, S., Moriwaki, Y., Misawa, H. & Kawashima, K., 2019 1 1, : : Frontiers in Immunology. 10, MAY, 1102.

研究成果: Article

公開
Nicotinic Receptors
Antigen-Presenting Cells
Cell Differentiation
T-Lymphocytes
Ovalbumin
9 引用 (Scopus)

Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis

Miyata, J., Fukunaga, K., Kawashima, Y., Watanabe, T., Saitoh, A., Hirosaki, T., Araki, Y., Kikawada, T., Betsuyaku, T., Ohara, O. & Arita, M., 2019 1 1, : : Allergy: European Journal of Allergy and Clinical Immunology.

研究成果: Article

Nasal Polyps
Eosinophils
Fatty Acids
Arachidonate 15-Lipoxygenase
Lipid Metabolism
3 引用 (Scopus)
Liposomes
Phase Transition
Small Interfering RNA
Transfection
Polymers
Charcoal
Phenobarbital
Drug Interactions
Food
Pharmaceutical Preparations
1 引用 (Scopus)
公開
Endocytosis
Indomethacin
Nanoparticles
Nystatin
Pharmaceutical Preparations
Praziquantel
Serum Albumin
Biological Availability
Emulsions
Solubility
1 引用 (Scopus)

Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging

Uchida, R., Saito, Y., Nogami, K., Kajiyama, Y., Suzuki, Y., Kawase, Y., Nakaoka, T., Muramatsu, T., Kimura, M. & Saito, H., 2019 12 1, : : npj Aging and Mechanisms of Disease. 5, 1, 1.

研究成果: Article

Organoids
Epigenomics
Nicotinamide Mononucleotide
Stem Cells
Cell Aging
Virus Replication
Human Herpesvirus 4
Genome
Nuclear Antigens
Neoplasms
5 引用 (Scopus)

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma

Saito, Y., Muramatsu, T., Kanai, Y., Ojima, H., Sukeda, A., Hiraoka, N., Arai, E., Sugiyama, Y., Matsuzaki, J., Uchida, R., Yoshikawa, N., Furukawa, R. & Saito, H., 2019 4 23, : : Cell Reports. 27, 4, p. 1265-1276.e4

研究成果: Article

公開
Organoids
Preclinical Drug Evaluations
Biliary Tract
Screening
Biomarkers
Vancomycin
Body Mass Index
Obesity
Body Weight
公開
Ganciclovir
Drug-Related Side Effects and Adverse Reactions
Databases
Acute Kidney Injury
Thrombocytopenia

Expression of precipitating factors of pruritus found in humans in an imiquimod-induced psoriasis mouse model

Oishi, N., Iwata, H., Kambe, N., Kobayashi, N., Fujimoto, K., Sato, H., Hisaka, A., Ueno, K. & Yamaura, K., 2019 6 1, : : Heliyon. 5, 6, e01981.

研究成果: Article

公開
imiquimod
Precipitating Factors
Pruritus
Psoriasis
Nerve Growth Factor
4 引用 (Scopus)

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

Nagai, M., Noguchi, R., Takahashi, D., Morikawa, T., Koshida, K., Komiyama, S., Ishihara, N., Yamada, T., Kawamura, Y. I., Muroi, K., Hattori, K., Kobayashi, N., Fujimura, Y., Hirota, M., Matsumoto, R., Aoki, R., Tamura-Nakano, M., Sugiyama, M., Katakai, T., Sato, S. および3人, Takubo, K., Dohi, T. & Hase, K., 2019 8 22, : : Cell. 178, 5, p. 1072-1087.e14

研究成果: Article

Mucosal Immunity
Peyer's Patches
Fasting
B-Lymphocytes
Cells
1 引用 (Scopus)

Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin

Sakurama, K., Nishi, K., Imoto, S., Hashimoto, M., Komatsu, T., Morita, Y., Taguchi, K., Otagiri, M. & Yamasaki, K., 2019 1 1, (Accepted/In press) : : Journal of Pharmaceutical Sciences.

研究成果: Article

Chlorine
Albumins
Binding Sites
Circular Dichroism
Aripiprazole
1 引用 (Scopus)

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

Katsuda, T., Matsuzaki, J., Yamaguchi, T., Yamada, Y., Prieto-Vila, M., Hosaka, K., Takeuchi, A., Saito, Y. & Ochiya, T., 2019 8 8, : : eLife. 8

研究成果: Article

公開
Hepatocytes
Stem Cells
Liver
Cell Transplantation
Liver Transplantation

Glucose depletion enhances the stem cell phenotype and gemcitabine resistance of cholangiocarcinoma organoids through AKT phosphorylation and reactive oxygen species

Yoshikawa, N., Saito, Y., Manabe, H., Nakaoka, T., Uchida, R., Furukawa, R., Muramatsu, T., Sugiyama, Y., Kimura, M. & Saito, H., 2019 12, : : Cancers. 11, 12, 1993.

研究成果: Article

公開
gemcitabine
Organoids
Cholangiocarcinoma
Reactive Oxygen Species
Stem Cells

Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

Miyamoto, J., Igarashi, M., Watanabe, K., Karaki, S. I., Mukouyama, H., Kishino, S., Li, X., Ichimura, A., Irie, J., Sugimoto, Y., Mizutani, T., Sugawara, T., Miki, T., Ogawa, J., Drucker, D. J., Arita, M., Itoh, H. & Kimura, I., 2019 12 1, : : Nature communications. 10, 1, 4007.

研究成果: Article

公開
obesity
diets
fatty acids
Nutrition
Unsaturated Fatty Acids

Identification of glycyrrhizin metabolites in humans and of a potential biomarker of liquorice-induced pseudoaldosteronism: a multi-centre cross-sectional study

Takahashi, K., Yoshino, T., Maki, Y., Ishiuchi, K., Namiki, T., Ogawa-Ochiai, K., Minamizawa, K., Makino, T., Nakamura, T., Mimura, M. & Watanabe, K., 2019 11 1, : : Archives of Toxicology. 93, 11, p. 3111-3119 9 p.

研究成果: Article

Liddle Syndrome
Glycyrrhizic Acid
Glycyrrhiza
Biomarkers
Metabolites

IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery

Albrecht, C., Chamley, L., Charnock-Jones, D. S., Collins, S., Fujiwara, H., Golos, T., Grayo, S., Hannan, N., Harris, L., Ichizuka, K., Illsley, N. P., Iwashita, M., Kallol, S., Al-Khan, A., Lash, G., Nagamatsu, T., Nakashima, A., Niimi, K., Nomoto, M., Redman, C. および8人, Saito, S., Tanimura, K., Tomi, M., Usui, H., Vatish, M., Wolfe, B., Yamamoto, E. & O'Tierney-Ginn, P., 2019 1 1, : : Placenta.

研究成果: Article

Gestational Trophoblastic Disease
Pre-Eclampsia
Placenta
Inflammation
Education
公開
Human Influenza
Japan
Vaccination
Datasets
Occupational Health
Cytochrome P-450 Enzyme System
Fruit
Citrus paradisi
Food-Drug Interactions
Omeprazole
3 引用 (Scopus)
Serum Albumin
Nanoparticles
Doxorubicin
Tumors
Neoplasms
irinotecan
P-Glycoprotein
Biological Availability
Partial Thromboplastin Time
Dabigatran

LAT1-Targeting Thermoresponsive Liposomes for Effective Cellular Uptake by Cancer Cells

Maekawa-Matsuura, M., Fujieda, K., Maekawa, Y., Nishimura, T., Nagase, K. & Kanazawa, H., 2019 4 8, : : ACS Omega. 4, 4, p. 6443-6451 9 p.

研究成果: Article

公開
Amino Acid Transport Systems
Liposomes
Amino acids
Cells
Tyrosine