薬学部

研究成果

年別の研究成果 1975 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 2191 Article
• 154 Review article
• 23 Comment/debate
• 22 Letter
• 55 その他
  • 19 Editorial
  • 18 Chapter
  • 7 Paper
  • 6 Conference contribution
  • 5 Short survey

年別の研究成果

年別の研究成果

検索結果

• 2005

  Diphenylprolinol silyl ethers as efficient organocatalysts for the asymmetric Michael reaction of aldehydes and nitroalkenes

  Hayashi, Y., Gotoh, H., Hayashi, T. & Shoji, M., 2005 7月 4, In: Angewandte Chemie - International Edition. 44, 27, p. 4212-4215 4 p.

  研究成果: Article › 査読

  • Aldehydes 100%
  • Nitroolefin 95%
  • Nitroalkene 92%
  • Silyl Ether 90%
  • Ethers 80%
  1130 被引用数 (Scopus)

• Effect of long-term interferon therapy for refractory chronic hepatitis C: Preventive effect on hepatocarcinogenesis

  Saito, Y., Saito, H., Tada, S., Nakamoto, N., Horikawa, H., Kurita, S., Kitamura, K., Ebinuma, H., Ishii, H. & Hibi, T., 2005 9月 1, In: Hepato-gastroenterology. 52, 65, p. 1491-1496 6 p.

  研究成果: Article › 査読

  • Chronic Hepatitis C 100%
  • Interferons 87%
  • Hepacivirus 37%
  • Alanine Transaminase 26%
  • Liver Cirrhosis 25%
  15 被引用数 (Scopus)

• Effect on duration of antibiotic therapy and drug cost by introducing critical pathway for patients with CAP in Japan

  Uchikura, T., Hashiguchi, M., Suzuki, Y., Takeshita, K., Tuchimoto, K., Ikeda, S., Sakamaki, H., Shimizu, K., Abe, T. & Mochizuki, M., 2005 8月, In: Yakugaku Zasshi. 125, 8, p. 659-663 5 p.

  研究成果: Article › 査読

  • Drug Costs 100%
  • Critical Pathways 96%
  • Duration of Therapy 77%
  • Japan 68%
  • Pneumonia 66%

• Enantio- and diastereoselective total synthesis of EI-1941-1, -2, and -3, inhibitors of interleukin-1β converting enzyme, and biological properties of their derivatives

  Shoji, M., Uno, T., Kakeya, H., Onose, R., Shiina, I., Osada, H. & Hayashi, Y., 2005 11月 25, In: Journal of Organic Chemistry. 70, 24, p. 9905-9915 11 p.

  研究成果: Article › 査読

  • Biological Property 100%
  • Total Synthesis 89%
  • Angiotensin-Converting Enzyme Inhibitor 71%
  • Cyclization Reaction 38%
  27 被引用数 (Scopus)

• Estrogen-mediated post transcriptional down-regulation of breast cancer resistance protein/ABCG2

  Imai, Y., Ishikawa, E., Asada, S. & Sugimoto, Y., 2005 1月 15, In: Cancer Research. 65, 2, p. 596-604 9 p.

  研究成果: Article › 査読

  • ATP Binding Cassette Transporter, Subfamily G, Member 2 100%
  • Estrogens 53%
  • Down-Regulation 45%
  • Breast Neoplasms 41%
  • Proteins 22%
  150 被引用数 (Scopus)

• Functional role of c-Src in IL-1-induced NF-κB activation: c-Src is a component of the IKK complex

  Funakoshi-Tago, M., Tago, K., Andoh, K., Sonoda, Y., Tominaga, S. I. & Kasahara, T., 2005 2月, In: Journal of biochemistry. 137, 2, p. 189-197 9 p.

  研究成果: Article › 査読

  • Interleukin-1 100%
  • Tyrosine 91%
  • PP2 89%
  • CSK Tyrosine-Protein Kinase 67%
  • Acid 17%
  37 被引用数 (Scopus)

• Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives

  Mashino, T., Shimotohno, K., Ikegami, N., Nishikawa, D., Okuda, K., Takahashi, K., Nakamura, S. & Mochizuki, M., 2005 2月 15, In: Bioorganic and Medicinal Chemistry Letters. 15, 4, p. 1107-1109 3 p.

  研究成果: Article › 査読

  • Fullerenes 100%
  • HIV Reverse Transcriptase 95%
  • RNA Replicase 83%
  • Hepacivirus 57%
  • Fullerene 56%
  167 被引用数 (Scopus)

• Inhibitory activities against topoisomerase I and II by isoaurostatin derivatives and their structure-activity relationships

  Suzuki, K., Okawara, T., Higashijima, T., Yokomizo, K., Mizushima, T. & Otsuka, M., 2005 4月 15, In: Bioorganic and Medicinal Chemistry Letters. 15, 8, p. 2065-2068 4 p.

  研究成果: Article › 査読

  • isoaurostatin 100%
  • Type I DNA Topoisomerase 50%
  • Type II DNA Topoisomerase 50%
  • Structure-Activity Relationship 45%
  • Etoposide 26%
  25 被引用数 (Scopus)

• Involvement of intracellular Ca²⁺ levels in nonsteroidal anti-inflammatory drug-induced apoptosis

  Tanaka, K. I., Tomisato, W., Hoshino, T., Ishihara, T., Namba, T., Aburaya, M., Katsu, T., Suzuki, K., Tsutsumi, S. & Mizushima, T., 2005 9月 2, In: Journal of Biological Chemistry. 280, 35, p. 31059-31067 9 p.

  研究成果: Article › 査読

  • Celecoxib 100%
  • Chelating Agent 67%
  • Antiinflammatory 67%
  • Calpain Inhibitor 61%
  • Anti-Inflammatory Agents 51%
  103 被引用数 (Scopus)

• Low direct cytotoxicity and cytoprotective effects of nitric oxide releasing indomethacin

  Tomisato, W., Tanaka, K. I., Tsutsumi, S., Hoshino, T., Yokomizo, K., Suzuki, K., Katsu, T., Mizushima, T. & Mizushima, T., 2005 10月, In: Digestive Diseases and Sciences. 50, 10, p. 1927-1937 11 p.

  研究成果: Article › 査読

  • 1-(4-chlorobenzoyl)-5-methoxy-2-1H-indole-3-acetic acid 3-(nitrooxymethyl)phenyl ester 100%
  • Indomethacin 42%
  • Nitric Oxide 34%
  • Celecoxib 23%
  • Necrosis 7%
  8 被引用数 (Scopus)

• p53-defective tumors with a functional apoptosome-mediated pathway: A new therapeutic target

  Mashima, T., Oh-hara, T., Sato, S., Mochizuki, M., Sugimoto, Y., Yamazaki, K., Hamada, J. I., Tada, M., Moriuchi, T., Ishikawa, Y., Kato, Y., Tomoda, H., Yamori, T. & Tsuruo, T., 2005 5月 18, In: Journal of the National Cancer Institute. 97, 10, p. 765-777 13 p.

  研究成果: Article › 査読

  Open Access

  • Apoptosomes 100%
  • Coenzyme A Ligases 31%
  • Neoplasms 20%
  • Cytochromes c 16%
  • Caspases 15%
  91 被引用数 (Scopus)

• Platelet-derived growth factor-BB (PDGF-BB) induces differentiation of bone marrow endothelial progenitor cell-derived cell line TR-BME2 into mural cells, and changes the phenotype

  Miyata, T., Iizasa, H., Sai, Y., Fujii, J., Terasaki, T. & Nakashima, E., 2005 9月 1, In: Journal of Cellular Physiology. 204, 3, p. 948-955 8 p.

  研究成果: Article › 査読

  • Cell Marker 100%
  • Becaplermin 79%
  • Endothelial Progenitor Cells 74%
  • Bone Marrow Cells 57%
  • Endothelial Cells 45%
  42 被引用数 (Scopus)

• Preparation and antioxidant activity of α-pyridoin and its derivatives

  Hatanaka, M., Takahashi, K., Nakamura, S. & Mashino, T., 2005 12月 15, In: Bioorganic and Medicinal Chemistry. 13, 24, p. 6763-6770 8 p.

  研究成果: Article › 査読

  • 1,1-diphenyl-2-picrylhydrazyl 100%
  • Antioxidant Agent 54%
  • Antioxidants 53%
  • Lipid Peroxidation 44%
  • Pyridines 43%
  34 被引用数 (Scopus)

• Randomized pharmacokinetic and pharmacodynamic study of docetaxel: Dosing based on body-surface area compared with individualized dosing based on cytochrome P450 activity estimated using a urinary metabolite of exogenous cortisol

  Yamamoto, N., Tamura, T., Murakami, H., Shimoyama, T., Nokihara, H., Ueda, Y., Sekine, I., Kunitoh, H., Ohe, Y., Kodama, T., Shimizu, M., Nishio, K., Ishizuka, N. & Saijo, N., 2005 2月 20, In: Journal of Clinical Oncology. 23, 6, p. 1061-1069 9 p.

  研究成果: Article › 査読

  • Docetaxel 100%
  • Body Surface Area 99%
  • Cytochrome P-450 Enzyme System 87%
  • Hydrocortisone 79%
  • Pharmacokinetics 67%
  76 被引用数 (Scopus)

• Remarkable synergies between baicalein and tetracycline, and baicalein and β-lactams against methicillin-resistant Staphylococcus aureus

  Fujita, M., Shiota, S., Kuroda, T., Hatano, T., Yoshida, T., Mizushima, T. & Tsuchiya, T., 2005, In: Microbiology and Immunology. 49, 4, p. 391-396 6 p.

  研究成果: Article › 査読

  • baicalein 100%
  • Lactams 96%
  • Tetracycline 71%
  • Methicillin-Resistant Staphylococcus aureus 69%
  • Thymus Plant 43%
  120 被引用数 (Scopus)

• Risk management--adverse effects of pharmaceutical products. Interpretation of the drug package inserts

  Mochizuki, M., 2005 8月, In: Nippon Jibiinkoka Gakkai kaiho. 108, 8, p. 814-817 4 p.

  研究成果: Article › 査読

  Open Access

• Role of Cys-603 in dimer/oligomer formation of the breast cancer resistance protein BCRP/ABCG2

  Kage, K., Fujita, T. & Sugimoto, Y., 2005 12月, In: Cancer science. 96, 12, p. 866-872 7 p.

  研究成果: Article › 査読

  • ATP Binding Cassette Transporter, Subfamily G, Member 2 100%
  • Breast Neoplasms 41%
  • Irinotecan 38%
  • Western Blotting 22%
  • ATP-Binding Cassette Transporters 19%
  80 被引用数 (Scopus)

• Short-step and scalable synthesis of (±)-cytoxazone

  Asano, M., Nagasawa, C., Suzuki, M., Nishiyama, S. & Sugai, T., 2005 1月, In: Bioscience, Biotechnology and Biochemistry. 69, 1, p. 145-148 4 p.

  研究成果: Article › 査読

  • cytoxazone 100%
  • Alkenes 60%
  • Azides 54%
  • Sodium Azide 53%
  • Epoxy Compounds 52%
  12 被引用数 (Scopus)

• Simple determination of fluoroquinolones with high-performance liquid chromatography

  Ogino, H., Kido, K., Tsuchiya, M., Kizu, J. & Hori, S., 2005 10月 1, In: Japanese Journal of Chemotherapy. 53, 10, p. 619-622 4 p.

  研究成果: Article › 査読

  • Fluoroquinolones 100%
  • High Pressure Liquid Chromatography 73%
  • Pharmacokinetics 50%
  • pazufloxacin 38%
  • tosufloxacin 36%
  2 被引用数 (Scopus)

• Spontaneous regression of hepatocellular carcinoma in S4 after another tumor in S1 was chemoembolized

  Takayama, T., Tada, S., Yoshizawa, S., Saito, H. & Hibi, T., 2005, In: Acta Hepatologica Japonica. 46, 2, p. 78-84 7 p.

  研究成果: Article › 査読

  • Hepatocellular Carcinoma 100%
  • Neoplasms 40%
  • Transaminases 16%
  • Blood Transfusion 14%
  • Necrosis 11%

• Synthetic studies on thiostrepton family of peptide antibiotics: Synthesis of the cyclic core portion containing the dehydropiperidine, dihydroquinoline, L-valine, and masked dehydroalanine segments

  Mori, T., Tohmiya, H., Satouchi, Y., Higashibayashi, S., Hashimoto, K. & Nakata, M., 2005 9月 19, In: Tetrahedron Letters. 46, 38, p. 6423-6427 5 p.

  研究成果: Article › 査読

  • dehydroalanine 100%
  • Thiostrepton 88%
  • L-Valine 69%
  • Valine 60%
  • Polypeptide Antibiotic Agent 56%
  16 被引用数 (Scopus)

• Synthetic studies on thiostrepton family of peptide antibiotics: Synthesis of the dihydroquinoline portion of thiostrepton, the siomycins, and the thiopeptins

  Mori, T., Satouchi, Y., Tohmiya, H., Higashibayashi, S., Hashimoto, K. & Nakata, M., 2005 9月 19, In: Tetrahedron Letters. 46, 38, p. 6417-6422 6 p.

  研究成果: Article › 査読

  • thiopeptin 100%
  • siomycin 99%
  • Thiostrepton 77%
  • Polypeptide Antibiotic Agent 49%
  • triethylamine 35%
  13 被引用数 (Scopus)

• The direct, enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes: The reason for the higher reactivity of aldimine versus aldehyde in proline-mediated Mannich and aldol reactions

  Hayashi, Y., Urushima, T., Shoji, M., Uchimaru, T. & Shiina, I., 2005 10月, In: Advanced Synthesis and Catalysis. 347, 11-13, p. 1595-1604 10 p.

  研究成果: Article › 査読

  • Aldehydes 100%
  • Aldimine 86%
  • Aldol Reaction 78%
  • Aldehyde 47%
  • Nucleophiles 47%
  43 被引用数 (Scopus)

• The effects of coffee on conjugation reactions in human colon carcinoma cells

  Okamura, S., Suzuki, K., Yanase, M., Koizumi, M. & Tamura, H. O., 2005 2月, In: Biological and Pharmaceutical Bulletin. 28, 2, p. 271-274 4 p.

  研究成果: Article › 査読

  • 1-Naphthol 100%
  • Coffee 89%
  • Colon 60%
  • Environmental Substance 53%
  • Carcinoma 50%
  20 被引用数 (Scopus)

• Topical application of a novel, water-soluble γ-tocopherol derivative prevents UV-induced skin damage in mice

  Yasuoka, S., Takata, J., Karube, Y., Katoh, E., Tsuzuki, T., Kizu, J., Tsuchiya, M. & Kobayashi, S., 2005 7月 1, In: Photochemistry and Photobiology. 81, 4, p. 908-913 6 p.

  研究成果: Article › 査読

  • tocopherol 100%
  • Tocopherols 81%
  • mice 64%
  • Water Soluble 47%
  • damage 43%
  9 被引用数 (Scopus)

• Total synthesis of epoxyquinols A, B, and C and epoxytwinol A and the reactivity of a 2H-pyran derivative as the diene component in the Diels-Alder reaction

  Shoji, M., Imai, H., Mukaida, M., Sakai, K., Kakeya, H., Osada, H. & Hayashi, Y., 2005 1月 7, In: Journal of Organic Chemistry. 70, 1, p. 79-91 13 p.

  研究成果: Article › 査読

  • Epoxytwinol A 100%
  • 2H-Pyran 74%
  • Diels-Alder Reaction 44%
  • Total Synthesis 40%
  • Furan 22%
  70 被引用数 (Scopus)

• Trapping effect of eugenol on hydroxyl radicals induced by L-DOPA in Vitro

  Ogata, M., Kaneya, D., Shin-Ya, K., Li, L., Abe, Y., Katoh, H., Seki, S., Seki, Y., Gonda, R., Urano, S. & Endo, T., 2005 9月, In: Chemical and Pharmaceutical Bulletin. 53, 9, p. 1167-1170 4 p.

  研究成果: Article › 査読

  • Eugenol 100%
  • Dihydroxyphenylalanine 91%
  • Hydroxyl Radical 77%
  • In Vitro Techniques 30%
  • ESR Spectrum 29%
  13 被引用数 (Scopus)

• Value of computed tomography-derived estimated liver volume/standard liver volume ratio for predicting the prognosis of adult fulminant hepatic failure in Japan

  Yamagishi, Y., Saito, H., Tada, S., Horie, Y., Kato, S., Ishii, H., Shimojima, N., Haga, J., Shimazu, M., Kitajima, M. & Hibi, T., 2005 12月, In: Journal of Gastroenterology and Hepatology (Australia). 20, 12, p. 1843-1849 7 p.

  研究成果: Article › 査読

  • Acute Liver Failure 100%
  • Japan 70%
  • Tomography 58%
  • Liver 43%
  • Artificial Liver 12%
  30 被引用数 (Scopus)

• Vitamins K₁ and K₂ potentiate hyperthermia by down-regulating Hsp72 expression in vitro and in vivo

  Shimohara, S., Murakami, T., Morikawa, M., Matsuo, J., Nagayama, S. I., Shuto, T., Suico, M. A., Okiyoneda, T., Yamatsu, I., Mizushima, T., Shimasaki, T. & Kai, H., 2005 12月 1, In: International journal of oncology. 27, 6, p. 1527-1533 7 p.

  研究成果: Article › 査読

  • HSP72 Heat-Shock Proteins 100%
  • Vitamin K 1 96%
  • Vitamin K 2 91%
  • Fever 49%
  • Induced Hyperthermia 39%
  6 被引用数 (Scopus)
• 2006

  A case of primary amyloidosis developing acute liver failure

  Yamagishi, Y., Mori, S., Matsumoto, M., Nakazawa, A., Kurita, S., Tada, S., Hashiguchi, A., Yokomori, H., Saito, H., Kato, S. & Hibi, T., 2006, In: Acta Hepatologica Japonica. 47, 1, p. 22-29 8 p.

  研究成果: Article › 査読

  • Immunoglobulin Light-chain Amyloidosis 100%
  • Acute Liver Failure 86%
  • Amyloid 46%
  • Liver 38%
  • Artificial Liver 36%
  1 被引用数 (Scopus)

• Adiponectin is regulated differently by chronic exercise than by weight-matched food restriction in hyperphagic and obese OLETF rats

  Kimura, M., Shinozaki, T., Tateishi, N., Yoda, E., Yamauchi, H., Suzuki, M., Hosoyamada, M. & Shibasaki, T., 2006 10月 26, In: Life Sciences. 79, 22, p. 2105-2111 7 p.

  研究成果: Article › 査読

  • Hyperphagic 100%
  • Adiponectin 80%
  • Inbred OLETF Rats 69%
  • Evans Reaction 60%
  • Food 31%
  23 被引用数 (Scopus)

• An expeditious chemo-enzymatic synthesis of dihydronorcapsaicin β-d-glucopyranoside

  Sultana, I., Shimamoto, M., Obata, R., Nishiyama, S. & Sugai, T., 2006 3月, In: Science and Technology of Advanced Materials. 7, 2, p. 197-201 5 p.

  研究成果: Article › 査読

  • Methyl Nonanoate 100%
  • Lipases 79%
  • Nutrition 65%
  • Vanillin 62%
  • Amines 60%
  8 被引用数 (Scopus)

• A novel sulfotransferase abundantly expressed in the dauer larvae of Caenorhabditis elegans

  Hattori, K., Inoue, M., Inoue, T., Arai, H. & Tamura, H. O., 2006 3月, In: Journal of biochemistry. 139, 3, p. 355-362 8 p.

  研究成果: Article › 査読

  • Sulfotransferases 100%
  • Caenorhabditis elegans 78%
  • Larva 75%
  • 2-Naphthol 45%
  • Developmental 43%
  29 被引用数 (Scopus)

• Application to the preparation of useful compounds based on enzyme- And microorganism-mediated reactions

  Fuhshuku, K. I., Nishiyama, S. & Sugai, T., 2006 6月, In: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 64, 6, p. 664-676 13 p.

  研究成果: Article › 査読

  Open Access

  • Chemical Transformation 100%
  • Purity 79%
  • Carbonyl Compound 75%
  • Occurrence in Nature 65%
  • Amide 56%
  4 被引用数 (Scopus)

• Aqueous chromatography system using pH- and temperature-responsive stationary phase with ion-exchange groups

  Ayano, E., Nambu, K., Sakamoto, C., Kanazawa, H., Kikuchi, A. & Okano, T., 2006 6月 30, In: Journal of Chromatography A. 1119, 1-2, p. 58-65 8 p.

  研究成果: Article › 査読

  • Ion Exchange 100%
  • Nonsteroid Antiinflammatory Agent 86%
  • Chromatography 74%
  • Temperature 53%
  • Copolymer 48%
  57 被引用数 (Scopus)

• A T3587G germ-line mutation of the MDR1 gene encodes a nonfunctional P-glycoprotein

  Mutoh, K., Mitsuhashi, J., Kimura, Y., Tsukahara, S., Ishikawa, E., Sai, K., Ozawa, S., Sawada, J. I., Ueda, K., Katayama, K. & Sugimoto, Y., 2006 4月, In: Molecular cancer therapeutics. 5, 4, p. 877-884 8 p.

  研究成果: Article › 査読

  • MDR Genes 100%
  • Germ-Line Mutation 81%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 79%
  • 3T3 Cells 39%
  • Genes 29%
  13 被引用数 (Scopus)

• C/EBPα inactivation in FAK-overexpressed HL-60 cells impairs cell differentiation

  Hashimoto, K. I., Sonoda, Y., Yamakado, M., Funakoshi-Tago, M., Yoshida, N., Rokudai, A., Aizu-Yokota, E. & Kasahara, T., 2006 7月, In: Cellular Signalling. 18, 7, p. 955-963 9 p.

  研究成果: Article › 査読

  • Focal Adhesion Protein-Tyrosine Kinases 100%
  • HL-60 Cells 93%
  • Cell Differentiation 65%
  • Tretinoin 44%
  • Tumor Necrosis Factors 11%
  8 被引用数 (Scopus)

• Chemical synthesis of 2′-deoxyguanosine-C8 adducts with heterocyclic amines: An application to synthesis of oligonucleotides site-specifically adducted with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

  Takamura-Enya, T., Ishikawa, S., Mochizuki, M. & Wakabayashi, K., 2006 6月 1, In: Chemical Research in Toxicology. 19, 6, p. 770-778 9 p.

  研究成果: Article › 査読

  • 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine 100%
  • Deoxyguanosine 91%
  • Amines 66%
  • Oligonucleotides 65%
  • PhIP 58%
  14 被引用数 (Scopus)

• Combined proline-surfactant organocatalyst for the highly diastereo- and enantioselective aqueous direct cross-aldol reaction of aldehydes

  Hayashi, Y., Aratake, S., Okano, T., Takahashi, J., Sumiya, T. & Shoji, M., 2006 8月 18, In: Angewandte Chemie - International Edition. 45, 33, p. 5527-5529 3 p.

  研究成果: Article › 査読

  • Enantioselectivity 100%
  • Aldehydes 71%
  • Aldol Reaction 56%
  • Surface active agents 54%
  • Emulsions 53%
  289 被引用数 (Scopus)

• Computational study on the reaction mechanism of the key thermal [4 + 4] cycloaddition reaction in the biosynthesis of epoxytwinol A

  Shiina, I., Uchimaru, T., Shoji, M., Kakeya, H., Osada, H. & Hayashi, Y., 2006 3月 16, In: Organic Letters. 8, 6, p. 1041-1044 4 p.

  研究成果: Article › 査読

  • epoxytwinol A 100%
  • Epoxytwinol A 83%
  • Cycloaddition Reaction 64%
  • cycloaddition 62%
  • biosynthesis 58%
  11 被引用数 (Scopus)

• Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin

  Yamaguchi, J., Toyoshima, M., Shoji, M., Kakeya, H., Osada, H. & Hayashi, Y., 2006 1月 23, In: Angewandte Chemie - International Edition. 45, 5, p. 789-793 5 p.

  研究成果: Article › 査読

  • Fumagillol 100%
  • Fumagillin 88%
  • Cyclohexane 72%
  • Cyclohexane Ring 66%
  • Epoxide 44%
  40 被引用数 (Scopus)

• Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals

  Misawa, H., Nakata, K., Matsuura, J., Moriwaki, Y., Kawashima, K., Shimizu, T., Shirasawa, T. & Takahashi, R., 2006 7月, In: Neurobiology of Disease. 23, 1, p. 169-177 9 p.

  研究成果: Article › 査読

  • Superoxides 100%
  • Motor Neurons 96%
  • Superoxide Dismutase 91%
  • Axons 58%
  • Neurons 40%
  43 被引用数 (Scopus)

• Continuous depolarization induces choline acetyltransferase activity in septal and hippocampal co-cultured embryonic rat neurons

  Suzuki, T. & Shimotohno, K., 2006 2月 6, In: Neuroscience Letters. 394, 1, p. 79-81 3 p.

  研究成果: Article › 査読

  • Choline O-Acetyltransferase 100%
  • Acetylcholine 75%
  • Neurons 50%
  • Coculture Techniques 48%
  • Cell Culture Techniques 24%

• Differential induction of cystathionine γ-lyase in the livers and kidneys of mouse dams during gestation and lactation

  Akahoshi, N., Izumi, T., Ishizaki, Y. & Ishii, I., 2006, In: Biological and Pharmaceutical Bulletin. 29, 9, p. 1799-1802 4 p.

  研究成果: Article › 査読

  • Cystathionine 100%
  • Lyases 92%
  • Lactation 70%
  • Pregnancy 38%
  • Kidney 34%
  12 被引用数 (Scopus)

• Differential regulation of eotaxin-1/CCL11 and eotaxin-3/CCL26 production by the TNF-α and IL-4 stimulated human lung fibroblast

  Rokudai, A., Terui, Y., Kuniyoshi, R., Mishima, Y., Mishima, Y., Aizu-Yokota, E., Sonoda, Y., Kasahara, T. & Hatake, K., 2006 6月, In: Biological and Pharmaceutical Bulletin. 29, 6, p. 1102-1109 8 p.

  研究成果: Article › 査読

  • Chemokine CCL26 100%
  • Bortezomib 96%
  • Chemokine CCL11 93%
  • Proteasome Inhibitor 86%
  • U0126 74%
  30 被引用数 (Scopus)

• Effects of 2′-demethoxy-2′-propoxygriseofulvin on microtubule distribution in Chinese hamster V79 cells

  Oda, T., 2006 2月, In: Journal of Antibiotics. 59, 2, p. 114-116 3 p.

  研究成果: Article › 査読

  • Griseofulvin 100%
  • Cricetulus 72%
  • Microtubules 66%
  • Mammalian Cell 35%
  • Dose 26%
  9 被引用数 (Scopus)

• Effects of bistheonellide A, an actin-polymerization inhibitor, on Chinese hamster V79 cells and on IL-8 production in PMA-stimulated HL-60 cells

  Oda, T., Xu, J., Fujita, A., Mochizuki, M. & Namikoshi, M., 2006 3月, In: Marine Drugs. 4, 1, p. 22-27 6 p.

  研究成果: Article › 査読

  • bistheonellide A 100%
  • Actin Polymerisation Inhibitor 94%
  • HL-60 Cells 51%
  • Cricetulus 46%
  • Polymerization 45%
  4 被引用数 (Scopus)

• Effects of clarithromycin and verapamil on rabeprazole pharmacokinetics between CYP2C19 genotypes

  Shimizu, M., Uno, T., Yasui-Furukori, N., Sugawara, K. & Tateishi, T., 2006 8月, In: European Journal of Clinical Pharmacology. 62, 8, p. 597-603 7 p.

  研究成果: Article › 査読

  • Rabeprazole 100%
  • Cytochrome P-450 CYP2C19 87%
  • rabeprazole-thioether 86%
  • Clarithromycin 78%
  • Verapamil 70%
  15 被引用数 (Scopus)

• Efficacy of natural BALL-1 interferon-α treatment for patients with chronic hepatitis C and a possible enhancing effect of a twice-daily starting regimen with interferon-β

  Ebinuma, H., Saito, H., Tada, S., Nakamoto, N., Kurita, S., Kitamaura, K., Horikawa, H., Kumagai, N., Tsuchimoto, K., Ishii, H. & Hibi, T., 2006 1月 1, In: Hepato-gastroenterology. 53, 67, p. 94-99 6 p.

  研究成果: Article › 査読

  • Chronic Hepatitis C 100%
  • Interferons 87%
  • Viral Load 25%
  • Genotype 24%
  • Therapeutics 15%

• Estrogen-mediated post transcriptional down-regulation of P-glycoprotein in MDR1-transduced human breast cancer cells

  Mutoh, K., Tsukahara, S., Mitsuhashi, J., Katayama, K. & Sugimoto, Y., 2006 11月, In: Cancer science. 97, 11, p. 1198-1204 7 p.

  研究成果: Article › 査読

  • MDR Genes 100%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 79%
  • Estradiol 63%
  • Estrogens 59%
  • Down-Regulation 50%
  87 被引用数 (Scopus)