薬学部

研究成果

年別の研究成果 1975 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 2191 Article
• 154 Review article
• 23 Comment/debate
• 22 Letter
• 55 その他
  • 19 Editorial
  • 18 Chapter
  • 7 Paper
  • 6 Conference contribution
  • 5 Short survey

年別の研究成果

年別の研究成果

検索結果

• A case of fulminant hepatitis E treated with artificial liver support

  Fujiyama, Y., Yamagishi, Y., Kikuchi, M., Shimoji, K., Kato, S., Nagata, H., Saito, H., Hibi, T. & Mishiro, S., 2007 2月 1, In: Japanese Journal of Gastroenterology. 104, 2, p. 219-225 7 p.

  研究成果: Article › 査読

  • Artificial Liver 100%
  • Hepatitis E 96%
  • Massive Hepatic Necrosis 92%
  • Hepatitis E virus 91%
  • China 55%
  1 被引用数 (Scopus)

• A case of fulminant hepatitis B occurred in an asymptomatic: Hepatitis B virus carrier

  Ooishi, T., Kumagai, N., Iwabuchi, N., Tsuchimoto, K., Kuramochi, S., Tada, S., Tsunematsu, S., Saito, H., Ishii, H. & Morizane, T., 1995 1月 1, In: Kanzo. 36, 12, p. 706-711 6 p.

  研究成果: Article › 査読

  Open Access

  • Massive Hepatic Necrosis 100%
  • Hepatitis B e Antigens 87%
  • DNA-Directed DNA Polymerase 82%
  • Hepatitis B virus 71%
  • Hepatitis B 71%

• A case of antibiotic-associated encephalopathy with very high blood concentrations of ceftriaxone in a low-body-weight patient on hemodialysis

  Uchida, H., Sakaguchi, T., Hongo, I., Shinoda, K., Tashiro, S., Matsumoto, K., Samura, M., Kato, T., Sekiguchi, M., Nakajima, M., Mitsuda, M. & Kawai, Y., 2021 11月, In: Japanese Journal of Chemotherapy. 69, 6, p. 433-439 7 p.

  研究成果: Article › 査読

  • Ceftriaxone 100%
  • Brain Diseases 81%
  • Renal Dialysis 74%
  • Body Weight 61%
  • Anti-Bacterial Agents 56%
  1 被引用数 (Scopus)

• A case of acute pancreatitis induced by telaprevir in the anti-HCV treatment with peginterferon and ribavirin

  Matsushita, M., Ebinuma, H., Fukuhara, S., Minami, K., Minami, K., Nakamoto, N., Funakoshi, S., Kanai, T., Saito, H. & Hibi, T., 2013 5月 30, In: Acta Hepatologica Japonica. 54, 5, p. 340-346 7 p.

  研究成果: Article › 査読

  • telaprevir 100%
  • Ribavirin 74%
  • Pancreatitis 64%
  • Gabexate 13%
  • peginterferon alfa-2b 13%

• A carrier‐mediated transport system for benzylpenicillin in isolated hepatocytes

  Tsuji, A., Terasaki, T., Tamai, I., Nakashima, E. & Takanosu, K., 1985 1月, In: Journal of Pharmacy and Pharmacology. 37, 1, p. 55-57 3 p.

  研究成果: Article › 査読

  • Benzylpenicillin 100%
  • Penicillin G 86%
  • Hepatocytes 57%
  • Phenoxymethylpenicillin 40%
  • Sodium Cyanide 37%
  17 被引用数 (Scopus)

• A candidate for cancer gene therapy: MIP-1α gene transfer to an adenocarcinoma cell line reduced tumorigenicity and induced protective immunity in immunocompetent mice

  Nakashima, E., Oya, A., Kubota, Y., Kanada, N., Matsushita, R., Takeda, K., Ichimura, F., Kuno, K., Mukaida, N., Hirose, K., Nakanishi, I., Ujiie, T. & Matsushima, K., 1996 12月 1, In: Pharmaceutical research. 13, 12, p. 1896-1901 6 p.

  研究成果: Article › 査読

  • Macrophage Inflammatory Proteins 100%
  • Neoplasm Genes 81%
  • Genetic Therapy 69%
  • Protective 62%
  • Immunity 61%
  65 被引用数 (Scopus)

• Absolute Lymphocyte Count Predicts Immune-Related Adverse Events in Patients With Non-Small-Cell Lung Cancer Treated With Nivolumab Monotherapy: A Multicenter Retrospective Study

  Egami, S., Kawazoe, H., Hashimoto, H., Uozumi, R., Arami, T., Sakiyama, N., Ohe, Y., Nakada, H., Aomori, T., Ikemura, S., Fukunaga, K., Yamaguchi, M. & Nakamura, T., 2021 5月 27, In: Frontiers in Oncology. 11, 618570.

  研究成果: Article › 査読

  Open Access

  • Nivolumab 100%
  • Lymphocyte Count 79%
  • Non-Small Cell Lung Carcinoma 65%
  • Multicenter Studies 63%
  • Retrospective Studies 49%
  7 被引用数 (Scopus)

• Absolute liquid scintillation counting of coloured samples of β-emitters using integral counting techniques

  Homma, Y., Murase, Y. & Sonehara, K., 1986 6月 1, In: Journal of Radioanalytical and Nuclear Chemistry Letters. 105, 4, p. 241-248 8 p.

  研究成果: Article › 査読

  • Scintillation Counting 100%
  • Scintillation 98%
  • Liquid Scintillation Counting 95%
  • Disintegration 94%
  • Scintillation counters 58%
  2 被引用数 (Scopus)

• Absolute liquid scintillation counting of³⁵S and⁴⁵Ca using a modified integral counting method

  Homma, Y., Murase, Y. & Handa, K., 1994 7月 1, In: Journal of Radioanalytical and Nuclear Chemistry Letters. 187, 5, p. 367-374 8 p.

  研究成果: Article › 査読

  • Scintillation Counting 100%
  • Scintillation 98%
  • Liquid Scintillation Counting 95%
  • Disintegration 94%
  • Scintillation counters 58%
  8 被引用数 (Scopus)

• Absence of high-risk stigmata predicts good prognosis even in severely anemic patients with suspected acute upper gastrointestinal bleeding

  Horibe, M., Ogura, Y., Matsuzaki, J., Kaneko, T., Yokota, T., Okawa, O., Nakatani, Y., Iwasaki, E., Nishizawa, T., Hosoe, N., Masaoka, T., Yahagi, N., Namiki, S. & Kanai, T., 2018 6月 1, In: United European Gastroenterology Journal. 6, 5, p. 684-690 7 p.

  研究成果: Article › 査読

  • Christianity 100%
  • Hemorrhage 47%
  • Blood Transfusion 43%
  • Hemoglobins 36%
  • Tokyo 10%
  5 被引用数 (Scopus)

• Abnormal lipid metabolism in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia

  Namekata, K., Enokido, Y., Ishii, I., Nagai, Y., Harada, T. & Kimura, H., 2004 12月 17, In: Journal of Biological Chemistry. 279, 51, p. 52961-52969 9 p.

  研究成果: Article › 査読

  • Cystathionine 100%
  • Hyperhomocysteinemia 80%
  • Lipid Metabolism 61%
  • Cholesterol 57%
  • High-Density Lipoprotein 54%
  126 被引用数 (Scopus)

• A bis-pyridinium fullerene derivative induces apoptosis through the generation of ROS in BCR-ABL-positive leukemia cells

  Sumi, K., Tago, K., Nakazawa, Y., Takahashi, K., Ohe, T., Mashino, T. & Funakoshi-Tago, M., 2022 2月 5, In: European journal of pharmacology. 916, 174714.

  研究成果: Article › 査読

  • Fullerenes 100%
  • Leukemia 50%
  • Reactive Oxygen Species 49%
  • Apoptosis 37%
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive 21%
  1 被引用数 (Scopus)

• A bis-malonic acid fullerene derivative significantly suppressed IL-33-induced IL-6 expression by inhibiting NF-κB activation

  Funakoshi-Tago, M., Miyagawa, Y., Ueda, F., Mashino, T., Moriwaki, Y., Tago, K., Kasahara, T. & Tamura, H., 2016 11月 1, In: International Immunopharmacology. 40, p. 254-264 11 p.

  研究成果: Article › 査読

  • Fullerenes 100%
  • malonic acid 96%
  • Interleukin-33 85%
  • Interleukin-6 48%
  • Mast Cells 17%
  8 被引用数 (Scopus)

• A bioinspired carbon monoxide delivery system prevents acute kidney injury and the progression to chronic kidney disease

  Nagasaki, T., Maeda, H., Taguchi, K., Yanagisawa, H., Nishida, K., Kobayashi, K., Wada, N., Noguchi, I., Murata, R., Sakai, H., Kitagishi, H., Saruwatari, J., Watanabe, H., Otagiri, M. & Maruyama, T., 2022 8月, In: Redox Biology. 54, 102371.

  研究成果: Article › 査読

  Open Access

  • Carbon Monoxide 100%
  • Acute Kidney Injury 93%
  • Chronic Renal Insufficiency 90%
  • Molecule 34%
  • Reperfusion 32%

• Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice

  Misawa, H., Fujigaya, H., Nishimura, T., Moriwaki, Y., Okuda, T., Kawashima, K., Nakata, K., Ruggiero, A. M., Blakely, R. D., Nakatsu, F. & Ohno, H., 2008 6月, In: European Journal of Neuroscience. 27, 12, p. 3109-3117 9 p.

  研究成果: Article › 査読

  • choline transporter 100%
  • Proteins 22%
  • Synaptic Vesicles 10%
  • Presynaptic Terminals 9%
  • Cell Body 8%
  9 被引用数 (Scopus)

• A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis

  Niino, T., Tago, K., Yasuda, D., Takahashi, K., Mashino, T., Tamura, H. & Funakoshi-Tago, M., 2018 9月, In: Biochemical Pharmacology. 155, p. 182-197 16 p.

  研究成果: Article › 査読

  • 5-hydroxyoxindole 100%
  • Cysteine 36%
  • Antioxidant Agent 32%
  • Cysteine Residue 22%
  • Antiinflammatory 20%
  8 被引用数 (Scopus)

• A 50-year-old man with ulcerative colitis and severe anemia.

  Saito, H., Inoue, J., Yamaguchi, W., Tashiro, H., Miura, S., Hibi, T., Tsuchiya, M., Handa, M., Nakatsuka, S. & Kuramochi, S., 1992 12月, In: The Keio Journal of Medicine. 41, 4, p. 225-232 8 p.

  研究成果: Article › 査読

• A ²H NMR study on biosynthesis. Evidence of hydrogen exchange at the chain-starter methyl group of griseofulvin manifested by ²H incorporation from deuterium oxide in medium and from sodium acetates

  Sato, Y., Oda, T., Miyata, E. & Saitô, H., 1979 2月 15, In: FEBS Letters. 98, 2, p. 271-275 5 p.

  研究成果: Article › 査読
  9 被引用数 (Scopus)

• A² H NMR study on alteration of the membrane organization of mouse b16 melanoma cells treated with 12-O-tetradecanoylphorbol-13-acetate

  Sugimoto, Y., Saito, H., Tabeta, R. & Kodama, M., 1986 10月, In: Journal of biochemistry. 100, 4, p. 867-874 8 p.

  研究成果: Article › 査読

  • Experimental Melanomas 100%
  • Fluidity 89%
  • Tetradecanoylphorbol Acetate 87%
  • varespladib methyl 83%
  • Lipid 54%
  5 被引用数 (Scopus)

• 7-Azabicyclo[2.2.1]heptane as a structural motif to block mutagenicity of nitrosamines

  Ohwada, T., Ishikawa, S., Mine, Y., Inami, K., Yanagimoto, T., Karaki, F., Kabasawa, Y., Otani, Y. & Mochizuki, M., 2011 4月 15, In: Bioorganic and Medicinal Chemistry. 19, 8, p. 2726-2741 16 p.

  研究成果: Article › 査読

  • 7-azabicyclo(2.2.1)heptane 100%
  • Nitrosamines 58%
  • Nitrosamine 55%
  • Heptane 45%
  • Block Like Crystal 28%
  10 被引用数 (Scopus)

• 6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs

  Lee, N. Y., Sai, Y., Nakashima, E., Ohtsuki, S. & Kang, Y. S., 2011 9月, In: Journal of Pharmaceutical Sciences. 100, 9, p. 3773-3782 10 p.

  研究成果: Article › 査読

  • Cefmetazole 100%
  • Sulfinpyrazone 97%
  • Azathioprine 88%
  • Probenecid 82%
  • Nucleoside Transport Proteins 81%
  14 被引用数 (Scopus)

• 5-Fluorouracil treatment alters the expression of intestinal transporters in rats

  Yotsumoto, K., Akiyoshi, T., Wada, N., Imaoka, A. & Ohtani, H., 2017 12月, In: Biopharmaceutics and Drug Disposition. 38, 9, p. 509-516 8 p.

  研究成果: Article › 査読

  • 5-Fluorouracil 100%
  • Fluorouracil 79%
  • Digoxin 58%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 45%
  • Drug 43%
  7 被引用数 (Scopus)

• 5-Fluororacil–Induced Gastrointestinal Damage Impairs the Absorption and Anticoagulant Effects of Dabigatran Etexilate

  Tsujii, K., Hattori, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2018 5月, In: Journal of Pharmaceutical Sciences. 107, 5, p. 1430-1433 4 p.

  研究成果: Article › 査読

  • Dabigatran Etexilate 100%
  • Dabigatran 70%
  • Anticoagulant 63%
  • Anticoagulants 49%
  • Activated Partial Thromboplastin Time 32%
  3 被引用数 (Scopus)

• 3EZ, 20Ac-ingenol-induced apoptosis in chemoresistant cancers with cyclin D1 accumulation

  Miyata, S., Nakamura, T. & Kitanaka, S., 2020 11月, In: Anticancer research. 40, 11, p. 6237-6246 10 p.

  研究成果: Article › 査読

  • 20Ac-ingenol 3EZ 100%
  • Cyclin D1 46%
  • Apoptosis 26%
  • DNA Damage 18%
  • Neoplasms 14%
  1 被引用数 (Scopus)

• 3-Alkoxycarbonyl-2-oxazolones and Their Homopolymers as Highly Preservable Amino-Protecting Reagents. tert-Butoxy-carbonylation and Benzyloxycarbonylation of Amino Groups

  Kunieda, T., Higuchi, T., Abe, Y. & Hirobe, M., 1984, In: Chemical and Pharmaceutical Bulletin. 32, 6, p. 2174-2181 8 p.

  研究成果: Article › 査読

  • tert-butoxy 100%
  • Benzyloxycarbonylation 90%
  • Methoxycarbonylation 69%
  • Oxazolone 67%
  • Chain Reaction 43%
  23 被引用数 (Scopus)

• 3-Acyl- and 3-alkoxycarbonyl-2-oxazolones and their homopolymers as amino-protecting reagents

  Kunieda, T., Higuchi, T., Abe, Y. & Hirobe, M., 1980, In: Tetrahedron Letters. 21, 32, p. 3065-3066 2 p.

  研究成果: Article › 査読

  • Oxazolone 100%
  • Amines 68%
  • Single Monomer Polymer 61%
  • Amino Acids 45%
  • Amine 41%
  23 被引用数 (Scopus)

• 3-Acetoxy-2,2′-bi-1H-indol as a novel inhibitor of ATP binding to DnaA, the protein initiating chromosomal replication in escherichia coli

  Sasaki, S., Mizushima, T., Hashimoto, T., Maeda, M. & Kazuhisa, S., 1994 7月 21, In: Bioorganic and Medicinal Chemistry Letters. 4, 14, p. 1771-1774 4 p.

  研究成果: Article › 査読

  • Adenosine Triphosphate 100%
  • Indigo Carmine 98%
  • Escherichia coli 90%
  • DNA Replication 64%
  • Inhibitory Concentration 50 58%
  8 被引用数 (Scopus)

• 2α-Hydroxyalantolactone from Pulicaria undulata: activity against multidrug-resistant tumor cells and modes of action

  Hegazy, M. E. F., Dawood, M., Mahmoud, N., Elbadawi, M., Sugimoto, Y., Klauck, S. M., Mohamed, N. & Efferth, T., 2021 1月, In: Phytomedicine. 81, 153409.

  研究成果: Article › 査読

  • Pulicaria 100%
  • Western Blotting 62%
  • Sesquiterpene Lactone 43%
  • DNA Damage 42%
  • Occurrence in Nature 40%
  11 被引用数 (Scopus)

• ²H nuclear magnetic resonance studies on biosynthesis: Stereochemistry of the 5′-hydrogen atoms of griseofulvin derived from griseophenone B and 4-demethyldehydrogriseofulvin

  Sato, Y., Oda, T. & Saitô, H., 1978, In: Journal of the Chemical Society, Chemical Communications. 3, p. 135-136 2 p.

  研究成果: Article › 査読

  • Griseophenone B 100%
  • Stereochemistry 79%
  • Biosynthesis 67%
  • Griseofulvin 62%
  • Deuterium 61%
  10 被引用数 (Scopus)

• 2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice

  Kamata, S., Akahoshi, N. & Ishii, I., 2015, In: FEBS Open Bio. 5, p. 535-541 7 p.

  研究成果: Article › 査読

  Open Access

  • Differential in Gel Electrophoresis 100%
  • Two-Dimensional Difference Gel Electrophoresis 93%
  • Homocystinuria 92%
  • Fetal Proteins 88%
  • Proteomics 57%
  5 被引用数 (Scopus)

• 2-5 As Activity in Serum and Peripheral Blood Mononuclear Cells for Chronic Active Hepatitis C and the Relationship to Clinical Outcome of Interferon Therapy

  Toda, K., Kumagai, N., Iwabuchi, N., Suzuki, T., Saito, H., Morizane, T., Hibi, T., Ishii, H. & Tsuchimoto, K., 1997, In: Japanese Journal of Clinical Immunology. 20, 5, p. 428-436 9 p.

  研究成果: Article › 査読

  Open Access

  • Chronic Hepatitis 100%
  • Chronic Hepatitis C 97%
  • 2',5'-oligoadenylate 97%
  • Interferons 85%
  • Blood Cells 76%
  4 被引用数 (Scopus)

• 12-OH-17,18-Epoxyeicosatetraenoic acid alleviates eosinophilic airway inflammation in murine lungs

  Mochimaru, T., Fukunaga, K., Miyata, J., Matsusaka, M., Masaki, K., Kabata, H., Ueda, S., Suzuki, Y., Goto, T., Urabe, D., Inoue, M., Isobe, Y., Arita, M. & Betsuyaku, T., 2018 2月, In: Allergy: European Journal of Allergy and Clinical Immunology. 73, 2, p. 369-378 10 p.

  研究成果: Article › 査読

  • 17,18-epoxy-5,8,11,14-eicosatetraenoic acid 100%
  • Eicosapentaenoic Acid 57%
  • hydroxide ion 53%
  • Inflammation 27%
  • Lung 25%
  17 被引用数 (Scopus)

• 12/15-Lipoxygenase Regulates IL-33-Induced Eosinophilic Airway Inflammation in Mice

  Miyata, J., Yokokura, Y., Moro, K., Arai, H., Fukunaga, K. & Arita, M., 2021 5月 19, In: Frontiers in Immunology. 12, 687192.

  研究成果: Article › 査読

  Open Access

  • 12-15-lipoxygenase 100%
  • Interleukin-33 81%
  • Inflammation 35%
  • Hydroxy Acids 21%
  • Docosahexaenoic Acids 17%
  11 被引用数 (Scopus)

• 10-Year Trends in Helicobacter pylori Eradication Rates by Sitafloxacin-Based Third-Line Rescue Therapy

  Mori, H., Suzuki, H., Matsuzaki, J., Masaoka, T. & Kanai, T., 2020 9月 1, In: Digestion. 101, 5, p. 644-650 7 p.

  研究成果: Article › 査読

  • sitafloxacin 100%
  • Amoxicillin 64%
  • Helicobacter pylori 56%
  • Mutation 28%
  • Microbial Drug Resistance 21%
  13 被引用数 (Scopus)

• 1,4-Asymmetric induction using a cobalt alkyne complex

  Hayashi, Y., Yamaguchi, H., Toyoshima, M., Nasu, S., Ochiai, K. & Shoji, M., 2008 1月 28, In: Organometallics. 27, 2, p. 163-165 3 p.

  研究成果: Article › 査読

  • alkynes 100%
  • cobalt 55%
  • induction 54%
  • Alkyne 51%
  • chelation 51%
  12 被引用数 (Scopus)

• 1,2-Rearrangement from o-Quinols to Multisubstituted Catechols via Retro Diels-Alder Reaction of o-Quinol Dimers

  Hashimoto, R., Hanaya, K., Sugai, T. & Higashibayashi, S., 2022, In: Bulletin of the Chemical Society of Japan. 95, 4, p. 663-672 10 p.

  研究成果: Article › 査読

  • 1,2 Rearrangement 100%
  • Retro-Diels-Alder Reaction 83%
  • Catechols 82%
  • Catechol 21%
  • Diels-Alder Reaction 19%
  1 被引用数 (Scopus)

• [Treatment of refractory and relapsed multiple myeloma].

  Hattori, Y., 2012 4月, In: Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 2, p. 597-602 6 p.

  研究成果: Article › 査読

• [Reporting system for adverse drug reactions and infections].

  Hashiguchi, M. & Mochizuki, M., 2012 8月, In: Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 6, p. 29-35 7 p.

  研究成果: Article › 査読

• [Historical consideration of the widespread infection of the hepatitis C virus in Japan and use of a fishbone diagram to investigate the cause].

  Haga, H. & Fukushima, N., 2011, In: Yakushigaku zasshi. The Journal of Japanese history of pharmacy. 46, 1, p. 21-28 8 p.

  研究成果: Article › 査読

  • Hepacivirus 100%
  • Japan 89%
  • Syringes 72%
  • Transfusion Medicine 60%
  • Infections 51%
  3 被引用数 (Scopus)

• [Classification criteria for severity of adverse drug reactions].

  Hashiguchi, M. & Mochizuki, M., 2012 8月, In: Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 6, p. 37-44 8 p.

  研究成果: Article › 査読

• [³H]2-(4-Phenylpiperidino)cyclohexanol (AH5183) binding to synaptosomes and subcellular fractions obtained from rat brain

  Suzuki, T., Kashima, Y., Fujimoto, K. & Kawashima, K., 1993 7月 9, In: Neuroscience Letters. 157, 1, p. 72-74 3 p.

  研究成果: Article › 査読

  • vesamicol 100%
  • Subcellular Fractions 72%
  • Synaptosomes 68%
  • Synaptic Vesicles 65%
  • Brain 27%
  1 被引用数 (Scopus)