薬科学科

2006

An expeditious chemo-enzymatic synthesis of dihydronorcapsaicin β-d-glucopyranoside

Sultana, I., Shimamoto, M., Obata, R., Nishiyama, S. & Sugai, T., 2006 3月, In: Science and Technology of Advanced Materials. 7, 2, p. 197-201 5 p.

研究成果: Article › 査読

8 被引用数 (Scopus)

Application to the preparation of useful compounds based on enzyme- And microorganism-mediated reactions

Fuhshuku, K. I., Nishiyama, S. & Sugai, T., 2006 6月, In: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 64, 6, p. 664-676 13 p.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

Aqueous chromatography system using pH- and temperature-responsive stationary phase with ion-exchange groups

Ayano, E., Nambu, K., Sakamoto, C., Kanazawa, H., Kikuchi, A. & Okano, T., 2006 6月 30, In: Journal of Chromatography A. 1119, 1-2, p. 58-65 8 p.

研究成果: Article › 査読

57 被引用数 (Scopus)

Combined proline-surfactant organocatalyst for the highly diastereo- and enantioselective aqueous direct cross-aldol reaction of aldehydes

Hayashi, Y., Aratake, S., Okano, T., Takahashi, J., Sumiya, T. & Shoji, M., 2006 8月 18, In: Angewandte Chemie - International Edition. 45, 33, p. 5527-5529 3 p.

研究成果: Article › 査読

289 被引用数 (Scopus)

Computational study on the reaction mechanism of the key thermal [4 + 4] cycloaddition reaction in the biosynthesis of epoxytwinol A

Shiina, I., Uchimaru, T., Shoji, M., Kakeya, H., Osada, H. & Hayashi, Y., 2006 3月 16, In: Organic Letters. 8, 6, p. 1041-1044 4 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin

Yamaguchi, J., Toyoshima, M., Shoji, M., Kakeya, H., Osada, H. & Hayashi, Y., 2006 1月 23, In: Angewandte Chemie - International Edition. 45, 5, p. 789-793 5 p.

研究成果: Article › 査読

40 被引用数 (Scopus)

Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals

Misawa, H., Nakata, K., Matsuura, J., Moriwaki, Y., Kawashima, K., Shimizu, T., Shirasawa, T. & Takahashi, R., 2006 7月, In: Neurobiology of Disease. 23, 1, p. 169-177 9 p.

研究成果: Article › 査読

43 被引用数 (Scopus)

Differential induction of cystathionine γ-lyase in the livers and kidneys of mouse dams during gestation and lactation

Akahoshi, N., Izumi, T., Ishizaki, Y. & Ishii, I., 2006, In: Biological and Pharmaceutical Bulletin. 29, 9, p. 1799-1802 4 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Highly diastereo- and enantioselective direct aldol reactions in water

Hayashi, Y., Sumiya, T., Takahashi, J., Gotoh, H., Urushima, T. & Shoji, M., 2006 1月 30, In: Angewandte Chemie - International Edition. 45, 6, p. 958-961 4 p.

研究成果: Article › 査読

469 被引用数 (Scopus)

Increased F2-isoprostane levels in the rat brain and plasma caused by oxidative stress and aging, and inhibitory effect of vitamin E

Nishio, T., Miyadera, R., Sakai, R., Abe, K., Kanazawa, H., Fukui, K. & Urano, S., 2006 5月, In: Journal of Clinical Biochemistry and Nutrition. 38, 3, p. 161-166 6 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

Large nonlinear effect observed in the enantiomeric excess of proline in solution and that in the solid state

Hayashi, Y., Matsuzawa, M., Yamaguchi, J., Yonehara, S., Matsumoto, Y., Shoji, M., Hashizume, D. & Koshino, H., 2006 7月 10, In: Angewandte Chemie - International Edition. 45, 28, p. 4593-4597 5 p.

研究成果: Article › 査読

105 被引用数 (Scopus)

Metabolic conversion of 24-methyl-Δ²⁵-cholesterol to 24-methylcholesterol in higher plants

Takahashi, K., Nasu, K., Mashino, T., Morisaki, M., Hara, N. & Fujimoto, Y., 2006 2月 1, In: Bioorganic and Medicinal Chemistry. 14, 3, p. 732-738 7 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Pharmacokinetics of fentanyl after single intravenous injection and constant rate infusion in dogs

Sano, T., Nishimura, R., Kanazawa, H., Igarashi, E., Nagata, Y., Mochizuki, M. & Sasaki, N., 2006 7月, In: Veterinary Anaesthesia and Analgesia. 33, 4, p. 266-273 8 p.

研究成果: Article › 査読

78 被引用数 (Scopus)

Screening, substrate specificity and stereoselectivity of yeast strains, which reduce sterically hindered isopropyl ketones

Hiraoka, C., Matsuda, M., Suzuki, Y., Fujieda, S., Tomita, M., Fuhshuku, K. I., Obata, R., Nishiyama, S. & Sugai, T., 2006 12月 27, In: Tetrahedron Asymmetry. 17, 24, p. 3358-3367 10 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Structural characterization of room-temperature synthesized fullerene nanowhiskers

Miyazawa, K., Minato, J. I., Mashino, T., Nakamura, S., Fujino, M. & Suga, T., 2006 6月 14, In: Nukleonika. 51, SUPPL. 1, p. S41-S48

研究成果: Article › 査読

12 被引用数 (Scopus)

Study of temperature-responsibility on the surfaces of a thermo-responsive polymer modified stationary phase

Ayano, E., Okada, Y., Sakamoto, C., Kanazawa, H., Kikuchi, A. & Okano, T., 2006 6月 30, In: Journal of Chromatography A. 1119, 1-2, p. 51-57 7 p.

研究成果: Article › 査読

47 被引用数 (Scopus)

Synthesis and biological assessment of hemiacetal spiro derivatives towards development of efficient chemotherapeutic agent

Ogamino, T., Ohnishi, S., Ishikawa, Y., Sugai, T., Obata, R. & Nishiyama, S., 2006 3月, In: Science and Technology of Advanced Materials. 7, 2, p. 175-183 9 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

2007

A developed determination of midazolam and 1′-hydroxymidazolam in plasma by liquid chromatography-mass spectrometry: Application of human pharmacokinetic study for measurement of CYP3A activity

Shimizu, M., Uno, T., Tamura, H. O., Kanazawa, H., Murakami, I., Sugawara, K. & Tateishi, T., 2007 3月 1, In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 847, 2, p. 275-281 7 p.

研究成果: Article › 査読

29 被引用数 (Scopus)

Analysis of melatonin using a pH- and temperature-responsive aqueous chromatography system

Ayano, E., Suzuki, Y., Kanezawa, M., Sakamoto, C., Morita-Murase, Y., Nagata, Y., Kanazawa, H., Kikuchi, A. & Okano, T., 2007 7月 13, In: Journal of Chromatography A. 1156, 1-2 SPEC. ISS., p. 213-219 7 p.

研究成果: Article › 査読

25 被引用数 (Scopus)

Bacillus subtilis epoxide hydrolase-catalyzed preparation of enantiopure 2-methylpropane-1,2,3-triol monobenzyl ether and its application to expeditious synthesis of (R)-bicalutamide

Fujino, A., Asano, M., Yamaguchi, H., Shirasaka, N., Sakoda, A., Ikunaka, M., Obata, R., Nishiyama, S. & Sugai, T., 2007 2月 5, In: Tetrahedron Letters. 48, 6, p. 979-983 5 p.

研究成果: Article › 査読

29 被引用数 (Scopus)

Differential effects of the ascorbyl and tocopheryl derivative on the methamphetamine-induced toxic behavior and toxicity

Ito, S., Mori, T., Kanazawa, H. & Sawaguchi, T., 2007 10月 30, In: Toxicology. 240, 1-2, p. 96-110 15 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Diminished antigen-specific IgG₁ and interleukin-6 production and acetylcholinesterase expression in combined M₁ and M₅ muscarinic acetylcholine receptor knockout mice

Fujii, Y. X., Tashiro, A., Arimoto, K., Fujigaya, H., Moriwaki, Y., Misawa, H., Fujii, T., Matsui, M., Kasahara, T. & Kawashima, K., 2007 8月, In: Journal of Neuroimmunology. 188, 1-2, p. 80-85 6 p.

研究成果: Article › 査読

42 被引用数 (Scopus)

Dry and wet prolines for asymmetric organic solvent-free aldehyde-aldehyde and aldehyde-ketone aldol reactions

Hayashi, Y., Aratake, S., Itoh, T., Okano, T., Sumiya, T. & Shoji, M., 2007, In: Chemical Communications. 9, p. 957-959 3 p.

研究成果: Article › 査読

121 被引用数 (Scopus)

Enhanced serum antigen-specific IgG₁ and proinflammatory cytokine production in nicotinic acetylcholine receptor α7 subunit gene knockout mice

Fujii, Y. X., Fujigaya, H., Moriwaki, Y., Misawa, H., Kasahara, T., Grando, S. A. & Kawashima, K., 2007 9月, In: Journal of Neuroimmunology. 189, 1-2, p. 69-74 6 p.

研究成果: Article › 査読

75 被引用数 (Scopus)

Expression and function of genes encoding cholinergic components in murine immune cells

Kawashima, K., Yoshikawa, K., Fujii, Y. X., Moriwaki, Y. & Misawa, H., 2007 5月 30, In: Life Sciences. 80, 24-25, p. 2314-2319 6 p.

研究成果: Article › 査読

169 被引用数 (Scopus)

First total synthesis of modiolide A, based on the whole-cell yeast-catalyzed asymmetric reduction of a propargyl ketone

Matsuda, M., Yamazaki, T., Fuhshuku, K. I. & Sugai, T., 2007 9月 3, In: Tetrahedron. 63, 36, p. 8752-8760 9 p.

研究成果: Article › 査読

28 被引用数 (Scopus)

Immune system expression of SLURP-1 and SLURP-2, two endogenous nicotinic acetylcholine receptor ligands

Moriwaki, Y., Yoshikawa, K., Fukuda, H., Fujii, Y. X., Misawa, H. & Kawashima, K., 2007 5月 30, In: Life Sciences. 80, 24-25, p. 2365-2368 4 p.

研究成果: Article › 査読

72 被引用数 (Scopus)

Involvement of up-regulation of PUMA in non-steroidal anti-inflammatory drug-induced apoptosis

Ishihara, T., Hoshino, T., Namba, T., Tanaka, K. I. & Mizushima, T., 2007 5月 11, In: Biochemical and Biophysical Research Communications. 356, 3, p. 711-717 7 p.

研究成果: Article › 査読

34 被引用数 (Scopus)

Metabolism of bisphenol A in the rat syncytiotrophoblast cell line, TR-TBT 18d-1

Ikeda, Y., Nakashima, E., Kanazawa, H. & Tamura, H., 2007 2月, In: Journal of Health Science. 53, 1, p. 146-150 5 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Novel metabolic pathways of p-n-nonylphenol catalyzed by cytochrome P450 and estrogen receptor binding activity of new metabolites

Tezuka, Y., Takahashi, K., Suzuki, T., Kitamura, S., Ohta, S., Nakamura, S. & Mashino, T., 2007 10月, In: Journal of Health Science. 53, 5, p. 552-561 10 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Production and regulation of eotaxin-2/CCL24 in a differentiated human leukemic cell line, HT93

Yoshida, N., Aizu-Yokota, E., Sonoda, Y., Moriwaki, Y., Kishi, K. & Kasahara, T., 2007 10月, In: Biological and Pharmaceutical Bulletin. 30, 10, p. 1826-1832 7 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Small organic molecule in enantioselective, direct aldol reaction "in water"

Aratake, S., Itoh, T., Okano, T., Usui, T., Shoji, M. & Hayashi, Y., 2007, In: Chemical Communications. 24, p. 2524-2526 3 p.

研究成果: Article › 査読

108 被引用数 (Scopus)

Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid

Ogata, M., Oka, K., Seki, M., Hoshi, M., Takatsu, H., Mashino, T., Urano, S. & Endo, T., 2007 8月, In: Biological and Pharmaceutical Bulletin. 30, 8, p. 1565-1568 4 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

Total synthesis of siomycin A

Mori, T., Higashibayashi, S., Goto, T., Kohno, M., Satouchi, Y., Shinko, K., Suzuki, K., Suzuki, S., Tohmiya, H., Hashimoto, K. & Nakata, M., 2007 2月 19, In: Tetrahedron Letters. 48, 8, p. 1331-1335 5 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Transcriptional activation of ATF6 by endoplasmic reticulum stressors

Namba, T., Ishihara, T., Tanaka, K. I., Hoshino, T. & Mizushima, T., 2007 4月 6, In: Biochemical and Biophysical Research Communications. 355, 2, p. 543-548 6 p.

研究成果: Article › 査読

41 被引用数 (Scopus)

Ubiquitous expression of acetylcholine and its biological functions in life forms without nervous systems

Kawashima, K., Misawa, H., Moriwaki, Y., Fujii, Y. X., Fujii, T., Horiuchi, Y., Yamada, T., Imanaka, T. & Kamekura, M., 2007 5月 30, In: Life Sciences. 80, 24-25, p. 2206-2209 4 p.

研究成果: Article › 査読

76 被引用数 (Scopus)

2008

1,4-Asymmetric induction using a cobalt alkyne complex

Hayashi, Y., Yamaguchi, H., Toyoshima, M., Nasu, S., Ochiai, K. & Shoji, M., 2008 1月 28, In: Organometallics. 27, 2, p. 163-165 3 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice

Misawa, H., Fujigaya, H., Nishimura, T., Moriwaki, Y., Okuda, T., Kawashima, K., Nakata, K., Ruggiero, A. M., Blakely, R. D., Nakatsu, F. & Ohno, H., 2008 6月, In: European Journal of Neuroscience. 27, 12, p. 3109-3117 9 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

Yamanaka, K., Chun, S. J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D. H., Takahashi, R., Misawa, H. & Cleveland, D. W., 2008 3月, In: Nature Neuroscience. 11, 3, p. 251-253 3 p.

研究成果: Article › 査読

872 被引用数 (Scopus)

C₆₀ nanowhisker field-effect-transistor application for nano-electronics

Ogawa, K. I., Aoki, N., Miyazawa, K., Nakamura, S., Mashino, T., Bird, J. P. & Ochiai, Y., 2008 1月 22, In: Japanese journal of applied physics. 47, 1 PART 2, p. 501-504 4 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Chemoenzymatic approach to enantiomerically pure (R)-3-Hydroxy-3-methyl-4- pentenoic acid ester and its application to a formal total synthesis of taurospongin A

Fujino, A. & Sugai, T., 2008 8月 4, In: Advanced Synthesis and Catalysis. 350, 11-12, p. 1712-1716 5 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Effects of graft densities and chain lengths on separation of bioactive compounds by nanolayered thermoresponsive Polymer brush surfaces

Nagase, K., Kobayashi, J., Kikuchi, A., Akiyama, Y., Kanazawa, H. & Okano, T., 2008 1月 15, In: Langmuir. 24, 2, p. 511-517 7 p.

研究成果: Article › 査読

150 被引用数 (Scopus)

Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation

Kamiyama, H., Usui, T., Uramoto, M., Takagi, H., Shoji, M., Hayashi, Y., Kakeya, H. & Osada, H., 2008 2月, In: Journal of Antibiotics. 61, 2, p. 94-97 4 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

Influence of graft interface polarity on hydration/dehydration of grafted thermoresponsive polymer brushes and steroid separation using all-aqueous chromatography

Nagase, K., Kobayashi, J., Kikuchi, A., Akiyama, Y., Annaka, M., Kanazawa, H. & Okano, T., 2008 10月 7, In: Langmuir. 24, 19, p. 10981-10987 7 p.

研究成果: Article › 査読

60 被引用数 (Scopus)

L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner

Moriwaki, Y., Kim, Y. J., Ido, Y., Misawa, H., Kawashima, K., Endo, S. & Takahashi, R., 2008 5月, In: Neuroscience Research. 61, 1, p. 43-48 6 p.

研究成果: Article › 査読

65 被引用数 (Scopus)

Licochalcone A is a potent inhibitor of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation

Funakoshi-Tago, M., Tago, K., Nishizawa, C., Takahashi, K., Mashino, T., Iwata, S., Inoue, H., Sonoda, Y. & Kasahara, T., 2008 12月 15, In: Biochemical Pharmacology. 76, 12, p. 1681-1693 13 p.

研究成果: Article › 査読

36 被引用数 (Scopus)

Preparation of thermoresponsive cationic copolymer brush surfaces and application of the surface to separation of biomolecules

Nagase, K., Kobayashi, J., Kikuchi, A., Akiyama, Y., Kanazawa, H. & Okano, T., 2008 4月 1, In: Biomacromolecules. 9, 4, p. 1340-1347 8 p.

研究成果: Article › 査読

116 被引用数 (Scopus)

Process development with Bifunctional chiral epoxides to access single enantiomrs of pharmaceutical intermediates

Ikunaka, M. & Sugai, T., 2008 10月, In: Journal of Oil Palm Research. SPEC. ISS. OCTOBE, p. 143-158 16 p.

研究成果: Article › 査読

Regio- and chemoselective manipulation under mild conditions on glucosamine derivatives for oligosaccharide synthesis and its application toward N-acetyl-d-lactosamine and Lewis X trisaccharide

Nagai, Y., Ito, N., Sultana, I. & Sugai, T., 2008 9月 29, In: Tetrahedron. 64, 40, p. 9599-9606 8 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Role of GluR1 in activity-dependent motor system development

Zhang, L., Schessl, J., Werner, M., Bonnemann, C., Xiong, G., Mojsilovic-Petrovic, J., Zhou, W., Cohen, A., Seeburg, P., Misawa, H., Jayaram, A., Personius, K., Hollmann, M., Sprengel, R. & Kalb, R., 2008 10月 1, In: Journal of Neuroscience. 28, 40, p. 9953-9968 16 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

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