薬科学科

2018

A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis

Tokuda, E., Nomura, T., Ohara, S., Watanabe, S., Yamanaka, K., Morisaki, Y., Misawa, H. & Furukawa, Y., 2018 6月, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 6, p. 2119-2130 12 p.

研究成果: Article › 査読

Open Access

18 被引用数 (Scopus)

A major component of vitamin E, α-tocopherol inhibits the anti-tumor activity of crizotinib against cells transformed by EML4-ALK

Uchihara, Y., Kidokoro, T., Tago, K., Mashino, T., Tamura, H. & Funakoshi-Tago, M., 2018 4月 15, In: European journal of pharmacology. 825, p. 1-9 9 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Application of Hydrazine-Embedded Heterocyclic Compounds to High Voltage Rechargeable Lithium Organic Batteries

Shimizu, T., Yamamoto, K., Pandit, P., Yoshikawa, H. & Higashibayashi, S., 2018 12月 1, In: Scientific reports. 8, 1, 579.

研究成果: Article › 査読

Open Access

11 被引用数 (Scopus)

Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail

Sawazaki, R., Imai, S., Yokogawa, M., Hosoda, N., Hoshino, S. I., Mio, M., Mio, K., Shimada, I. & Osawa, M., 2018 12月 1, In: Scientific reports. 8, 1, 1455.

研究成果: Article › 査読

Open Access

15 被引用数 (Scopus)

Chemoenzymatic approaches to the synthesis of the (1S,2R)-isomer of benzyl 2-hydroxycyclohexanecarboxylate

Tsunekawa, R., Hanaya, K., Higashibayashi, S., Shoji, M. & Sugai, T., 2018 1月, In: Molecular Catalysis. 444, p. 84-89 6 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Dearomative Oxidative Rearrangement of [3]Cyclo-1,8-carbazolylene

Yasui, M., Ohtsu, H., Kawano, M., Hanaya, K., Sugai, T. & Higashibayashi, S., 2018, In: Chemistry Letters. 47, 11, p. 1357-1359 3 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Design of functional thermoresponsive polymer brushes and their application to bioseparation

Nagase, K., Okano, T. & Kanazawa, H., 2018 3月, In: KOBUNSHI RONBUNSHU. 75, 2, p. 143-154 12 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling

Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R. & Ohno, H., 2018 2月 1, In: Journal of Experimental Medicine. 215, 2, p. 501-519 19 p.

研究成果: Article › 査読

Open Access

50 被引用数 (Scopus)

Development of nanocarriers functionalized with stimuli-responsive polymer for controlled cellular uptake

Yamanouchi, T., Katsuyama, N., Hiruta, Y., Ayano, E. & Kanazawa, H., 2018 3月, In: KOBUNSHI RONBUNSHU. 75, 2, p. 116-127 12 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis

Watanabe-Matsumoto, S., Moriwaki, Y., Okuda, T., Ohara, S., Yamanaka, K., Abe, Y., Yasui, M. & Misawa, H., 2018 8月, In: Neuroscience Research. 133, p. 48-57 10 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Effect of hesperetin derivatives on the development of selenite-induced cataracts in rats

Nakazawa, Y., Pauze, M., Fukuyama, K., Nagai, N., Funakoshi-Tago, M., Sugai, T. & Tamura, H., 2018 7月, In: Molecular Medicine Reports. 18, 1, p. 1043-1050 8 p.

研究成果: Article › 査読

Open Access

10 被引用数 (Scopus)

Formal synthesis of englerin A utilizing regio- and diastereoselective [4+3] cycloaddition

Hagihara, S., Hanaya, K., Sugai, T. & Shoji, M., 2018 2月 1, In: Journal of Antibiotics. 71, 2, p. 257-262 6 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Formal total synthesis of (−)-hamigeran B from a chemo-enzymatically prepared building block with quaternary chiral center

Kuwata, K., Fujita, R., Hanaya, K., Higashibayashi, S. & Sugai, T., 2018 2月 15, In: Tetrahedron. 74, 7, p. 740-745 6 p.

研究成果: Article › 査読

10 被引用数 (Scopus)

Functional roles of Mg ²⁺ binding sites in ion-dependent gating of a Mg ²⁺ channel, MgtE, revealed by solution NMR

Maruyama, T., Imai, S., Kusakizako, T., Hattori, M., Ishitani, R., Nureki, O., Ito, K., Maturana, A. D., Shimada, I. & Osawa, M., 2018 4月 3, In: eLife. 7, e31596.

研究成果: Article › 査読

Open Access

6 被引用数 (Scopus)

Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2/HO-1 axis in SH-SY5Y cells

Funakohi-Tago, M., Sakata, T., Fujiwara, S., Sakakura, A., Sugai, T., Tago, K. & Tamura, H., 2018 9月 5, In: European journal of pharmacology. 834, p. 246-256 11 p.

研究成果: Article › 査読

40 被引用数 (Scopus)

Identification of mesothelioma-specific sialylated epitope recognized with monoclonal antibody SKM9-2 in a mucin-like membrane protein HEG1

Matsuura, R., Kaji, H., Tomioka, A., Sato, T., Narimatsu, H., Moriwaki, Y., Misawa, H., Imai, K. & Tsuji, S., 2018 12月 1, In: Scientific reports. 8, 1, 14251.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes

Komine, O., Yamashita, H., Fujimori-Tonou, N., Koike, M., Jin, S., Moriwaki, Y., Endo, F., Watanabe, S., Uematsu, S., Akira, S., Uchiyama, Y., Takahashi, R., Misawa, H. & Yamanaka, K., 2018 12月 1, In: Cell Death and Differentiation. 25, 12, p. 2130-2146 17 p.

研究成果: Article › 査読

Open Access

25 被引用数 (Scopus)

Intestinal epithelial cell-specific deletion of α-mannosidase II ameliorates experimental colitis

Suzuki, K., Yamada, T., Yamazaki, K., Hirota, M., Ishihara, N., Sakamoto, M., Takahashi, D., Iijima, H. & Hase, K., 2018, In: Cell structure and function. 43, 1, p. 25-39 15 p.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

LAT1-targeting thermoresponsive fluorescent polymer probes for cancer cell imaging

Matsuura, M., Ohshima, M., Hiruta, Y., Nishimura, T., Nagase, K. & Kanazawa, H., 2018 6月 1, In: International journal of molecular sciences. 19, 6, 1646.

研究成果: Article › 査読

28 被引用数 (Scopus)

LIGHT-HVEM Signaling in Innate Lymphoid Cell Subsets Protects Against Enteric Bacterial Infection

Seo, G. Y., Shui, J. W., Takahashi, D., Song, C., Wang, Q., Kim, K., Mikulski, Z., Chandra, S., Giles, D. A., Zahner, S., Kim, P. H., Cheroutre, H., Colonna, M. & Kronenberg, M., 2018 8月 8, In: Cell Host and Microbe. 24, 2, p. 249-260.e4

研究成果: Article › 査読

Open Access

27 被引用数 (Scopus)

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

Okubo, K., Kurosawa, M., Kamiya, M., Urano, Y., Suzuki, A., Yamamoto, K., Hase, K., Homma, K., Sasaki, J., Miyauchi, H., Hoshino, T., Hayashi, M., Mayadas, T. N. & Hirahashi, J., 2018 2月 1, In: Nature medicine. 24, 2, p. 232-238 7 p.

研究成果: Article › 査読

97 被引用数 (Scopus)

Macrophages switch their phenotype by regulating maf expression during different phases of inflammation

Kikuchi, K., Iida, M., Ikeda, N., Moriyama, S., Hamada, M., Takahashi, S., Kitamura, H., Watanabe, T., Hasegawa, Y., Hase, K., Fukuhara, T., Sato, H., Kobayashi, E. H., Suzuki, T., Yamamoto, M., Tanaka, M. & Asano, K., 2018 7月 15, In: Journal of Immunology. 201, 2, p. 635-651 17 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

Mesenchylmal stem cell culture on poly(N-isopropylacrylamide) hydrogel with repeated thermo-stimulation

Akimoto, A. M., Niitsu, E. H., Nagase, K., Okano, T., Kanazawa, H. & Yoshida, R., 2018 4月 21, In: International journal of molecular sciences. 19, 4, 1253.

研究成果: Article › 査読

Open Access

17 被引用数 (Scopus)

Molecular Arrangements of Corannulene and Sumanene in Single-Walled Carbon Nanotubes

Iizumi, Y., Liu, Z., Suenaga, K., Okada, S., Higashibayashi, S., Sakurai, H. & Okazaki, T., 2018 6月, In: ChemNanoMat. 4, 6, p. 557-561 5 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Oral administration of Porphyromonas gingivalis alters the gut microbiome and serum metabolome

Kato, T., Yamazaki, K., Nakajima, M., Date, Y., Kikuchi, J., Hase, K., Ohno, H. & Yamazaki, K., 2018 9月 1, In: mSphere. 3, 5, e00460-18.

研究成果: Article › 査読

Open Access

83 被引用数 (Scopus)

Protein purification using solid-phase extraction on temperature-responsive hydrogel-modified silica beads

Okubo, K., Ikeda, K., Oaku, A., Hiruta, Y., Nagase, K. & Kanazawa, H., 2018 9月 21, In: Journal of Chromatography A. 1568, p. 38-48 11 p.

研究成果: Article › 査読

31 被引用数 (Scopus)

SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes

Moriwaki, Y., Ohno, Y., Ishii, T., Takamura, Y., Kita, Y., Watabe, K., Sango, K., Tsuji, S. & Misawa, H., 2018 6月, In: PloS one. 13, 6, e0199829.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

Structural basis for the ethanol action on G-protein-activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy

Toyama, Y., Kano, H., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 15, p. 3858-3863 6 p.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

Synthesis and Properties of Hydrazine-Embedded Biphenothiazines and Application of Hydrazine-Embedded Heterocyclic Compounds to Fluorescence Cell Imaging

Shindo, Y., Nomura, S., Saikawa, Y., Nakata, M., Tanaka, K., Hanaya, K., Sugai, T. & Higashibayashi, S., 2018 9月, In: Asian Journal of Organic Chemistry. 7, 9, p. 1797-1801 5 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Synthesis of 3β-tert-Butyldimethylsiloxy-22-phenylthio-23,24-bisnorchola-5,9(11)-diene and Reductive Nucleophilic Attack on a Branched Aliphatic Aldehyde

Nagai, T., Hanaya, K., Higashibayashi, S., Shoji, M. & Sugai, T., 2018, In: Chemical and Pharmaceutical Bulletin. 66, 3, p. 334-338 5 p.

研究成果: Article › 査読

Open Access

Synthesis of enantiomerically enriched drug precursors and an insect pheromone via reduction of ketones using commercially available carbonyl reductase screening kit “Chiralscreen® OH”

Nagai, T., Sakurai, S., Natori, N., Hataoka, M., Kinoshita, T., Inoue, H., Hanaya, K., Shoji, M. & Sugai, T., 2018 4月 1, In: Bioorganic and Medicinal Chemistry. 26, 7, p. 1304-1313 10 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Synthesis of fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation

Tsunekawa, R., Hanaya, K., Higashibayashi, S. & Sugai, T., 2018, In: Bioscience, Biotechnology and Biochemistry. 82, 8, p. 1316-1322 7 p.

研究成果: Article › 査読

Open Access

7 被引用数 (Scopus)

Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation

Ohe, T., Umezawa, R., Kitagawara, Y., Yasuda, D., Takahashi, K., Nakamura, S., Abe, A., Sekine, S., Ito, K., Okunushi, K., Morio, H., Furihata, T., Anzai, N. & Mashino, T., 2018 12月 15, In: Bioorganic and Medicinal Chemistry Letters. 28, 23-24, p. 3708-3711 4 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Synthesis of oroxylin A starting from naturally abundant baicalin

Fujita, R., Hanaya, K., Higashibayashi, S. & Sugai, T., 2018, In: Heterocycles. 97, 2, p. 1165-1174 10 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Synthesis of trilobatin from naringin via prunin as the key intermediate: Acidic hydrolysis of the α-rhamnosidic linkage in naringin under improved conditions

Kurahayashi, K., Hanaya, K., Higashibayashi, S. & Sugai, T., 2018, In: Bioscience, Biotechnology and Biochemistry. 82, 9, p. 1463-1467 5 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Therapeutic effect of vitamin D₃-containing nanostructured lipid carriers on inflammatory bowel disease

Zai, K., Hirota, M., Yamada, T., Ishihara, N., Mori, T., Kishimura, A., Suzuki, K., Hase, K. & Katayama, Y., 2018 9月 28, In: Journal of Controlled Release. 286, p. 94-102 9 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Triazasumanene: An isoelectronic heteroanalogue of sumanene

Tan, Q., Kaewmati, P., Higashibayashi, S., Kawano, M., Yakiyama, Y. & Sakurai, H., 2018, In: Bulletin of the Chemical Society of Japan. 91, 4, p. 531-537 7 p.

研究成果: Article › 査読

30 被引用数 (Scopus)

Tris(2-hydroxyphenyl)triazasumanene: Bowl-shaped excited-state intramolecular proton transfer (ESIPT) fluorophore coupled with aggregation-induced enhanced emission (AIEE)

Kaewmati, P., Yakiyama, Y., Ohtsu, H., Kawano, M., Haesuwannakij, S., Higashibayashi, S. & Sakurai, H., 2018, In: Materials Chemistry Frontiers. 2, 3, p. 514-519 6 p.

研究成果: Article › 査読

24 被引用数 (Scopus)

粘膜面におけるバリア機能と免疫恒常性の維持に果たす M 細胞の役割

Ishihara, N., Kobayashi, N. & Hase, K., 2018, In: Japanese Journal of Allergology. 67, 3, p. 171-178 8 p.

研究成果: Article › 査読

2017

Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK

Uchihara, Y., Ueda, F., Tago, K., Nakazawa, Y., Ohe, T., Mashino, T., Yokota, S., Kasahara, T., Tamura, H. & Funakoshi-Tago, M., 2017 8月, In: PloS one. 12, 8, e0183003.

研究成果: Article › 査読

11 被引用数 (Scopus)

A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis

Anzai, I., Tokuda, E., Mukaiyama, A., Akiyama, S., Endo, F., Yamanaka, K., Misawa, H. & Furukawa, Y., 2017 3月 1, In: Protein Science. 26, 3, p. 484-496 13 p.

研究成果: Article › 査読

20 被引用数 (Scopus)

A novel phenylphthalimide derivative, pegylated TC11, improves pharmacokinetic properties and induces apoptosis of high-risk myeloma cells via G2/M cell-cycle arrest

Aida, S., Hozumi, M., Ichikawa, D., Iida, K., Yonemura, Y., Tabata, N., Yamada, T., Matsushita, M., Sugai, T., Yanagawa, H. & Hattori, Y., 2017 11月 4, In: Biochemical and Biophysical Research Communications. 493, 1, p. 514-520 7 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Attenuation of CD4⁺ CD25⁺ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

Kunisada, Y., Eikawa, S., Tomonobu, N., Domae, S., Uehara, T., Hori, S., Furusawa, Y., Hase, K., Sasaki, A. & Udono, H., 2017 11月, In: EBioMedicine. 25, p. 154-164 11 p.

研究成果: Article › 査読

Open Access

74 被引用数 (Scopus)

Chemo-enzymatic synthesis of (R)-5-hydroxymethyl-2-isopropyl-5-methylcyclopent-1-en-1-yl trifluoromethylsulfonate, a potential chiral building block for multicyclic terpenoids

Kuwata, K., Hanaya, K., Sugai, T. & Shoji, M., 2017, In: Tetrahedron Asymmetry. 28, 7, p. 964-968 5 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Construction of 2,6,9,11-tetraoxatricyclo[6.2.1.0^3,8]undecane containing 4-keto-D-glucose skeleton

Fujitani, B., Hanaya, K., Higashibayashi, S., Shoji, M. & Sugai, T., 2017 12月 21, In: Tetrahedron. 73, 51, p. 7217-7222 6 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Design and synthesis of temperature-responsive polymer/silica hybrid nanoparticles and application to thermally controlled cellular uptake

Hiruta, Y., Nemoto, R. & Kanazawa, H., 2017 5月 1, In: Colloids and Surfaces B: Biointerfaces. 153, p. 2-9 8 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor

Yasuda, D., Yuasa, A., Obata, R., Nakajima, M., Takahashi, K., Ohe, T., Ichimura, Y., Komatsu, M., Yamamoto, M., Imamura, R., Kojima, H., Okabe, T., Nagano, T. & Mashino, T., 2017 11月 15, In: Bioorganic and Medicinal Chemistry Letters. 27, 22, p. 5006-5009 4 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

Dual temperature-and pH-responsive polymeric micelle for selective and efficient two-step doxorubicin delivery

Hiruta, Y., Kanda, Y., Katsuyama, N. & Kanazawa, H., 2017, In: RSC Advances. 7, 47, p. 29540-29549 10 p.

研究成果: Article › 査読

23 被引用数 (Scopus)

Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses

Toyama, Y., Kano, H., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2017 2月 22, In: Nature communications. 8, 14523.

研究成果: Article › 査読

Open Access

27 被引用数 (Scopus)

Enhanced cellular uptake and gene silencing activity of siRNA using temperature-responsive polymer-modified liposome

Wang, J., Ayano, E., Maitani, Y. & Kanazawa, H., 2017 5月 15, In: International Journal of Pharmaceutics. 523, 1, p. 217-228 12 p.

研究成果: Article › 査読

30 被引用数 (Scopus)

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