薬科学科

2006

Aqueous chromatography system using pH- and temperature-responsive stationary phase with ion-exchange groups

Ayano, E., Nambu, K., Sakamoto, C., Kanazawa, H., Kikuchi, A. & Okano, T., 2006 6月 30, In: Journal of Chromatography A. 1119, 1-2, p. 58-65 8 p.

研究成果: Article › 査読

57 被引用数 (Scopus)

Combined proline-surfactant organocatalyst for the highly diastereo- and enantioselective aqueous direct cross-aldol reaction of aldehydes

Hayashi, Y., Aratake, S., Okano, T., Takahashi, J., Sumiya, T. & Shoji, M., 2006 8月 18, In: Angewandte Chemie - International Edition. 45, 33, p. 5527-5529 3 p.

研究成果: Article › 査読

289 被引用数 (Scopus)

Computational study on the reaction mechanism of the key thermal [4 + 4] cycloaddition reaction in the biosynthesis of epoxytwinol A

Shiina, I., Uchimaru, T., Shoji, M., Kakeya, H., Osada, H. & Hayashi, Y., 2006 3月 16, In: Organic Letters. 8, 6, p. 1041-1044 4 p.

研究成果: Article › 査読

11 被引用数 (Scopus)

Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin

Yamaguchi, J., Toyoshima, M., Shoji, M., Kakeya, H., Osada, H. & Hayashi, Y., 2006 1月 23, In: Angewandte Chemie - International Edition. 45, 5, p. 789-793 5 p.

研究成果: Article › 査読

40 被引用数 (Scopus)

Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals

Misawa, H., Nakata, K., Matsuura, J., Moriwaki, Y., Kawashima, K., Shimizu, T., Shirasawa, T. & Takahashi, R., 2006 7月, In: Neurobiology of Disease. 23, 1, p. 169-177 9 p.

研究成果: Article › 査読

43 被引用数 (Scopus)

Differential induction of cystathionine γ-lyase in the livers and kidneys of mouse dams during gestation and lactation

Akahoshi, N., Izumi, T., Ishizaki, Y. & Ishii, I., 2006, In: Biological and Pharmaceutical Bulletin. 29, 9, p. 1799-1802 4 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Highly diastereo- and enantioselective direct aldol reactions in water

Hayashi, Y., Sumiya, T., Takahashi, J., Gotoh, H., Urushima, T. & Shoji, M., 2006 1月 30, In: Angewandte Chemie - International Edition. 45, 6, p. 958-961 4 p.

研究成果: Article › 査読

469 被引用数 (Scopus)

Increased F2-isoprostane levels in the rat brain and plasma caused by oxidative stress and aging, and inhibitory effect of vitamin E

Nishio, T., Miyadera, R., Sakai, R., Abe, K., Kanazawa, H., Fukui, K. & Urano, S., 2006 5月, In: Journal of Clinical Biochemistry and Nutrition. 38, 3, p. 161-166 6 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

Large nonlinear effect observed in the enantiomeric excess of proline in solution and that in the solid state

Hayashi, Y., Matsuzawa, M., Yamaguchi, J., Yonehara, S., Matsumoto, Y., Shoji, M., Hashizume, D. & Koshino, H., 2006 7月 10, In: Angewandte Chemie - International Edition. 45, 28, p. 4593-4597 5 p.

研究成果: Article › 査読

105 被引用数 (Scopus)

Metabolic conversion of 24-methyl-Δ²⁵-cholesterol to 24-methylcholesterol in higher plants

Takahashi, K., Nasu, K., Mashino, T., Morisaki, M., Hara, N. & Fujimoto, Y., 2006 2月 1, In: Bioorganic and Medicinal Chemistry. 14, 3, p. 732-738 7 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Pharmacokinetics of fentanyl after single intravenous injection and constant rate infusion in dogs

Sano, T., Nishimura, R., Kanazawa, H., Igarashi, E., Nagata, Y., Mochizuki, M. & Sasaki, N., 2006 7月, In: Veterinary Anaesthesia and Analgesia. 33, 4, p. 266-273 8 p.

研究成果: Article › 査読

78 被引用数 (Scopus)

Screening, substrate specificity and stereoselectivity of yeast strains, which reduce sterically hindered isopropyl ketones

Hiraoka, C., Matsuda, M., Suzuki, Y., Fujieda, S., Tomita, M., Fuhshuku, K. I., Obata, R., Nishiyama, S. & Sugai, T., 2006 12月 27, In: Tetrahedron Asymmetry. 17, 24, p. 3358-3367 10 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Structural characterization of room-temperature synthesized fullerene nanowhiskers

Miyazawa, K., Minato, J. I., Mashino, T., Nakamura, S., Fujino, M. & Suga, T., 2006 6月 14, In: Nukleonika. 51, SUPPL. 1, p. S41-S48

研究成果: Article › 査読

12 被引用数 (Scopus)

Study of temperature-responsibility on the surfaces of a thermo-responsive polymer modified stationary phase

Ayano, E., Okada, Y., Sakamoto, C., Kanazawa, H., Kikuchi, A. & Okano, T., 2006 6月 30, In: Journal of Chromatography A. 1119, 1-2, p. 51-57 7 p.

研究成果: Article › 査読

47 被引用数 (Scopus)

Synthesis and biological assessment of hemiacetal spiro derivatives towards development of efficient chemotherapeutic agent

Ogamino, T., Ohnishi, S., Ishikawa, Y., Sugai, T., Obata, R. & Nishiyama, S., 2006 3月, In: Science and Technology of Advanced Materials. 7, 2, p. 175-183 9 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

2005

Analysis of benzimidazole anthelmintics in livestock foods by HPLC/MS/MS

Kai, S., Akaboshi, T., Kishi, M., Kanazawa, H. & Kobayashi, S., 2005, In: BUNSEKI KAGAKU. 54, 9, p. 775-782 8 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Analysis of herbicides in water using temperature-responsive chromatography and an aqueous mobile phase

Ayano, E., Okada, Y., Sakamoto, C., Kanazawa, H., Okano, T., Ando, M. & Nishimura, T., 2005 4月 1, In: Journal of Chromatography A. 1069, 2, p. 281-285 5 p.

研究成果: Article › 査読

34 被引用数 (Scopus)

Biodegradable polymers in chondrogenesis of human articular chondrocytes

Banu, N., Banu, Y., Sakai, M., Mashino, T. & Tsuchiya, T., 2005 9月 1, In: Journal of Artificial Organs. 8, 3, p. 184-191 8 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Chemoenzymatic route to both enantiomers of a 1-isopropyl-3a- methyloctahydroinden-4-one derivative: A synthetic intermediate for sesqui- and diterpenoids

Fujieda, S., Tomita, M., Fuhshuku, K. I., Ohba, S., Nishiyama, S. & Sugai, T., 2005 6月, In: Advanced Synthesis and Catalysis. 347, 7-8, p. 1099-1109 11 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Chemo-enzymatic short-step total synthesis of symbioramide

Takanami, T., Tokoro, H., Kato, D. I., Nishiyama, S. & Sugai, T., 2005 5月 9, In: Tetrahedron Letters. 46, 19, p. 3291-3295 5 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction

Hayashi, Y., Gotoh, H., Tamura, T., Yamaguchi, H., Masui, R. & Shoji, M., 2005 11月 23, In: Journal of the American Chemical Society. 127, 46, p. 16028-16029 2 p.

研究成果: Article › 査読

199 被引用数 (Scopus)

Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells

Yamaguchi, J., Kakeya, H., Uno, T., Shoji, M., Osada, H. & Hayashi, Y., 2005 5月 13, In: Angewandte Chemie - International Edition. 44, 20, p. 3110-3115 6 p.

研究成果: Article › 査読

31 被引用数 (Scopus)

Development of temperature-responsive chromatography using functional polymers

Ayano, E. & Kanazawa, H., 2005, In: BUNSEKI KAGAKU. 54, 7, p. 593-603 11 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Diphenylprolinol silyl ethers as efficient organocatalysts for the asymmetric Michael reaction of aldehydes and nitroalkenes

Hayashi, Y., Gotoh, H., Hayashi, T. & Shoji, M., 2005 7月 4, In: Angewandte Chemie - International Edition. 44, 27, p. 4212-4215 4 p.

研究成果: Article › 査読

1127 被引用数 (Scopus)

Efficient route to (S)-azetidine-2-carboxylic acid

Futamura, Y., Kurokawa, M., Obata, R., Nishiyama, S. & Sugai, T., 2005 10月 23, In: Bioscience, Biotechnology and Biochemistry. 69, 10, p. 1892-1897 6 p.

研究成果: Article › 査読

22 被引用数 (Scopus)

Enantio- and diastereoselective total synthesis of EI-1941-1, -2, and -3, inhibitors of interleukin-1β converting enzyme, and biological properties of their derivatives

Shoji, M., Uno, T., Kakeya, H., Onose, R., Shiina, I., Osada, H. & Hayashi, Y., 2005 11月 25, In: Journal of Organic Chemistry. 70, 24, p. 9905-9915 11 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives

Mashino, T., Shimotohno, K., Ikegami, N., Nishikawa, D., Okuda, K., Takahashi, K., Nakamura, S. & Mochizuki, M., 2005 2月 15, In: Bioorganic and Medicinal Chemistry Letters. 15, 4, p. 1107-1109 3 p.

研究成果: Article › 査読

165 被引用数 (Scopus)

Involvement of intracellular Ca²⁺ levels in nonsteroidal anti-inflammatory drug-induced apoptosis

Tanaka, K. I., Tomisato, W., Hoshino, T., Ishihara, T., Namba, T., Aburaya, M., Katsu, T., Suzuki, K., Tsutsumi, S. & Mizushima, T., 2005 9月 2, In: Journal of Biological Chemistry. 280, 35, p. 31059-31067 9 p.

研究成果: Article › 査読

103 被引用数 (Scopus)

Preparation and antioxidant activity of α-pyridoin and its derivatives

Hatanaka, M., Takahashi, K., Nakamura, S. & Mashino, T., 2005 12月 15, In: Bioorganic and Medicinal Chemistry. 13, 24, p. 6763-6770 8 p.

研究成果: Article › 査読

34 被引用数 (Scopus)

Short-step and scalable synthesis of (±)-cytoxazone

Asano, M., Nagasawa, C., Suzuki, M., Nishiyama, S. & Sugai, T., 2005 1月, In: Bioscience, Biotechnology and Biochemistry. 69, 1, p. 145-148 4 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Synthetic studies on thiostrepton family of peptide antibiotics: Synthesis of the cyclic core portion containing the dehydropiperidine, dihydroquinoline, L-valine, and masked dehydroalanine segments

Mori, T., Tohmiya, H., Satouchi, Y., Higashibayashi, S., Hashimoto, K. & Nakata, M., 2005 9月 19, In: Tetrahedron Letters. 46, 38, p. 6423-6427 5 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Synthetic studies on thiostrepton family of peptide antibiotics: Synthesis of the dihydroquinoline portion of thiostrepton, the siomycins, and the thiopeptins

Mori, T., Satouchi, Y., Tohmiya, H., Higashibayashi, S., Hashimoto, K. & Nakata, M., 2005 9月 19, In: Tetrahedron Letters. 46, 38, p. 6417-6422 6 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

The direct, enantioselective, one-pot, three-component, cross-Mannich reaction of aldehydes: The reason for the higher reactivity of aldimine versus aldehyde in proline-mediated Mannich and aldol reactions

Hayashi, Y., Urushima, T., Shoji, M., Uchimaru, T. & Shiina, I., 2005 10月, In: Advanced Synthesis and Catalysis. 347, 11-13, p. 1595-1604 10 p.

研究成果: Article › 査読

43 被引用数 (Scopus)

Total synthesis of epoxyquinols A, B, and C and epoxytwinol A and the reactivity of a 2H-pyran derivative as the diene component in the Diels-Alder reaction

Shoji, M., Imai, H., Mukaida, M., Sakai, K., Kakeya, H., Osada, H. & Hayashi, Y., 2005 1月 7, In: Journal of Organic Chemistry. 70, 1, p. 79-91 13 p.

研究成果: Article › 査読

70 被引用数 (Scopus)

2004

Abnormal lipid metabolism in cystathionine β-synthase-deficient mice, an animal model for hyperhomocysteinemia

Namekata, K., Enokido, Y., Ishii, I., Nagai, Y., Harada, T. & Kimura, H., 2004 12月 17, In: Journal of Biological Chemistry. 279, 51, p. 52961-52969 9 p.

研究成果: Article › 査読

126 被引用数 (Scopus)

A highly active 4-siloxyproline catalyst for asymmetric synthesis

Hayashi, Y., Yamaguchi, J., Hibino, K., Sumiya, T., Urushima, T., Shoji, M., Hashizume, D. & Koshino, H., 2004 10月 1, In: Advanced Synthesis and Catalysis. 346, 12, p. 1435-1439 5 p.

研究成果: Article › 査読

130 被引用数 (Scopus)

An expeditious route to N-Acetyl-D-galactosamine from N-Acetyl-D- glucosamine based on the selective protection of hydroxy groups

Ito, N., Tokuda, Y., Ohba, S. & Sugai, T., 2004, In: Bulletin of the Chemical Society of Japan. 77, 6, p. 1181-1186 6 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Both enantiomers of N-Boc-indoline-2-carboxylic esters

Kurokawa, M. & Sugai, T., 2004, In: Bulletin of the Chemical Society of Japan. 77, 5, p. 1021-1025 5 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Concise synthesis of 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) as a protected form based on a new transformation of α,β-unsaturated ester to α-oxocarboxylic acid ester via diol cyclic sulfite

Kuboki, A., Tajimi, T., Tokuda, Y., Kato, D. I., Sugai, T. & Ohira, S., 2004 5月 31, In: Tetrahedron Letters. 45, 23, p. 4545-4548 4 p.

研究成果: Article › 査読

18 被引用数 (Scopus)

Control of the nitrile-hydrolyzing enzyme activity in Rhodococcus rhodochrous IFO 15564: Preferential action of nitrile hydratase and amidase depending on the reaction condition factors and its application to the one-pot preparation of amides from aldehydes

Kashiwagi, M., Fuhshuku, K. I. & Sugai, T., 2004 6月 21, In: Journal of Molecular Catalysis B: Enzymatic. 29, 1-6, p. 249-258 10 p.

研究成果: Article › 査読

20 被引用数 (Scopus)

Determination and quantitation of sulfonylurea and urea herbicides in water samples using liquid chromatography with electrospray ionization mass spectrometric detection

Ayano, E., Kanazawa, H., Ando, M. & Nishimura, T., 2004 4月 8, In: Analytica Chimica Acta. 507, 2, p. 211-218 8 p.

研究成果: Article › 査読

78 被引用数 (Scopus)

Determination of midazolam and its metabolite as a probe for cytochrome P450 3A4 phenotype by liquid chromatography-mass spectrometry

Kanazawa, H., Okada, A., Igarashi, E., Higaki, M., Miyabe, T., Sano, T. & Nishimura, R., 2004 3月 26, In: Journal of Chromatography A. 1031, 1-2, p. 213-218 6 p.

研究成果: Article › 査読

30 被引用数 (Scopus)

Different Reaction Modes for the Oxidative Dimerization of Epoxyquinols and Epoxyquinones. Importance of Intermolecular Hydrogen-Bonding

Shoji, M., Imai, H., Shiina, I., Kakeya, H., Osada, H. & Hayashi, Y., 2004 3月 5, In: Journal of Organic Chemistry. 69, 5, p. 1548-1556 9 p.

研究成果: Article › 査読

35 被引用数 (Scopus)

Direct proline-catalyzed asymmetric α-aminoxylation of aldehydes and ketones

Hayashi, Y., Yamaguchi, J., Sumiya, T., Hibino, K. & Shoji, M., 2004 9月 3, In: Journal of Organic Chemistry. 69, 18, p. 5966-5973 8 p.

研究成果: Article › 査読

148 被引用数 (Scopus)

Distinguishing the 5,5-dimethyl-1-pyrroline N-oxide (DMPO)-OH radical quenching effect from the hydroxyl radical scavenging effect in the ESR spin-trapping method

Li, L., Abe, Y., Kanagawa, K., Usui, N., Imai, K., Mashino, T., Mochizuki, M. & Miyata, N., 2004 6月 4, In: Analytica Chimica Acta. 512, 1, p. 121-124 4 p.

研究成果: Article › 査読

79 被引用数 (Scopus)

Mechanistic studies on nitrosation-deaminocyclization of mono-carbamoylated vicinal amino alcohols and diols: A new preparative in situ formation of ethanediazo hydroxide for the ethylation of carboxylates under mild conditions

Suzuki, M. & Sugai, T., 2004, In: Bulletin of the Chemical Society of Japan. 77, 6, p. 1217-1227 11 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Plant-growth inhibitory activity of heliannuol derivatives

Doi, F., Ohara, T., Ogamino, T., Sugai, T., Higashinakasu, K., Yamada, K., Shigemori, H., Hasegawa, K. & Nishiyama, S., 2004 5月, In: Phytochemistry. 65, 10, p. 1405-1411 7 p.

研究成果: Article › 査読

19 被引用数 (Scopus)

Products of the reaction between α- or γ-tocopherol and nitrogen oxides analyzed by high-performance liquid chromatography with UV-visible and atmospheric pressure chemical ionization mass spectrometric detection

Nagata, Y., Matsumoto, Y. & Kanazawa, H., 2004 5月 21, In: Journal of Chromatography A. 1036, 2, p. 177-182 6 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Realization of the synthesis of α,α-disubstituted carbamylacetates and cyanoacetates by either enzymatic or chemical functional group transformation, depending upon the substrate specificity of Rhodococcus amidase

Yokoyama, M., Kashiwagi, M., Iwasaki, M., Fuhshuku, K. I., Ohta, H. & Sugai, T., 2004 9月 20, In: Tetrahedron Asymmetry. 15, 18, p. 2817-2820 4 p.

研究成果: Article › 査読

31 被引用数 (Scopus)

S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR).

Baudhuin, L. M., Jiang, Y., Zaslavsky, A., Ishii, I., Chun, J. & Xu, Y., 2004 2月, In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 2, p. 341-343 3 p.

研究成果: Article › 査読

74 被引用数 (Scopus)

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