薬科学科

Synthesis of methyl epi-anhydroquinate utilizing [2,3]-sigmatropic rearrangement of iodosoalkene

Inomata, S., Ueda, M., Sugai, T. & Shoji, M., 2013, In: Chemistry Letters. 42, 10, p. 1273-1275 3 p.

研究成果: Article › 査読

Synthesis of linezolid metabolites PNU-142300 and PNU-142586 toward the exploration of metabolite-related events

Hanaya, K., Matsumoto, K., Yokoyama, Y., Kizu, J., Shoji, M. & Sugai, T., 2017, In: Chemical and Pharmaceutical Bulletin. 65, 2, p. 194-199 6 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity

Yasuda, D., Nakajima, M., Yuasa, A., Obata, R., Takahashi, K., Ohe, T., Ichimura, Y., Komatsu, M., Yamamoto, M., Imamura, R., Kojima, H., Okabe, T., Nagano, T. & Mashino, T., 2016, In: Bioorganic and Medicinal Chemistry Letters. 26, 24, p. 5956-5959 4 p.

研究成果: Article › 査読

34 被引用数 (Scopus)

Synthesis of fisetin and 2′,4′,6′-trihydroxydihyrochalcone 4′-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation

Tsunekawa, R., Hanaya, K., Higashibayashi, S. & Sugai, T., 2018, In: Bioscience, Biotechnology and Biochemistry. 82, 8, p. 1316-1322 7 p.

研究成果: Article › 査読

Open Access

7 被引用数 (Scopus)

Synthesis of enantiomers of indanoxazolidinone based on the lipase-catalyzed resolution of the corresponding N-carbamylamino derivative

Suzuki, M., Nagasawa, C. & Sugai, T., 2001 6月 4, In: Tetrahedron. 57, 23, p. 4841-4848 8 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Synthesis of enantiomerically enriched drug precursors and an insect pheromone via reduction of ketones using commercially available carbonyl reductase screening kit “Chiralscreen® OH”

Nagai, T., Sakurai, S., Natori, N., Hataoka, M., Kinoshita, T., Inoue, H., Hanaya, K., Shoji, M. & Sugai, T., 2018 4月 1, In: Bioorganic and Medicinal Chemistry. 26, 7, p. 1304-1313 10 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Synthesis of citronellyl acetate via a transacetylation to citronellol from acetyl coenzyme A produced from glucose and acetate in growing yeasts

Oda, S., Sugai, T. & Ohta, H., 2001, In: Chemistry Letters. 6, p. 500-501 2 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Synthesis of bioactive sesquiterpene heliannuol E involving a ring-expansion reaction of spirodienones

Doi, F., Ogamino, T., Sugai, T. & Nishiyama, S., 2003, In: Synlett. 3, p. 411-413 3 p.

研究成果: Article › 査読

31 被引用数 (Scopus)

Synthesis of benzyl tetra-O-acetyl-α-L-glucopyranoside from benzyl 2,3-dideoxy-β-D-Erythro-hex-2-enopyranoside

Okazaki, H., Ueda, Y., Hanaya, K., Shoji, M. & Sugai, T., 2017, In: Heterocycles. 95, 2, p. 862-871 10 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Synthesis of acacetin and resveratrol 3,5-di-O-β-glucopyranoside using lipase-catalyzed regioselective deacetylation of polyphenol glycoside peracetates as the key step

Hanamura, S., Hanaya, K., Shoji, M. & Sugai, T., 2016 6月 1, In: Journal of Molecular Catalysis B: Enzymatic. 128, p. 19-26 8 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Synthesis of a C₇₀ Fragment Buckybowl C₂₈H₁₄ from a C₆₀ fragment sumanene

Hishikawa, S., Okabe, Y., Tsuruoka, R., Higashibayashi, S., Ohtsu, H., Kawano, M., Yakiyama, Y. & Sakurai, H., 2017, In: Chemistry Letters. 46, 10, p. 1556-1559 4 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

Synthesis of 5-Hydroxy-3′,4′,7-trimethoxyflavone and Related Compounds and Elucidation of Their Reversal Effects on BCRP/ABCG2-Mediated Anticancer Drug Resistance

Tsunekawa, R., Katayama, K., Hanaya, K., Higashibayashi, S., Sugimoto, Y. & Sugai, T., 2019 1月 18, In: ChemBioChem. 20, 2, p. 210-220 11 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Synthesis of 3β-tert-Butyldimethylsiloxy-22-phenylthio-23,24-bisnorchola-5,9(11)-diene and Reductive Nucleophilic Attack on a Branched Aliphatic Aldehyde

Nagai, T., Hanaya, K., Higashibayashi, S., Shoji, M. & Sugai, T., 2018, In: Chemical and Pharmaceutical Bulletin. 66, 3, p. 334-338 5 p.

研究成果: Article › 査読

Open Access

Synthesis of 1H-2-Benzopyran-5,8-dione Skeleton through a Cascade Reaction between Benzoquinone and β-Ketoester

Nakahara, M., Ohtsu, H., Kawano, M., Hanaya, K., Sugai, T. & Higashibayashi, S., 2022 4月, In: Chemistry Letters. 51, 4, p. 356-359 4 p.

研究成果: Article › 査読

Synthesis of (Rc,Ss)-1,1,1-trifluoro-3-(p-molylsulfinyl)-2-propanol by an asymmetric reduction with a yeast, Yamadazyma farinosa, as a key-step

Sakai, A., Bakke, M., Ohta, H., Kosugi, H. & Sugai, T., 1999, In: Chemistry Letters. 11, p. 1255-1256 2 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Synthesis and property of three-dimensional curved heterocyclic π-electron molecules with embedded nitrogen atoms

Higashibayashi, S., 2019, In: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 77, 12, p. 1209-1221 13 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Synthesis and Properties of Hydrazine-Embedded Biphenothiazines and Application of Hydrazine-Embedded Heterocyclic Compounds to Fluorescence Cell Imaging

Shindo, Y., Nomura, S., Saikawa, Y., Nakata, M., Tanaka, K., Hanaya, K., Sugai, T. & Higashibayashi, S., 2018 9月, In: Asian Journal of Organic Chemistry. 7, 9, p. 1797-1801 5 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Synthesis and evaluation of tofacitinib analogs designed to mitigate metabolic activation

Tateishi, Y., Shibazaki, C., Takahashi, K., Nakamura, S., Kazuki, Y., Mashino, T. & Ohe, T., 2022 4月, In: Drug Metabolism And Pharmacokinetics. 43, 100439.

研究成果: Article › 査読

1 被引用数 (Scopus)

Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine

Tateishi, Y., Ohe, T., Yasuda, D., Takahashi, K., Nakamura, S., Kazuki, Y. & Mashino, T., 2020 4月, In: Drug Metabolism And Pharmacokinetics. 35, 2, p. 238-243 6 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2- oxocyclopentyl)methyl]phenyl}propanoic acid: Nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity

Yamakawa, N., Suemasu, S., Okamoto, Y., Tanaka, K. I., Ishihara, T., Asano, T., Miyata, K., Otsuka, M. & Mizushima, T., 2012 6月 14, In: Journal of Medicinal Chemistry. 55, 11, p. 5143-5150 8 p.

研究成果: Article › 査読

23 被引用数 (Scopus)

Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

Nicolaou, K. C., Namoto, K., Li, J., Ritzén, A., Ulven, T., Shoji, M., Zaharevitz, D., Gussio, R., Sackett, D. L., Ward, R. D., Hensler, A., Fojo, T. & Giannakakou, P., 2001 1月 1, In: ChemBioChem. 2, 1, p. 69-75 7 p.

研究成果: Article › 査読

37 被引用数 (Scopus)

Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities

Yamashita, Y., Tanaka, K. I., Asano, T., Yamakawa, N., Kobayashi, D., Ishihara, T., Hanaya, K., Shoji, M., Sugai, T., Wada, M., Mashimo, T., Fukunishi, Y. & Mizushima, T., 2014 7月 1, In: Bioorganic and Medicinal Chemistry. 22, 13, p. 3488-3497 10 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Synthesis and biological assessment of hemiacetal spiro derivatives towards development of efficient chemotherapeutic agent

Ogamino, T., Ohnishi, S., Ishikawa, Y., Sugai, T., Obata, R. & Nishiyama, S., 2006 3月, In: Science and Technology of Advanced Materials. 7, 2, p. 175-183 9 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Synthesis and antitumor activity of novel pyridinium fullerene derivatives

Yasuno, T., Ohe, T., Ikeda, H., Takahashi, K., Nakamura, S. & Mashino, T., 2019, In: International journal of nanomedicine. 14, p. 6325-6337 13 p.

研究成果: Article › 査読

Open Access

12 被引用数 (Scopus)

Synthesis, radical scavenging activity and structure-activity relationship of uric acid analogs

Yasuda, D., Takahashi, K., Kakinoki, T., Tanaka, Y., Ohe, T., Nakamura, S. & Mashino, T., 2013 3月, In: MedChemComm. 4, 3, p. 527-529 3 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

Syntheses of optically active citronellol, citronellal, and citronellic acid by microbial oxidation and double coupling system in an interface bioreactor

Oda, S., Sugai, T. & Ohta, H., 2000 12月 1, In: Bulletin of the Chemical Society of Japan. 73, 12, p. 2819-2823 5 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Syntheses of indirubins by aldol condensation of isatins with indoxyl anion generated in situ by lipase-catalyzed deacetylation of indoxyl acetate

Sugai, T., Hanaya, K. & Higashibayashi, S., 2020, In: Heterocycles. 100, 1, p. 129-136 8 p.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Syntheses of Highly Oxygen-functionalized Derivatives of Dihydrodihydroxyphthalic Acid in Enantiomerically Enriched Forms

Ikeda, H., Hosomi, H., Ohba, S., Ohta, H. & Sugai, T., 1998, In: Bioscience, Biotechnology and Biochemistry. 62, 2, p. 396-400 5 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon

Nakamura, A., Kurihara, S., Takahashi, D., Ohashi, W., Nakamura, Y., Kimura, S., Onuki, M., Kume, A., Sasazawa, Y., Furusawa, Y., Obata, Y., Fukuda, S., Saiki, S., Matsumoto, M. & Hase, K., 2021 12月 1, In: Nature communications. 12, 1, 2105.

研究成果: Article › 査読

Open Access

38 被引用数 (Scopus)

Sustained subcutaneous infusion of nicotine enhances cholinergic vasodilation in the cerebral cortex induced by stimulation of the nucleus basalis of Meynert in rats

Uchida, S., Hotta, H., Misawa, H. & Kawashima, K., 2011 3月 11, In: European journal of pharmacology. 654, 3, p. 235-240 6 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Substrate recognition of renally eliminated angiotensin II receptor blockers by organic anion transporter 4

Noguchi, S., Okochi, M., Atsuta, H., Kimura, R., Fukumoto, A., Takahashi, K., Nishimura, T. & Tomi, M., 2021 2月, In: Drug Metabolism And Pharmacokinetics. 36, 100363.

研究成果: Article › 査読

1 被引用数 (Scopus)

Substrate-induced internalization of the high-affinity choline transporter

Okuda, T., Konishi, A., Misawa, H. & Haga, T., 2011 10月 19, In: Journal of Neuroscience. 31, 42, p. 14989-14997 9 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Substituent elimination from p-substituted phenols by cytochrome P450 ipso-substitution by the oxygen atom of the active species

Ohe, T., Mashino, T. & Hirobe, M., 1997 1月 1, In: Drug Metabolism and Disposition. 25, 1, p. 116-122 7 p.

研究成果: Article › 査読

60 被引用数 (Scopus)

Study of temperature-responsibility on the surfaces of a thermo-responsive polymer modified stationary phase

Ayano, E., Okada, Y., Sakamoto, C., Kanazawa, H., Kikuchi, A. & Okano, T., 2006 6月 30, In: Journal of Chromatography A. 1119, 1-2, p. 51-57 7 p.

研究成果: Article › 査読

47 被引用数 (Scopus)

Studies on catecholamine by HPLC with multi ECD

Takai, N., Shinozuka, N., Mashige, F., Ohkubo, A., Nukina, N., Iijima, S., Fukui, Y., Sakuma, I., Itou, F., Matsushima, Y. & Nagata, Y., 1991 1月, In: analytical sciences. 7, p. 955-956 2 p.

研究成果: Article › 査読

Open Access

Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

Kano, H., Toyama, Y., Imai, S., Iwahashi, Y., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2019 12月 1, In: Nature communications. 10, 1, 2008.

研究成果: Article › 査読

Open Access

21 被引用数 (Scopus)

Structural characterization of room-temperature synthesized fullerene nanowhiskers

Miyazawa, K., Minato, J. I., Mashino, T., Nakamura, S., Fujino, M. & Suga, T., 2006 6月 14, In: Nukleonika. 51, SUPPL. 1, p. S41-S48

研究成果: Article › 査読

12 被引用数 (Scopus)

Structural basis for the inhibition of voltage-dependent K⁺ channel by gating modifier toxin

Ozawa, S. I., Kimura, T., Nozaki, T., Harada, H., Shimada, I. & Osawa, M., 2015 9月 18, In: Scientific reports. 5, 14226.

研究成果: Article › 査読

Open Access

16 被引用数 (Scopus)

Structural basis for the ethanol action on G-protein-activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy

Toyama, Y., Kano, H., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 15, p. 3858-3863 6 p.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

Structural and Functional Analyses of the Tridomain-Nonribosomal Peptide Synthetase FmoA3 for 4-Methyloxazoline Ring Formation

Katsuyama, Y., Sone, K., Harada, A., Kawai, S., Urano, N., Adachi, N., Moriya, T., Kawasaki, M., Shin-ya, K., Senda, T. & Ohnishi, Y., 2021 6月 21, In: Angewandte Chemie - International Edition. 60, 26, p. 14554-14562 9 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Strategic Synthesis of Asymmetrically Substituted C4N4 Fluorophores

Xu, W., Kohei, M., Shibasaki, M. & Kumagai, N., 2021 9月 16, In: Synthesis (Germany). 53, 18, p. 3355-3360 6 p.

研究成果: Article › 査読

Stereospecific analysis of omeprazole in human plasma as a probe for CYP2C19 phenotype

Kanazawa, H., Okada, A., Higaki, M., Yokota, H., Mashige, F. & Nakahara, K., 2003 1月 15, In: Journal of Pharmaceutical and Biomedical Analysis. 30, 6, p. 1817-1824 8 p.

研究成果: Article › 査読

57 被引用数 (Scopus)

Stereospecific analysis of loxoprofen in plasma by chiral column liquid chromatography with a circular dichroism-based detector

Kanazawa, H., Tsubayashi, A., Nagata, Y., Matsushima, Y., Mori, C., Kizu, J. & Higaki, M., 2002 3月 1, In: Journal of Chromatography A. 948, 1-2, p. 303-308 6 p.

研究成果: Article › 査読

26 被引用数 (Scopus)

Stereospecific analysis of lorazepam in plasma by chiral column chromatography with a circular dichroism-based detector

Kanazawa, H., Kunito, Y., Matsushima, Y., Okubo, S. & Mashige, F., 2000 2月 25, In: Journal of Chromatography A. 871, 1-2, p. 181-188 8 p.

研究成果: Article › 査読

40 被引用数 (Scopus)

Stereoselective total synthesis of ent-El-1941-2 and epi-ent-El-1941-2

Shoji, M., Uno, T. & Hayashi, Y., 2004 11月 25, In: Organic Letters. 6, 24, p. 4535-4538 4 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Stereoselective synthesis of the LM ring moiety of ciguatoxin: Reagent control of asymmetric dihydroxylation

Oishi, T., Shoji, M., Kumahara, N. & Hirama, M., 1997 1月 1, In: Chemistry Letters. 9, p. 845-846 2 p.

研究成果: Article › 査読

37 被引用数 (Scopus)

Stereoselective synthesis of scyphostatin hydrophilic moiety

Kuwata, K., Suzuki, M., Inami, Y., Hanaya, K., Sugai, T. & Shoji, M., 2014 4月 23, In: Tetrahedron Letters. 55, 17, p. 2856-2858 3 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Stereoselective construction of cis-decalin framework via radical domino cyclization

Suzuki, E., Ueda, M., Ohba, S., Sugai, T. & Shoji, M., 2013 3月 20, In: Tetrahedron Letters. 54, 12, p. 1589-1592 4 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Stereochemistry of reduction of the C-24,25 double bond in the conversion of desmosterol into cholesterol

Takahashi, K., Hashimoto, K., Fujiyama, A., Yamada, J., Kobayashi, N., Morisaki, M., Nakano, S., Hara, N. & Fujimoto, Y., 2003 1月 6, In: Tetrahedron Letters. 44, 2, p. 341-344 4 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Stereochemical fate of C-26 and C-27 during the conversion of isofucosterol to sitosterol and of 24-methylenecholesterol to campesterol and dihydrobrassicasterol in Oryza sativa cell cultures

Nasu, K., Takahashi, K., Morisaki, M. & Fujimoto, Y., 2000 6月 1, In: Phytochemistry. 54, 4, p. 381-385 5 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

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