薬科学科

Article

Single-molecule electric switching induced by acid-base reaction

Yoshihara, Y., Fujii, S., Higashibayashi, S., Kiguchi, M. & Nishino, T., 2021 6月 5, In: Chemistry Letters. 50, 6, p. 1271-1273 3 p.

研究成果: Article › 査読

Single-Step N-Terminal Modification of Proteins via a Bio-Inspired Copper(II)-Mediated Aldol Reaction

Hanaya, K., Yamoto, K., Taguchi, K., Matsumoto, K., Higashibayashi, S. & Sugai, T., 2022 8月 22, In: Chemistry - A European Journal. 28, 47, e202201677.

研究成果: Article › 査読

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system

Watanabe, S., Ageta-Ishihara, N., Nagatsu, S., Takao, K., Komine, O., Endo, F., Miyakawa, T., Misawa, H., Takahashi, R., Kinoshita, M. & Yamanaka, K., 2014 8月 29, In: Molecular brain. 7, 1, 62.

研究成果: Article › 査読

66 被引用数 (Scopus)

Site-selective synthesis of acacetin and genkwanin through lipase-catalyzed deacetylation of apigenin 5,7-diacetate and subsequent methylation

Fujita, R., Mandal, S., Hanaya, K., Shoji, M., Higashibayashi, S. & Sugai, T., 2019, In: Heterocycles. 99, 1, p. 638-648 11 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

Skate-skin mucin, rich in sulfated sugars and threonine, promotes proliferation of Akkermansia muciniphila in feeding tests in rats and in vitro fermentation using human feces

Miyata, T., Mizushima, T., Miyamoto, N., Yamada, T., Hase, K., Fukushima, M., Nishimura, N., Hino, S. & Morita, T., 2022 3月 1, In: Bioscience, Biotechnology and Biochemistry. 86, 3, p. 397-406 10 p.

研究成果: Article › 査読

SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205⁺ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity

Fujii, T., Horiguchi, K., Sunaga, H., Moriwaki, Y., Misawa, H., Kasahara, T., Tsuji, S. & Kawashima, K., 2014, In: Journal of Neuroimmunology. 267, 1-2, p. 43-49 7 p.

研究成果: Article › 査読

30 被引用数 (Scopus)

Small organic molecule in enantioselective, direct aldol reaction "in water"

Aratake, S., Itoh, T., Okano, T., Usui, T., Shoji, M. & Hayashi, Y., 2007, In: Chemical Communications. 24, p. 2524-2526 3 p.

研究成果: Article › 査読

108 被引用数 (Scopus)

Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid

Ogata, M., Oka, K., Seki, M., Hoshi, M., Takatsu, H., Mashino, T., Urano, S. & Endo, T., 2007 8月, In: Biological and Pharmaceutical Bulletin. 30, 8, p. 1565-1568 4 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

Solvolysis of Pyridoxal Hydrochloride in Alcohols

Nagata, Y., Yoda, R. & Matsushima, Y., 1993, In: Chemical and Pharmaceutical Bulletin. 41, 6, p. 1019-1022 4 p.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice

Kimura, S., Kobayashi, N., Nakamura, Y., Kanaya, T., Takahashi, D., Fujiki, R., Mutoh, M., Obata, Y., Iwanaga, T., Nakagawa, T., Kato, N., Sato, S., Kaisho, T., Ohno, H. & Hase, K., 2019 4月 1, In: Journal of Experimental Medicine. 216, 4, p. 831-846 16 p.

研究成果: Article › 査読

Open Access

23 被引用数 (Scopus)

Species absorbing in the 500-nm region in the reactions of pyridoxamine with pyrroloquinoline quinone and phenathrolinequinones

Nagata, Y., Matsushima, Y., Fujii, N., Fukuda, S., Kanazawa, H., Yoda, R. & Matsumoto, S., 1999 12月, In: Chemical and Pharmaceutical Bulletin. 47, 12, p. 1774-1777 4 p.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

Specific adsorption of a β-lactam antibiotic: In vivo by an anion-exchange resin for protection of the intestinal microbiota

Li, S., Yakabe, K., Zai, K., Liu, Y., Kishimura, A., Hase, K., Kim, Y. G., Mori, T. & Katayama, Y., 2021 11月 7, In: Biomaterials Science. 9, 21, p. 7219-7227 9 p.

研究成果: Article › 査読

Specific racemization and isomerization of the aspartyl residue of αA- crystallin due to UV-B irradiation

Fujii, N., Momose, Y., Ishibashi, Y., Uemura, T., Takita, M. & Takehana, M., 1997 7月, In: Experimental Eye Research. 65, 1, p. 99-104 6 p.

研究成果: Article › 査読

40 被引用数 (Scopus)

Sphingosine Kinase Type 1 Induces G_12/13-mediated Stress Fiber Formation, yet Promotes Growth and Survival Independent of G Protein-coupled Receptors

Olivera, A., Rosenfeldt, H. M., Bektas, M., Wang, F., Ishii, I., Chun, J., Milstien, S. & Spiegel, S., 2003 11月 21, In: Journal of Biological Chemistry. 278, 47, p. 46452-46460 9 p.

研究成果: Article › 査読

135 被引用数 (Scopus)

Stagnation of glymphatic interstitial fluid flow and delay in waste clearance in the SOD1-G93A mouse model of ALS

Hirose, M., Asano, M., Watanabe-Matsumoto, S., Yamanaka, K., Abe, Y., Yasui, M., Tokuda, E., Furukawa, Y. & Misawa, H., 2021 10月, In: Neuroscience Research. 171, p. 74-82 9 p.

研究成果: Article › 査読

Open Access

7 被引用数 (Scopus)

Stepwise approach for sterically hindered C_sp³-C_sp³ bond formation by dehydrogenative: O -alkylation and Lewis acid-catalyzed [1,3]-rearrangement towards the arylalkylcyclopentane skeleton of sesquiterpenes

Fujitani, B., Hanaya, K., Sugai, T. & Higashibayashi, S., 2020 3月 28, In: Chemical Communications. 56, 25, p. 3621-3624 4 p.

研究成果: Article › 査読

2 被引用数 (Scopus)

Stereochemical fate of C-26 and C-27 during the conversion of isofucosterol to sitosterol and of 24-methylenecholesterol to campesterol and dihydrobrassicasterol in Oryza sativa cell cultures

Nasu, K., Takahashi, K., Morisaki, M. & Fujimoto, Y., 2000 6月 1, In: Phytochemistry. 54, 4, p. 381-385 5 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Stereochemistry of reduction of the C-24,25 double bond in the conversion of desmosterol into cholesterol

Takahashi, K., Hashimoto, K., Fujiyama, A., Yamada, J., Kobayashi, N., Morisaki, M., Nakano, S., Hara, N. & Fujimoto, Y., 2003 1月 6, In: Tetrahedron Letters. 44, 2, p. 341-344 4 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Stereoselective construction of cis-decalin framework via radical domino cyclization

Suzuki, E., Ueda, M., Ohba, S., Sugai, T. & Shoji, M., 2013 3月 20, In: Tetrahedron Letters. 54, 12, p. 1589-1592 4 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Stereoselective synthesis of scyphostatin hydrophilic moiety

Kuwata, K., Suzuki, M., Inami, Y., Hanaya, K., Sugai, T. & Shoji, M., 2014 4月 23, In: Tetrahedron Letters. 55, 17, p. 2856-2858 3 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

Stereoselective synthesis of the LM ring moiety of ciguatoxin: Reagent control of asymmetric dihydroxylation

Oishi, T., Shoji, M., Kumahara, N. & Hirama, M., 1997 1月 1, In: Chemistry Letters. 9, p. 845-846 2 p.

研究成果: Article › 査読

37 被引用数 (Scopus)

Stereoselective total synthesis of ent-El-1941-2 and epi-ent-El-1941-2

Shoji, M., Uno, T. & Hayashi, Y., 2004 11月 25, In: Organic Letters. 6, 24, p. 4535-4538 4 p.

研究成果: Article › 査読

21 被引用数 (Scopus)

Stereospecific analysis of lorazepam in plasma by chiral column chromatography with a circular dichroism-based detector

Kanazawa, H., Kunito, Y., Matsushima, Y., Okubo, S. & Mashige, F., 2000 2月 25, In: Journal of Chromatography A. 871, 1-2, p. 181-188 8 p.

研究成果: Article › 査読

40 被引用数 (Scopus)

Stereospecific analysis of loxoprofen in plasma by chiral column liquid chromatography with a circular dichroism-based detector

Kanazawa, H., Tsubayashi, A., Nagata, Y., Matsushima, Y., Mori, C., Kizu, J. & Higaki, M., 2002 3月 1, In: Journal of Chromatography A. 948, 1-2, p. 303-308 6 p.

研究成果: Article › 査読

26 被引用数 (Scopus)

Stereospecific analysis of omeprazole in human plasma as a probe for CYP2C19 phenotype

Kanazawa, H., Okada, A., Higaki, M., Yokota, H., Mashige, F. & Nakahara, K., 2003 1月 15, In: Journal of Pharmaceutical and Biomedical Analysis. 30, 6, p. 1817-1824 8 p.

研究成果: Article › 査読

57 被引用数 (Scopus)

Strategic Synthesis of Asymmetrically Substituted C4N4 Fluorophores

Xu, W., Kohei, M., Shibasaki, M. & Kumagai, N., 2021 9月 16, In: Synthesis (Germany). 53, 18, p. 3355-3360 6 p.

研究成果: Article › 査読

Structural and Functional Analyses of the Tridomain-Nonribosomal Peptide Synthetase FmoA3 for 4-Methyloxazoline Ring Formation

Katsuyama, Y., Sone, K., Harada, A., Kawai, S., Urano, N., Adachi, N., Moriya, T., Kawasaki, M., Shin-ya, K., Senda, T. & Ohnishi, Y., 2021 6月 21, In: Angewandte Chemie - International Edition. 60, 26, p. 14554-14562 9 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Structural basis for the ethanol action on G-protein-activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy

Toyama, Y., Kano, H., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 15, p. 3858-3863 6 p.

研究成果: Article › 査読

Open Access

8 被引用数 (Scopus)

Structural basis for the inhibition of voltage-dependent K⁺ channel by gating modifier toxin

Ozawa, S. I., Kimura, T., Nozaki, T., Harada, H., Shimada, I. & Osawa, M., 2015 9月 18, In: Scientific reports. 5, 14226.

研究成果: Article › 査読

Open Access

16 被引用数 (Scopus)

Structural characterization of room-temperature synthesized fullerene nanowhiskers

Miyazawa, K., Minato, J. I., Mashino, T., Nakamura, S., Fujino, M. & Suga, T., 2006 6月 14, In: Nukleonika. 51, SUPPL. 1, p. S41-S48

研究成果: Article › 査読

12 被引用数 (Scopus)

Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

Kano, H., Toyama, Y., Imai, S., Iwahashi, Y., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2019 12月 1, In: Nature communications. 10, 1, 2008.

研究成果: Article › 査読

Open Access

21 被引用数 (Scopus)

Studies on catecholamine by HPLC with multi ECD

Takai, N., Shinozuka, N., Mashige, F., Ohkubo, A., Nukina, N., Iijima, S., Fukui, Y., Sakuma, I., Itou, F., Matsushima, Y. & Nagata, Y., 1991 1月, In: analytical sciences. 7, p. 955-956 2 p.

研究成果: Article › 査読

Open Access

Study of temperature-responsibility on the surfaces of a thermo-responsive polymer modified stationary phase

Ayano, E., Okada, Y., Sakamoto, C., Kanazawa, H., Kikuchi, A. & Okano, T., 2006 6月 30, In: Journal of Chromatography A. 1119, 1-2, p. 51-57 7 p.

研究成果: Article › 査読

47 被引用数 (Scopus)

Substituent elimination from p-substituted phenols by cytochrome P450 ipso-substitution by the oxygen atom of the active species

Ohe, T., Mashino, T. & Hirobe, M., 1997 1月 1, In: Drug Metabolism and Disposition. 25, 1, p. 116-122 7 p.

研究成果: Article › 査読

60 被引用数 (Scopus)

Substrate-induced internalization of the high-affinity choline transporter

Okuda, T., Konishi, A., Misawa, H. & Haga, T., 2011 10月 19, In: Journal of Neuroscience. 31, 42, p. 14989-14997 9 p.

研究成果: Article › 査読

16 被引用数 (Scopus)

Substrate recognition of renally eliminated angiotensin II receptor blockers by organic anion transporter 4

Noguchi, S., Okochi, M., Atsuta, H., Kimura, R., Fukumoto, A., Takahashi, K., Nishimura, T. & Tomi, M., 2021 2月, In: Drug Metabolism And Pharmacokinetics. 36, 100363.

研究成果: Article › 査読

Sustained subcutaneous infusion of nicotine enhances cholinergic vasodilation in the cerebral cortex induced by stimulation of the nucleus basalis of Meynert in rats

Uchida, S., Hotta, H., Misawa, H. & Kawashima, K., 2011 3月 11, In: European journal of pharmacology. 654, 3, p. 235-240 6 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon

Nakamura, A., Kurihara, S., Takahashi, D., Ohashi, W., Nakamura, Y., Kimura, S., Onuki, M., Kume, A., Sasazawa, Y., Furusawa, Y., Obata, Y., Fukuda, S., Saiki, S., Matsumoto, M. & Hase, K., 2021 12月 1, In: Nature communications. 12, 1, 2105.

研究成果: Article › 査読

Open Access

38 被引用数 (Scopus)

Syntheses of Highly Oxygen-functionalized Derivatives of Dihydrodihydroxyphthalic Acid in Enantiomerically Enriched Forms

Ikeda, H., Hosomi, H., Ohba, S., Ohta, H. & Sugai, T., 1998, In: Bioscience, Biotechnology and Biochemistry. 62, 2, p. 396-400 5 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

Syntheses of indirubins by aldol condensation of isatins with indoxyl anion generated in situ by lipase-catalyzed deacetylation of indoxyl acetate

Sugai, T., Hanaya, K. & Higashibayashi, S., 2020, In: Heterocycles. 100, 1, p. 129-136 8 p.

研究成果: Article › 査読

Open Access

3 被引用数 (Scopus)

Syntheses of optically active citronellol, citronellal, and citronellic acid by microbial oxidation and double coupling system in an interface bioreactor

Oda, S., Sugai, T. & Ohta, H., 2000 12月 1, In: Bulletin of the Chemical Society of Japan. 73, 12, p. 2819-2823 5 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Synthesis, radical scavenging activity and structure-activity relationship of uric acid analogs

Yasuda, D., Takahashi, K., Kakinoki, T., Tanaka, Y., Ohe, T., Nakamura, S. & Mashino, T., 2013 3月, In: MedChemComm. 4, 3, p. 527-529 3 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

Synthesis and antitumor activity of novel pyridinium fullerene derivatives

Yasuno, T., Ohe, T., Ikeda, H., Takahashi, K., Nakamura, S. & Mashino, T., 2019, In: International journal of nanomedicine. 14, p. 6325-6337 13 p.

研究成果: Article › 査読

Open Access

12 被引用数 (Scopus)

Synthesis and biological assessment of hemiacetal spiro derivatives towards development of efficient chemotherapeutic agent

Ogamino, T., Ohnishi, S., Ishikawa, Y., Sugai, T., Obata, R. & Nishiyama, S., 2006 3月, In: Science and Technology of Advanced Materials. 7, 2, p. 175-183 9 p.

研究成果: Article › 査読

12 被引用数 (Scopus)

Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities

Yamashita, Y., Tanaka, K. I., Asano, T., Yamakawa, N., Kobayashi, D., Ishihara, T., Hanaya, K., Shoji, M., Sugai, T., Wada, M., Mashimo, T., Fukunishi, Y. & Mizushima, T., 2014 7月 1, In: Bioorganic and Medicinal Chemistry. 22, 13, p. 3488-3497 10 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

Nicolaou, K. C., Namoto, K., Li, J., Ritzén, A., Ulven, T., Shoji, M., Zaharevitz, D., Gussio, R., Sackett, D. L., Ward, R. D., Hensler, A., Fojo, T. & Giannakakou, P., 2001 1月 1, In: ChemBioChem. 2, 1, p. 69-75 7 p.

研究成果: Article › 査読

37 被引用数 (Scopus)

Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2- oxocyclopentyl)methyl]phenyl}propanoic acid: Nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity

Yamakawa, N., Suemasu, S., Okamoto, Y., Tanaka, K. I., Ishihara, T., Asano, T., Miyata, K., Otsuka, M. & Mizushima, T., 2012 6月 14, In: Journal of Medicinal Chemistry. 55, 11, p. 5143-5150 8 p.

研究成果: Article › 査読

23 被引用数 (Scopus)

Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine

Tateishi, Y., Ohe, T., Yasuda, D., Takahashi, K., Nakamura, S., Kazuki, Y. & Mashino, T., 2020 4月, In: Drug Metabolism And Pharmacokinetics. 35, 2, p. 238-243 6 p.

研究成果: Article › 査読

3 被引用数 (Scopus)

Synthesis and evaluation of tofacitinib analogs designed to mitigate metabolic activation

Tateishi, Y., Shibazaki, C., Takahashi, K., Nakamura, S., Kazuki, Y., Mashino, T. & Ohe, T., 2022 4月, In: Drug Metabolism And Pharmacokinetics. 43, 100439.

研究成果: Article › 査読

1 被引用数 (Scopus)

Synthesis and Properties of Hydrazine-Embedded Biphenothiazines and Application of Hydrazine-Embedded Heterocyclic Compounds to Fluorescence Cell Imaging

Shindo, Y., Nomura, S., Saikawa, Y., Nakata, M., Tanaka, K., Hanaya, K., Sugai, T. & Higashibayashi, S., 2018 9月, In: Asian Journal of Organic Chemistry. 7, 9, p. 1797-1801 5 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

研究成果

検索結果