医学部百寿総合研究センター

研究成果

年別の研究成果 1995 2001 2003 2007 2014 2015 2017 2018 2019 2020 2021 2022 2023

• 130 Article
• 20 Letter
• 11 Review article
• 2 Comment/debate
• 1 その他
  • 1 Chapter

年別の研究成果

年別の研究成果

検索結果

• 2023

  CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia

  Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study Group, 2023 3月, In: Kidney Medicine. 5, 3, 100593.

  研究成果: Article › 査読

  Open Access

  • White Matter 100%
  • Atrophy 95%
  • Dementia 91%
  • Japan 90%
  • Prospective Studies 69%

• DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation

  Nakamichi, R., Hishikawa, A., Chikuma, S., Yoshimura, A., Sasaki, T., Hashiguchi, A., Abe, T., Tokuhara, T., Yoshimoto, N., Nishimura, E. S., Hama, E. Y., Azegami, T., Nakayama, T., Hayashi, K. & Itoh, H., 2023 4月 25, In: Cell Reports. 42, 4, 112302.

  研究成果: Article › 査読

  Open Access

  • Podocytes 100%
  • DNA Methylation 80%
  • Epigenome 61%
  • T-Lymphocytes 50%
  • DNA 45%

• Group multi-component programme based on cognitive behavioural therapy and positive psychology for family caregivers of people with dementia: a randomised controlled study (3C study)

  Tamura, N. T., Shikimoto, R., Nagashima, K., Sato, Y., Nakagawa, A., Irie, S., Iwashita, S., Mimura, M. & Fujisawa, D., 2023 1月, In: Psychogeriatrics. 23, 1, p. 141-156 16 p.

  研究成果: Article › 査読

  • Positive Psychology 100%
  • Cognitive Behavioral Therapy 66%
  • Caregivers 55%
  • Dementia 54%
  • Emotions 34%

• Impact of Amyloid and Tau PET on Changes in Diagnosis and Patient Management

  Shimohama, S., Tezuka, T., Takahata, K., Bun, S., Tabuchi, H., Seki, M., Momota, Y., Suzuki, N., Morimoto, A., Iwabuchi, Y., Kubota, M., Yamamoto, Y., Sano, Y., Shikimoto, R., Funaki, K., Mimura, Y., Nishimoto, Y., Ueda, R., Jinzaki, M., Nakahara, J., & 2 othersMimura, M. & Ito, D., 2023 1月 17, In: Neurology. 100, 3, p. E264-E274

  研究成果: Article › 査読

  • Amyloid 100%
  • Dementia 88%
  • Cognitive Dysfunction 57%
  • 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene 21%
  • Change Management 17%
  2 被引用数 (Scopus)

• Osteoporosis and sarcopenia are associated with each other and reduced IGF1 levels are a risk for both diseases in the very old elderly

  Hata, R., Miyamoto, K., Abe, Y., Sasaki, T., Oguma, Y., Tajima, T., Arai, Y., Matsumoto, M., Nakamura, M., Kanaji, A. & Miyamoto, T., 2023 1月, In: Bone. 166, 116570.

  研究成果: Article › 査読

  • Sarcopenia 100%
  • Somatomedins 85%
  • Osteoporosis 71%
  • Elderly 54%
  • Long-Term Care 14%
  1 被引用数 (Scopus)
• 2022

  A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer

  Shimada, H., Sato, Y., Sasaki, T., Shimozawa, A., Imaizumi, K., Shindo, T., Miyao, S., Kiyama, K., Kondo, T., Shibata, S., Ishii, S., Kuromitsu, J., Aoyagi, H., Ito, D. & Okano, H., 2022 9月 19, In: Cell Reports Methods. 2, 9, 100289.

  研究成果: Article › 査読

  Open Access

  • Gene transfer 100%
  • Stem cells 83%
  • Tauopathies 80%
  • Organoids 77%
  • Dependovirus 73%
  1 被引用数 (Scopus)

• Association between vegetable, fruit, and flavonoid-rich fruit consumption in midlife and major depressive disorder in later life: the JPHC Saku Mental Health Study

  Narita, Z., Nozaki, S., Shikimoto, R., Hori, H., Kim, Y., Mimura, M., Tsugane, S. & Sawada, N., 2022 12月, In: Translational psychiatry. 12, 1, 412.

  研究成果: Article › 査読

  Open Access

  • Major Depressive Disorder 100%
  • Flavonoids 97%
  • Vegetables 95%
  • Fruit 90%
  • Mental Health 75%
  1 被引用数 (Scopus)

• Clinical course of the longest-lived man in the world: A case report

  Shikimoto, R., Arai, Y., Yuasa, S., Gondo, Y., Yasumoto, S., Abe, Y. & Hirose, N., 2022 3月, In: Experimental Gerontology. 159, 111679.

  研究成果: Article › 査読

  Open Access

  • Longevity 100%
  • Atrioventricular Block 98%
  • Block Like Crystal 75%
  • Electrocardiography 68%
  • Brain Natriuretic Peptide 64%

• Coping in Mid- to Late Life and Risk of Mild Cognitive Impairment Subtypes and Dementia: A JPHC Saku Mental Health Study

  Shikimoto, R., Nozaki, S., Sawada, N., Shimizu, Y., Svensson, T., Nakagawa, A., Mimura, M. & Tsugane, S., 2022, In: Journal of Alzheimer's Disease. 90, 3, p. 1085-1101 17 p.

  研究成果: Article › 査読

  Open Access

  • coping behavior 100%
  • cognitive impairment 92%
  • dementia 76%
  • Dementia 63%
  • Cognitive Dysfunction 62%

• Disentangling the varying associations between systolic blood pressure and health outcomes in the very old: An individual patient data meta-analysis

  Bogaerts, J. M. K., Poortvliet, R. K. E., Van Der Klei, V. M. G. T. H., Achterberg, W. P., Blom, J. W., Teh, R., Muru-Lanning, M., Kerse, N., Rolleston, A., Jagger, C., Kingston, A., Robinson, L., Arai, Y., Shikimoto, R. & Gussekloo, J., 2022 9月 1, In: Journal of hypertension. 40, 9, p. 1786-1794 9 p.

  研究成果: Article › 査読

  Open Access

  • Data Analysis 100%
  • Meta-Analysis 99%
  • Blood Pressure 85%
  • Health 65%
  • Aged, 80 and over 30%
  2 被引用数 (Scopus)

• Microbiota-Independent Spontaneous Dermatitis Associated with Increased Sebaceous Lipid Production in Tmem79-Deficient Mice

  Morimoto, A., Fukuda, K., Ito, Y., Tahara, U., Sasaki, T., Shiohama, A., Kawasaki, H., Kawakami, E., Naganuma, T., Arita, M., Sasaki, H., Koseki, H., Matsui, T. & Amagai, M., 2022 11月, In: Journal of Investigative Dermatology. 142, 11, p. 2864-2872.e6

  研究成果: Article › 査読

  • Dermatitis 100%
  • Microbiota 90%
  • Fatty Acid 73%
  • Lipid 62%
  • Lipids 59%
  2 被引用数 (Scopus)

• Neurofibromatosis type 2 with mild Pierre-Robin sequence showing a heterozygous chromosome 22q12 microdeletion encompassing NF2 and MN1

  Saito, S., Ono, N., Sasaki, T., Aoki, S., Kosaki, K., Kuze, B., Nakabayashi, K., Amagai, M. & Kubo, A., 2022 11月, In: Journal of Human Genetics. 67, 11, p. 675-678 4 p.

  研究成果: Article › 査読

  • Pierre Robin Syndrome 100%
  • Neurofibromatosis 2 92%
  • Chromosomes 51%
  • Cleft Palate 41%
  • Glossoptosis 32%

• Neuroimaging-derived brain age is associated with life satisfaction in cognitively unimpaired elderly: A community-based study

  Sone, D., Beheshti, I., Shinagawa, S., Niimura, H., Kobayashi, N., Kida, H., Shikimoto, R., Noda, Y., Nakajima, S., Bun, S., Mimura, M. & Shigeta, M., 2022 12月, In: Translational psychiatry. 12, 1, 25.

  研究成果: Article › 査読

  Open Access

  • Neuroimaging 100%
  • Elderly 74%
  • Brain 54%
  • Alcohols 20%
  • Mental Health 14%
  5 被引用数 (Scopus)

• Palmar whitish change after water exposure in a familial mild case of loricrin keratoderma (loricrin ichthyosis)

  Saito, S., Tanaka, R., Ono, N., Umegaki-Arao, N., Sasaki, T., Aoki, S., Amagai, M. & Kubo, A., 2022 11月, In: Journal of Dermatology. 49, 11, p. e405-e406

  研究成果: Letter › 査読

• Superimposition of checkerboard distribution of ephelides and neurofibromas in a patient with segmental neurofibromatosis

  Iriki, H., Umegaki-Arao, N., Kakuta, R., Fujita, H., Aoki, S., Amagai, M., Sasaki, T., Hamamoto, Y., Nakayama, R. & Kubo, A., 2022 7月, In: JAAD Case Reports. 25, p. 89-92 4 p.

  研究成果: Article › 査読

  Open Access

• The association between midlife living arrangement and psychiatrist-diagnosed depression in later life: who among your family members reduces the risk of depression?

  For the Japan Public Health Center-based Prospective Study Group, 2022 12月, In: Translational psychiatry. 12, 1, 156.

  研究成果: Article › 査読

  Open Access

  • Major Depressive Disorder 100%
  • Psychiatry 71%
  • Depression 63%
  • Child 25%
  • Spouses 19%
  1 被引用数 (Scopus)
• 2021

  Aldh2 p.E504k variation and sex are major factors associated with current and quitting alcohol drinking in Japanese oldest old

  Sasaki, T., Arai, Y., Nishimoto, Y., Hirata, T., Abe, Y. & Takebayashi, T., 2021 6月, In: Genes. 12, 6, 799.

  研究成果: Article › 査読

  Open Access

  • Sex Factors 100%
  • Aged, 80 and over 93%
  • Alcohol Drinking 69%
  • Drinking 57%
  • Aldehyde Dehydrogenase 33%
  3 被引用数 (Scopus)

• Association between dietary fish and PUFA intake in midlife and dementia in later life: The JPHC Saku mental health study

  Nozaki, S., Sawada, N., Matsuoka, Y. J., Shikimoto, R., Mimura, M. & Tsugane, S., 2021, In: Journal of Alzheimer's Disease. 79, 3, p. 1091-1104 14 p.

  研究成果: Article › 査読

  • Unsaturated Fatty Acids 100%
  • dementia 93%
  • Fishes 85%
  • Dementia 78%
  • Mental Health 73%
  9 被引用数 (Scopus)

• Association between resilience and cortical thickness in the posterior cingulate cortex and the temporal pole in Japanese older people: A population-based cross-sectional study

  Shikimoto, R., Noda, Y., Kida, H., Nakajima, S., Tsugawa, S., Mimura, Y., Ochi, R., Takayama, M., Niimura, H. & Mimura, M., 2021 10月, In: Journal of Psychiatric Research. 142, p. 89-100 12 p.

  研究成果: Article › 査読

  • Gyrus Cinguli 100%
  • Geriatrics 92%
  • Mental Status and Dementia Tests 67%
  • Cross-Sectional Studies 63%
  • Regression Analysis 42%
  2 被引用数 (Scopus)

• Caregiver self-efficacy and associated factors among caregivers of patients with dementia with Lewy bodies and caregivers of patients with Alzheimer's disease

  Sato, H., Nakaaki, S., Sato, J., Shikimoto, R., Furukawa, T. A., Mimura, M. & Akechi, T., 2021 9月, In: Psychogeriatrics. 21, 5, p. 783-794 12 p.

  研究成果: Article › 査読

  • Lewy Body Disease 100%
  • Self Efficacy 80%
  • Caregivers 67%
  • Alzheimer Disease 61%
  • Dementia 17%
  2 被引用数 (Scopus)

• Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell–mediated inflammation in the skin

  Takahashi, H., Nomura, H., Iriki, H., Kubo, A., Isami, K., Mikami, Y., Mukai, M., Sasaki, T., Yamagami, J., Kudoh, J., Ito, H., Kamata, A., Kurebayashi, Y., Yoshida, H., Yoshimura, A., Sun, H. W., Suematsu, M., O’Shea, J. J., Kanno, Y. & Amagai, M., 2021, In: Science Immunology. 6, 64, eabb6444.

  研究成果: Article › 査読

  • cholesterol 25-hydroxylase 100%
  • Interleukin-27 43%
  • T-Lymphocytes 31%
  • Inflammation 30%
  • Skin 28%
  4 被引用数 (Scopus)

• Detection of residual disease in chronic myeloid leukemia utilizing genomic next generation sequencing reveals persistence of differentiated Ph⁺ B cells but not bone marrow stem/progenitors

  Karigane, D., Kasahara, H., Shiroshita, K., Fujita, S., Kobayashi, H., Tamaki, S., Yamazaki, R., Yahagi, K., Yatabe, Y., Kondoh, N., Arai, T., Katagiri, H., Shimizu, N., Sakurai, M., Kikuchi, T., Kato, J., Shimizu, T., Hayakawa, T., Yaguchi, T., Matsushita, M., & 7 othersNakajima, H., Kawakami, Y., Murata, M., Mori, T., Sasaki, T., Okamoto, S. & Takubo, K., 2021, In: Leukemia and Lymphoma. 62, 3, p. 679-687 9 p.

  研究成果: Article › 査読

  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive 100%
  • High-Throughput Nucleotide Sequencing 91%
  • B-Lymphocytes 73%
  • Stem Cells 69%
  • Bone Marrow 69%

• Filaggrin-gene mutation has minimal effect on the disease severity in the lesions of atopic dermatitis

  Ota, M., Sasaki, T., Ebihara, T., Yokosawa, E., Murakami, Y., Matsunaka, H., Chinuki, Y., Amagai, M. & Morita, E., 2021 11月, In: Journal of Dermatology. 48, 11, p. 1688-1699 12 p.

  研究成果: Article › 査読

  • filaggrin 100%
  • Atopic Dermatitis 72%
  • Mutation 38%
  • Genes 27%
  • Skin 19%
  4 被引用数 (Scopus)

• Group cognitive behavioural therapy for family caregivers of people with dementia: A single-arm pilot study

  Shikimoto, R., Tamura, N., Irie, S., Iwashita, S., Mimura, M. & Fujisawa, D., 2021 1月, In: Psychogeriatrics. 21, 1, p. 134-136 3 p.

  研究成果: Comment/debate › 査読
  1 被引用数 (Scopus)

• Intragenic copy number variation in mouse epiplakin 1 (Eppk1) and the conservation of the repeat structures in the lower vertebrates

  Ueo, D., Furuhashi, M., Sasaki, T., Kudo, J., Parry, D. A. D., Winter, D. J., Sasaki, T., Hashimoto, T., Tsuruta, D. & Fujiwara, S., 2021 9月, In: Journal of Dermatological Science. 103, 3, p. 186-189 4 p.

  研究成果: Letter › 査読
  3 被引用数 (Scopus)

• Plasma phospholipid n-3 polyunsaturated fatty acids and major depressive disorder in Japanese elderly: the Japan Public Health Center-based Prospective Study

  Hamazaki, K., Matsuoka, Y. J., Yamaji, T., Sawada, N., Mimura, M., Nozaki, S., Shikimoto, R. & Tsugane, S., 2021 12月, In: Scientific reports. 11, 1, 4003.

  研究成果: Article › 査読

  Open Access

  • Omega-3 Fatty Acids 100%
  • Major Depressive Disorder 94%
  • Phospholipids 81%
  • Japan 75%
  • Public Health 64%
  2 被引用数 (Scopus)

• Single nucleotide variations in genes associated with innate immunity are enriched in Japanese adult cases of face and neck type atopic dermatitis

  Yasuda-Sekiguchi, F., Shiohama, A., Fukushima, A., Obata, S., Mochimaru, N., Honda, A., Kawasaki, H., Kubo, A., Ebihara, T., Amagai, M. & Sasaki, T., 2021 2月, In: Journal of Dermatological Science. 101, 2, p. 93-100 8 p.

  研究成果: Article › 査読

  • Atopic Dermatitis 100%
  • Innate Immunity 88%
  • Nucleotide 78%
  • Nucleotides 77%
  • Neck 72%
  2 被引用数 (Scopus)

• Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation

  Ito, Y., Sasaki, T., Li, Y., Tanoue, T., Sugiura, Y., Skelly, A. N., Suda, W., Kawashima, Y., Okahashi, N., Watanabe, E., Horikawa, H., Shiohama, A., Kurokawa, R., Kawakami, E., Iseki, H., Kawasaki, H., Iwakura, Y., Shiota, A., Yu, L., Hisatsune, J., & 10 othersKoseki, H., Sugai, M., Arita, M., Ohara, O., Matsui, T., Suematsu, M., Hattori, M., Atarashi, K., Amagai, M. & Honda, K., 2021 4月 27, In: Cell Reports. 35, 4, 109052.

  研究成果: Article › 査読

  Open Access

  • Staphylococcus 100%
  • Strain 68%
  • Inflammation 57%
  • Skin 53%
  • Antiinflammatory 46%
  15 被引用数 (Scopus)
• 2020

  A nonepidermolytic keratinocytic epidermal naevus associated with a postzygotic mutation in the gene encoding epidermal growth factor receptor

  Umegaki-Arao, N., Ono, N., Tanaka, R., Sasaki, T., Fujita, H., Shiohama, A., Aoki, S., Amagai, M. & Kubo, A., 2020 5月 1, In: British Journal of Dermatology. 182, 5, p. 1303-1305 3 p.

  研究成果: Letter › 査読
  1 被引用数 (Scopus)

• Approach-oriented coping strategy level may be related to volume of the whole hippocampus in the elderly

  Kida, H., Nakajima, S., Shikimoto, R., Ochi, R., Noda, Y., Tsugawa, S., Fujii, S., Takayama, M., Mimura, M. & Niimura, H., 2020 4月 1, In: Psychiatry and Clinical Neurosciences. 74, 4, p. 270-276 7 p.

  研究成果: Article › 査読

  Open Access

  • Neurobehavioral Manifestations 100%
  • Hippocampus 99%
  • Elderly 83%
  • Depression 81%
  • Cognition 65%
  7 被引用数 (Scopus)

• Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

  Hirata, T., Arai, Y., Yuasa, S., Abe, Y., Takayama, M., Sasaki, T., Kunitomi, A., Inagaki, H., Endo, M., Morinaga, J., Yoshimura, K., Adachi, T., Oike, Y., Takebayashi, T., Okano, H. & Hirose, N., 2020 12月 1, In: Nature communications. 11, 1, 3820.

  研究成果: Article › 査読

  Open Access

  • biomarkers 100%
  • albumins 93%
  • Serum Albumin 77%
  • mortality 70%
  • Biological Marker 67%
  32 被引用数 (Scopus)

• Comparison of various items of the quality of life in Alzheimer's disease scale (QOL-AD) in patients with mild or moderate stages of dementia: a cross-sectional study

  Shikimoto, R., Nakaaki, S., Sato, J., Sato, H. & Mimura, M., 2020 11月, In: Psychogeriatrics. 20, 6, p. 926-928 3 p.

  研究成果: Comment/debate › 査読

• Factor structure of the Japanese version of the Quality of Life in Alzheimer's Disease Scale (QOL-AD)

  Yamada, T., Nakaaki, S., Sato, J., Sato, H., Shikimoto, R., Furukawa, T. A., Mimura, M. & Akechi, T., 2020 1月 1, In: Psychogeriatrics. 20, 1, p. 79-86 8 p.

  研究成果: Article › 査読

  • Alzheimer Disease 100%
  • Quality of Life 82%
  • Social Environment 58%
  • Caregivers 55%
  • Psychology 32%
  3 被引用数 (Scopus)

• Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s disease

  Kobayashi, N., Shinagawa, S., Niimura, H., Kida, H., Nagata, T., Tagai, K., Shimada, K., Oka, N., Shikimoto, R., Noda, Y., Nakajima, S., Mimura, M., Shigeta, M. & Kondo, K., 2020 12月 1, In: Scientific reports. 10, 1, 12217.

  研究成果: Article › 査読

  Open Access

  • DNA Methylation 100%
  • Alzheimer Disease 78%
  • Biomarkers 65%
  • Pathology 64%
  • Methylation 30%
  8 被引用数 (Scopus)

• Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation

  Fujita, H., Sasaki, T., Miyamoto, T., Akutsu, S. N., Sato, S., Mori, T., Nakabayashi, K., Hata, K., Suzuki, H., Kosaki, K., Matsuura, S., Matsubara, Y., Amagai, M. & Kubo, A., 2020 11月, In: Aging Cell. 19, 11, e13251.

  研究成果: Article › 査読

  Open Access

  • M Phase Cell Cycle Checkpoints 100%
  • Premature Aging 98%
  • Chromosomal Instability 91%
  • Aneuploidy 53%
  • Mutation 41%
  7 被引用数 (Scopus)

• Quantitative Assessment of the Retina Using OCT and Associations with Cognitive Function

  Ito, Y., Sasaki, M., Takahashi, H., Nozaki, S., Matsuguma, S., Motomura, K., Ui, R., Shikimoto, R., Kawasaki, R., Yuki, K., Sawada, N., Mimura, M., Tsubota, K. & Tsugane, S., 2020 1月, In: Ophthalmology. 127, 1, p. 107-118 12 p.

  研究成果: Article › 査読

  • Nerve Fibers 100%
  • Retina 88%
  • Cognition 80%
  • Ganglia 56%
  • Dementia 48%
  26 被引用数 (Scopus)

• Sex-specific effects of apolipo proteinε 4 alleleon mortality in very old and centenarian Japanese Men

  Sasaki, T., Nishimoto, Y., Abe, Y., Takayama, M., Hirose, N., Okano, H. & Arai, Y., 2020 10月 1, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 75, 10, p. 1874-1879 6 p.

  研究成果: Article › 査読

  • Apolipoprotein E4 100%
  • Aged, 80 and over 89%
  • Alleles 39%
  • Mortality 37%
  • Proteins 27%
  2 被引用数 (Scopus)

• Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD)

  on behalf of the JPSFC-AD Study Group, 2020 12月 1, In: Environmental Health and Preventive Medicine. 25, 1, 64.

  研究成果: Article › 査読

  Open Access

  • Population Characteristics 100%
  • dementia 85%
  • Dementia 70%
  • Japan 70%
  • Cohort Studies 57%
  22 被引用数 (Scopus)

• Subclinical hypopigmentation of the skin and hair in a Japanese patient with Hermansky–Pudlak syndrome type 3

  Saito, S., Tanaka, R., Sasaki, T., Aoki, S., Yasuhara, R., Nakayama, Y., Nagai, T., Sonobe, H., Ozawa, Y. & Kubo, A., 2020 1月 1, In: Journal of Dermatology. 47, 1, p. e18-e20

  研究成果: Letter › 査読
  4 被引用数 (Scopus)
• 2019

  APOE Alleles and extreme human longevity

  Sebastiani, P., Gurinovich, A., Nygaard, M., Sasaki, T., Sweigart, B., Bae, H., Andersen, S. L., Villa, F., Atzmon, G., Christensen, K., Arai, Y., Barzilai, N., Puca, A., Christiansen, L., Hirose, N. & Perls, T. T., 2019 1月 1, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 1, p. 44-51 8 p.

  研究成果: Article › 査読

  Open Access

  • Longevity 100%
  • Alleles 81%
  • Aged, 80 and over 58%
  • Genotype 22%
  • New England 20%
  61 被引用数 (Scopus)

• Case of Conradi–Hünermann–Happle syndrome due to a nonsense mutation of c.245G>A (p.W82*)

  Satake, M., Kudo, K., Sasaki, T., Furue, M. & Kubo, A., 2019, In: Journal of Dermatology. 46, 8, p. e296-e298

  研究成果: Letter › 査読

• Clonal Expansion of Second-Hit Cells with Somatic Recombinations or C>T Transitions Form Porokeratosis in MVD or MVK Mutant Heterozygotes

  Kubo, A., Sasaki, T., Suzuki, H., Shiohama, A., Aoki, S., Sato, S., Fujita, H., Ono, N., Umegaki-Arao, N., Kawai, T., Nakabayashi, K., Hata, K., Yamada, D., Matsubara, Y., Kosaki, K. & Amagai, M., 2019 12月, In: Journal of Investigative Dermatology. 139, 12, p. 2458-2466.e9

  研究成果: Article › 査読

  Open Access

  • Porokeratosis 100%
  • Heterozygote 66%
  • Genetic Recombination 60%
  • Mutation 52%
  • Mevalonate 29%
  29 被引用数 (Scopus)

• Diet quality and depression risk in a Japanese population: the Japan Public Health Center (JPHC)-based Prospective Study

  Okubo, R., Matsuoka, Y. J., Sawada, N., Mimura, M., Kurotani, K., Nozaki, S., Shikimoto, R. & Tsugane, S., 2019 12月 1, In: Scientific reports. 9, 1, 7150.

  研究成果: Article › 査読

  Open Access

  • Japan 100%
  • Public Health 86%
  • Diet 83%
  • Depression 79%
  • Prospective Studies 77%
  13 被引用数 (Scopus)

• Genetic Protective Factors for Dementia Isolated by Centenarian Researches

  Sasaki, T., Nishimoto, Y., Hirose, N. & Arai, Y., 2019 10月 1, In: Brain and nerve = Shinkei kenkyu no shinpo. 71, 10, p. 1061-1070 10 p.

  研究成果: Review article › 査読

  • Aged, 80 and over 100%
  • Protective Factors 88%
  • Dementia 68%
  • Elderly 55%
  • Maintenance 38%

• Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

  Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M. S. H., Tada, N., Okano, H. & Akamatsu, W., 2019 2月 12, In: Stem cell reports. 12, 2, p. 305-318 14 p.

  研究成果: Article › 査読

  Open Access

  • Induced Pluripotent Stem Cells 100%
  • Marker 77%
  • Pluripotent Stem Cells 51%
  • Fibroblast Growth Factor 4 36%
  • Protein 36%
  8 被引用数 (Scopus)

• Midlife cancer/diabetes and risk of dementia and mild cognitive impairment: A population-based prospective cohort study in Japan

  For the Japan Public Health Center-based Prospective Study Group, 2019 9月 1, In: Psychiatry and Clinical Neurosciences. 73, 9, p. 597-599 3 p.

  研究成果: Letter › 査読
  3 被引用数 (Scopus)

• Novel gene mutations in Chédiak–Higashi syndrome with hyperpigmentation

  Fukuchi, K., Tatsuno, K., Sakaguchi, K., Sano, S., Sasaki, T., Aoki, S., Kubo, A. & Tokura, Y., 2019 11月 1, In: Journal of Dermatology. 46, 11, p. e416-e418

  研究成果: Letter › 査読

• Recovery of FRI-5 carbapenemase at a Japanese hospital where FRI-4 carbapenemase was discovered

  Uwamino, Y., Kubota, H., Sasaki, T., Kosaka, A., Furuhashi, M., Uno, S., Kudoh, J., Murata, M. & Hasegawa, N., 2019 11月 1, In: Journal of Antimicrobial Chemotherapy. 74, 11, p. 3390-3392 3 p.

  研究成果: Letter › 査読
  5 被引用数 (Scopus)

• Reproductive history and risk of cognitive impairment in Japanese women

  For the Japan Public Health Center-based Prospective Study Group, 2019 10月, In: Maturitas. 128, p. 22-28 7 p.

  研究成果: Article › 査読

  • Reproductive History 100%
  • Estrogen 86%
  • Cognitive Dysfunction 66%
  • Marker 23%
  • Reproduction 23%
  17 被引用数 (Scopus)

• Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

  Hashimoto, K., Kouno, T., Ikawa, T., Hayatsu, N., Miyajima, Y., Yabukami, H., Terooatea, T., Sasaki, T., Suzuki, T., Valentine, M., Pascarella, G., Okazaki, Y., Suzuki, H., Shin, J. W., Minoda, A., Taniuchi, I., Okano, H., Arai, Y., Hirose, N. & Carninci, P., 2019 11月 26, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24242-24251 10 p.

  研究成果: Article › 査読

  Open Access

  • Cytotoxic T-Lymphocytes 100%
  • T-Lymphocytes 57%
  • Single-Cell Analysis 20%
  • Healthy Aging 19%
  • Gene Expression Profiling 15%
  102 被引用数 (Scopus)