病院薬剤学教室

研究成果

年別の研究成果 2009 2017 2019 2020 2021 2022 2022

• 35 Article
• 1 Comment/debate

年別の研究成果

年別の研究成果

検索結果

• 2022

  Analysis of inhibition kinetics of three beverage ingredients, bergamottin, dihydroxybergamottin and resveratrol, on CYP2C9 activity

  Akiyoshi, T., Uchiyama, M., Inada, R., Imaoka, A. & Ohtani, H., 2022 2月, In: Drug Metabolism And Pharmacokinetics. 42, 100429.

  研究成果: Article › 査読

  Open Access

  • bergamottin 100%
  • Cytochrome P-450 CYP2C9 69%
  • Resveratrol 65%
  • Beverages 60%
  • Cytochrome P-450 CYP2C19 51%
  2 被引用数 (Scopus)

• Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants

  Araki, N., Morita, T., Akiyoshi, T., Kataoka, H., Yajima, K., Katayama, K., Imaoka, A. & Ohtani, H., 2022 10月, In: Drug Metabolism And Pharmacokinetics. 46, 100464.

  研究成果: Article › 査読

  • narirutin 100%
  • naringenin 93%
  • Narirutin 89%
  • Naringenin 87%
  • prunin 78%
  1 被引用数 (Scopus)

• Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants

  Han, H., Akiyoshi, T., Morita, T., Kataoka, H., Katayama, K., Yajima, K., Imaoka, A. & Ohtani, H., 2022 12月, In: Drug Metabolism And Pharmacokinetics. 47, 100470.

  研究成果: Article › 査読

  • Fexofenadine 100%
  • fexofenadine 92%
  • Kinetics 42%
  • Estrone 3-Sulfate 35%
  • estrone sulfate 29%

• Evaluation of hepatic CYP3A enzyme activity using endogenous markers in lung cancer patients treated with cisplatin, dexamethasone, and aprepitant

  Hibino, H., Sakiyama, N., Makino, Y., Makihara-Ando, R., Horinouchi, H., Fujiwara, Y., Kanda, S., Goto, Y., Yoshida, T., Okuma, Y., Shinno, Y., Murakami, S., Hashimoto, H., Akiyoshi, T., Imaoka, A., Ohe, Y., Yamaguchi, M. & Ohtani, H., 2022 4月, In: European Journal of Clinical Pharmacology. 78, 4, p. 613-621 9 p.

  研究成果: Article › 査読

  • Aprepitant 100%
  • Cytochrome P-450 CYP3A 76%
  • Dexamethasone 61%
  • Cisplatin 60%
  • Lung Neoplasms 52%
  1 被引用数 (Scopus)

• Inhibitory Effects of Cranberry Juice and Its Components on Intestinal OATP1A2 and OATP2B1: Identification of Avicularin as a Novel Inhibitor

  Morita, T., Akiyoshi, T., Tsuchitani, T., Kataoka, H., Araki, N., Yajima, K., Katayama, K., Imaoka, A. & Ohtani, H., 2022 3月 16, In: Journal of agricultural and food chemistry. 70, 10, p. 3310-3320 11 p.

  研究成果: Article › 査読

  • avicularin 100%
  • Avicularin 89%
  • Fexofenadine 82%
  • Vaccinium macrocarpon 75%
  • cranberries 64%
  2 被引用数 (Scopus)

• Mechanistic bottom-up estimation of passive drug absorption from the gastrointestinal tract: Comparison among primary cultured human intestinal cells, Caco-2 cells, artificial membrane, and animal scale-up

  Tsuchitani, T., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2022 5月, In: International journal of clinical pharmacology and therapeutics. 60, 5, p. 217-224 8 p.

  研究成果: Article › 査読

  • Artificial Membranes 100%
  • Caco-2 Cells 79%
  • Gastrointestinal Tract 58%
  • Cell Membrane 49%
  • Epithelial Cells 32%
• 2021

  Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants

  Yamaguchi, Y., Akiyoshi, T., Kawamura, G., Imaoka, A., Miyazaki, M., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2021 6月, In: Drug Metabolism And Pharmacokinetics. 38, 100384.

  研究成果: Article › 査読

  Open Access

  • Azoles 100%
  • Azole 94%
  • Itraconazole 93%
  • Cytochrome P-450 CYP3A 89%
  • Cytochrome P450 83%
  4 被引用数 (Scopus)

• Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage

  Tsuchitani, T., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2021 12月, In: Journal of Pharmaceutical Health Care and Sciences. 7, 1, 24.

  研究成果: Article › 査読

  Open Access

  • Digoxin 100%
  • Irinotecan 99%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 92%
  • Biological Availability 25%
  • Dabigatran 24%

• Dual kinetics of OATP2B1: Inhibitory potency and pH-dependence of OATP2B1 inhibitors

  Sato, R., Akiyoshi, T., Morita, T., Katayama, K., Yajima, K., Kataoka, H., Imaoka, A. & Ohtani, H., 2021 12月, In: Drug Metabolism And Pharmacokinetics. 41, 100416.

  研究成果: Article › 査読

  Open Access

  • Kinetics 100%
  • pH Value 58%
  • Estrone 3-Sulfate 20%
  • Fexofenadine 19%
  • Gefitinib 18%
  5 被引用数 (Scopus)

• Estimation of absolute oral bioavailability without performing an intravenous clinical study

  Ohtani, H., Iwata, R., Imaoka, A. & Akiyoshi, T., 2021 6月, In: Drug Metabolism And Pharmacokinetics. 38, 100392.

  研究成果: Article › 査読

  Open Access

  • Bioavailability 100%
  • Biological Availability 92%
  • Clinical Studies 71%
  • Clearance 63%
  • Drug 46%

• Exacerbation of atrioventricular block associated with concomitant use of amlodipine and aprepitant in a lung cancer patient: A case report

  Hibino, H., Makino, Y., Sakiyama, N., Makihara-Ando, R., Hashimoto, H., Akiyoshi, T., Imaoka, A., Fujiwara, Y., Ohe, Y., Yamaguchi, M. & Ohtani, H., 2021 4月, In: International journal of clinical pharmacology and therapeutics. 59, 4, p. 328-332 5 p.

  研究成果: Article › 査読

  • Aprepitant 100%
  • Amlodipine 86%
  • Atrioventricular Block 78%
  • Lung Neoplasms 52%
  • Drug Interactions 26%
  3 被引用数 (Scopus)

• Relative contributions of metabolic enzymes to systemic elimination can be estimated from clinical DDI studies: Validation using an in silico approach

  Koinuma, K., Tsuchitani, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2021 3月, In: International journal of clinical pharmacology and therapeutics. 59, 3, p. 231-238 8 p.

  研究成果: Article › 査読

  • Validation Studies 100%
  • Drug Interactions 88%
  • Computer Simulation 85%
  • Area Under Curve 73%
  • Enzymes 49%
  2 被引用数 (Scopus)

• Time-dependent inhibition of CYP3A4- mediated midazolam metabolism by macrolide antibiotics in CYP3A4 genetic variants: Comparison with testosterone metabolism

  Akiyoshi, T., Naitou, R., Imaoka, A., Miyazaki, M., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2021 12月, In: International journal of clinical pharmacology and therapeutics. 59, 12, p. 745-782 38 p.

  研究成果: Article › 査読

  • Macrolides 100%
  • Cytochrome P-450 CYP3A 99%
  • Midazolam 98%
  • Testosterone 77%
  • Anti-Bacterial Agents 57%
• 2020

  Citrus Fruit-Derived Flavanone Glycoside Narirutin is a Novel Potent Inhibitor of Organic Anion-Transporting Polypeptides

  Morita, T., Akiyoshi, T., Sato, R., Uekusa, Y., Katayama, K., Yajima, K., Imaoka, A., Sugimoto, Y., Kiuchi, F. & Ohtani, H., 2020 12月 2, In: Journal of agricultural and food chemistry. 68, 48, p. 14182-14191 10 p.

  研究成果: Article › 査読

  • narirutin 100%
  • Narirutin 89%
  • Flavanone Glycoside 86%
  • flavanone 80%
  • Citrus 68%
  7 被引用数 (Scopus)

• Novel method to estimate the appropriate dosing interval for activated charcoal to avoid interaction with other drugs

  Ohtani, H., Nakamura, K., Imaoka, A. & Akiyoshi, T., 2020 11月 1, In: European Journal of Clinical Pharmacology. 76, 11, p. 1529-1536 8 p.

  研究成果: Article › 査読

  • Charcoal 100%
  • Pharmaceutical Preparations 33%
  • Drug Interactions 22%
  • Pharmacokinetics 17%
  • Enterohepatic Circulation 16%

• pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A2

  Morita, T., Akiyoshi, T., Sato, R., Katayama, K., Yajima, K., Kataoka, H., Imaoka, A., Sugimoto, Y. & Ohtani, H., 2020 4月, In: Drug Metabolism And Pharmacokinetics. 35, 2, p. 220-227 8 p.

  研究成果: Article › 査読

  • Anions 100%
  • Polypeptide 76%
  • Kinetics 67%
  • Peptides 59%
  • Estrone 3-Sulfate 41%
  13 被引用数 (Scopus)

• Profile of the inhibitory effects of gefitinib in CYP2D6 variants in vitro

  Semba, Y., Akiyoshi, T., Hibino, H., Imaoka, A. & Ohtani, H., 2020 10月, In: International journal of clinical pharmacology and therapeutics. 58, 10, p. 539-542 4 p.

  研究成果: Article › 査読

  • Cytochrome P-450 CYP2D6 100%
  • Gefitinib 99%
  • In Vitro Techniques 34%
  • Dextromethorphan 28%
  • Psychological Inhibition 24%
  1 被引用数 (Scopus)
• 2019

  Effects of food type on the extent of drug-drug interactions between activated charcoal and phenobarbital in rats

  Ogata, Y., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2019 1月 1, In: Drug Metabolism And Pharmacokinetics.

  研究成果: Article › 査読

  • Phenobarbital 100%
  • Charcoal 96%
  • Drug Interactions 76%
  • Food 56%
  • Enteral 52%
  1 被引用数 (Scopus)

• Inhibitory kinetics of fruit components on CYP2C19 activity

  Seki, H., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2019 6月, In: Drug Metabolism And Pharmacokinetics. 34, 3, p. 181-186 6 p.

  研究成果: Article › 査読

  • Cytochrome P450 100%
  • Cytochrome P-450 Enzyme System 91%
  • bergamottin 89%
  • Fruit 88%
  • Kinetics 67%
  8 被引用数 (Scopus)

• Irinotecan-induced gastrointestinal damage impairs the absorption of dabigatran etexilate

  Hattori, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2019 11月 1, In: Biopharmaceutics and Drug Disposition. 40, 9, p. 315-324 10 p.

  研究成果: Article › 査読

  • Dabigatran Etexilate 100%
  • Dabigatran 70%
  • Irinotecan 62%
  • Bioavailability 25%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 19%
  6 被引用数 (Scopus)

• The extent of drug-drug interaction between amlodipine and activated charcoal is attenuated by food intake in rats

  Imaoka, A., Seki, K., Akiyoshi, T. & Ohtani, H., 2019 2月, In: Drug Metabolism And Pharmacokinetics. 34, 1, p. 108-110 3 p.

  研究成果: Article › 査読

  • Amlodipine 100%
  • Charcoal 86%
  • Drug Interactions 68%
  • Eating 53%
  • Food 50%
  2 被引用数 (Scopus)
• 2017

  5-Fluorouracil treatment alters the expression of intestinal transporters in rats

  Yotsumoto, K., Akiyoshi, T., Wada, N., Imaoka, A. & Ohtani, H., 2017 12月, In: Biopharmaceutics and Drug Disposition. 38, 9, p. 509-516 8 p.

  研究成果: Article › 査読

  • 5-Fluorouracil 100%
  • Fluorouracil 79%
  • Digoxin 58%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 45%
  • Drug 43%
  7 被引用数 (Scopus)

• Analysis of the mechanism of prolonged persistence of drug interaction between terbinafine and amitriptyline or nortriptyline

  Mikami, A., Hori, S., Ohtani, H. & Sawada, Y., 2017, In: Biological and Pharmaceutical Bulletin. 40, 7, p. 1010-1020 11 p.

  研究成果: Article › 査読

  • Terbinafine 100%
  • Nortriptyline 89%
  • Amitriptyline 84%
  • Drug Interactions 58%
  • Drug 31%

• Development and evaluation of an overseas clinical rotation program for undergraduate pharmacy students in Japan

  Ohtani, H., Mitsui, R., Akiyoshi, T., Imaoka, A., Abe, Y., Kanke, M., Nakamura, T., Foster, P. & Mochizuki, M., 2017 5月, In: Currents in Pharmacy Teaching and Learning. 9, 3, p. 452-459 8 p.

  研究成果: Article › 査読

  • Pharmacy Students 100%
  • Japan 59%
  • Pharmaceutical 52%
  • Students 36%
  • Diagnostic Self Evaluation 24%
  2 被引用数 (Scopus)

• Development of a new scholastic program for medication counseling practice in preclinical training, constructed for junior students by senior students based on their experiences of on-site practice

  Suzuki, S., Aono, I., Imai, N., Kuwabara, A., Kenda, Y., Matsumoto, M., Yoshida, A., Watanabe, A., Takagi, A., Kobayashi, N., Saeki, H., Ohtani, H., Nakamur, T. & Kizud, J., 2017, In: Yakugaku Zasshi. 137, 11, p. 1391-1408 18 p.

  研究成果: Article › 査読

  • Communication 100%
  • Counseling 93%
  • Pharmaceutical 80%
  • Students 77%
  • Pharmacy Education 42%

• Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin

  Ishikawa, Y., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2017 10月, In: Biopharmaceutics and Drug Disposition. 38, 7, p. 420-425 6 p.

  研究成果: Article › 査読

  • Erythromycin 100%
  • Cytochrome P-450 CYP3A 85%
  • Cytochrome P450 80%
  • Kinetics 54%
  • Nifedipine 33%
  4 被引用数 (Scopus)
• 2016

  In silico evaluation of warfarin–bucolome therapy

  Ohtani, H., Hakoda, R., Imaoka, A. & Akiyoshi, T., 2016, In: Biopharmaceutics and Drug Disposition. p. 233-242 10 p.

  研究成果: Article › 査読

  • bucolome 100%
  • (S)-Warfarin 84%
  • Computer Simulation 47%
  • Warfarin 44%
  • Clearance 36%
  2 被引用数 (Scopus)
• 2015

  Current status of illegal trade in pharmaceutical products on internet auction sites in japan and responses of site administrators to such transactions

  Ohtani, H., Imaoka, A. & Akiyoshi, T., 2015 3月 1, In: Yakugaku Zasshi. 135, 3, p. 529-534 6 p.

  研究成果: Article › 査読

  Open Access

  • Administrative Personnel 100%
  • Internet 94%
  • Japan 80%
  • Pharmaceutical 71%
  • Pharmaceutical Preparations 40%
  2 被引用数 (Scopus)

• Variation in the inhibitory potency of terbinafine among genetic variants of CYP2D6

  Akiyoshi, T., Ishiuchi, M., Imaoka, A. & Ohtani, H., 2015 8月 1, In: Drug Metabolism And Pharmacokinetics. 30, 4, p. 321-324 4 p.

  研究成果: Article › 査読

  • Terbinafine 100%
  • Cytochrome P-450 CYP2D6 75%
  • Cytochrome P450 63%
  • Drug Interactions 14%
  • Drug 11%
  5 被引用数 (Scopus)
• 2014

  Decrease in ciprofloxacin absorption by polyvalent metal cations is not fully attributable to chelation or adsorption

  Imaoka, A., Hattori, M., Akiyoshi, T. & Ohtani, H., 2014, In: Drug Metabolism And Pharmacokinetics. 29, 5, p. 414-418 5 p.

  研究成果: Article › 査読

  • Ciprofloxacin 100%
  • Adsorption 93%
  • Cations 87%
  • Metals 74%
  • Metal Ion 54%
  4 被引用数 (Scopus)

• Prediction of the extent and variation of grapefruit juice-drug interactions from the pharmacokinetic profile in the absence of grapefruit juice

  Kogure, N., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2014 10月 1, In: Biopharmaceutics and Drug Disposition. 35, 7, p. 373-381 9 p.

  研究成果: Article › 査読

  • Citrus paradisi 100%
  • Drug Interactions 64%
  • Area Under Curve 53%
  • Pharmacokinetics 49%
  • Nisoldipine 37%
  5 被引用数 (Scopus)
• 2013

  Effect of aromatase inhibitors on bone mineral density in a Japanese breast cancer population

  Akiyoshi, T., Shimomura, Y., Masuda, S., Okamoto, Y., Hiura, S., Kato, H., Asayama, T. & Ohtani, H., 2013, In: Drug Metabolism And Pharmacokinetics. 28, 5, p. 446-450 5 p.

  研究成果: Article › 査読

  • Aromatase Inhibitor 100%
  • Aromatase Inhibitors 83%
  • Bone Density 60%
  • Breast Neoplasms 42%
  • Population 26%
  2 被引用数 (Scopus)

• Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants

  Akiyoshi, T., Ito, M., Murase, S., Miyazaki, M., Peter Guengerich, F., Nakamura, K., Yamamoto, K. & Ohtani, H., 2013, In: Drug Metabolism And Pharmacokinetics. 28, 5, p. 411-415 5 p.

  研究成果: Article › 査読

  • Clarithromycin 100%
  • Erythromycin 87%
  • Cytochrome P-450 CYP3A 74%
  • Cytochrome P450 70%
  • Kinact 26%
  25 被引用数 (Scopus)
• 2011

  Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants

  Akiyoshi, T., Saito, T., Murase, S., Miyazaki, M., Murayama, N., Yamazaki, H., Guengerich, F. P., Nakamura, K., Yamamoto, K. & Ohtani, H., 2011 4月, In: Drug Metabolism and Disposition. 39, 4, p. 724-728 5 p.

  研究成果: Article › 査読

  • Itraconazole 100%
  • Cimetidine 96%
  • Cytochrome P-450 CYP3A 76%
  • Cytochrome P450 72%
  • Testosterone 39%
  24 被引用数 (Scopus)
• 2009

  The potential of vitamin K₃ as an anticancer agent against breast cancer that acts via the mitochondria-related apoptotic pathway

  Akiyoshi, T., Matzno, S., Sakai, M., Okamura, N. & Matsuyama, K., 2009, In: Cancer Chemotherapy and Pharmacology. 65, 1, p. 143-150 8 p.

  研究成果: Article › 査読

  • 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine 100%
  • Vitamin K 3 97%
  • Apoptotic 79%
  • DNA Fragmentation 74%
  • Vitamin 70%
  62 被引用数 (Scopus)