内科学(消化器)

Article

Aortic carboxypeptidase-like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis

Teratani, T., Tomita, K., Suzuki, T., Furuhashi, H., Irie, R., Nishikawa, M., Yamamoto, J., Hibi, T., Miura, S., Minamino, T., Oike, Y., Hokari, R. & Kanai, T., 2018 4月 2, In: Journal of Clinical Investigation. 128, 4, p. 1581-1596 16 p.

研究成果: Article › 査読

Open Access

25 被引用数 (Scopus)

A Phase II Study of Regorafenib With a Lower Starting Dose in Patients With Metastatic Colorectal Cancer: Exposure–Toxicity Analysis of Unbound Regorafenib and Its Active Metabolites (RESET Trial)

Suzuki, T., Sukawa, Y., Imamura, C. K., Masuishi, T., Satake, H., Kumekawa, Y., Funakoshi, S., Kotaka, M., Horie, Y., Kawai, S., Okuda, H., Terazawa, T., Kondoh, C., Kato, K., Yoshimura, K., Ishikawa, H., Hamamoto, Y., Boku, N., Takaishi, H. & Kanai, T., 2020 3月, In: Clinical Colorectal Cancer. 19, 1, p. 13-21.e3

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10 被引用数 (Scopus)

A pilot open-labeled prospective randomized study between weekly and intensive treatment of granulocyte and monocyte adsorption apheresis for active ulcerative colitis

Sakuraba, A., Sato, T., Naganuma, M., Morohoshi, Y., Matsuoka, K., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2008 1月 1, In: Journal of gastroenterology. 43, 1, p. 51-56 6 p.

研究成果: Article › 査読

27 被引用数 (Scopus)

Applicability of second-generation colon capsule endoscope to ulcerative colitis: A clinical feasibility study

Hosoe, N., Matsuoka, K., Naganuma, M., Ida, Y., Ishibashi, Y., Kimura, K., Yoneno, K., Usui, S., Kashiwagi, K., Hisamatsu, T., Inoue, N., Kanai, T., Imaeda, H., Ogata, H. & Hibi, T., 2013 7月, In: Journal of Gastroenterology and Hepatology (Australia). 28, 7, p. 1174-1179 6 p.

研究成果: Article › 査読

50 被引用数 (Scopus)

A prospective analysis of the incidence of and risk factors for opportunistic infections in patients with inflammatory bowel disease

Naganuma, M., Kunisaki, R., Yoshimura, N., Takeuchi, Y. & Watanabe, M., 2013 5月 1, In: Journal of gastroenterology. 48, 5, p. 595-600 6 p.

研究成果: Article › 査読

78 被引用数 (Scopus)

A prospective study on symptom generation according to spicy food intake and TRPV1 genotypes in functional dyspepsia patients

Lee, S. Y., Masaoka, T., Han, H. S., Matsuzaki, J., Hong, M. J., Fukuhara, S., Choi, H. S. & Suzuki, H., 2016 9月 1, In: Neurogastroenterology and Motility. 28, 9, p. 1401-1408 8 p.

研究成果: Article › 査読

13 被引用数 (Scopus)

Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios⁺ Tregs in the gut

Yoshimatsu, Y., Sujino, T., Miyamoto, K., Harada, Y., Tanemoto, S., Ono, K., Umeda, S., Yoshida, K., Teratani, T., Suzuki, T., Mikami, Y., Nakamoto, N., Sasaki, N., Takabayashi, K., Hosoe, N., Ogata, H., Sawada, K., Imamura, T., Yoshimura, A. & Kanai, T., 2022 5月 10, In: Cell Reports. 39, 6, 110773.

研究成果: Article › 査読

Open Access

4 被引用数 (Scopus)

A significant association of non-obese non-alcoholic fatty liver disease with osteosarcopenic obesity in females 50 years and older

Kashiwagi, K., Takayama, M., Ichikawa, H., Takaishi, H., Iwao, Y. & Kanai, T., 2021 4月, In: Clinical Nutrition ESPEN. 42, p. 166-172 7 p.

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2 被引用数 (Scopus)

A significant association of non-obese non-alcoholic fatty liver disease with sarcopenic obesity

Kashiwagi, K., Takayama, M., Fukuhara, K., Shimizu-Hirota, R., Chu, P. S., Nakamoto, N., Inoue, N., Iwao, Y. & Kanai, T., 2020 8月, In: Clinical Nutrition ESPEN. 38, p. 86-93 8 p.

研究成果: Article › 査読

Open Access

12 被引用数 (Scopus)

A significant risk of metabolic dysfunction-associated fatty liver disease plus diabetes on subclinical atherosclerosis

Bessho, R., Kashiwagi, K., Ikura, A., Yamataka, K., Inaishi, J., Takaishi, H. & Kanai, T., 2022 5月, In: PloS one. 17, 5 May, e0269265.

研究成果: Article › 査読

Open Access

A simple scoring system to assess the need for an endoscopic intervention in suspected upper gastrointestinal bleeding: A prospective cohort study

Horibe, M., Kaneko, T., Yokogawa, N., Yokota, T., Okawa, O., Nakatani, Y., Ogura, Y., Matsuzaki, J., Iwasaki, E., Hosoe, N., Masaoka, T., Inadomi, J. M., Suzuki, H., Kanai, T. & Namiki, S., 2016 10月 1, In: Digestive and Liver Disease. 48, 10, p. 1180-1186 7 p.

研究成果: Article › 査読

14 被引用数 (Scopus)

A single species of clostridium Subcluster XIVa decreased in ulcerative colitis patients

Takeshita, K., Mizuno, S., Mikami, Y., Sujino, T., Saigusa, K., Matsuoka, K., Naganuma, M., Sato, T., Takada, T., Tsuji, H., Kushiro, A., Nomoto, K. & Kanai, T., 2016 12月 1, In: Inflammatory bowel diseases. 22, 12, p. 2802-2810 9 p.

研究成果: Article › 査読

69 被引用数 (Scopus)

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice

Hayashi, A., Sato, T., Kamada, N., Mikami, Y., Matsuoka, K., Hisamatsu, T., Hibi, T., Roers, A., Yagita, H., Ohteki, T., Yoshimura, A. & Kanai, T., 2013 6月 12, In: Cell Host and Microbe. 13, 6, p. 711-722 12 p.

研究成果: Article › 査読

186 被引用数 (Scopus)

Association Between Clinical Backgrounds and Malignant Progression of Suspected Intraductal Papillary Mucinous Neoplasm

Fukushima, G., Abe, K., Kitago, M., Iwasaki, E., Hirata, A., Takemura, R., Ishii, R., Yagi, H., Abe, Y., Hasegawa, Y., Fukuhara, S., Hori, S., Tanaka, M., Nakano, Y., Yokose, T., Shimane, G. & Kitagawa, Y., 2022 7月 1, In: Pancreas. 51, 6, p. 617-623 7 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Association between computerized tomography (CT) study of body composition and severity of acute pancreatitis: Use of a novel Z-score supports obesity paradox

Horibe, M., Takahashi, N., Weston, A. D., Philbrick, K., Yamamoto, S., Takahashi, H. & Vege, S. S., 2022 8月, In: Clinical Nutrition. 41, 8, p. 1676-1679 4 p.

研究成果: Article › 査読

Association between increased gastric juice acidity and sliding hiatal hernia development in humans

Kishikawa, H., Kimura, K., Ito, A., Arahata, K., Takarabe, S., Kaida, S., Kanai, T., Miura, S. & Nishida, J., 2017 1月, In: PloS one. 12, 1, e0170416.

研究成果: Article › 査読

Open Access

7 被引用数 (Scopus)

Association of visceral fat area, smoking, and alcohol consumption with reflux esophagitis and Barrett's esophagus in Japan

Matsuzaki, J., Suzuki, H., Kobayakawa, M., Inadomi, J. M., Takayama, M., Makino, K., Iwao, Y., Sugino, Y. & Kanai, T., 2015 7月 30, In: PloS one. 10, 7, e0133865.

研究成果: Article › 査読

Open Access

44 被引用数 (Scopus)

Associations among liver disease, serum lipid profile, body mass index, ketonuria, meal skipping, and the alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese men with alcohol dependence

Yokoyama, A., Taniki, N., Nakamoto, N., Tomita, K., Hara, S., Mizukami, T., Maruyama, K. & Yokoyama, T., 2020 5月 1, In: Hepatology Research. 50, 5, p. 565-577 13 p.

研究成果: Article › 査読

5 被引用数 (Scopus)

A successful case of endoscopic submucosal dissection using the water pressure method for early gastric cancer with severe fibrosis

Miyazaki, K., Kato, M., Kanai, T. & Yahagi, N., 2022 6月, In: VideoGIE. 7, 6, p. 219-222 4 p.

研究成果: Article › 査読

Open Access

Author’s reply: can budesonide form be alterative treatment for ulcerative proctosigmoiditis?

Naganuma, M., 2018 4月 3, (Accepted/In press) In: Journal of Gastroenterology. p. 1-2 2 p.

研究成果: Article › 査読

Autoimmune hepatitis in Japan: trends in a nationwide survey

Autoimmune Hepatitis Study Group-Subgroup of the Intractable Hepato-Biliary Disease Study Group in Japan, 2017 5月 1, In: Journal of gastroenterology. 52, 5, p. 631-640 10 p.

研究成果: Article › 査読

40 被引用数 (Scopus)

Autoimmune pancreatitis with pseudocysts

Nishimura, T., Masaoka, T., Suzuki, H., Aiura, K., Nagata, H. & Ishii, H., 2004 10月 1, In: Journal of gastroenterology. 39, 10, p. 1005-1010 6 p.

研究成果: Article › 査読

54 被引用数 (Scopus)

Benefit of rebiopsy for deciding treatment strategy in rectal cancer: A case report

Kawasaki, K., Hamamoto, Y., Suzuki, T., Hirata, K., Sukawa, Y., Kasuga, A., Hayashi, Y., Takaishi, H., Kameyama, K. & Kanai, T., 2017, In: Oncology Letters. 14, 3, p. 3697-3700 4 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Bifidobacterium -Rich Fecal Donor May Be a Positive Predictor for Successful Fecal Microbiota Transplantation in Patients with Irritable Bowel Syndrome

Mizuno, S., Masaoka, T., Naganuma, M., Kishimoto, T., Kitazawa, M., Kurokawa, S., Nakashima, M., Takeshita, K., Suda, W., Mimura, M., Hattori, M. & Kanai, T., 2017 8月 1, In: Digestion. 96, 1, p. 29-38 10 p.

研究成果: Article › 査読

83 被引用数 (Scopus)

Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway

Ichikawa, R., Takayama, T., Yoneno, K., Kamada, N., Kitazume, M. T., Higuchi, H., Matsuoka, K., Watanabe, M., Itoh, H., Kanai, T., Hisamatsu, T. & Hibi, T., 2012 6月, In: Immunology. 136, 2, p. 153-162 10 p.

研究成果: Article › 査読

81 被引用数 (Scopus)

Biliary Findings Assist in Predicting Enlargement of Intraductal Papillary Mucinous Neoplasms of the Pancreas

Matsuzaki, J., Suzuki, H., Okuda, S., Tanimoto, A., Asakura, K., Fukuhara, S., Okada, S., Hirata, K., Mori, H., Masaoka, T., Higuchi, H., Hozawa, S., Kuribayashi, S., Takebayashi, T. & Hibi, T., 2013 5月, In: Clinical Gastroenterology and Hepatology. 11, 5, p. 548-554 7 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

Blatchford scoring system is a useful scoring system for detecting patients with upper gastrointestinal bleeding who do not need endoscopic intervention

Masaoka, T., Suzuki, H., Hori, S., Aikawa, N. & Hibi, T., 2007 9月, In: Journal of Gastroenterology and Hepatology (Australia). 22, 9, p. 1404-1408 5 p.

研究成果: Article › 査読

96 被引用数 (Scopus)

Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis

Amiya, T., Nakamoto, N., Chu, P. S., Teratani, T., Nakajima, H., Fukuchi, Y., Taniki, N., Yamaguchi, A., Shiba, S., Miyake, R., Katayama, T., Ebinuma, H. & Kanai, T., 2016 10月 11, In: Scientific reports. 6, 35146.

研究成果: Article › 査読

Open Access

21 被引用数 (Scopus)

Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells

Nemoto, Y., Kanai, T., Takahara, M., Oshima, S., Nakamura, T., Okamoto, R., Tsuchiya, K. & Watanabe, M., 2013 8月, In: Gut. 62, 8, p. 1142-1152 11 p.

研究成果: Article › 査読

51 被引用数 (Scopus)

Burden of impaired sleep quality on work productivity in functional dyspepsia

Matsuzaki, J., Suzuki, H., Togawa, K., Yamane, T., Mori, H., Komori, T., Masaoka, T. & Kanai, T., 2018 4月 1, In: United European Gastroenterology Journal. 6, 3, p. 398-406 9 p.

研究成果: Article › 査読

15 被引用数 (Scopus)

Carcinoembryonic antigen mediates in vitro cell aggregation induced by interferon-γ in a human colon cancer cell line: requirement for active metabolism and intact cytoskeleton

Kanai, T., Hibi, T., Hayashi, A., Takashima, J., Shiozawa, M., Aiso, S., Toda, K., Iwao, Y., Watanabe, M. & Tsuchiya, M., 1993 7月 30, In: Cancer Letters. 71, 1-3, p. 109-117 9 p.

研究成果: Article › 査読

7 被引用数 (Scopus)

CCL2-induced migration and SOCS3-mediated activation of macrophages are involved in cerulein-induced pancreatitis in mice

Saeki, K., Kanai, T., Nakano, M., Nakamura, Y., Miyata, N., Sujino, T., Yamagishi, Y., Ebinuma, H., Takaishi, H., Ono, Y., Takeda, K., Hozawa, S., Yoshimura, A. & Hibi, T., 2012 4月, In: Gastroenterology. 142, 4, p. 1010-1020.e9

研究成果: Article › 査読

66 被引用数 (Scopus)

C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice

Chu, P. S., Nakamoto, N., Ebinuma, H., Usui, S., Saeki, K., Matsumoto, A., Mikami, Y., Sugiyama, K., Tomita, K., Kanai, T., Saito, H. & Hibi, T., 2013 7月, In: Hepatology. 58, 1, p. 337-350 14 p.

研究成果: Article › 査読

71 被引用数 (Scopus)

C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice

Amiya, T., Nakamoto, N., Irie, J., Taniki, N., Chu, P. S., Koda, Y., Miyamoto, K., Yamaguchi, A., Shiba, S., Morikawa, R., Itoh, H. & Kanai, T., 2021 3月, In: Diabetologia. 64, 3, p. 603-617 15 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion

Nakamura, Y., Kanai, T., Saeki, K., Takabe, M., Irie, J., Miyoshi, J., Mikami, Y., Teratani, T., Suzuki, T., Miyata, N., Hisamatsu, T., Nakamoto, N., Yamagishi, Y., Higuchi, H., Ebinuma, H., Hozawa, S., Saito, H., Itoh, H. & Hibi, T., 2013, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 8, p. G700-G707

研究成果: Article › 査読

8 被引用数 (Scopus)

CCR9⁺ macrophages are required for acute liver inflammation in mouse models of hepatitis

Nakamoto, N., Ebinuma, H., Kanai, T., Chu, P., Ono, Y., Mikami, Y., Ojiro, K., Lipp, M., Love, P. E., Saito, H. & Hibi, T., 2012 2月, In: Gastroenterology. 142, 2, p. 366-376 11 p.

研究成果: Article › 査読

63 被引用数 (Scopus)

CCR9⁺ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis

Mizukami, T., Kanai, T., Mikami, Y., Hayashi, A., Doi, T., Handa, T., Matsumoto, A., Jun, L., Matsuoka, K., Sato, T., Hisamatsu, T. & Hibi, T., 2012 9月, In: Immunology Letters. 147, 1-2, p. 75-79 5 p.

研究成果: Article › 査読

6 被引用数 (Scopus)

CCR9⁺ plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice

Mizuno, S., Kanai, T., Mikami, Y., Sujino, T., Ono, Y., Hayashi, A., Handa, T., Matsumoto, A., Nakamoto, N., Matsuoka, K., Hisamatsu, T., Takaishi, H. & Hibi, T., 2012 8月 30, In: Immunology Letters. 146, 1-2, p. 64-69 6 p.

研究成果: Article › 査読

29 被引用数 (Scopus)

CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury

Koda, Y., Nakamoto, N., Chu, P. S., Teratani, T., Ueno, A., Amiya, T., Taniki, N., Chiba, S., Miyamoto, K., Sakamoto, M. & Kanai, T., 2022 9月 8, In: JCI Insight. 7, 17, e159910.

研究成果: Article › 査読

Open Access

1 被引用数 (Scopus)

CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence

Hirata, K., Suzuki, H., Imaeda, H., Matsuzaki, J., Tsugawa, H., Nagano, O., Asakura, K., Saya, H. & Hibi, T., 2013 7月 23, In: British Journal of Cancer. 109, 2, p. 379-386 8 p.

研究成果: Article › 査読

92 被引用数 (Scopus)

CD8⁺ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells

Koda, Y., Teratani, T., Chu, P. S., Hagihara, Y., Mikami, Y., Harada, Y., Tsujikawa, H., Miyamoto, K., Suzuki, T., Taniki, N., Sujino, T., Sakamoto, M., Kanai, T. & Nakamoto, N., 2021 12月 1, In: Nature communications. 12, 1, 4474.

研究成果: Article › 査読

Open Access

32 被引用数 (Scopus)

Changes in the clinical features and long-term outcomes of colonic diverticulitis in Japanese patients

Mizuki, A., Tatemichi, M., Nakazawa, A., Tsukada, N., Nagata, H. & Kanai, T., 2017, In: Internal Medicine. 56, 22, p. 2971-2977 7 p.

研究成果: Article › 査読

9 被引用数 (Scopus)

Characteristics of the Mucosal Surface on Scanning Electron Microscopy in Patients with Remitting Ulcerative Colitis

Nomura, E., Sujino, T., Hosoe, N., Yoshimatsu, Y., Tanemoto, S., Takabayashi, K., Mutaguchi, M., Shimoda, M., Naganuma, M., Ogata, H. & Kanai, T., 2021 9月, In: Digestive Diseases and Sciences. 66, 9, p. 3141-3148 8 p.

研究成果: Article › 査読

1 被引用数 (Scopus)

Characterization of structures with T-lymphocyte aggregates in ileal villi of Crohn's disease

Naganuma, M., Watanabe, M., Kanai, T., Iwao, Y., Mukai, M., Ishii, H. & Hibi, T., 2002, In: American Journal of Gastroenterology. 97, 7, p. 1741-1747 7 p.

研究成果: Article › 査読

4 被引用数 (Scopus)

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., Kanai, T. & Sato, T., 2020 2月, In: Gastroenterology. 158, 3, p. 638-651.e8

研究成果: Article › 査読

40 被引用数 (Scopus)

Chronic enteropathy associated with SLCO2A1 gene [CEAS]-Characterisation of an enteric disorder to be considered in the differential diagnosis of Crohn's disease

CEAS Atlas Group, 2017 10月 1, In: Journal of Crohn's and Colitis. 11, 10, p. 1277-1281 5 p.

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Open Access

27 被引用数 (Scopus)

Chronic Enteropathy Associated with Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1) with Positive Immunohistochemistry for SLCO2A1 Protein

Ariake, C., Hosoe, N., Sakurai, H., Tojo, A., Hayashi, Y., Limpias Kamiya, K. J. L., Sujino, T., Takabayashi, K., Kosaki, K., Seki, S., Hisamatsu, T., Ogata, H. & Kanai, T., 2022, In: Internal Medicine. 61, 17, p. 2607-2611 5 p.

研究成果: Article › 査読

Open Access

Circadian rhythms in the tissue-specificity from metabolism to immunity: insights from omics studies

Kinouchi, K., Mikami, Y., Kanai, T. & Itoh, H., 2021 8月, In: Molecular Aspects of Medicine. 80, 100984.

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Open Access

7 被引用数 (Scopus)

Circulating autoantibodies against purified colonic mucin in ulcerative colitis

Takaishi, H., Ohara, S., Hotta, K., Yajima, T., Kanai, T., Inoue, N., Iwao, Y., Watanabe, M., Ishii, H. & Hibi, T., 2000 1月, In: Journal of gastroenterology. 35, 1, p. 20-27 8 p.

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17 被引用数 (Scopus)

Clarithromycin expands CD11b⁺Gr-1⁺cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia

Namkoong, H., Ishii, M., Fujii, H., Yagi, K., Asami, T., Asakura, T., Suzuki, S., Hegab, A. E., Kamata, H., Tasaka, S., Atarashi, K., Nakamoto, N., Iwata, S., Honda, K., Kanai, T., Hasegawa, N., Koyasu, S. & Betsuyaku, T., 2018 4月, In: PLoS Pathogens. 14, 4, e1006955.

研究成果: Article › 査読

Open Access

29 被引用数 (Scopus)

内科学(消化器)

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