内科学(神経)

研究成果

年別の研究成果 1994 2011 2012 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 337 Article
• 51 Review article
• 31 Letter
• 9 Comment/debate
• 6 その他
  • 3 Chapter
  • 3 Editorial

年別の研究成果

年別の研究成果

検索結果

• 2000

  Astroglial cell death induced by excessive influx of sodium ions

  Takahashi, S., Shibata, M., Gotoh, J. & Fukuuchi, Y., 2000 11月 17, In: European journal of pharmacology. 408, 2, p. 127-135 9 p.

  研究成果: Article › 査読

  • Veratridine 100%
  • Monensin 80%
  • Sodium 58%
  • Ions 57%
  • Cell Death 52%
  28 被引用数 (Scopus)

• C242T polymorphism of NADPH oxidase p22 PHOX gene and ischemic cerebrovascular disease in the Japanese population

  Ito, D., Murata, M., Watanabe, K., Yoshida, T., Saito, I., Tanahashi, N. & Fukuuchi, Y., 2000 4月, In: Stroke. 31, 4, p. 936-939 4 p.

  研究成果: Article › 査読

  Open Access

  • NADPH Oxidases 100%
  • Cerebrovascular Disorders 90%
  • Genes 35%
  • Population 34%
  • Lacunar Stroke 33%
  88 被引用数 (Scopus)

• Effects of blockade of voltage-sensitive Ca²⁺/Na⁺ channels by a novel phenylpyrimidine derivative, NS-7, on CREB phosphorylation in focal cerebral ischemia in the rat

  Tanaka, K., Nogawa, S., Nagata, E., Suzuki, S., Dembo, T., Kosakai, A. & Fukuuchi, Y., 2000 8月 4, In: Brain Research. 873, 1, p. 83-93 11 p.

  研究成果: Article › 査読

  • 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride 100%
  • Cyclic AMP Response Element-Binding Protein 62%
  • Brain Ischemia 48%
  • Phosphorylation 33%
  • Middle Cerebral Artery Infarction 13%
  12 被引用数 (Scopus)

• Expression of interleukin-6 is suppressed by inhibition of voltage-sensitive Na⁺/Ca²⁺ channels after cerebral ischemia

  Suzuki, S., Tanaka, K., Nogawa, S., Dembo, T., Kosakai, A. & Fukuuchi, Y., 2000 8月 3, In: NeuroReport. 11, 11, p. 2565-2569 5 p.

  研究成果: Article › 査読

  • 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride 100%
  • Brain Ischemia 58%
  • Interleukin-6 45%
  • Reperfusion 34%
  • Membranes 11%
  14 被引用数 (Scopus)

• Immunohistochemical detection of leukemia inhibitory factor after focal cerebral ischemia in rats

  Suzuki, S., Tanaka, K., Nogawa, S., Ito, D., Dembo, T., Kosakai, A. & Fukuuchi, Y., 2000, In: Journal of Cerebral Blood Flow and Metabolism. 20, 4, p. 661-668 8 p.

  研究成果: Article › 査読

  • Leukemia Inhibitory Factor 100%
  • Brain Ischemia 74%
  • Reperfusion 26%
  • Glial Fibrillary Acidic Protein 16%
  • Interleukin-6 11%
  48 被引用数 (Scopus)

• Interleukin-6 protein expression during reperfusion after focal cerebral ischemia in rats

  Suzuki, S., Fukuuchi, Y., Tanaka, K., Nogawa, S., Nozaki, H., Nagata, E., Ito, D., Dembo, T. & Kosakai, A., 2000, In: Journal of Stroke and Cerebrovascular Diseases. 9, 2 SUPPL., p. 87-88 2 p.

  研究成果: Article › 査読

• Persistent CREB phosphorylation with protection of hippocampal CA1 pyramidal neurons following temporary occlusion of the middle cerebral artery in the rat

  Tanaka, K., Nogawa, S., Nagata, E., Ito, D., Suzuki, S., Dembo, T., Kosakai, A. & Fukuuchi, Y., 2000 2月, In: Experimental Neurology. 161, 2, p. 462-471 10 p.

  研究成果: Article › 査読

  • Cyclic AMP Response Element-Binding Protein 100%
  • Middle Cerebral Artery Infarction 87%
  • Pyramidal Cells 83%
  • Phosphorylation 54%
  • Ischemia 26%
  37 被引用数 (Scopus)

• POEMS syndrome with necrotizing vasculitis: A novel feature of vascular abnormalities

  Shibata, M., Yamada, T., Tanahashi, N., Koto, A., Kuramochi, S., Fukushima, S. & Fukuuchi, Y., 2000 2月 8, In: Neurology. 54, 3, p. 772-773 2 p.

  研究成果: Article › 査読
  14 被引用数 (Scopus)

• Role of voltage-sensitive Na⁺/Ca²⁺ channels in the ischemic damage of PKA-mediated signal transduction - The effect of a novel channel blocker NS-7

  Tanaka, K., Fukuuchi, Y., Nogawa, S., Nagata, E., Suzuki, S., Dembo, T. & Kosakai, A., 2000 11月 11, In: Journal of Stroke and Cerebrovascular Diseases. 9, 2 SUPPL., p. 215-216 2 p.

  研究成果: Article › 査読

• Soluble P-selectin in the plasma of patients with cerebral infarction

  Tanahashi, N., Fukuuchi, Y., Tomita, M., Takao, M., Itoh, D. & Handa, M., 2000 1月 1, In: Journal of Stroke and Cerebrovascular Diseases. 9, 2 SUPPL., p. 193-194 2 p.

  研究成果: Article › 査読
• 1999

  Alteration of cAMP-mediated signal transduction in cerebral ischemia - Binding activity of PKA and phosphorylation of CREB

  Tanaka, K., Fukuuchi, Y., Nogawa, S., Nozaki, H., Nagata, E., Suzuki, S., Dembo, T. & Kosakai, A., 1999 12月 1, In: Clinical Neurology. 39, 12, p. 1298-1299 2 p.

  研究成果: Article › 査読

  • Cyclic AMP Response Element-Binding Protein 100%
  • Brain Ischemia 78%
  • Protein Kinases 73%
  • Carrier Proteins 67%
  • Signal Transduction 61%
  1 被引用数 (Scopus)

• Cerebral neurons express interleukin-6 after transient forebrain ischemia in gerbils

  Suzuki, S., Tanaka, K., Nagata, E., Ito, D., Dembo, T. & Fukuuchi, Y., 1999 3月 5, In: Neuroscience Letters. 262, 2, p. 117-120 4 p.

  研究成果: Article › 査読

  • Gerbillinae 100%
  • Prosencephalon 86%
  • Interleukin-6 62%
  • Ischemia 60%
  • Neurons 49%
  47 被引用数 (Scopus)

• Immunohistochemical analysis of cyclic AMP response element binding protein phosphorylation in focal cerebral ischemia in rats

  Tanaka, K., Nagata, E., Suzuki, S., Dembo, T., Nogawa, S. & Fukuuchi, Y., 1999 2月 13, In: Brain Research. 818, 2, p. 520-526 7 p.

  研究成果: Article › 査読

  • Cyclic AMP Response Element-Binding Protein 100%
  • Brain Ischemia 78%
  • Phosphorylation 54%
  • Infarction 24%
  • Middle Cerebral Artery Infarction 15%
  64 被引用数 (Scopus)

• Inhibition of cyclic AMP-dependent protein kinase in the acute phase of focal cerebral ischemia in the rat

  Tanaka, K., Nogawa, S., Nagata, E., Suzuki, S., Dembo, T., Kosakai, A. & Fukuuchi, Y., 1999 9月, In: Neuroscience. 94, 2, p. 361-371 11 p.

  研究成果: Article › 査読

  • Cyclic AMP-Dependent Protein Kinases 100%
  • Brain Ischemia 95%
  • Cyclic AMP 94%
  • Cerebrovascular Circulation 34%
  • Putamen 33%
  16 被引用数 (Scopus)

• Selective inhibition of inositol 1,4,5-trisphosphate-induced Ca²⁺ release in the CA1 region of the hippocampus in the ischemic gerbil

  Nagata, E., Tanaka, K., Suzuki, S., Dembo, T., Fukuuchi, Y., Futatsugi, A. & Mikoshiba, K., 1999 8月 1, In: Neuroscience. 93, 3, p. 995-1001 7 p.

  研究成果: Article › 査読

  • Inositol 1,4,5-Trisphosphate Receptors 100%
  • Inositol 1,4,5-Trisphosphate 94%
  • Gerbillinae 93%
  • Endoplasmic Reticulum 61%
  • Hippocampus 60%
  11 被引用数 (Scopus)

• Temporal profile and cellular localization of interleukin-6 protein after focal cerebral ischemia in rats

  Suzuki, S., Tanaka, K., Nogawa, S., Nagata, E., Ito, D., Dembo, T. & Fukuuchi, Y., 1999 1月 1, In: Journal of Cerebral Blood Flow and Metabolism. 19, 11, p. 1256-1262 7 p.

  研究成果: Article › 査読

  Open Access

  • Brain Ischemia 100%
  • Interleukin-6 77%
  • Reperfusion 39%
  • Proteins 37%
  • Middle Cerebral Artery Infarction 24%
  101 被引用数 (Scopus)

• Temporal profile of CREB phosphorylation after focal ischemia in rat brain

  Tanaka, K., Nogawa, S., Nagata, E., Suzuki, S., Dembo, T., Kosakai, A. & Fukuuchi, Y., 1999 8月 2, In: NeuroReport. 10, 11, p. 2245-2250 6 p.

  研究成果: Article › 査読

  • Cyclic AMP Response Element-Binding Protein 100%
  • Ischemia 59%
  • Phosphorylation 54%
  • Brain 38%
  • Middle Cerebral Artery Infarction 14%
  38 被引用数 (Scopus)

• Uncoupling of cerebral blood flow and glucose utilization in the regenerating facial nucleus after axotomy

  Ito, D., Tanaka, K., Nagata, E., Suzuki, S., Dembo, T. & Fukuuchi, Y., 1999 12月 1, In: Neuroscience Research. 35, 3, p. 207-215 9 p.

  研究成果: Article › 査読

  • Facial Nucleus 100%
  • Axotomy 90%
  • Cerebrovascular Circulation 65%
  • Blood Glucose 56%
  • Retrograde Degeneration 20%
  9 被引用数 (Scopus)
• 1998

  A case of recurrent attacks of Amaurosis Fugax

  Matsumoto, Y., Nozaki, H., Kato, K., Oguchi, Y. & Shibata, M., 1998 1月 1, In: Neuro-Ophthalmology Japan. 15, 1, p. 63-70 8 p.

  研究成果: Article › 査読

  • Amaurosis Fugax 100%
  • Aspirin 59%
  • Ocular Vision 54%
  • Dipyridamole 39%
  • Emergency Treatment 39%

• Amplification of JC virus regulatory DNA sequences from cerebrospinal fluid: Diagnostic value for progressive multifocal leukoencephalopathy

  Sugimoto, C., Ito, D., Tanaka, K., Matsuda, H., Saito, H., Sakai, H., Fujihara, K., Itoyama, Y., Yamada, T., Kira, J., Matsumoto, R., Mori, M., Nagashima, K. & Yogo, Y., 1998, In: Archives of Virology. 143, 2, p. 249-262 14 p.

  研究成果: Article › 査読

  • JC Virus 100%
  • Progressive Multifocal Leukoencephalopathy 98%
  • Nucleic Acid Regulatory Sequences 63%
  • Cerebrospinal Fluid 62%
  • Polymerase Chain Reaction 14%
  49 被引用数 (Scopus)

• Hydrogen peroxide enhances phagocytic activity of ameboid microglia

  Takeda, H., Tomita, M., Tanahashi, N., Kobari, M., Yokoyama, M., Takao, M., Ito, D. & Fukuuchi, Y., 1998 1月 2, In: Neuroscience Letters. 240, 1, p. 5-8 4 p.

  研究成果: Article › 査読

  • Microglia 100%
  • Hydrogen Peroxide 98%
  • Pseudopodia 47%
  • Interference Microscopy 30%
  • Phagosomes 25%
  23 被引用数 (Scopus)

• Progressive multifocal leukoencephalopathy (PML) -Report of a case diagnosed by amplification of JC virus DNA from cerebrospinal fluid (CSF)

  Ito, D., Yogo, Y., Okita, H., Tanaka, K. & Koto, A., 1998 1月 1, In: Clinical Neurology. 38, 1, p. 46-50 5 p.

  研究成果: Article › 査読

  • JC Virus 100%
  • Progressive Multifocal Leukoencephalopathy 98%
  • Cerebrospinal Fluid 62%
  • Nucleic Acid Regulatory Sequences 41%
  • DNA 39%
• 1997

  Chest wall reconstruction with pasteurized autogenous bone grafts after resection of desmoid tumor--a case report

  Seki, M., Kawamura, M., Horinouchi, H., Kikuchi, K. & Kobayashi, K., 1997 8月, In: [Zasshi] [Journal]. Nihon Kyōbu Geka Gakkai. 45, 8, p. 1143-1146 4 p.

  研究成果: Article › 査読

  • Aggressive Fibromatosis 100%
  • Thoracic Wall 78%
  • Transplants 45%
  • Bone and Bones 43%
  • Ribs 39%
  4 被引用数 (Scopus)

• Effects of increased extracellular potassium on influx of sodium ions in cultured rat astroglia and neurons

  Takahashi, S., Shibata, M. & Fukuuchi, Y., 1997 12月 19, In: Developmental Brain Research. 104, 1-2, p. 111-117 7 p.

  研究成果: Article › 査読

  • Astrocytes 100%
  • Potassium 97%
  • Sodium 90%
  • Ions 89%
  • Veratridine 89%
  22 被引用数 (Scopus)

• Regional difference in nitric oxide production during forebrain ischemia

  Shibata, M., Araki, N., Hamada, J., Sasaki, T., Ohta, K., Shimazu, K. & Fukuuchi, Y., 1997 6月, In: Microchemical Journal. 56, 2, p. 188-191 4 p.

  研究成果: Article › 査読

  • Nitric Oxide 100%
  • Pentobarbital 31%
  • Oxide(2-) 26%
  • Neurotoxicity 26%
  • Nitrite 20%
• 1996

  Acute Wernicke’s Encephalopathy: Comparison of Magnetic Resonance Images and Autopsy Findings

  Suzuki, S., Ichijo, M., Fujii, H., Matsuoka, Y. & Ogawa, Y., 1996, In: Internal Medicine. 35, 10, p. 831-834 4 p.

  研究成果: Article › 査読

  Open Access

  • Wernicke Encephalopathy 100%
  • Autopsy 55%
  • Magnetic Resonance Spectroscopy 55%
  • Fourth Ventricle 28%
  • Third Ventricle 27%
  55 被引用数 (Scopus)

• Brain nitrite production during global ischemia and reperfusion: An in vivo microdialysis study

  Shibata, M., Araki, N., Hamada, J., Sasaki, T., Shimazu, K. & Fukuuchi, Y., 1996 9月 23, In: Brain Research. 734, 1-2, p. 86-90 5 p.

  研究成果: Article › 査読

  • Microdialysis 100%
  • Nitrites 97%
  • Reperfusion 78%
  • Nitric Oxide 72%
  • Ischemia 67%
  53 被引用数 (Scopus)

• Cerebral metabolic disturbance in hypoxic encephalopathy: Evaluation with H-1 MR spectroscopy

  Suzuki, S., Ichijo, M., Fujii, H., Ikeda, K. & Hitosugi, M., 1996 7月, In: Clinical Neurology. 36, 7, p. 844-849 6 p.

  研究成果: Article › 査読

  • Brain Hypoxia 100%
  • Creatine 90%
  • N-acetylaspartate 65%
  • Magnetic Resonance Spectroscopy 64%
  • Choline 54%
  1 被引用数 (Scopus)

• Correlation of in vivo nitric oxide and cGMP with glutamate/glutamine metabolism in the rat striatum

  Ohta, K., Araki, N., Shibata, M., Hamada, J., Komatsumoto, S., Shimazu, K. & Fukuuchi, Y., 1996 8月, In: Neuroscience Research. 25, 4, p. 379-384 6 p.

  研究成果: Article › 査読

  • Glutamine 100%
  • Glutamic Acid 83%
  • Nitric Oxide 77%
  • NG-Nitroarginine Methyl Ester 48%
  • Corpus Striatum 41%
  13 被引用数 (Scopus)

• Nitric oxide regulates NMDA-induced dopamine release in rat striatum

  Shibata, M., Araki, N., Ohta, K., Hamada, J., Shimazu, K. & Fukuuchi, Y., 1996 1月 1, In: NeuroReport. 7, 2, p. 605-608 4 p.

  研究成果: Article › 査読

  • N-Methylaspartate 100%
  • Dopamine 77%
  • Nitric Oxide 74%
  • NG-Nitroarginine Methyl Ester 52%
  • Homovanillic Acid 20%
  40 被引用数 (Scopus)

• Reconstruction of chest wall defects with autogenous ribs grafts

  Kawamura, M., Seki, M., Yoshizu, A., Naruke, M., Yamahata, J., Izumi, Y., Eguchi, K., Horinouchi, H., Kato, R., Kikuchi, K. & Kobayashi, K., 1996 1月, In: Kyobu geka. The Japanese journal of thoracic surgery. 49, 1, p. 53-56 4 p.

  研究成果: Article › 査読

  • Ribs 100%
  • Thoracic Wall 97%
  • Transplants 56%
  • Aggressive Fibromatosis 17%
  • Bone and Bones 15%
  7 被引用数 (Scopus)

• Swift transformation and locomotion of polymorphonuclear leukocytes and microglia as observed by VEC-DIC microscopy (video microscopy)

  Tomita, M., Fukuuchi, Y., Tanahashi, N., Kobari, M., Takeda, H., Yokoyama, M., Ito, D. & Terakawa, S., 1996 9月, In: Keio Journal of Medicine. 45, 3, p. 213-224 12 p.

  研究成果: Article › 査読

  Open Access

  • Interference Microscopy 100%
  • Video Microscopy 85%
  • Microglia 66%
  • Locomotion 63%
  • Pseudopodia 51%
  13 被引用数 (Scopus)
• 1995

  Effect of single intravenous administration of batroxobin on erythrocyte aggregability in patients with acute-stage cerebral infarction

  Tanahashi, N., Fukuuchi, Y., Tomita, M., Kobari, M., Takeda, H., Yokoyama, M. & Itoh, D., 1995 1月 1, In: Clinical Hemorheology and Microcirculation. 15, 1, p. 89-96 8 p.

  研究成果: Article › 査読

  • Batroxobin 100%
  • Cerebral Infarction 65%
  • Intravenous Administration 57%
  • Erythrocytes 47%
  • Fibrinogen 47%
  3 被引用数 (Scopus)
• 1994

  A novel in vivo assay system for consecutive measurement of brain nitric oxide production combined with the microdialysis technique

  Ohta, K., Araki, N., Shibata, M., Hamada, J., Komatsumoto, S., Shimazu, K. & Fukuuchi, Y., 1994 8月 1, In: Neuroscience Letters. 176, 2, p. 165-168 4 p.

  研究成果: Article › 査読

  • Microdialysis 100%
  • Nitric Oxide 72%
  • Brain 43%
  • Corpus Striatum 28%
  • Nitric Oxide Synthase 28%
  99 被引用数 (Scopus)

• Modification of striatal arginine and citrulline metabolism by nitric oxide synthase inhibitors

  Ohta, K., Shimazu, K., Komatsumoto, S., Araki, N., Shibata, M. & Fukuuchi, Y., 1994 3月, In: NeuroReport. 5, 7, p. 766-768 3 p.

  研究成果: Article › 査読

  • Citrulline 100%
  • Corpus Striatum 75%
  • Nitric Oxide Synthase 74%
  • Arginine 71%
  • omega-N-Methylarginine 42%
  33 被引用数 (Scopus)

• Presynaptic glutamate receptors facilitate release of norepinephrine and 5-hydroxytryptamine as well as dopamine in the normal and ischemic striatum

  Ohta, K., Fukuuchi, Y., Shimazu, K., Komatsumoto, S., Ichijo, M., Araki, N. & Shibata, M., 1994 9月, In: Journal of the Autonomic Nervous System. 49, SUPPL., p. 195-202 8 p.

  研究成果: Article › 査読

  • Presynaptic Receptors 100%
  • Glutamate Receptors 80%
  • Glutamic Acid 64%
  • Serotonin 62%
  • Norepinephrine 61%
  19 被引用数 (Scopus)

• Presynaptic ionotropic glutamate receptors modulate in vivo release and metabolism of striatal dopamine, noradrenaline, and 5-hydroxytryptamine: involvement of both NMDA and AMPA/kainate subtypes

  Ohta, K., Araki, N., Shibata, M., Komatsumoto, S., Shimazu, K. & Fukuuchi, Y., 1994 11月, In: Neuroscience Research. 21, 1, p. 83-89 7 p.

  研究成果: Article › 査読

  • Ionotropic Glutamate Receptors 100%
  • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 92%
  • Kainic Acid 86%
  • Aspartic Acid 77%
  • Corpus Striatum 72%
  51 被引用数 (Scopus)