先端医科学研究所（脳科学）

研究成果

年別の研究成果 1988 2015 2017 2018 2021 2022 2023

• 112 Article
• 5 Review article
• 2 Conference contribution
• 1 Chapter
• 1 その他
  • 1 Comment/debate

年別の研究成果

年別の研究成果

検索結果

• 2018

  Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships

  Zhang, P., Lu, H., Peixoto, R. T., Pines, M. K., Ge, Y., Oku, S., Siddiqui, T. J., Xie, Y., Wu, W., Archer-Hartmann, S., Yoshida, K., Tanaka, K. F., Aricescu, A. R., Azadi, P., Gordon, M. D., Sabatini, B. L., Wong, R. O. L. & Craig, A. M., 2018 9月 6, In: Cell. 174, 6, p. 1450-1464.e23

  研究成果: Article › 査読

  Open Access

  • Heparan Sulfate 100%
  • Heparitin Sulfate 95%
  • Synapses 71%
  • Polysaccharides 36%
  • Protein Domains 26%
  88 被引用数 (Scopus)

• Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics

  Chen, S., Weitemier, A. Z., Zeng, X., He, L., Wang, X., Tao, Y., Huang, A. J. Y., Hashimotodani, Y., Kano, M., Iwasaki, H., Parajuli, L. K., Okabe, S., Loong Teh, D. B., All, A. H., Tsutsui-Kimura, I., Tanaka, K. F., Liu, X. & McHugh, T. J., 2018 2月 9, In: Science. 359, 6376, p. 679-684 6 p.

  研究成果: Article › 査読

  • Optogenetics 100%
  • Deep Brain Stimulation 89%
  • Nanoparticles 68%
  • Light 54%
  • Neurons 35%
  657 被引用数 (Scopus)

• Optogenetic astrocyte activation evokes BOLD fMRI response with oxygen consumption without neuronal activity modulation

  Takata, N., Sugiura, Y., Yoshida, K., Koizumi, M., Hiroshi, N., Honda, K., Yano, R., Komaki, Y., Matsui, K., Suematsu, M., Mimura, M., Okano, H. & Tanaka, K. F., 2018 9月, In: Glia. 66, 9, p. 2013-2023 11 p.

  研究成果: Article › 査読

  • Optogenetics 100%
  • Oxygen Consumption 76%
  • Astrocytes 70%
  • Magnetic Resonance Imaging 50%
  • Acetylcarnitine 16%
  47 被引用数 (Scopus)

• Quantitative temporal changes in DTI values coupled with histological properties in cuprizone-induced demyelination and remyelination

  Yano, R., Hata, J., Abe, Y., Seki, F., Yoshida, K., Komaki, Y., Okano, H. & Tanaka, K. F., 2018 10月, In: Neurochemistry International. 119, p. 151-158 8 p.

  研究成果: Article › 査読

  • Cuprizone 100%
  • Remyelination 83%
  • Diffusion Tensor Imaging 70%
  • Demyelinating Diseases 66%
  • Anisotropy 59%
  22 被引用数 (Scopus)

• Reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience

  Miyazaki, K., Miyazaki, K. W., Yamanaka, A., Tokuda, T., Tanaka, K. F. & Doya, K., 2018 12月 1, In: Nature communications. 9, 1, 2048.

  研究成果: Article › 査読

  Open Access

  • serotonin 100%
  • Dorsal Raphe Nucleus 78%
  • Serotonin 67%
  • neurons 61%
  • Reward 59%
  39 被引用数 (Scopus)

• Role of purinergic receptor P2Y1 in spatiotemporal Ca ²⁺ dynamics in astrocytes

  Shigetomi, E., Hirayama, Y. J., Ikenaka, K., Tanaka, K. F. & Koizumi, S., 2018 2月 7, In: Journal of Neuroscience. 38, 6, p. 1383-1395 13 p.

  研究成果: Article › 査読

  Open Access

  • Purinergic P2Y1 Receptors 100%
  • Astrocytes 60%
  • Synaptic Transmission 46%
  • Gq-G11 GTP-Binding Protein alpha Subunits 12%
  • Ligands 11%
  28 被引用数 (Scopus)

• Visualization of myelinated fiber bundles orientation during brain slice preparation by reflection polarized light microscopy

  Takata, N., Kusayanagi, K., Maruyama, H., Eitai, K., Abo, M., Akiyama, F., Tajima, R., Inaba, S., Tanaka, K. F., Mimura, M. & Sanaka, K., 2018 12月, In: Microscopy Research and Technique. 81, 12, p. 1366-1373 8 p.

  研究成果: Article › 査読

  • Light polarization 100%
  • Polarization Microscopy 98%
  • Optical microscopy 73%
  • Fiber reinforced materials 71%
  • bundles 66%
  1 被引用数 (Scopus)
• 2017

  Abrogated freud-1/Cc2d1a repression of 5-HT1A autoreceptors induces fluoxetine-resistant anxiety/ depression-like behavior

  Vahid-Ansari, F., Daigle, M., Manzini, M. C., Tanaka, K. F., Hen, R., Geddes, S. D., Béïque, J. C., James, J., Merali, Z. & Albert, P. R., 2017 12月 6, In: Journal of Neuroscience. 37, 49, p. 11967-11978 12 p.

  研究成果: Article › 査読

  Open Access

  • Autoreceptors 100%
  • Fluoxetine 88%
  • Serotonin 65%
  • Anxiety 54%
  • Depression 49%
  29 被引用数 (Scopus)

• A New Paradigm for Evaluating Avoidance/Escape Motivation

  Tsutsui-Kimura, I., Bouchekioua, Y., Mimura, M. & Tanaka, K. F., 2017 7月 1, In: International Journal of Neuropsychopharmacology. 20, 7, p. 593-601 9 p.

  研究成果: Article › 査読

  Open Access

  • Motivation 100%
  • Buspirone 74%
  • Ketamine 58%
  • Avoidance Learning 21%
  • Neurobiology 20%
  1 被引用数 (Scopus)

• Association of impaired neuronal migration with cognitive deficits in extremely preterm infants

  Kubo, K. I., Deguchi, K., Nagai, T., Ito, Y., Yoshida, K., Endo, T., Benner, S., Shan, W., Kitazawa, A., Aramaki, M., Ishii, K., Shin, M., Matsunaga, Y., Hayashi, K., Kakeyama, M., Tohyama, C., Tanaka, K. F., Tanaka, K., Takashima, S., Nakayama, M., & 7 othersItoh, M., Hirata, Y., Antalffy, B., Armstrong, D. D., Yamada, K., Inoue, K. & Nakajima, K., 2017 5月 18, In: JCI Insight. 2, 10, e88609.

  研究成果: Article › 査読

  Open Access

  • Extremely Premature Infants 100%
  • Brain Injuries 53%
  • Cognitive Dysfunction 34%
  • Neocortex 31%
  • White Matter 25%
  17 被引用数 (Scopus)

• Establishment of pten knockout medaka with transcription activator–like effector nucleases (TALENs) as a model of PTEN deficiency disease

  Matsuzaki, Y., Sakuma, T., Yamamoto, T. & Saya, H., 2017 10月, In: PloS one. 12, 10, e0186878.

  研究成果: Article › 査読

  Open Access

  • Oryzias 100%
  • deficiency diseases 98%
  • Deficiency Diseases 95%
  • Tensins 88%
  • Phosphatidylinositol 82%
  2 被引用数 (Scopus)

• Hearing loss controlled by optogenetic stimulation of nonexcitable nonglial cells in the cochlea of the inner ear

  Sato, M. P., Higuchi, T., Nin, F., Ogata, G., Sawamura, S., Yoshida, T., Ota, T., Hori, K., Komune, S., Uetsuka, S., Choi, S., Masuda, M., Watabe, T., Kanzaki, S., Ogawa, K., Inohara, H., Sakamoto, S., Takebayashi, H., Doi, K., Tanaka, K. F., & 1 othersHibino, H., 2017 9月 21, In: Frontiers in Molecular Neuroscience. 10, 300.

  研究成果: Article › 査読

  Open Access

  • Optogenetics 100%
  • Inner Ear 83%
  • Cochlea 80%
  • Hearing Loss 73%
  • Channelrhodopsins 70%
  2 被引用数 (Scopus)

• High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates

  Seiriki, K., Kasai, A., Hashimoto, T., Schulze, W., Niu, M., Yamaguchi, S., Nakazawa, T., Inoue, K. I., Uezono, S., Takada, M., Naka, Y., Igarashi, H., Tanuma, M., Waschek, J. A., Ago, Y., Tanaka, K. F., Hayata-Takano, A., Nagayasu, K., Shintani, N., Hashimoto, R., & 10 othersKunii, Y., Hino, M., Matsumoto, J., Yabe, H., Nagai, T., Fujita, K., Matsuda, T., Takuma, K., Baba, A. & Hashimoto, H., 2017 6月 21, In: Neuron. 94, 6, p. 1085-1100.e6

  研究成果: Article › 査読

  Open Access

  • Primates 100%
  • Neuroimaging 97%
  • Rodentia 88%
  • Microscopy 59%
  • Brain 52%
  75 被引用数 (Scopus)

• Mitochondrial DNA double-strand breaks in oligodendrocytes cause demyelination, axonal injury, and CNS inflammation

  Madsen, P. M., Pinto, M., Patel, S., McCarthy, S., Gao, H., Taherian, M., Karmally, S., Pereira, C. V., Dvoriantchikova, G., Ivanov, D., Tanaka, K. F., Moraes, C. T. & Brambilla, R., 2017 10月 18, In: Journal of Neuroscience. 37, 42, p. 10185-10199 15 p.

  研究成果: Article › 査読

  Open Access

  • Oligodendroglia 100%
  • Demyelinating Diseases 95%
  • Mitochondrial DNA 95%
  • Inflammation 53%
  • Multiple Sclerosis 45%
  25 被引用数 (Scopus)

• OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior

  Zike, I. D., Chohan, M. O., Kopelman, J. M., Krasnow, E. N., Flicker, D., Nautiyal, K. M., Bubser, M., Kellendonk, C., Jones, C. K., Stanwood, G., Tanaka, K. F., Moore, H., Ahmari, S. E. & Veenstra-VanderWeele, J., 2017 5月 30, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 22, p. 5719-5724 6 p.

  研究成果: Article › 査読

  Open Access

  • Excitatory Amino Acid Transporter 3 100%
  • Obsessive-Compulsive Disorder 57%
  • Basal Ganglia 52%
  • Amphetamine 37%
  • Grooming 33%
  32 被引用数 (Scopus)

• Progression of Human Renal Cell Carcinoma via Inhibition of RhoA-ROCK Axis by PARG1

  Miyazaki, J., Ito, K., Fujita, T., Matsuzaki, Y., Asano, T., Hayakawa, M., Asano, T. & Kawakami, Y., 2017 4月 1, In: Translational Oncology. 10, 2, p. 142-152 11 p.

  研究成果: Article › 査読

  Open Access

  • Renal Cell Carcinoma 100%
  • Recurrence 23%
  • Cell Proliferation 20%
  • Cell Line 18%
  • G1 Phase Cell Cycle Checkpoints 13%
  6 被引用数 (Scopus)

• Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor

  Imada, T., Nakamura, S., Hisamura, R., Izuta, Y., Jin, K., Ito, M., Kitamura, N., Tanaka, K. F., Mimura, M., Shibuya, I. & Tsubota, K., 2017 12月 1, In: Scientific reports. 7, 1, 6965.

  研究成果: Article › 査読

  Open Access

  • Lacrimal Apparatus 100%
  • Serotonin Receptors 96%
  • Tears 79%
  • Serotonin 70%
  • Meibomian Glands 30%
  17 被引用数 (Scopus)

• The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model

  Shimizu, T., Wisessmith, W., Li, J., Abe, M., Sakimura, K., Chetsawang, B., Sahara, Y., Tohyama, K., Tanaka, K. F. & Ikenaka, K., 2017 6月, In: Glia. 65, 6, p. 917-930 14 p.

  研究成果: Article › 査読

  • Cathepsin C 100%
  • Cystatins 90%
  • Remyelination 80%
  • Demyelinating Diseases 64%
  • Chronic Disease 45%
  17 被引用数 (Scopus)

• Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice

  Watabe, T., Xu, M., Watanabe, M., Nabekura, J., Higuchi, T., Hori, K., Sato, M. P., Nin, F., Hibino, H., Ogawa, K., Masuda, M. & Tanaka, K. F., 2017 12月 1, In: Scientific reports. 7, 1, 13605.

  研究成果: Article › 査読

  Open Access

  • Doxycycline 100%
  • Hearing Loss 82%
  • Tetracycline 55%
  • Transgenic Mice 46%
  • Cochlea 36%
  7 被引用数 (Scopus)

• Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y₁ Receptor Downregulation

  Shinozaki, Y., Shibata, K., Yoshida, K., Shigetomi, E., Gachet, C., Ikenaka, K., Tanaka, K. F. & Koizumi, S., 2017 5月 9, In: Cell Reports. 19, 6, p. 1151-1164 14 p.

  研究成果: Article › 査読

  Open Access

  • Purinergic P2Y1 Receptors 100%
  • Neuroprotective 83%
  • Microglia 66%
  • Astrocytes 60%
  • Down-Regulation 45%
  194 被引用数 (Scopus)

• Ventrolateral striatal medium spiny neurons positively regulate food-incentive, goal-directed behavior independently of D1 and D2 selectivity

  Natsubori, A., Tsutsui-Kimura, I., Nishida, H., Bouchekioua, Y., Sekiya, H., Uchigashima, M., Watanabe, M., De Kerchove D’Exaerde, A., Mimura, M., Takata, N. & Tanaka, K. F., 2017 3月 8, In: Journal of Neuroscience. 37, 10, p. 2723-2733 11 p.

  研究成果: Article › 査読

  Open Access

  • Corpus Striatum 100%
  • Motivation 82%
  • Food 72%
  • Ventral Striatum 68%
  • Neurons 63%
  68 被引用数 (Scopus)
• 2016

  Immune modulation of the T cell response in asthma through Wnt10b

  Trischler, J., Shiomi, T., Turner, D. L., Sklepkiewicz, P. L., Goldklang, M. P., Tanaka, K. F., Xu, M., Farber, D. L. & D'Armiento, J. M., 2016 4月, In: American journal of respiratory cell and molecular biology. 54, 4, p. 584-593 10 p.

  研究成果: Article › 査読

  • Dust 100%
  • Asthma 70%
  • Polarization 67%
  • T-Lymphocytes 56%
  • Effector 49%
  21 被引用数 (Scopus)

• Microglial phospholipase D4 deficiency influences myelination during brain development

  Chiba, T., Otani, Y., Yamaguchi, Y., Ishibashi, T., Hayashi, A., Tanaka, K. F., Yamazaki, M., Sakimura, K. & Baba, H., 2016, In: Proceedings of the Japan Academy Series B: Physical and Biological Sciences. 92, 7, p. 237-254 18 p.

  研究成果: Article › 査読

  • cerebellum 100%
  • myelination 90%
  • Phospholipases 78%
  • phospholipases 74%
  • brain 61%
  2 被引用数 (Scopus)

• Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis

  Zhou, Z., Tanaka, K. F., Matsunaga, S., Iseki, M., Watanabe, M., Matsuki, N., Ikegaya, Y. & Koyama, R., 2016 1月 22, In: Scientific reports. 5, 19679.

  研究成果: Article › 査読

  Open Access

  • Adenylyl Cyclases 100%
  • Morphogenesis 98%
  • Cyclic AMP-Dependent Protein Kinases 34%
  • Light 23%
  • Growth 16%
  34 被引用数 (Scopus)

• Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe

  Yoshida, K., Mimura, Y., Ishihara, R., Nishida, H., Komaki, Y., Minakuchi, T., Tsurugizawa, T., Mimura, M., Okano, H., Tanaka, K. F. & Takata, N., 2016 12月 1, In: Journal of Neuroscience Methods. 274, p. 38-48 11 p.

  研究成果: Article › 査読

  • Magnetic Resonance Imaging 100%
  • Head 55%
  • Signal-To-Noise Ratio 28%
  • Electromyography 25%
  • Skull 24%
  46 被引用数 (Scopus)
• 2015

  5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response

  Samuels, B. A., Anacker, C., Hu, A., Levinstein, M. R., Pickenhagen, A., Tsetsenis, T., Madroñal, N., Donaldson, Z. R., Drew, L. J., Dranovsky, A., Gross, C. T., Tanaka, K. F. & Hen, R., 2015 11月 1, In: Nature Neuroscience. 18, 11, p. 1606-1616 11 p.

  研究成果: Article › 査読

  • Receptor, Serotonin, 5-HT1A 100%
  • Dentate Gyrus 87%
  • Antidepressive Agents 72%
  • Serotonin Uptake Inhibitors 70%
  • Fluoxetine 56%
  120 被引用数 (Scopus)

• Adaptive changes of extracellular amino acid concentrations in mouse dorsal striatum by 4-AP-induced cortical seizures

  Nagai, T., Takata, N., Shinohara, Y. & Hirase, H., 2015 6月 4, In: Neuroscience. 295, p. 229-236 8 p.

  研究成果: Article › 査読

  • 4-Aminopyridine 100%
  • Amino Acid Transport System X-AG 82%
  • Corpus Striatum 75%
  • Seizures 60%
  • Amino Acids 54%
  7 被引用数 (Scopus)

• Adult hippocampal neurogenesis modulates fear learning through associative and nonassociative mechanisms

  Seo, D. O., Carillo, M. A., Lim, S. C. H., Tanaka, K. F. & Drew, M. R., 2015 8月 12, In: Journal of Neuroscience. 35, 32, p. 11330-11345 16 p.

  研究成果: Article › 査読

  Open Access

  • Neurogenesis 100%
  • Fear 82%
  • Learning 69%
  • Anxiety 13%
  • Ganciclovir 11%
  66 被引用数 (Scopus)

• Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice

  Aida, T., Yoshida, J., Nomura, M., Tanimura, A., Iino, Y., Soma, M., Bai, N., Ito, Y., Cui, W., Aizawa, H., Yanagisawa, M., Nagai, T., Takata, N., Tanaka, K. F., Takayanagi, R., Kano, M., Götz, M., Hirase, H. & Tanaka, K., 2015 2月 4, In: Neuropsychopharmacology. 40, 7, p. 1569-1579 11 p.

  研究成果: Article › 査読

  Open Access

  • Amino Acid Transport System X-AG 100%
  • Astrocytes 46%
  • Synapses 46%
  • Memantine 33%
  • Grooming 32%
  90 被引用数 (Scopus)

• Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice

  Aida, T., Chiyo, K., Usami, T., Ishikubo, H., Imahashi, R., Wada, Y., Tanaka, K. F., Sakuma, T., Yamamoto, T. & Tanaka, K., 2015 4月 29, In: Genome biology. 16, 1, 87.

  研究成果: Article › 査読

  Open Access

  • CRISPR-Cas Systems 100%
  • CRISPR-Cas systems 89%
  • cloning 79%
  • RNA 65%
  • Organism Cloning 57%
  208 被引用数 (Scopus)

• Identification of the extent of cortical spreading depression propagation by Npas4 mRNA expression

  Yoshida, K., Xu, M., Natsubori, A., Mimura, M., Takata, N. & Tanaka, K. F., 2015 9月 1, In: Neuroscience Research. 98, p. 1-8 8 p.

  研究成果: Article › 査読

  • Cortical Spreading Depression 100%
  • Messenger RNA 38%
  • Immediate-Early Genes 27%
  • Potassium Chloride 14%
  • Hippocampus 8%
  4 被引用数 (Scopus)

• Neuronal heterotopias affect the activities of distant brain areas and lead to behavioral deficits

  Ishii, K., Kubo, K. I., Endo, T., Yoshida, K., Benner, S., Ito, Y., Aizawa, H., Aramaki, M., Yamanaka, A., Tanaka, K., Takata, N., Tanaka, K. F., Mimura, M., Tohyama, C., Kakeyama, M. & Nakajima, K., 2015 9月 9, In: Journal of Neuroscience. 35, 36, p. 12432-12445 14 p.

  研究成果: Article › 査読

  Open Access

  • Prefrontal Cortex 100%
  • Memory Disorders 78%
  • Short-Term Memory 69%
  • Competitive Behavior 64%
  • Designer Drugs 55%
  28 被引用数 (Scopus)

• Optogenetic activation of CA1 pyramidal neurons at the dorsal and ventral hippocampus evokes distinct brain-wide responses revealed by mouse fMRI

  Takata, N., Yoshida, K., Komaki, Y., Xu, M., Sakai, Y., Hikishima, K., Mimura, M., Okano, H. & Tanaka, K. F., 2015 3月 20, In: PloS one. 10, 3, e0121417.

  研究成果: Article › 査読

  • optogenetics 100%
  • Optogenetics 83%
  • hippocampus 74%
  • Oxygenation 70%
  • Pyramidal Cells 67%
  40 被引用数 (Scopus)

• Unveiling astrocytic control of cerebral blood flow with optogenetics

  Masamoto, K., Unekawa, M., Watanabe, T., Toriumi, H., Takuwa, H., Kawaguchi, H., Kanno, I., Matsui, K., Tanaka, K. F., Tomita, Y. & Suzuki, N., 2015 6月 16, In: Scientific reports. 5, 11455.

  研究成果: Article › 査読

  Open Access

  • Optogenetics 100%
  • Cerebrovascular Circulation 74%
  • Channelrhodopsins 39%
  • Astrocytes 35%
  • Lasers 20%
  52 被引用数 (Scopus)
• 2014

  Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis

  Denny, C. A., Kheirbek, M. A., Alba, E. L., Tanaka, K. F., Brachman, R. A., Laughman, K. B., Tomm, N. K., Turi, G. F., Losonczy, A. & Hen, R., 2014 7月 2, In: Neuron. 83, 1, p. 189-201 13 p.

  研究成果: Article › 査読

  • Neurogenesis 100%
  • Memory 68%
  • Dentate Gyrus 45%
  • Fear 18%
  309 被引用数 (Scopus)

• In Vivo visualization of subtle, transient, and local activity of astrocytes using an ultrasensitive Ca²⁺ indicator

  Kanemaru, K., Sekiya, H., Xu, M., Satoh, K., Kitajima, N., Yoshida, K., Okubo, Y., Sasaki, T., Moritoh, S., Hasuwa, H., Mimura, M., Horikawa, K., Matsui, K., Nagai, T., Iino, M. & Tanaka, K. F., 2014 7月 10, In: Cell Reports. 8, 1, p. 311-318 8 p.

  研究成果: Article › 査読

  • Astrocytes 100%
  • Indicator 94%
  • Calcium(0) 83%
  • yellow cameleon 74%
  • Cell Body 72%
  125 被引用数 (Scopus)

• Optogenetic activation of dorsal raphe serotonin neurons enhances patience for future rewards

  Miyazaki, K. W., Miyazaki, K., Tanaka, K. F., Yamanaka, A., Takahashi, A., Tabuchi, S. & Doya, K., 2014 9月 8, In: Current Biology. 24, 17, p. 2033-2040 8 p.

  研究成果: Article › 査読

  Open Access

  • optogenetics 100%
  • Optogenetics 83%
  • Dorsal Raphe Nucleus 82%
  • Serotonin 71%
  • Reward 62%
  158 被引用数 (Scopus)

• Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage

  Beppu, K., Sasaki, T., Tanaka, K. F., Yamanaka, A., Fukazawa, Y., Shigemoto, R. & Matsui, K., 2014 1月 22, In: Neuron. 81, 2, p. 314-320 7 p.

  研究成果: Article › 査読

  Open Access

  • Optogenetics 100%
  • Acidosis 79%
  • Neuroglia 68%
  • Glutamic Acid 67%
  • Channelrhodopsins 47%
  129 被引用数 (Scopus)

• Optogenetic manipulation of activity and temporally controlled cell-specific ablation reveal a role for MCH neurons in sleep/wake regulation

  Tsunematsu, T., Ueno, T., Tabuchi, S., Inutsuka, A., Tanaka, K. F., Hasuwa, H., Kilduff, T. S., Terao, A. & Yamanaka, A., 2014, In: Journal of Neuroscience. 34, 20, p. 6896-6909 14 p.

  研究成果: Article › 査読

  • melanin-concentrating hormone 100%
  • Optogenetics 84%
  • Sleep 50%
  • Neurons 40%
  • REM Sleep 39%
  149 被引用数 (Scopus)

• Short- and long-term functional plasticity of white matter induced by oligodendrocyte depolarization in the hippocampus

  Yamazaki, Y., Fujiwara, H., Kaneko, K., Hozumi, Y., Xu, M., Ikenaka, K., Fujii, S. & Tanaka, K. F., 2014 8月, In: Glia. 62, 8, p. 1299-1312 14 p.

  研究成果: Article › 査読

  • Oligodendroglia 100%
  • White Matter 82%
  • Hippocampus 72%
  • Action Potentials 41%
  • Microglia 23%
  40 被引用数 (Scopus)
• 2013

  Cerebral Blood Flow Modulation by Basal Forebrain or Whisker Stimulation Can Occur Independently of Large Cytosolic Ca²⁺ Signaling in Astrocytes

  Takata, N., Nagai, T., Ozawa, K., Oe, Y., Mikoshiba, K. & Hirase, H., 2013 6月 13, In: PloS one. 8, 6, e66525.

  研究成果: Article › 査読

  Open Access

  • Vibrissae 100%
  • Basal Forebrain 96%
  • calcium signaling 94%
  • astrocytes 92%
  • Cerebrovascular Circulation 73%
  71 被引用数 (Scopus)

• Influence of inhibitory serotonergic inputs to orexin/hypocretin neurons on the diurnal rhythm of sleep and wakefulness

  Tabuchi, S., Tsunematsu, T., Kilduff, T. S., Sugio, S., Xu, M., Tanaka, K. F., Takahashi, S., Tominaga, M. & Yamanaka, A., 2013 9月 1, In: Sleep. 36, 9, p. 1391-1404 14 p.

  研究成果: Article › 査読

  Open Access

  • Orexins 100%
  • Wakefulness 88%
  • Circadian Rhythm 81%
  • Sleep 59%
  • Neurons 47%
  34 被引用数 (Scopus)
• 2012

  Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation

  Sasaki, T., Beppu, K., Tanaka, K. F., Fukazawa, Y., Shigemoto, R. & Matsui, K., 2012 12月 11, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 50, p. 20720-20725 6 p.

  研究成果: Article › 査読

  Open Access

  • Optogenetics 100%
  • Neuroglia 68%
  • Purkinje Cells 17%
  • Astrocytes 14%
  • Channelrhodopsins 11%
  116 被引用数 (Scopus)

• Expanding the Repertoire of Optogenetically Targeted Cells with an Enhanced Gene Expression System

  Tanaka, K. F., Matsui, K., Sasaki, T., Sano, H., Sugio, S., Fan, K., Hen, R., Nakai, J., Yanagawa, Y., Hasuwa, H., Okabe, M., Deisseroth, K., Ikenaka, K. & Yamanaka, A., 2012 8月 30, In: Cell Reports. 2, 2, p. 397-406 10 p.

  研究成果: Article › 査読

  • Developmental 100%
  • Cell Lineage 86%
  • Drosophila 76%
  • Stem Cells 60%
  • Gene Expression 49%
  127 被引用数 (Scopus)

• Identification of Optogenetically Activated Striatal Medium Spiny Neurons by Npas4 Expression

  Bepari, A. K., Sano, H., Tamamaki, N., Nambu, A., Tanaka, K. F. & Takebayashi, H., 2012 12月 29, In: PloS one. 7, 12, e52783.

  研究成果: Article › 査読

  Open Access

  • Light Blue 100%
  • optogenetics 93%
  • Corpus Striatum 87%
  • Illumination 79%
  • Marker 78%
  23 被引用数 (Scopus)

• Preinspiratory calcium rise in putative pre-Bötzinger complex astrocytes

  Okada, Y., Sasaki, T., Oku, Y., Takahashi, N., Seki, M., Ujita, S., Tanaka, K. F., Matsuki, N. & Ikegaya, Y., 2012 10月, In: Journal of Physiology. 590, 19, p. 4933-4944 12 p.

  研究成果: Article › 査読

  • Astrocytes 100%
  • Calcium 74%
  • Optogenetics 23%
  • Neurons 22%
  • Tetrodotoxin 20%
  51 被引用数 (Scopus)

• Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism

  Baudouin, S. J., Gaudias, J., Gerharz, S., Hatstatt, L., Zhou, K., Punnakkal, P., Tanaka, K. F., Spooren, W., Hen, R., De Zeeuw, C. I., Vogt, K. & Scheiffele, P., 2012 10月 5, In: Science. 338, 6103, p. 128-132 5 p.

  研究成果: Article › 査読

  • Autistic Disorder 100%
  • Rodentia 83%
  • neuroligin 3 63%
  • Neuronal Plasticity 31%
  • Fragile X Syndrome 21%
  216 被引用数 (Scopus)
• 2010

  C-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis

  Shimizu, T., Ishikawa, T., Sugihara, E., Kuninaka, S., Miyamoto, T., Mabuchi, Y., Matsuzaki, Y., Tsunoda, T., Miya, F., Morioka, H., Nakayama, R., Kobayashi, E., Toyama, Y., Kawai, A., Ichikawa, H., Hasegawa, T., Okada, S., Ito, T., Ikeda, Y., Suda, T., & 1 othersSaya, H., 2010 10月 21, In: Oncogene. 29, 42, p. 5687-5699 13 p.

  研究成果: Article › 査読

  • Adipogenesis 100%
  • Osteosarcoma 86%
  • Mesenchymal Stem Cells 74%
  • Peroxisome Proliferator-Activated Receptors 22%
  • Stem Cells 13%
  122 被引用数 (Scopus)
• 2009

  Reversible whole-organism cell cycle arrest in a living vertebrate

  Sampetrean, O., Lida, S. I., Makino, S., Matsuzaki, Y., Ohno, K. & Saya, H., 2009 2月 15, In: Cell Cycle. 8, 4, p. 620-627 8 p.

  研究成果: Article › 査読

  • Oryzias 100%
  • Cell Cycle Checkpoints 88%
  • Vertebrates 81%
  • Cell Cycle 71%
  • Acclimatization 29%
  10 被引用数 (Scopus)
• 2007

  Dendritic cells transduced with autoantigen FCRLA induce cytotoxic lymphocytes and vaccinate against murine B-cell lymphoma

  Inozume, T., Mitsui, H., Okamoto, T., Matsuzaki, Y., Kawakami, Y., Shibagaki, N. & Shimada, S., 2007 12月, In: Journal of Investigative Dermatology. 127, 12, p. 2818-2822 5 p.

  研究成果: Article › 査読

  • Autoantigens 100%
  • B-Cell Lymphoma 93%
  • Fc Receptors 81%
  • Dendritic Cells 81%
  • Antigen 75%
  13 被引用数 (Scopus)